Nature Reviews Nephrology, Published online: 25 September 2026; doi:10.1038/s41581-026-01128-3Frailty is highly prevalent in patients with chronic kidney disease (CKD) and is associated with increased mortality, hospitalization and disability and with poorer quality of life. This Consensus Statement provides recommendations across four domains covering the assessment of frailty, interventions aimed at targeting the modifiable contributors to frailty in patients with CKD, considerations related to conservative kidney management and kidney replacement therapy, and the management of stage 5 CKD in the presence of frailty.

Nature Reviews Nephrology, Published online: 24 September 2026; doi:10.1038/s41581-026-01127-4In this Review, the authors propose a mitochondria-centred, systems-level interpretation of cardiovascular–kidney–metabolic (CKM) syndrome. They highlight mitochondrial ‘failure modes’ that recur across organs, inter-organ routes by which mitochondrial stress can be sensed or communicated and opportunities for clinical translation.

Nature Reviews Nephrology, Published online: 24 September 2026; doi:10.1038/s41581-026-01135-4An integrated single-cell atlas of hypertension

Nature Reviews Nephrology, Published online: 29 September 2026; doi:10.1038/s41581-026-01111-yGluconeogenesis, nitrogen metabolism and acid–base regulation are fundamental for the maintenance of metabolic homeostasis. This Review describes how these processes form an interconnected triangle, with liver–kidney crosstalk and the hormone glucagon at its core, and discusses how changes in these processes contribute to kidney, liver and metabolic disease.

Nature Reviews Nephrology, Published online: 23 September 2026; doi:10.1038/s41581-026-01123-8This Review examines the dual role of cellular senescence as a crucial physiological process and a potential contributor to kidney ageing and disease. The authors also discuss key considerations for targeting senescence therapeutically in humans and the need to address the current evidence gap between experimental studies and human disease.

The kidney research community needs to change. We're all passionate experts. We care deeply. But we're not seeing the progress that kidney patients need. To be blunt, we need to do more, and faster....

Nature Reviews Nephrology, Published online: 28 September 2026; doi:10.1038/s41581-026-01125-6The aldosterone–mineralocorticoid receptor pathway promotes inflammation, fibrosis, oxidative stress and metabolic alterations. Here, the authors discuss evidence that suggests a role of this pathway as a central therapeutic target to reduce organ dysfunction and improve outcomes in cardiovascular–kidney–metabolic syndrome.

Nature Reviews Nephrology, Published online: 22 September 2026; doi:10.1038/s41581-026-01134-5Enhanced urea uptake promotes bleeding in advanced CKD

Nature Reviews Nephrology, Published online: 21 September 2026; doi:10.1038/s41581-026-01129-2Ciliary dysfunction underlies a broad spectrum of ciliopathies that affect virtually all organ systems, including the kidney. In this Review, the authors discuss how primary cilia regulate signalling pathways in physiological and pathological contexts.

Nature Reviews Nephrology, Published online: 25 September 2026; doi:10.1038/s41581-026-01128-3Frailty is highly prevalent in patients with chronic kidney disease (CKD) and is associated with increased mortality, hospitalization and disability and with poorer quality of life. This Consensus Statement provides recommendations across four domains covering the assessment of frailty, interventions aimed at targeting the modifiable contributors to frailty in patients with CKD, considerations related to conservative kidney management and kidney replacement therapy, and the management of stage 5 CKD in the presence of frailty.

Nature Reviews Nephrology, Published online: 24 September 2026; doi:10.1038/s41581-026-01127-4In this Review, the authors propose a mitochondria-centred, systems-level interpretation of cardiovascular–kidney–metabolic (CKM) syndrome. They highlight mitochondrial ‘failure modes’ that recur across organs, inter-organ routes by which mitochondrial stress can be sensed or communicated and opportunities for clinical translation.

