Endogenous retroelements (EREs) are a subset of transposable elements (TEs) that mobilize via an RNA intermediate. They include retrotransposable elements such as long interspersed nuclear elements (L...

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11th Edition Theme: Targeting Immune Aging | Time: 9:00am-1.15pm NYC; 14:00-18.15h Paris; 10:00am-2.15pm Sao Paulo

11th Edition Theme: Targeting Immune Aging | Time: 9:00am-1.15pm NYC; 14:00-18.15h Paris; 10:00am-2.15pm Sao Paulo

11th Edition Theme: Targeting Immune Aging | Time: 9:00am-1.15pm NYC; 14:00-18.15h Paris; 10:00am-2.15pm Sao Paulo

For decades, research universities have relied on federal funding, with no guarantee that it will last. Now their survival may depend on compliance with the government.

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A preprint by Rivera et al. explores how retroelement expression establishes a tolerogenic environment towards food antigens in the gut, shedding new insights into the immune regulatory role of retroe...

Y-RNA activates RIG-I gain-of-function mutants in the kidney, causing lethal autoimmune diseases including lupus nephritis.

mRNA vaccines have revolutionized vaccine development against infectious diseases, as demonstrated by the rapid creation and deployment of vaccines for SARS-CoV-2. In this chapter, we present a protoc...

It’s the latest salvo against universities, many of whom rely heavily on foreign students for funds.

Author summary Viruses face a critical challenge of disabling or avoiding host immune defenses. Cells typically recognize the presence of a virus through specific molecular markers, including triphosp...

Exogenous messenger RNAs (mRNAs) require cellular machinery for delivery and translation but also encounter inhibitory factors. To investigate their regulation, we performed genome-wide CRISPR screens...

A preprint by Liu et al. shows that resident tissue macrophages in the conventional outflow tract regulate intraocular pressure in the steady state.

Two senior scientists say National Institutes of Health officials advised them to remove references to mRNA vaccines in grant applications, and they fear the Trump administration will abandon a promis...

Move reflects vaccine skepticism of health secretary Robert F. Kennedy Jr.

A preprint by Villar-Vesga et al. shows that monocyte-derived cells in the central nervous system produce mitochondrial reactive oxygen species to promote neuroinflammation.