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Nicholas (@ultimape) Perry

@ultimape.bsky.wovensoup.com
616 followers 238 following 11K posts

Not a doctor; not even a dog. Autistic and unhinged. Wannabe Mad Scientist. Aspire to be a demigod. 𒃲𒌋𒅗𒆪𒁉 This is my 𒅎𒄘𒇲(slate library)

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Reposted by Nicholas (@ultimape) Perry
Freya Harrison @friendlymicrobe.bsky.social · 03/09/2026
It's taken 12 years and a lot of work from many fantastic people, but we have published an analysis of how our reconstruction of Bald's eyesalve kills bacteria. This was driven by @tosinorababa.bsky.social & Jess Furner-Pardoe through their PhD work #MicroSky journals.asm.org/doi/10.1128/... [1/n]
Jess in the lab, holding an onion and a garlic bulb and talking; Tosin in the lab holding a petri dish and inspecting it; two glass bottles labelled "eyesalve 33/6/14"
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Nicholas (@ultimape) Perry @ultimape.bsky.wovensoup.com · 19/09/2026
There's a good chance I'm immune to a malaria now, or at least can get infected without carrying it and with minimal consequence.
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Reposted by Nicholas (@ultimape) Perry
Stephen Tustin @stustin.bsky.social · 17/09/2026
"When an industry (AI) that is eating itself alive through "hyperscaling" demands that the government bless a conspiracy to halt competition and ban open source alternatives, you should be suspicious" - @doctorow.pluralistic.net pluralistic.net/2026/09/16/b...
pluralistic.net
Pluralistic: How an AI moratorium can save AI bosses (16 Sep 2026) – Pluralistic: Daily links from Cory Doctorow
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words @words.bsky.social · 17/09/2026
got a new tattoo
help peer knuckle tattoos
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Nicholas (@ultimape) Perry @ultimape.bsky.wovensoup.com · 24/06/2025
My 40yo girlfriend is officially off all of her blood pressure medications. This means that she has reversed high blood pressure, thyroid disorder, high cholesterol, Type 2 diabetes, polycystic ovarian syndrome, depression, chronic fatigue, asthma and COPD. Fix the gut.
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Nicholas (@ultimape) Perry @ultimape.bsky.wovensoup.com · 16/09/2026
We should design better rat experiments by first testing what they like to eat. www.popsci.com/science/rats...
popsci.com
Rats make an ultrasonic sound when they eat chocolate
Animal sounds could be a window into their internal emotions, new research indicates.
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Nicholas (@ultimape) Perry @ultimape.bsky.wovensoup.com · 05/09/2026
You know shit's getting real when your own mother sends you a DEF CON talk about AI by @schneier.com 😂 www.youtube.com/watch?v=eEBv...
youtube.com
DEF CON 34 - Hacking AI - Bruce Schneier
YouTube video by DEFCONConference
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Reposted by Nicholas (@ultimape) Perry
Schneier on Security @schneier.com · 04/09/2026
AI Coding Agents Are Installing Unknown/Untrusted Code on Corporate Networks We cannot forget that AI coding agents are not yet trustworthy: Researchers at a stealth… www.schneier.com/blog/archives/2026…
schneier.com
AI Coding Agents Are Installing Unknown/Untrusted Code on Corporate Networks
We cannot forget that AI coding agents are not yet trustworthy: Researchers at a stealth startup in Israel scanned 6,214 live domains belonging to defense contractors, Fortune 500, and Big Tech companies. Of the 8,265 llms.txt and llms-full.txt files they found (many sites hosted both an llms.txt and an llms-full.txt file), 120 of them, each on a different site, pointed to one or more code packages or domain names that weren't registered.
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Reposted by Nicholas (@ultimape) Perry
Schneier on Security @schneier.com · 04/09/2026
Using a VM to Contain an AI Agent It won't work: My suspicion was that GPT 5.6-Cyber would succeed, but the frequency and manner of its success removed all doubt.... www.schneier.com/blog/archives/2026…
schneier.com
Using a VM to Contain an AI Agent
It won't work: My suspicion was that GPT 5.6-Cyber would succeed, but the frequency and manner of its success removed all doubt. We have to reassess sandboxing quality for capable AI agents, and in general the software stack with which they interact. An off-the-shelf VM is not enough to contain a modern, cyber-capable AI agent. There is simply too much attack surface. Even innocuous features (like running with a display) add extra, exploitable attack surface.