Nature Reviews Nephrology, Published online: 24 September 2026; doi:10.1038/s41581-026-01135-4An integrated single-cell atlas of hypertension

Nature Reviews Nephrology, Published online: 18 September 2026; doi:10.1038/s41581-026-01131-8In this Review, the authors discuss the role of ferroptosis in kidney diseases including acute kidney injury, chronic kidney disease, renal cell carcinoma and polycystic kidney disease. They also highlight the potential of ferroptosis as an early pathological marker and a therapeutic target for the prevention and treatment of these diseases.

Nature Reviews Nephrology, Published online: 18 September 2026; doi:10.1038/s41581-026-01130-9Megalin and cubilin are the main endocytic receptors that bind and retrieve proteins that pass through the glomerular filtration barrier. This Review discusses advances in understanding megalin structure and proximal tubule endocytic pathway organization. It also examines emerging roles for megalin in transcriptional regulation, metabolism and susceptibility to kidney disease.

Nature Reviews Nephrology, Published online: 23 September 2026; doi:10.1038/s41581-026-01123-8This Review examines the dual role of cellular senescence as a crucial physiological process and a potential contributor to kidney ageing and disease. The authors also discuss key considerations for targeting senescence therapeutically in humans and the need to address the current evidence gap between experimental studies and human disease.

Nature Reviews Nephrology, Published online: 22 September 2026; doi:10.1038/s41581-026-01134-5Enhanced urea uptake promotes bleeding in advanced CKD

Nature Reviews Nephrology, Published online: 16 September 2026; doi:10.1038/s41581-026-01126-5Heat extremes associated with climate change are increasingly recognized to have adverse health effects. Here, the authors consider thermoregulatory physiology and examine the evidence connecting heat stress to kidney injury, as well as its potential impact on chronic kidney disease, highlighting research gaps and clinical implications.

Nature Reviews Nephrology, Published online: 21 September 2026; doi:10.1038/s41581-026-01129-2Ciliary dysfunction underlies a broad spectrum of ciliopathies that affect virtually all organ systems, including the kidney. In this Review, the authors discuss how primary cilia regulate signalling pathways in physiological and pathological contexts.

Nature Reviews Nephrology, Published online: 15 September 2026; doi:10.1038/s41581-026-01133-6Indigenous peoples in Aotearoa New Zealand, Australia and the USA experience a disproportionate burden of kidney disease yet remain markedly underrepresented within the nephrologist workforce. These inequities reflect broad failures in institutional accountability. Addressing these failures requires reforms in workforce planning, training and governance, designed around social accountability and Indigenous partnership.

Nature Reviews Nephrology, Published online: 14 September 2026; doi:10.1038/s41581-026-01132-7Approaches for the prevention of kidney disease focus mainly on clinical risk factors but overlook risks embedded in urban planning and governance. Urban policies should be treated as population-level, multisectoral interventions that have potential to influence chronic disease risk. Considerations around kidney health should inform the design of transport, housing and climate policies and be evaluated on the basis of health and equity outcomes.

Nature Reviews Nephrology, Published online: 18 September 2026; doi:10.1038/s41581-026-01131-8In this Review, the authors discuss the role of ferroptosis in kidney diseases including acute kidney injury, chronic kidney disease, renal cell carcinoma and polycystic kidney disease. They also highlight the potential of ferroptosis as an early pathological marker and a therapeutic target for the prevention and treatment of these diseases.

Nature Reviews Nephrology, Published online: 18 September 2026; doi:10.1038/s41581-026-01130-9Megalin and cubilin are the main endocytic receptors that bind and retrieve proteins that pass through the glomerular filtration barrier. This Review discusses advances in understanding megalin structure and proximal tubule endocytic pathway organization. It also examines emerging roles for megalin in transcriptional regulation, metabolism and susceptibility to kidney disease.

