Nature Metabolism, Published online: 04 September 2026; doi:10.1038/s42255-026-01590-0Hepatocyte UBE2N regulates K63-linked ubiquitination of p62 to modulate mitophagy and PANoptosis in the context of MASH and fibrosis.

The mitochondrial phosphatase PPTC7 is required to sustain mammalian metabolism, as its global knockout (KO) triggers hypoketotic hypoglycemia and perinatal lethality in mice. However, the extent to w...

Proteins stalled during endoplasmic reticulum translocation clog Sec61 channels and require translocon quality control (TQC) mechanisms for clearance. Genetic screens implicated the derlin Dfm1 in TQC...

Mitochondria convert nutrients into ATP through coordinated molecular machines and metabolic pathways. Here, the authors show that ATP synthase contacts TCA cycle enzymes in mouse heart and that defec...

Raghu Mirmira, MD, PhD, ENDO 2026 Annual Committee Clinical Science Chair, highlights sessions for Translational Clinical Researchers with three notable sessions, focusing on debates and a "meet the scientist" session relevant to translational research....

BMC Methods - Pancreatic islet transplantation is a promising therapeutic strategy to restore insulin independence in patients with type 1 diabetes mellitus. In addition to primary human islets,...

Aims/hypothesis Loss of islet beta cell function and mass are critical in the pathogenesis of type 2 diabetes, a disease in which ~90% of individuals exhibit islet amyloid deposition. Amyloid deposits...

Some units at the US funding giant are so understaffed, they are focusing on mandated grant renewals rather than new awards.

Pancreatic islets of Langerhans are central to the pathogenesis of all major forms of diabetes. The ability to study human islets ex vivo has advanced our understanding of diabetes and aided in the de...

Mitochondria have a plethora of roles in cells, many of which are related to dynamic changes in their size, shape, and intracellular location. Mitochondrial morphology is commonly assessed by microsco...

When will Chinese research pull ahead of the U.S.’s?

We show that bi-allelic variants in the minor spliceosome snRNAs RNU6ATAC and RNU4ATAC cause early-onset autoimmune diabetes with immune dysregulation. We define a shared mechanism involving U12 intro...

Many programs may be pushed into the next fiscal year, and some could face funding gaps

2026 bracket Welcome to STAT Madness, a bracket-style contest to find the best innovation in science and medicine. Explore groundbreaking innovations from

Who should pay for American science? In the current political climate, many are looking to the private sector to compensate for cuts in public funding. At the Harvard School of Public Health—particula...

Understanding how human pancreatic α and β cell electrical activities mature is critical for building fully functional stem cell–derived (SC-) pancreatic organoids for research and therapeutics. We im...

Mito-nuclear communication extends beyond the cell. This review explores how mitochondrial stress engages UPRmt and ISRmt signaling and scales through mitokines and neural circuits to shape systemic p...

A leader in the global fight against smallpox and a champion of vaccine science, William Foege died last Saturday

Nature Communications - Mitochondrial respiration involves super-complexes whose assembly pathway is debated. Here, authors reveal structural intermediates showing that complex IV matures last,...

Aims/hypothesis In people with type 2 diabetes and obesity, Roux-en-Y gastric bypass (RYGB) can induce remission of diabetes. While RYGB has been reported to improve beta cell function in individuals ...

Diet-induced obesity (DIO) promotes the accumulation of stromal cells with senescent characteristics in the adipose tissue (AT). Selectively clearing these cells—either through chemical senolytics or ...

Cryo-EM structures of hIAPP fibrils extracted from the surgically excised pancreases of patients with type 2 diabetes revealed a distinct fold with unique ligand binding compared to those prepared in vitro.

Trump administration declines to renew appointment of Walter Koroshetz, against NIH director’s wishes

Habener led research that discovered the GLP-1 hormone, a key ingredient in Ozempic and Mounjaro.