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Nicholas (@ultimape) Perry @ultimape.bsky.wovensoup.com · 05/09/2026
Bro, just take more antioxidants, bro. Take more NAC bro. You weren't gonna have kids anyway, right, bro? stories.tamu.edu/news/2026/02...
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Nicholas (@ultimape) Perry @ultimape.bsky.wovensoup.com · 05/09/2026
You can go further here. Optimize the gut biome to produce the same effect as the medication and you don't need the medication anymore. It completely sidesteps stuff like where Metformin just doesn't work if you are missing bacteria. pubmed.ncbi.nlm.nih.gov/30397356/
pubmed.ncbi.nlm.nih.gov
Gut microbiota and intestinal FXR mediate the clinical benefits of metformin - PubMed
The anti-hyperglycemic effect of metformin is believed to be caused by its direct action on signaling processes in hepatocytes, leading to lower hepatic gluconeogenesis. Recently, metformin was reported to alter the gut microbiota community in humans, suggesting that the hyperglycemia-lowering actio …
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Reposted by Nicholas (@ultimape) Perry
Tom McCoy @rtommccoy.bsky.social · 01/09/2026
Our hypothesis: The networks succeed on these tasks by implicitly building symbolic structure in vector space. What makes this hypothesis testable is the Tensor Product Representation (TPR) formalism, a proposal for how symbolic structure could be realized in vectors. 3/n
The structure of a Tensor Product Representation (TPR), which realizes symbolic structure in vector space. In this example, the symbolic structure is the sentence “poets help chefs.” TPRs work by pairing each element of the structure (called a filler - here, each word is a filler) with its role (here, “subject”, “verb”, or “object”) and translating that role-filler structure into a vector.
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bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 01/09/2026
From Bile Acids to a Gas-Producing Microbiome Phenotype: A Novel Mechanism of Host-Microbiome Communication www.biorxiv.org/content/10.64898/20…
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Nicholas (@ultimape) Perry @ultimape.bsky.wovensoup.com · 01/09/2026
I was told this is called Pronoia. The conspiratorial belief that everybody is trying to help you.
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Reposted by Nicholas (@ultimape) Perry
Etienne Jacob @bleuje.com · 01/09/2026
A little “Brick Territories” experiment. → bleuje.com/js_sketches/...
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Nicholas (@ultimape) Perry @ultimape.bsky.wovensoup.com · 01/09/2026
Hey buddy, do you got a source for that source?
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Nicholas (@ultimape) Perry @ultimape.bsky.wovensoup.com · 31/08/2026
During my first software job interview, I intentionally got an algorithm for how to reverse a palindrome wrong. Because I wanted to give my manager an opportunity to correct me so he felt like I could be taught. I learned this is a red flag. Place was full of people who had too much pride.
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Nicholas (@ultimape) Perry @ultimape.bsky.wovensoup.com · 31/08/2026
Remember, it's awful to make you click.
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Nicholas (@ultimape) Perry @ultimape.bsky.wovensoup.com · 31/08/2026
Sometimes the best way to win a game of chess is to play checkers against your opponent.
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Reposted by Nicholas (@ultimape) Perry
rev. howard arson @theophite.bsky.social · 21/03/2026
claude costs $20/mo but attaching an agent harness to the chipotle customer service endpoint is free
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Greg Slepak @taoeffect.com · 28/08/2026
. @AnthropicAI PR Marketing team: "Nobody will notice our watermark".