Nature Reviews Nephrology, Published online: 16 September 2026; doi:10.1038/s41581-026-01126-5Heat extremes associated with climate change are increasingly recognized to have adverse health effects. Here, the authors consider thermoregulatory physiology and examine the evidence connecting heat stress to kidney injury, as well as its potential impact on chronic kidney disease, highlighting research gaps and clinical implications.

Nature Reviews Nephrology, Published online: 10 September 2026; doi:10.1038/s41581-026-01115-8The repair trajectory after acute kidney injury (AKI) is determined through the interconnected responses of tubular epithelial cells, immune cells and fibroblasts. This Review describes the current understanding of adaptive and maladaptive repair processes after AKI, focusing on relevant signalling cascades, cellular crosstalk and the main drivers of maladaptive repair processes that can lead to the development of chronic kidney disease.

Nature Reviews Nephrology, Published online: 15 September 2026; doi:10.1038/s41581-026-01133-6Indigenous peoples in Aotearoa New Zealand, Australia and the USA experience a disproportionate burden of kidney disease yet remain markedly underrepresented within the nephrologist workforce. These inequities reflect broad failures in institutional accountability. Addressing these failures requires reforms in workforce planning, training and governance, designed around social accountability and Indigenous partnership.

Nature Reviews Nephrology, Published online: 14 September 2026; doi:10.1038/s41581-026-01132-7Approaches for the prevention of kidney disease focus mainly on clinical risk factors but overlook risks embedded in urban planning and governance. Urban policies should be treated as population-level, multisectoral interventions that have potential to influence chronic disease risk. Considerations around kidney health should inform the design of transport, housing and climate policies and be evaluated on the basis of health and equity outcomes.

Nature Reviews Nephrology, Published online: 07 September 2026; doi:10.1038/s41581-026-01124-7Kidney disease is a growing global health challenge, yet research remains fragmented and under-resourced. To realize advances from emerging technologies, kidney research must become more collaborative, data-driven and interdisciplinary. A connected ecosystem from discovery to implementation with equity at its core is essential to translate scientific opportunity into kidney health impact.

Nature Reviews Nephrology, Published online: 10 September 2026; doi:10.1038/s41581-026-01115-8The repair trajectory after acute kidney injury (AKI) is determined through the interconnected responses of tubular epithelial cells, immune cells and fibroblasts. This Review describes the current understanding of adaptive and maladaptive repair processes after AKI, focusing on relevant signalling cascades, cellular crosstalk and the main drivers of maladaptive repair processes that can lead to the development of chronic kidney disease.

Nature Reviews Nephrology, Published online: 04 September 2026; doi:10.1038/s41581-026-01117-6Chronic kidney disease (CKD) is characterized by a pro-inflammatory state that contributes to kidney damage, atherosclerosis and cardiac dysfunction. This Review describes the epidemiology and pathogenesis of inflammation in CKD and outlines the therapeutic rationale for targeting inflammation to improve kidney and cardiovascular outcomes in patients with CKD.

Nature Reviews Nephrology, Published online: 07 September 2026; doi:10.1038/s41581-026-01124-7Kidney disease is a growing global health challenge, yet research remains fragmented and under-resourced. To realize advances from emerging technologies, kidney research must become more collaborative, data-driven and interdisciplinary. A connected ecosystem from discovery to implementation with equity at its core is essential to translate scientific opportunity into kidney health impact.

Nature Reviews Nephrology, Published online: 01 September 2026; doi:10.1038/s41581-026-01120-xNucleic acid sensing is emerging as an important contributor to inflammation and tissue injury in the kidney. Here, the authors provide an overview of key DNA and RNA sensors, discuss evidence of their involvement in kidney pathology and consider the potential of these pathways as therapeutic targets.

Nature Reviews Nephrology, Published online: 04 September 2026; doi:10.1038/s41581-026-01117-6Chronic kidney disease (CKD) is characterized by a pro-inflammatory state that contributes to kidney damage, atherosclerosis and cardiac dysfunction. This Review describes the epidemiology and pathogenesis of inflammation in CKD and outlines the therapeutic rationale for targeting inflammation to improve kidney and cardiovascular outcomes in patients with CKD.

