Type 1 diabetes (T1D) results from autoimmune destruction of pancreatic β-cells. While anti-CD3 therapy can delay disease progression and preserve residual β-cell function, disease reversal will likel...

Type 1 diabetes proceeds through well-defined stages, from autoantibody positivity in early-stage disease to progressive loss of insulin secretion after diagnosis. Disease-modifying therapies aiming t...

Aims/hypothesis Type 1 diabetes is an autoimmune disease with a strong genetic component. Nevertheless, the genetic underpinnings linking type 1 diabetes susceptibility to both insulin secretion and i...

Signal Transduction and Targeted Therapy - β-cell-targeted RNA activation of vascular endothelial growth factor-A improves islet transplantation

In the prospective, multicentre TEDDY study, distinct patterns of gut microbiome maturation are associated with differential risk of type 1 diabetes, with host genetics modifying the strength of this ...

Pancreatic β cells are essential for glucose homeostasis and are progressively lost during the development of type 1 diabetes. We previously demonstrated that the use-dependent Na+ channel inhibitor, ...

Pancreatic islet macrophages support islet homeostasis and adapt their metabolic program in response to environmental cues, including beta cell released factors. Intercellular mitochondrial transfer i...

Engineered probiotics equipped with a synthetic glucose-responsive circuit transiently colonize the gut and secrete therapeutic factors when glucose levels increase, enabling safe, oral, sense-and-res...

Pancreatic beta cells are dedicated factories in the production, storage and secretion of impressive amounts of insulin. In the human pancreas, beta cells are found in clusters known as islets of Lang...

Mereu et al. present ESPACE, a single-cell multi-omic atlas of the human pancreas spanning fetal development, adulthood, and type 2 diabetes. Combining transcriptomics, chromatin accessibility, and sp...

Clustering and nesting (C&N) arise in many preclinical studies, such as when animals are group-housed or share litters, or in cell culture. Ignoring C&N undermines the validity of analyses. Here, we explain how C&N arise, as well as valid designs and analyses.

A chemical screen identified a PRC2–AR–ETV1–PPP axis that regulates β cell identity features in α cells. An intermediate PPP metabolite, methyl esterified 6-phosphogluconate, induced metabolic reprogr...

The decline in first-phase insulin response (FPIR) during the presymptomatic period of type 1 diabetes (T1D) is well established. In-situ functional studies with pancreas tissue slices showed that β-c...

Aims Especially, the coxsackievirus B group of enteroviruses has been linked to the development of islet autoimmunity and type 1 diabetes in genetically susceptible individuals. Our aim was to study...

Accumulation of DNA damage drives β-cell dysfunction, senescence, and death in type 1 and type 2 diabetes. Although α-cell dysfunction also contributes to

Pancreatic β-cells undergo different stress responses during the development of type 1 diabetes (T1D), such as the type I interferon (IFN) response and senescence. Although the IFN response leads t...

These findings support the existence of biological heterogeneity in disease progression after diagnosis of type 1 diabetes and contribute to an improved understanding of the molecular dynamics associa...

Islet α cells are required for meal tolerance by tuning synchrony, cluster size, and signal propagation of β cell networks.

Islets of Langerhans constitute the endocrine component of the pancreas and comprise the main cell types responsible for the regulation of glucose homeostasis. Beta cells produce and secrete insulin, ...

The human pancreas contains diverse endocrine and exocrine cell populations whose spatial organization is essential for tissue physiology. While single-cell and spatial transcriptomics revealed molecu...

Trimigliozzi et al. show that α-cells integrate neuronal and immune signals to release glucagon, which acts on β-cell glucagon and GLP-1 receptors to drive insulin secretion at fasting glucose concent...

Aims/hypothesis Pancreatic delta cells secrete somatostatin (SST), which can inhibit both alpha cells and beta cells of the pancreatic islet. By controlling insulin and glucagon release, delta cells p...

Coxsackievirus evades CD8+ T cell immunity in the gut, leaving CD4+ T cells as the main line of antiviral defense.

Human pancreatic islets exhibit greater anatomic and cellular heterogeneity than previously appreciated, raising fundamental questions about how their composition varies with age, sex, region, and isl...

SC-β and SC-MReg coaggregates have improved insulin secretion, metabolic function, and reverse hyperglycemia in diabetic mice.

SC-β and SC-MReg coaggregates have improved insulin secretion, metabolic function, and reverse hyperglycemia in diabetic mice.

Type 1 diabetes is a chronic autoimmune disease driven by immune-mediated destruction of pancreatic β-cells. While technological advances in insulin delive

Human pluripotent stem cell-derived islets (SC-islets) offer an excellent medium for human pancreatic disease modelling and mechanistic studies into diabetes. While substantial progress has been made ...

3D mapping of an entire pancreas exposes a marked shift in how residual β cells are organized in late-onset type 1 diabetes.