iiinova — where your digital self keeps evolving

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Allergy EAACI @allergy-eaaci.bsky.social · 05/10/2026

Open Access: Revisiting Platelet-Activating Factor in Asthma: An Exploratory Metabolomics Analysis of PAF C-18:1 and Type 2 Inflammation. Noeul Kang, Young Jin Pyung, Deog Kyeom Kim, Cheol-Heui Yun, Hyun Woo Lee 👉 doi.org/10.1111/all.70499 #Allergy_journal journalallergy.com

Kang and Pyung et al., investigate type 2 inflammation mediated by various platelet-activating factors (PAF) in asthma and their association with achieving clinical remission. Only PAF C18:1 was found to be inversely associated with T2 inflammatory markers, in contrast to other PAF species detected in the plasma of asthma patients (alkyl-PAF and lyso-PAF). The authors suggest a structure-dependent relationship, whereby the double bond in PAF C18:1 may alter receptor binding or signaling.

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Allergy EAACI @allergy-eaaci.bsky.social · 06/10/2026

Open Access: Initial OX40–OX40L Signaling Promotes a Skin-Resident Memory T-Cell Reservoir in Atopic Dermatitis. First author: Takayoshi Komatsu-Fujii; corresponding authors: Ryota Asahina, Toshiaki Kogame, Kenji Kabashima Read the article: doi.org/10.1111/all.70493 #Allergy_journal

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Allergy EAACI @allergy-eaaci.bsky.social · 30/09/2026

Open Access: Human IgE Antibodies Recognize the Vicilin and Alpha-Hairpinin Domains of Peanut Allergen Ara h 1. First author: Taylor M. Cosey; corresponding author: Geoffrey A. Mueller Read the article here: doi.org/10.1111/all.70495

The ɑ-hairpinin of Ara h 1 contains a dominant epitope that is both frequently recognized and blocks a majority of the IgE against this domain. Including this region in tests may improve diagnosis of peanut allergy. The trimeric structure of the vicilin region explains the ability of Ara h 1 to induce anaphylaxis with a single antibody.

Read more articles published in #Allergy on #foodallergy here: journalallergy.com/Food-Allergy-and-Gastrointestinal-Disease
#Allergy_journal

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Allergy EAACI @allergy-eaaci.bsky.social · 01/10/2026

Open Access: Need to Assess On-Demand Versus Continuous Treatment in Allergic Rhinitis in ARIA-EAACI Guidelines. Corresponding author: Jean Bousquet Read the article here: doi.org/10.1111/all.70498

There is ongoing discussion on whether patients with allergic rhinitis should receive continuous long-term or on-demand treatment. In this Letter, Bousquet et al., point to the low medication adherence observed in MASK-air studies and by physicians with allergic rhinitis. The study recognizes that this data was obtained from selected populations and that there is a need for dedicated guideline recommendations.

Read more articles published in #Allergy on #rhinitis here: journalallergy.com/Rhinitis-Sinusitis-Upper-Airways

#Allergy_journal

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Allergy EAACI @allergy-eaaci.bsky.social · 18/09/2026

Efficacy of Full and Limited Endoscopic Sinus Surgery in Chronic #Rhinosinusitis With Nasal Polyps: A Randomised Controlled Trial. First author: Paula Virkkula 👉 doi.org/10.1111/all.70438 #Allergy_journal Read more articles: journalallergy.com/Rhinitis-Sinusitis-Upper-Airways

Both Full and Limited FESS result in clinically meaningful relief of disease-specific health-related quality of life (HRQoL) and nasal breathing, effectively improving nasal symptoms and sleep disturbance in chronic rhinosinusitis with nasal polyps (#CRSwNP) patients. Clinically meaningful differences in decreases of SNOT-22 scores (22-item Sino-nasal Outcome Test) between the groups were not found at 12- and 24–month follow-up. Differences in improvement of anosmia, and decreases in polyp load were seen between the groups.

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Allergy EAACI @allergy-eaaci.bsky.social · 21/09/2026

Open Access: Efficacy and Safety of Intralymphatic Immunotherapy With Grass Allergoid and Microcrystalline Tyrosine: A Double-Blind Randomised Placebo-Controlled Trial. First authorLara Šošić; corresponding author: Pål Johansen Read the article here: doi.org/10.1111/all.70463

This is the first randomised placebo-controlled trial of intralymphatic #immunotherapy using a microcrystalline tyrosine-adjuvanted grass pollen allergoid. Three ultrasound-guided intralymphatic immunotherapy (ILIT) injections were well tolerated and reduced combined symptom-medication scores compared with placebo. The findings support further optimisation and clinical development of allergoid-based ILIT for #grasspollen allergy.

