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semeigazin.bsky.social

@semeigazin.bsky.social

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semeigazin.bsky.social @semeigazin.bsky.social · 29/07/2025

My intern, Shakhira, completed her NIG-INTERN 2025 Summer #Research Program! I am very proud of her! Similar to what I did in my HCB #paper (link.springer.com/article/10.100…), she isolated several #mutant human cell lines and conducted single-nucleosome #imaging experiments in them.

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semeigazin.bsky.social @semeigazin.bsky.social · 16/07/2025

My #PhD defense work is on #Biorxiv! Link: biorxiv.org/content/10.110… Using single-molecule #imaging, we showed that liquid-like BRD4-NUT condensates locally constrain #chromatin via #bromodomain-dependent crosslinking. I thank my supervisor, Prof. @kazu-maeshima.bsky.social, for his support!

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Kazuhiro Maeshima @kazu-maeshima.bsky.social · 10/07/2025

Our new preprint 🧬🔗 www.biorxiv.org/content/10.1... BRD4-NUT forms liquid-like condensates that locally constrain nucleosomes via BRD4-mediated crosslinking— physical control of #chromatin by #LLPS transcription condensates. @semeigazin.bsky.social @katsuminami.bsky.social @masaashimazoe.bsky.social

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Kazuhiro Maeshima @kazu-maeshima.bsky.social · 18/06/2025

Our new review paper is out@JMB!🧬 @katsuminami.bsky.social‬ @semeigazin.bsky.social‬ ‪@kakonakazato.bsky.social‬ discuss DNA accessibility in euchromatin and heterochromatin of live cells. Free access: authors.elsevier.com/a/1lHgb54HFZ... Also check our previous work: www.science.org/doi/10.1126/...

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Kazuhiro Maeshima @kazu-maeshima.bsky.social · 07/03/2025

Using single-H1 imaging and computational modeling, we show that most H1 behaves like a liquid inside chromatin domains rather than binding stably to nucleosomes as in the textbook model. Congrats @masaashimazoe.bsky.social & all contributors! 🎉 2/ 🔗 bit.ly/4h7S3Dn

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Masa A. Shimazoe @masaashimazoe.bsky.social · 10/03/2025

My first, first author paper is now on bioRxiv! 🤩 Linker histone H1 is a liquid-like "glue" condensing chromatin, which revises textbooks! 📖✨ biorxiv.org/content/10.1... Huge thanks to my PI, @kazu-maeshima.bsky.social, for supervision. Amazing collab with @rcollepardo.bsky.social’s group!" (1/n)

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Kazuhiro Maeshima @kazu-maeshima.bsky.social · 07/03/2025

Our new preprint is out＠bioRxiv: www.biorxiv.org/content/10.1... @masaashimazoe.bsky.social et al. reveal that linker histone H1 acts as a liquid-like glue to organize chromatin in living cells. 🎉 Fantastic collab with @rcollepardo.bsky.social @janhuemar.bsky.social and others—huge thanks! 🙌 1/

semeigazin.bsky.social @semeigazin.bsky.social · 12/11/2024

We are finally published in HCB journal! My sincere gratitude to all co-authors who made it possible, and separate thanks to my supervisor, Dr. Kazuhiro Maeshima, for his strong initiative to reporting our important findings! PDF link: rdcu.be/dHXJF