The Max Planck Institute for Molecular Biomedicine in Münster, Germany, has an opening for a

Tran et al. determined that the protein deacetylase SIRT7 is degraded during senescence by the E3 ligase TRIP12. SIRT7 binds to NUCKS1 and, upon SIRT7 loss, NUCKS1 is acetylated and recruited onto chromatin, where it regulates genes involved in senescence and aging. This SIRT7-NUCKS1 relationship was also demonstrated during liver aging.

Ageing is characterised by persistent low-grade inflammation that is linked to impaired tissue homeostasis and functionality. However, the molecular mechanisms driving age-associated inflammation rema...

Ageing is characterised by persistent low-grade inflammation that is linked to impaired tissue homeostasis and functionality. However, the molecular mechanisms driving age-associated inflammation rema...

Nature Reviews Molecular Cell Biology - Communication between the circadian clocks of different cell and tissue types supports the daily rhythms of homeostatic processes that maintain bodily...