#Allergy_journal
Read more articles published in #Allergy on allergen immunotherapy here: journalallergy.com/Allergen-Specific-Immunotherapy

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Allergy EAACI @allergy-eaaci.bsky.social · 17/09/2026

Tezepelumab Reverses TSLP-Driven Immunometabolic Rewiring in Human cDC2s Underlying Pathogenic Th2 and Dysfunctional Treg Responses. First author: Leticia Martín-Cruz; corresponding author: Oscar Palomares 🌟 doi.org/10.1111/all.70470

This study aimed to determine whether thymic stromal lymphopoietin (TSLP) induces a pathogenic immunometabolic program in human type 2 conventional dendritic cells (cDC2s) and whether tezepelumab can directly reverse this process. TSLP rewires human cDC2 metabolism by increasing both glycolysis and mitochondrial oxidative phosphorylation. This metabolic shift drives a pro-type 2 phenotype required to generate pathogenic Th2 cells and functionally impaired FOXP3+ Tregs. Tezepelumab effectively restores normal metabolic and functional properties in cDC2s, inhibiting Th2 polarization and rescuing Treg function.

#Allergy_journal
Read more articles published in #Allergy on basic and clinical immunology here: https://journalallergy.com/Basic-and-Translational

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Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 08/09/2026

Here's another excellent study supporting my developing Regulation Theory of Aging wherein loss of physiological regulation underpins all #aging phenotypes "structural aging is coordinated across organs within individuals" credit to researchers @sbpdiscovery.bsky.social #science 🧪 #GeroSky

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Allergy EAACI @allergy-eaaci.bsky.social · 11/09/2026

Melittin in AllergoOncology: From Honey Bee Venom to Anti-Cancer Therapeutic Innovation—An #EAACI Position Paper Corresponding author: Teodorikez-Wilfox Jimenez-Rodriguez 👉 doi.org/10.1111/all.70421 #Allergy_journal Read more articles published in #Allergy here: journalallergy.com

With over 100 references, this #EAACI Position Paper reviews the potential of the honey bee venom allergen melittin as a potential candidate for the treatment of cancer. It provides mechanistic insights into its anti-tumor activity across various types of cancer, safety considerations, limitations and advancements.

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Allergy EAACI @allergy-eaaci.bsky.social · 13/09/2026

Open access: Serum‐Proteomic Profiling Reveals Distinct #AtopicDermatitis Severity‐Linked Signatures. First author: Jag S. Lally; corresponding author: Anna De Benedetto 👉 doi.org/10.1111/all.70464 #Allergy_journal More articles 👉 journalallergy.com/Atopic_Dermatitis_Urticaria_and_Skin_Disease

This study aimed to identify a set of serum biomarkers that robustly distinguish prespecified severe from mild atopic dermatitis groups. Serum proteomic profiling distinguishes severe from mild atopic dermatitis, revealing an epithelial-enriched severity footprint linked to lactate dehydrogenase (LDH)-associated tissue injury and Th2/Th22 inflammation. Machine learning identified a 9-protein biomarker signature that discriminated severity groups with high cross-validation accuracy (AUC = 0.989).

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Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 07/09/2026

Conclusion: Tumor-targeted multifunctional extracellular vesicles — selective and enhanced tumor-targeted cell killing in vitro — opportunity for developing EV-based drug carriers for cancer therapy

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Allergy EAACI @allergy-eaaci.bsky.social · 03/09/2026

Open access: Distinct Gene Expression Profiles of Ara h 2‐Specific B Cells in Desensitization and Tolerance During Peanut Oral Immunotherapy. First author: Stephan R. Schneider; corresponding author: Mübeccel Akdis Read the article here: doi.org/10.1111/all.70472

Gene expression of Ara h 2-specific B cells over the course of the peanut oral #immunotherapy (OIT). Isotype of allergen-specific B cells changes through OIT towards IgG4. Peanut OIT changes the gene expression of allergen-specific memory B cells. OIT patients showed increased gene expression for regulatory B cells and immune regulation. Desensitized patients had upregulated antiviral genes compared to tolerant patients.

