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Yohsuke T. Fukai

@fukaity.bsky.social
48 followers 80 following 15 posts

Associate Professor, Kyushu University Twitter: twitter.com/fukaity HP: yfukai.net

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Reposted by Yohsuke T. Fukai
Christophe 🔬 Leterrier @christlet.bsky.social · 02/09/2026
Really cool! Smaller than GFP and reversibly binding last-generation rhodamine dyes. De novo pan-rhodamine binders for fluorescence microscopy from mammalian cells to extremophiles www.cell.com/cell/fulltex... Congrats @bohuang.bsky.social @rhodamine110.bsky.social @mullinslab.bsky.social et al
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Yohsuke T. Fukai @fukaity.bsky.social · 02/09/2026
Delighted to share that I've joined Kyushu University as an Associate Professor in the Department of Physics! I'm looking forward to working on nonequilibrium physics and biophysics with students here. Feel free to reach out about JSPS postdoc opportunities or collaborations!
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Reposted by Yohsuke T. Fukai
RIKEN Center for Biosystems Dynamics Research (BDR) @riken-bdr.bsky.social · 28/11/2025
Yohsuke T. Fukai, Kyogo Kawaguchi, et al. reconstituted gene-scale #chromatin arrays with controlled #histone modification patterns in vitro and showed that heterogeneous #acetylation alone can drive pattern-dependent changes in chromatin architecture and dynamics. doi.org/10.1126/scia...
doi.org
Gene-scale in vitro reconstitution reveals histone acetylation directly controls chromatin architecture
Reconstituting 20-kb chromatin shows that tuning acetylation alone reshapes its folding, dynamics, and contact domain formation.
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Reposted by Yohsuke T. Fukai
Jean-Yves Tinevez @jytinevez.bsky.social · 20/11/2025
We just released a new major version of TrackMate (v8), the cell and organelle tracking plugin of Fiji. It ships many new features, detailed below, but that are articulated around the following:
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Reposted by Yohsuke T. Fukai
Kyogo Kawaguchi @kyogok.bsky.social · 20/11/2025
To probe gene-scale chromatin physics, we built 96-mer (20 kb) arrays with defined histone marks. Combining single-molecule tracking, AFM imaging, and developing in vitro Hi-C, we saw how specific modifications dictate chromatin structure and dynamics. www.science.org/doi/10.1126/...
science.org
Gene-scale in vitro reconstitution reveals histone acetylation directly controls chromatin architecture
Reconstituting 20-kb chromatin shows that tuning acetylation alone reshapes its folding, dynamics, and contact domain formation.
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Yohsuke T. Fukai @fukaity.bsky.social · 20/11/2025
Published in Science Advances! Looking forward to discussing the implications of our results and their applications with many researchers. www.science.org/doi/10.1126/...
science.org
Gene-scale in vitro reconstitution reveals histone acetylation directly controls chromatin architecture
Reconstituting 20-kb chromatin shows that tuning acetylation alone reshapes its folding, dynamics, and contact domain formation.
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Yohsuke T. Fukai @fukaity.bsky.social · 31/10/2025
I truly appreciate the organizers, core contributors, and all attendees for this wonderful opportunity! I enjoyed learning and working on napari in a welcoming environment. Those interested in talking about and contributing to napari, let’s join the regular community meeting together!
napari.org
Community
There are several different ways to be a part of the napari community. From being a code or documentation contributor, to creating educational content or examples, you are welcome to help develop and ...
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Reposted by Yohsuke T. Fukai
napari @napari.org · 30/10/2025
Longer wrap-up to come, but in the meantime: we had a fantastic and productive time at the napari hackathon at @globias.bsky.social 2025 conference! Thanks to all the participants and to the GloBIAS team for hosting us!
napari core team members coding with community members at the GloBIAS 2025 hackathon at RIKEN BDR in Kobe, Japan.napari core team members and community members in a discussion at the GloBIAS 2025 hackathon at RIKEN BDR in Kobe, Japan.napari core team members coding with community members at the GloBIAS 2025 hackathon at RIKEN BDR in Kobe, Japan.napari core team members and community members posing together for a group photo on a staircase at the GloBIAS 2025 hackathon at RIKEN BDR in Kobe, Japan.
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Reposted by Yohsuke T. Fukai
Ulrike Endesfelder @uendesfelder.bsky.social · 22/10/2025