Nature Reviews Nephrology, Published online: 01 September 2026; doi:10.1038/s41581-026-01120-xNucleic acid sensing is emerging as an important contributor to inflammation and tissue injury in the kidney. Here, the authors provide an overview of key DNA and RNA sensors, discuss evidence of their involvement in kidney pathology and consider the potential of these pathways as therapeutic targets.

Nature Reviews Nephrology, Published online: 25 August 2026; doi:10.1038/s41581-026-01121-wCreatine supplementation is unlikely to harm healthy kidneys, but a normal estimated glomerular filtration rate does not guarantee low risk. Adolescents and young adults with reduced nephron endowment, previous kidney disease or additional nephrotoxic exposures require targeted assessment and pragmatic harm reduction, including avoidance of loading and excessive protein intake.

Nature Reviews Nephrology, Published online: 25 August 2026; doi:10.1038/s41581-026-01122-9A podocyte-specific damage score to enable mapping of disease progression

Nature Reviews Nephrology, Published online: 20 August 2026; doi:10.1038/s41581-026-01119-4Missed acute interstitial nephritis diagnoses without a biopsy

Nature Reviews Nephrology, Published online: 25 August 2026; doi:10.1038/s41581-026-01121-wCreatine supplementation is unlikely to harm healthy kidneys, but a normal estimated glomerular filtration rate does not guarantee low risk. Adolescents and young adults with reduced nephron endowment, previous kidney disease or additional nephrotoxic exposures require targeted assessment and pragmatic harm reduction, including avoidance of loading and excessive protein intake.

Nature Reviews Nephrology, Published online: 25 August 2026; doi:10.1038/s41581-026-01122-9A podocyte-specific damage score to enable mapping of disease progression

Nature Reviews Nephrology, Published online: 18 August 2026; doi:10.1038/s41581-026-01118-5People with advanced kidney disease manage a heavy symptom burden in addition to the emotional, mental and social toll of chronic illness and kidney replacement therapy. Addressing misconceptions surrounding palliative care in nephrology might increase incorporation of palliative approaches, thereby improving symptom management and quality of life.

Nature Reviews Nephrology, Published online: 20 August 2026; doi:10.1038/s41581-026-01119-4Missed acute interstitial nephritis diagnoses without a biopsy

Nature Reviews Nephrology, Published online: 13 August 2026; doi:10.1038/s41581-026-01116-7Despite unprecedented advances in the treatment of non-diabetic chronic kidney disease (CKD) and CKD in type 2 diabetes mellitus in the past decade, no new drugs have been approved for CKD in type 1 diabetes mellitus. Urgent action is needed to develop new therapies and improve outcomes for this population.

Nature Reviews Nephrology, Published online: 18 August 2026; doi:10.1038/s41581-026-01118-5People with advanced kidney disease manage a heavy symptom burden in addition to the emotional, mental and social toll of chronic illness and kidney replacement therapy. Addressing misconceptions surrounding palliative care in nephrology might increase incorporation of palliative approaches, thereby improving symptom management and quality of life.

Nature Reviews Nephrology, Published online: 12 August 2026; doi:10.1038/s41598-026-62801-yModel-free multiparametric analysis of SHG images reveals collagen signatures in breast cancer

Nature Reviews Nephrology, Published online: 12 August 2026; doi:10.1038/s41598-026-64954-2AlzheiNN: a convolutional neural network-based model for Alzheimer’s disease classification

Nature Reviews Nephrology, Published online: 12 August 2026; doi:10.1057/s41599-026-08677-9The impact of CEOs’ multidisciplinary backgrounds on corporate financing and investment maturity mismatch

Nature Reviews Nephrology, Published online: 12 August 2026; doi:10.1038/s41598-026-66068-1Multi-level violence recognition via hybrid convolutional-attention and recurrent architectures