#Allergy_journal
Read more articles published in #Allergy on #foodallergy here: journalallergy.com/Food-Allergy-and-Gastrointestinal-Disease

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Allergy EAACI @allergy-eaaci.bsky.social · 04/09/2026

Plasma Metabolomes Identify Distinct #Asthma Metabotypes: Findings From the COREA Cohort. First authors: Woori Chae, Jin An; corresponding authors: Joo-Youn Cho, Tae-Bum Kim 👉 doi.org/10.1111/all.70469 #Allergy_journal Read more articles 👉 journalallergy.com/Asthma-Lower-Airways

This study aimed to identify metabolic subgroups (metabotypes) of adult #asthma using plasma metabolomics, with potential implications for personalized treatment. Four metabotypes with distinct lipid-class signatures were identified. Group 1 had elevated ether-linked phosphatidylcholines with young, female-predominant early onset; Group 2 showed elevated lyso-phosphatidylcholines and altered amino acid metabolism; Group 3 exhibited reduced sphingomyelins and phosphatidylcholines in middle-aged, non-obese patients; and Group 4 demonstrated elevated triacylglycerols and diacylglycerols with the highest body mass index.

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Allergy EAACI @allergy-eaaci.bsky.social · 05/09/2026

Simultaneous Dual Type 2 Biologic Therapy Improves Sinonasal Outcomes in Selected Patients With Chronic Rhinosinusitis With Nasal Polyps. Corresponding author: Friederike Bärhold Read the article here: doi.org/10.1111/all.70452 #Allergy_journal

Data from 34 patients with severe chronic rhinosinusitis with nasal polyps (CRSwNP) were collected retrospectively from 6 European study centers. Patients showed high type-2 comorbidity burden, supporting dual therapy as a potential option in complex type-2 diseases. Significant improvements were observed in SNOT-22, olfactory function, and nasal polyp score after 6 months compared to baseline with single biologic therapy.

Read more articles published in #Allergy on #rhinitis here: journalallergy.com/Rhinitis-Sinusitis-Upper-Airways

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Allergy EAACI @allergy-eaaci.bsky.social · 06/09/2026

Effect of Abrocitinib on the Skin Microbiome in Patients with Moderate‐to‐Severe Atopic Dermatitis. First author: Madeline Kim; corresponding author: Emma Guttman-Yassky 👉 doi.org/10.1111/all.70467 Watch the video abstract here: youtube.com/watch?v=03MspazqW0E #Allergy_journal

Atopic dermatitis (AD) is characterized by microbial dysbiosis. This study aimed to evaluate the effects of abrocitinib, a JAK1-selective inhibitor, on the skin microbiome and its potential associations with clinical outcomes in patients with AD. Abrocitinib treatment was associated with increased skin microbial diversity and decreased Staphylococcus aureus burden over 12 weeks that corresponded with efficacy improvements. %BSA, percentage of body surface affected; AD, atopic dermatitis; EASI, Eczema Area and Severity Index; FCH, fold change; IGA, Investigator's Global Assessment; Jak1, Janus kinase 1; PP-NRS, Peak Pruritus Numerical Rating Scale.

Read more articles published in #Allergy here: journalallergy.com/

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Nicholas (@ultimape) Perry @ultimape.bsky.wovensoup.com · 31/08/2026

Vaccine injury, adverse events & retrogenicity is reduced wnd can be avoided by having a healthy gut microbiome. In particular, the inflammatory M1 macrophage expression can be reduced, which reduces my mycarditis even in non-vaccinated people, facilitates recovery. academic.oup.com/eschf/articl...

academic.oup.com

Gut Microbiota-Related Modulation of Immune Mechanisms in Post-Infarction Remodelling and Heart Failure

Abstract. The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune ef

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Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 29/08/2026

Month of #vegan vs. #carnivore #diet? www.verywellhealth.com/vegan-reduce... — epigenetic changes reduce #cancer risk, slow #aging — reduces pro-inflammatory white blood cells — increases anti-inflammatory CD4+ T cells via @miramiller.bsky.social verywellheath #plantbased #health #lifestyle

verywellhealth.com

1 Month of Eating Vegan May Reduce Inflammation and Slow Aging, Study Shows

A new study suggests just a month of plant-based eating can reduce inflammation slow biological aging.