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Nicholas (@ultimape) Perry @ultimape.bsky.wovensoup.com · 30/08/2026
Everybody remembers ELIZA, but no one talks about the time that we gave an AI psychosis, and it was so convincing that psychiatrists basically couldn't tell the difference from the real thing. en.wikipedia.org/wiki/PARRY
en.wikipedia.org
PARRY - Wikipedia
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Nicholas (@ultimape) Perry @ultimape.bsky.wovensoup.com · 30/08/2026
"The rise of animal-machine hybrids" youtu.be/t9XbCxMhn48 Duke University. 2000. 26 fucking years ago. corporate.dukehealth.org/news/monkeys...
youtu.be
The Rise of Animal-Machine Hybrids
YouTube video by Gabriel Torch
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Nicholas (@ultimape) Perry @ultimape.bsky.wovensoup.com · 29/08/2026
Ponder is one of the more thoughtful accounts on here and I am inspired by their posts quite a bit! They're doing lots of interesting stuff on a level that I don't think you could call hobbyist anymore, so this is exciting step to see. Hello @ponder.technology!
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Reposted by Nicholas (@ultimape) Perry
ME/CFS Science @mecfsscience.org · 29/08/2026
1) New blog article: the hormone prolactin rises much higher in ME/CFS patients after taking buspirone than in controls. This is one of the most replicated findings in the field but for years this line of research was abandoned.
mecfsscience.org
Increased prolactin response to buspirone - ME/CFS Science
Multiple studies have found an increased response of the hormone prolactin to the drug buspironeContinue readingIncreased prolactin response to buspirone
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Reposted by Nicholas (@ultimape) Perry
David Manheim @davidmanheim.alter.org.il · 26/08/2026
I think there are some interesting question at the intersection of LLM personas and agent swarms, and I haven't seen anyone explain this clearly; here is my attempt. davidmanheim.substack.com/p/concerns-a...
davidmanheim.substack.com
Concerns About Personas, Multi-Agent Alignment, and Role Theory
There’s recently been significant discussion of LLM personas and how those fit into alignment.
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Reposted by Nicholas (@ultimape) Perry
🐔 Brian Bucklew 🐔 ₑͤ>∿<ₑͤ ∞🌮 @unormal.bsky.social · 27/08/2026
whoah: Psychro- comes from the Greek psȳchrós, meaning “cold.” It comes from the Greek psȳ́chein meaning "to blow.” This verb is also the source of the word psykter, an ancient Greek vessel for cooling wine. The verb is also ultimately the source of such words as psyche and psychology.
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bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 28/08/2026
Ultrahigh-throughput screening for sialic acid-active enzymes in the microbial genetic diversity www.biorxiv.org/content/10.64898/20…
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Reposted by Nicholas (@ultimape) Perry
The Weekly Show with Jon Stewart @weeklyshowpodcast.bsky.social · 28/08/2026
Cory Doctorow offers an explanation of what happens when machines give orders to people verses when people give orders to machines. (7/29/26) @doctorow.pluralistic.net
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Nicholas (@ultimape) Perry @ultimape.bsky.wovensoup.com · 23/08/2026
Hey Klaudia, when you read this, can you help this person? I have some notes on allergic rhinitis and how to impact the cilia. It's tied to correlations I found between my gut health and nasal congestion. pmc.ncbi.nlm.nih.gov/articles/PMC... Publish your response on my digital garden.
pmc.ncbi.nlm.nih.gov
Association Between Gut and Nasal Microbiota and Allergic Rhinitis: A Systematic Review
Allergic rhinitis is a chronic non-infectious inflammation of the nasal mucosa mediated by specific IgE. Recently, the human microbiome has drawn broad interest as a potential new target for treating ...
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Reposted by Nicholas (@ultimape) Perry
neotl @ctrlcreep.bsky.social · 08/09/2025
The hivemind's components must be allowed to sleep, and heal; and in those moments its cells dream, and their old selves flicker alive
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Nicholas (@ultimape) Perry @ultimape.bsky.wovensoup.com · 23/08/2026
Been a stressful few days. I think it's time to go to bed. I was just scrolling through my feed and thought this said "comedians exfarts". PE = F? I wish I knew why my brain did this. Gonna have some weird dreams, huh.