Last call for Les Houches! Apply now or never! ;) (ok, in 2 years again then) and share with your friends.
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Reposted by Yohsuke T. Fukai
Kyogo Kawaguchi @kyogok.bsky.social · 23/05/2025
Call for RIKEN ECL Team / Unit Leaders. In my (biased) opinion, this is probably the best option if you are seeking an independent position in Japan. I will be happy to chat/answer questions via email. www.riken.jp/en/careers/p...
riken.jp
FY 2025 Call for RIKEN ECL Team / Unit Leaders
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Reposted by Yohsuke T. Fukai
Sergio Cruz-León @sergiocruzleon.bsky.social · 11/04/2025
Excited to share our preprint on the molecular architecture of heterochromatin in human cells 🧬🔬w/ @jpkreysing.bsky.social, @johannesbetz.bsky.social, @marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social 🔗 Preprint here tinyurl.com/3a74uanv
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Reposted by Yohsuke T. Fukai
Kyogo Kawaguchi @kyogok.bsky.social · 13/03/2025
Congratulations to Zihui, Sano-san, and the team on this interesting work! They found that +1 topological defects attract neural progenitors—an observation that seems at odds with expectations for an extensile active nematic. www.nature.com/articles/s41...
nature.com
Integer topological defects offer a methodology to quantify and classify active cell monolayers - Nature Communications
The orientation of elongated cells often rotates once around the center in tissue. Such structures are called +1 topological defects and play some roles in biological development. By inducing various ...
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Reposted by Yohsuke T. Fukai
Kyogo Kawaguchi @kyogok.bsky.social · 14/02/2025
I feel like this post is becoming even more relevant for our early-career researcher friends in the US—unless it’s already too late. It doesn’t have to be our lab or RIKEN; if you’re interested in coming to Japan, I’m always happy to chat!
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Reposted by Yohsuke T. Fukai
Kyogo Kawaguchi @kyogok.bsky.social · 04/02/2025
Starting in April 2025, our RIKEN Hakubi Lab will transition to a Chief Scientist Lab, and we plan to move to Wako in 2026. My affiliation with the IPI, Department of Physics at The University of Tokyo, will continue as before.
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Reposted by Yohsuke T. Fukai
Luis G. Palma @luigalpal.bsky.social · 06/01/2025
In vitro synthesis of up to 96 nucleosomes. Amazing platform to study chromatin folding!! Gene-scale in vitro reconstitution reveals histone acetylation directly controls chromatin architecture | BioRxiv #chromatin #nucleosome #3Dchromatin #preprint www.biorxiv.org/content/10.1...
biorxiv.org
Gene-scale in vitro reconstitution reveals histone acetylation directly controls chromatin architecture
Chromatin organization plays a crucial role in gene regulation [[1][1], [2][2], [3][3]], but disentangling the contributions of various epigenetic components to gene-scale chromatin structure remains ...
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Yohsuke T. Fukai @fukaity.bsky.social · 05/01/2025
Re-posting from my twitter: LapTrack ( github.com/yfukai/laptr... ) provides you the linear-assignment based robust tracking algorithm, aware of splitting and merging particles, in a simple, Pythonic and flexible API. Installable with “pip install laptrack”.
github.com
GitHub - yfukai/laptrack: Particle tracking by solving linear assignment problem.
Particle tracking by solving linear assignment problem. - yfukai/laptrack
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Yohsuke T. Fukai @fukaity.bsky.social · 05/01/2025
Thrilled to share our latest preprint on bioRxiv! 🎉 This collaboration with @kyogok.bsky.social and lab members, Kurumizaka lab(Kujirai-san in particular!) and Umehara lab sheds new light on how histone modification shapes chromatin architecture. 1/5 biorxiv.org/content/10.1...
biorxiv.org
Gene-scale in vitro reconstitution reveals histone acetylation directly controls chromatin architecture
Chromatin organization plays a crucial role in gene regulation [[1][1], [2][2], [3][3]], but disentangling the contributions of various epigenetic components to gene-scale chromatin structure remains ...
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Reposted by Yohsuke T. Fukai
Kyogo Kawaguchi @kyogok.bsky.social · 27/11/2024
And our new preprint! "Gene-scale in vitro reconstitution reveals histone acetylation directly controls chromatin architecture", biorxiv (2024). Led by Yohsuke T Fukai, in collaboration with Kurumizaka lab (U Tokyo) and Umehara lab (RIKEN BDR). www.biorxiv.org/content/10.1...
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