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Allergy EAACI @allergy-eaaci.bsky.social · 29/08/2026

Open access: m6A-Related Regulation of Ferroptosis Contributes to Nasal Epithelial Barrier Dysfunction in Allergic Rhinitis. First author: Zehua Lin; corresponding authors: Zuhong He, Xiong Chen Read the article here: doi.org/10.1111/all.70476 #Allergy_journal

This study uses human nasal epithelial cells and BALB/c mice to evaluate the role and molecular mechanism of ferroptosis in house dust mite (HDM)-induced allergic #rhinitis (AR), focusing on ferroptosis-related responses and nasal #epithelialbarrier disruption. HDM exposure induces lipid peroxidation-driven ferroptosis and epithelial barrier disruption. GPX4 protects against this damage, whereas GAS1 promotes ferroptosis by suppressing GPX4, a mechanism validated in GAS1-knockdown mice.

Read more articles published in #Allergy on #rhinitis here: journalallergy.com/Rhinitis-Sinusitis-Upper-Airways

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Allergy EAACI @allergy-eaaci.bsky.social · 28/08/2026

Open Access: Postcode-Level Variation and Environmental Determinants of Respiratory Allergies in a Large German Cohort. First author: Trang Dao-Siebel; corresponding author: Evelyn Lamy 👉 doi.org/10.1111/all.70406 Read more articles 👉 journalallergy.com/climate-change #allergy_journal

Young children (0–9 years) and residents of urban areas appeared particularly vulnerable to respiratory allergy development and exacerbation. Incidence showed nonlinear associations with particular matter 10 (PM10) PM2.5, temperature, and alder/birch pollen, while dispensed prescribed medication rate showed similar patterns, except for NO2 and the interaction O3*NO2. Combined reductions in PM10 exposure and alder pollen may have the greatest potential to reduce respiratory allergy burden.

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Allergy EAACI @allergy-eaaci.bsky.social · 24/08/2026

Open Access: Clinical Features of Cellular Senescence Pathways in Severe Asthma. First author: Woo-Jung Song; corresponding author: Kian Fan Chung 👉 doi.org/10.1111/all.70416 #Allergy_journal Read more articles published in #Allergy on #asthma here: journalallergy.com/Asthma-Lower-Airways

In bronchial biopsies, senescence-associated secretory phenotype (SASP) and p53 pathway enrichment scores are elevated in severe asthma versus non-severe asthma and healthy controls. SASP enrichment is validated in the independent Newcastle severe asthma cohort (NOVA). SASP enrichment is also elevated in nasal brushings of participants with nasal polyps, independently of asthma status. Senescence pathway enrichment associates with exacerbations, daily oral corticosteroid (OCS), lower post-bronchodilator (post-BD) forced expiratory volume in 1 s (FEV1%) and macrophage/oxidative phosphorylation (OXPHOS) signatures, but not with Th2/eosinophil signatures, supporting a non-T2 mechanism.

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shahriyar-ssk.bsky.social @shahriyar-ssk.bsky.social · 08/05/2026

New review in the European Journal of Pediatrics From air pollution and heat stress to wildfires, evidence links climate-related exposures to respiratory, neurological, metabolic, and perinatal harms in children. link.springer.com/article/10.1...

link.springer.com

Climate change and child health in Europe: a scoping review of emerging impacts - European Journal of Pediatrics

Children are extremely vulnerable to climate-related environmental impacts and air pollution due to both biological and behavioral factors. Despite the emerging evidence of the increasing effects of c...

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Allergy EAACI @allergy-eaaci.bsky.social · 26/08/2026

Open Access: Differential Roles for IL-4Rα and IL-13Rα1 in Immune Cell Infiltration and Epithelial Remodeling in Experimental Eosinophilic Gastritis. First author: Anish Dsilva; corresponding author: Ariel Munitz 👉 doi.org/10.1111/all.70420 #Allergy_journal

This study described the development of an experimental model for eosinophilic gastritis (EoG). Experimental EoG recapitulates histopathological features of human disease, including foveolar elongation, fibrosis, eosinophilia, mastocytosis and shared transcriptional programs. Eosinophilia and mastocytosis were regulated by IL-4Rα, whereas mucosal thickening and foveolar elongation were regulated by IL-4Rα and IL-13Rα1.