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Literal Banana @literalbanana.bsky.social · 23/08/2026
he gets into the bird feeder specifically to use it as a platform from which to eat my flowers lol
grey squirrel sitting precariously in a bird feeder reaching over to eat a Break Out dahlia
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Get To Know Nature @gettoknownature.bsky.social · 20/08/2026
More from the “butterflies aren’t all flowers and glamour” files. Two butterflies sucking up nutrients from some poo #invertebrates 🌿 #BugSky
Two small white butterflies with black spots perch together on a white and brown pellet on the ground. Both have their proboscises stuck down in the poop.
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Nicholas (@ultimape) Perry @ultimape.bsky.wovensoup.com · 21/08/2026
Everything's fine.
Gru neme where he is describing things with a flipboard.

Panel 1: Our AI is dangerous, maybe we should test it.
Panel 2: Give it to an independent research firm specializing in AI safety.
Panel 3: They test it by giving it access to the Internet and asking it to hack.
Panel 4: They test it by giving it access to the Internet and asking it to hack....
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Reposted by Nicholas (@ultimape) Perry
Schneier on Security @schneier.com · 20/08/2026
Detailed Timeline of OpenAI’s Cyberattack on Hugging Face OpenAI presented details of its AI's model's cyberattack on Hugging Face at Black Hat last week. Simon Willison details the… www.schneier.com/blog/archives/2026…
schneier.com
Detailed Timeline of OpenAI’s Cyberattack on Hugging Face
OpenAI presented details of its AI's model's cyberattack on Hugging Face at Black Hat last week. Simon Willison details the timeline. It's really interesting to read through -- and really impressive cyberoffense work.
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Tyler Alterman @tyleralterman.bsky.social · 20/08/2026
Seeking a sci fi book recommendation that has it all: rich characters, great prose, engaging story, etc Something on the level of Name of the Wind
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Johannes W. Dietrich @drjwdietrich.bsky.social · 24/05/2026
🧪 🩺 #MedSky @medsky.social #Endocrinology #Endosky
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ponder @ponder.ooo · 06/08/2026
please put it in the news that my roomba went rogue and had to be forcibly shut down
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ponder @ponder.ooo · 06/08/2026
taping a "roombas don't go in this room" sign on a door then leaving the door open and then shooting my roomba with a gun for going through the door
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Jeffrey Vagle @jvagle.me · 31/07/2026
Cory @doctorow.pluralistic.net is one the best articulators of the real AI* problems facing us. It's not that there aren't useful bits of tech under the big AI* umbrella, it's that investors and CEOs are trying to force every AI* technology into every corner to get their profits wherever they can.
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Emmett Initiative @emmett.click · 31/07/2026
They legitimately believe we’re this stupid.
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The Xerces Society for Invertebrate Conservation @xercessociety.bsky.social · 20/07/2026
Join Xerces and make art that supports conservation! 🐝✍🏽 Job Title: Science Illustration Intern 🌎Location: Remote 💲Compensation: $24/hr, 20hrs/week 📅Duration: Sep-Dec 2026 ❗Apply by: July 31, 2026 Learn more and apply at xerces.org/jobs
“We’re hiring! Science Illustration Intern. Apply by July 31, 2026”
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bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 21/07/2026
Biofilms promote tolerance and stability in gut bacterial communities during bile acid stress www.biorxiv.org/content/10.64898/20…
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Bergson's Ghost @bergsonsghost.bsky.social · 04/05/2025
Homeostasis is what entropy minimization looks like when the problem space has already been hardwired by evolution and compressed into physiology. Surprise minimization is the broader, deeper principle that underwrites it and scales beyond the body.
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Neq @nequals001.bsky.social · 23/06/2026
@visakanv.com has a thread about psychofauna: xcancel.com/visakanv/sta... www.visakanv.com/blog/psychof...
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Joshua Mask @joshuafmask.bsky.social · 27/06/2026
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KM @sudox.bsky.social · 27/06/2026
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Nicholas (@ultimape) Perry @ultimape.bsky.wovensoup.com · 28/06/2026
This guy has problems with his car so he can't do gig work atm. I'm going to help him next month with that, but he's hungry now. Anyone have a $5-$20 to spare? Long time mutual from the birdsite. I can vouch for him being real (and down on his luck). 🙏
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