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Allergy EAACI @allergy-eaaci.bsky.social · 21/08/2026

M. Czarnobilska, M. Bulanda, E. Czarnobilska, et al.“Influence of Environmental Pollution on Basophil Reactivity to Birch Pollen Allergens in Atopic and Non-Atopic Subjects,” 👉 doi.org/10.1111/all.70474 #Allergy_journal Watch more videos👉 youtube.com/@Allergy-TV www.youtube.com/watch?v=ri9-...

youtube.com

Environmental Pollution on Basophil Reactivity to Birch Pollen in Atopic and Non-Atopic Subjects

YouTube video by Allergy

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APC Microbiome Ireland @apcmicrobiomeirel.bsky.social · 18/08/2026

Why is everyone’s microbiome different? Diet, age, medicines, environment and lifestyle can all shape our microbial communities. No two microbiomes are exactly alike and there isn’t one single “perfect” microbiome. #MicrobiomeMatters #Microbiome #GutMicrobiome #Microbiology #Microsky

Infographic stating "Why everyone's gut microbiome is different" with a central stylized intestine and five influences: diet; medicines (especially antibiotics); age; environment (home, travel, pets); and lifestyle (sleep, stress, activity).

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Allergy EAACI @allergy-eaaci.bsky.social · 22/08/2026

Open Access: Algorithms in Allergy: Diagnosis of Concomitant Inducible Laryngeal Obstruction in Adults With Asthma. Andrew P. Hearn, Claire Slinger, Jennifer M. Butler, Jemma Haines, James Hull, Stephen J. Fowler Read the article here: doi.org/10.1111/all.70425

Inducible laryngeal obstruction (ILO) and #asthma have distinct pathophysiological mechanisms and present different clinical symptoms. This article outlines clinical features to distinguish between the two and a medical diagnostic algorithm for identifying ILO in patients with asthma. It further summarizes treatment options for confirmed cases.

#Allergy_journal
Read other medical algorithms published in #Allergy here: journalallergy.com/Asthma-Lower-Airways

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Allergy EAACI @allergy-eaaci.bsky.social · 20/08/2026

Open Access: Determinants of Poor Health-Related Quality of Life in Patients With Food Allergy. First author: Rosialzira Natasha Vera-Berrios; corresponding author: Montserrat Fernández-Rivas Read the article here: doi.org/10.1111/all.70418

Machine-learning analysis of 502 well-characterised food-allergic patients was used to identify key determinants of poor food allergy-health-related quality of life (FA-HRQL), defined as FAQLQ ≥ 5. The most relevant predictors were adult age, female sex, multiple food allergies, severe reactions, need for urgent care, onset before 18 years, and longer disease duration. Adult women with multiple food allergies showed the poorest FA-HRQL.

#Allergy_journal
Read more articles published in #Allergy on #foodallergy here: journalallergy.com/Food-Allergy-and-Gastrointestinal-Disease

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shahriyar-ssk.bsky.social @shahriyar-ssk.bsky.social · 06/10/2025

Our study showed how exhaled metabolites can help classify asthma control and predict attacks in children, published @atsblueeditor.bsky.social nearly a year ago and still sparking interest! If you haven't already, read it here: t.co/DCGk0WaTd5

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APC Microbiome Ireland @apcmicrobiomeirel.bsky.social · 19/08/2026

2 reviews in @allergy-eaaci.bsky.social examine iron deficiency in atopic disease & the immune sequence during IgE-mediated food reactions. Group Leader Liam O’Mahony contributed to both. buff.ly/fu6r6Qh buff.ly/FJbWULo #Allergy #Immunology #FoodAllergy #AtopicDisease @uccmicrobiology.bsky.social

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Allergy EAACI @allergy-eaaci.bsky.social · 19/08/2026

L. Martín-Cruz, A. de la Rocha-Muñoz, I. M. Peñalver-Fernández, et al.“Tezepelumab Reverses TSLP-Driven Immunometabolic Rewiring in Human cDC2s Underlying Pathogenic Th2 and Dysfunctional Treg Responses,” doi.org/10.1111/all.70470 #Allergy_journal www.youtube.com/watch?v=uzNd...

youtube.com

Tezepelumab Reverses TSLP-Driven Immunometabolic Rewiring in Human cDC2s

YouTube video by Allergy

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Allergy EAACI @allergy-eaaci.bsky.social · 17/08/2026

D. Villalta, G. Marcassa, G. Cusa, et al., “Hazelnut and Walnut Vicilins in Tree Nut Allergy: Co-Sensitization Patterns and Clinical Severity Associations,” Allergy (2026),👉 doi.org/10.1111/all.70482 #Allergy_journal Watch videos of recent disc www.youtube.com/watch?v=e3KY...

youtube.com

Hazelnut and Walnut Vicilins in Tree Nut Allergy

YouTube video by Allergy

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Allergy EAACI @allergy-eaaci.bsky.social · 18/08/2026

Open Access: Distinct Skin Penetration and Immune Responses to Ionic and Nanoparticulate Cobalt in Allergic Contact Dermatitis. P. Werner, M. Schaier, G. Braun, A. Julander, K. Midander, M. Isaksson, G. Koellensperger, L. Wisgrill, N. Fyhrquist Read the article here: doi.org/10.1111/all.70422

Cobalt chloride (CoCl2) and cobalt nanoparticles (CoNPs) induce a shared, severity-dependent inflammatory response in cobalt-sensitized skin characterized by activation of interferon signaling, inflammatory pathways (TNF/NF-κβ, IL6-STAT3), apoptosis/unfolded protein response (UPR), cell cycle programs, and glycolysis. Despite comparable nominal exposure, the two cobalt forms exhibit distinct tissue distribution: CoCl2 penetrates deeply and accumulates intracellularly across epidermal and dermal compartments, whereas CoNPs are largely retained in the stratum corneum. Direct comparison reveals divergent transcriptional programs, with CoCl2 preferentially inducing interferon and antiviral responses (e.g., IRF7), and CoNPs promoting keratinization and epithelial differentiation (e.g., KRT25). Together, these findings demonstrate that cobalt speciation and penetration depth shape tissue exposure and downstream immune responses in allergic contact dermatitis.

Read more articles published in #Allergy on #atopicdermatitis here: journalallergy.com/Atopic_Dermatitis_Urticaria_and_Skin_Disease

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Allergy EAACI @allergy-eaaci.bsky.social · 12/08/2026

Free to Read: EAACI Guidelines on Environmental Science for Allergy and Asthma—Evidence-Based Recommendations for Prevention and Public Health Action to Mitigate the Impact of Pollen Exposure on Respiratory Allergy. Corresponding author: Lorenzo Cecchi 👉 doi.org/10.1111/all.70423 #Allergy_journal

These guidelines (180 references) on pollen-induced allergic #rhinitis and #asthma were written by the European Academy of Allergy and Clinical Immunology (#EAACI) using a GRADE approach. It provides key recommendations on measures to mitigate pollen exposure, pollen monitoring systems, and public health measures.

Read more articles published in #Allergy on #asthma here: journalallergy.com/Asthma-Lower-Airways

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Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 12/08/2026

Editorial on anti- #aging by @natmed.nature.com www.nature.com/articles/s41... My faves: — clinical trials using surrogate markers of biological aging — #proteomics, #metabolomics, #transcriptomics, #imaging — functional tests of body systems, physical strength, exercise capacity 🧪 #longevity

nature.com

Anti-aging interventions need less hype and more clinical evidence - Nature Medicine

The aging field needs to develop reliable biomarkers of aging and a solid evidence base for the safety and efficacy of anti-aging treatments.

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Feinstein Journals -Molecular Medicine & Bioelectronic Medicine @northwell-journals.bsky.social · 13/08/2026

MOME August article highlight -In Press: Elucidating the mechanism underlying incomplete immune recovery in people living with HIV through CD4⁺ and CD8⁺ T cell multi-omics | #MolecularMedicine #HIV #Multiomics #Metabolomics #Proteomics #Bioinformatics link.springer.com/article/10.1...

Figure 1. Flowchart illustrating patient cohort enrolment and analysis. Participants were initially classified as controls or cases based on their basal CD4+ T cell count, specifically whether they had more
or fewer than 200 CD4+ T cells/µL. After 48 weeks of treatment, the cases were reclassified as either immunological responders (IR) or immunological non-responders (INR) based on whether they had
recovered to 250 CD4+ T cells/µL. This system of classification has been validated in several cohort studies12–15. The subsequent procedure involved the isolation of proteins and metabolites from CD4+ and CD8+ T cells in basal blood samples for each omics analysis. For experimental validation, a separate subset of participants was selected for targeted qRT-PCR analysis of miRNAs (5 IR and 5 INR) and mRNAs (6 controls, 5 IR, and 5 INR) in CD4⁺ T cells.

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MedChemExpress @medchemexpress.bsky.social · 11/08/2026

#ReferenceStandards in Food Metabolomics 🧪A study mapped 500 foods using untargeted LC-MS metabolomics, revealing ~24,000 molecular features. Reference standards enabled high-confidence identification of 900 features, supporting accurate identification, quantification, and quality control.

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shahriyar-ssk.bsky.social @shahriyar-ssk.bsky.social · 11/08/2026

Can we monitor biological changes following severe asthma treatment through a patient’s breath? Our new study shows exhaled breath profiles change within 4 months of initiating biologic therapy. Read the full study: doi.org/10.1016/j.rm... #Breathomics #PrecisionMedicine

doi.org

Redirecting

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Allergy EAACI @allergy-eaaci.bsky.social · 07/08/2026

Open Access: Surgical Management of Non-Allergic #Rhinitis —An #EAACI Task Force Position Paper. First author: Marie Lundberg; corresponding author: Laura Van Gerven 👉 doi.org/10.1111/all.70424 #Allergy_journal Read more articles here: journalallergy.com/Rhinitis-Sinusitis-Upper-Airways

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Sarah Ashley @sarah-ashley.bsky.social · 08/08/2026

Long-term outcomes following Probiotic and Peanut Oral Immunotherapy out now 📣 Online at Allergy, read open access here: onlinelibrary.wiley.com/doi/10.1111/... Paxton summarises our findings in the YouTube video below 👇

onlinelibrary.wiley.com

Three‐Year Post‐Treatment Outcomes Following Cessation of Peanut Oral Immunotherapy: Comparisons by Clinical Allergy Status and Treatment Group

Click on the article title to read more.

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The Lancet Respiratory Medicine @lancetrespirmed.bsky.social · 23/07/2026

📊 New Article available #OpenAccess 📈 FEF25–75% trajectories from age 7 to 53 years, associations with childhood and parental preconception factors, and midlife COPD risk: a prospective cohort study Could your risk of #COPD be shaped before you were even born? www.thelancet.com/journals/lan...

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The Lancet Respiratory Medicine @lancetrespirmed.bsky.social · 30/07/2026

❇️ New Article available #OpenAccess Why does #asthma cost the US economy roughly 100 times more than it costs low-income countries — even though LMICs carry the larger share of the disease burden? Read the full paper: www.thelancet.com/journals/lan...

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Allergy EAACI @allergy-eaaci.bsky.social · 29/07/2026

Free Access: Trace Elements in Allergy: Narrative Review. Corresponding author: Michal Ordak 👉 doi.org/10.1111/all.70383 Read more articles published in #Allergy on clinical immunology here: journalallergy.com/Autoimmunity-and-Clinical-Immunology #Allergy_journal

With over 150 references, this review article provides an overview of the effect of both nutritional and toxic trace elements on allergic diseases. It includes a discussion on the role of trace elements in the pathophysiology of allergies (iron, zinc, selenium, copper, fluorides, manganese, iodine, molybdenum, chromium, cobalt, silicon, nickel and boron) and a summary of reported studies. Overall, additional nutritional supplementation of trace elements is not currently supported for the prevention or management of allergic diseases, unless there is a clinical deficiency.

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Reposted by @sciencistints.bsky.social

Allergy EAACI @allergy-eaaci.bsky.social · 31/07/2026

Open Access: Algorithms of Patient Selection for Allergen Immunotherapy. U. Petra Zieglmayer, Stefania Arasi, Thomas Eiwegger, Thilo Jakob, Ludger Klimek, Markus Ollert 👉 doi.org/10.1111/all.70373 Read other medical algorithms here: journalallergy.com/Medical-Algo... #Allergy_journal

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Reposted by @sciencistints.bsky.social

Allergy EAACI @allergy-eaaci.bsky.social · 04/08/2026

Open Access: Molecular Characterization of Non-Specific Esophagitis Reveals a Distinct Non-Eosinophilic Phenotype With Fibrotic Traits. First author: Marc Pfefferle; corresponding authors: Hans-Uwe Simon, Thomas Greuter 👉 doi.org/10.1111/all.70364 #Allergy_journal

This study comprehensively characterizes non-specific #esophagitis (NSE) and elucidates eosinophil-independent fibrosis mechanisms. NSE appears to be a distinct fibrotic phenotype of the esophagus, without any considerable overlap with gastroesophageal reflux disease (GERD) and other chronic inflammatory disorders such as eosinophilic esophagitis (EoE) or lymphocytic esophagitis. Our data suggest the development of fibrotic traits independently of inflammatory changes, in particular tissue eosinophilia.

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