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MedChemExpress

@medchemexpress.bsky.social
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MedChemExpress (MCE) | US Headquartered 🌎 Global Warehousing Inhibitors & Agonists | Proteins | Drug Screening Platform

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MedChemExpress @medchemexpress.bsky.social · 02/10/2026
🏆#NobelPrize 2026 Countdown | 06 Integrins & cell adhesion How do immune cells know where to go? Timothy A. Springer helped reveal how integrins control immune-cell adhesion and migration, paving the way for therapies like #vedolizumab. 🔬Countdown complete. Nobel Prize announcement: Oct. 5.
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MedChemExpress @medchemexpress.bsky.social · 02/10/2026
🏆#NobelPrize 2026 Countdown | 05 cGAS–STING & innate immunity How does the immune system detect dangerous DNA? Zhijian “James” Chen & Glen Barber helped reveal how cGAS senses cytoplasmic DNA and activates STING, triggering innate immunity. From DNA sensing to cancer immunotherapy.
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MedChemExpress @medchemexpress.bsky.social · 02/10/2026
🏆 #NobelPrize 2026 Countdown | 04 CAR-T & cancer therapy Can a patient’s own immune cells become a living cancer treatment? Zelig Eshhar, Carl June & Michel Sadelain helped turn CAR-T from concept into clinical therapy—engineering T cells to recognize and attack cancer cells.
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MedChemExpress @medchemexpress.bsky.social · 01/10/2026
🏆#NobelPrize2026 Countdown | 03🩸Bispecific antibodies&hemophilia In 2026, Hiroshi Hattori, Tomoyuki Igawa&Takehisa Kitazawa received the Lasker Clinical Medical Research Award for developing emicizumab. By binding factor IXa&X, emicizumab mimics factor VIII and helps prevent bleeding in hemophiliaA.
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MedChemExpress @medchemexpress.bsky.social · 01/10/2026
🏆#NobelPrize 2026 Countdown | 02 😴Orexin & sleep In 2026, Yanagisawa & Emmanuel Mignot received the Lasker Basic Medical Research Award for discovering orexin and its link to narcolepsy. From receptor biology to disease research, their work revealed how orexin helps regulate sleep and wakefulness.
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MedChemExpress @medchemexpress.bsky.social · 01/10/2026
🏆#NobelPrize 2026 Countdown | 01 GLP-1 has reshaped metabolic medicine, from diabetes and obesity to cardiovascular health. In 2026, Daniel J. Drucker, Jens Juul Holst&Svetlana Mojsov were named Citation Laureates for their work on GLP-1. From discovery→drug development→clinical impact 👀What’s next?
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MedChemExpress @medchemexpress.bsky.social · 30/09/2026
🧬Can one kinase be targeted at two sites? A study introduces bitopic inhibition using BCR::ABL1 as a model. PonatiLink-2 links ponatinib and asciminib to target the ATP and allosteric sites, improving activity against resistant mutants and kinase selectivity. The strategy was also extended to EGFR.
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MedChemExpress @medchemexpress.bsky.social · 30/09/2026
September: #MuscularDystrophy Awareness Month 🔹DMD | PMO exon skipping; PPMOs & AOCs aim to improve muscle delivery 🔹DM1 | ASOs & AOCs target DMPK RNA 🔹OPMD | Gene therapy approaches are under exploration 🔹LGMD | Gene therapy & oligonucleotide approaches are being investigated for selected subtypes
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MedChemExpress @medchemexpress.bsky.social · 29/09/2026
🩺World Heart Day | Sept. 29: “Don’t Miss a Beat” Cardiovascular disease (CVD) can develop silently. Everyone needs to raise awareness. Ongoing research is uncovering new therapeutic opportunities across lipid metabolism, thrombosis, and heart failure. ow.ly/aX3Y50ZSvfK
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MedChemExpress @medchemexpress.bsky.social · 28/09/2026
Cell death is not a single process. Beyond well-known apoptosis, researchers have uncovered diverse regulated cell-death pathways, including: 🔹Apoptosis 🔹Necroptosis 🔹Pyroptosis 🔹Ferroptosis 🔹Autophagy-dependent cell death and other emerging mechanisms 📰Read more: ow.ly/XrWZ50ZQpky
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MedChemExpress @medchemexpress.bsky.social · 28/09/2026
🧬How is the drug target landscape evolving? A review found 686 biomolecular targets behind 1,702 approved drugs as of June 2025. 🔹 Peptide targets ↑ 7.2-fold 🔹 136 kinase inhibitors target 67 kinases 🔹 New modalities are expanding the druggable space.
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MedChemExpress @medchemexpress.bsky.social · 25/09/2026
🧬What if we could degrade ALK instead of just inhibiting it? Nature highlights TRI-611, a brain-penetrant molecular glue degrader targeting ALK fusion proteins, including TKI-resistant variants. Could targeted protein degradation offer a new strategy for ALK+ NSCLC?
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MedChemExpress @medchemexpress.bsky.social · 25/09/2026
#MYH9 Emerges as a Key Executor of #Cuproptosis A new study in Cell identifies MYH9 as a key executioner of cuproptosis, a copper-dependent form of cell death. 🧫Copper binds MYH9 → MYH9 polymerization → Cytoskeleton disruption → Cell death
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MedChemExpress @medchemexpress.bsky.social · 25/09/2026
A new review in Trends in Microbiology examines how, when, and through which routes microbes are shared between mothers and infants. 🔗Read more: www.cell.com/trends/microbiology/fu…
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MedChemExpress @medchemexpress.bsky.social · 24/09/2026
💊 #FDA Drug Approvals — September 2026 #Lirafugratinib, #Isembyld & #Zanvastro bring new approaches targeting FGFR, myostatin & RNA. #Sevabertinib, #Camizestrant, #Imlunestrant, #Aqneursa & #Joenja expand therapeutic options across cancer, rare diseases & genetic disorders.
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MedChemExpress @medchemexpress.bsky.social · 24/09/2026
🩸Where do activated platelets go after a blood clot forms? A new Science study points to the spleen, which can capture and clear highly activated platelets. Could this reveal a new angle on thrombosis? #Platelets #Thrombosis #Science
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MedChemExpress @medchemexpress.bsky.social · 23/09/2026
The FDA has approved #Aqneursa (#levacetylleucine) oral suspension to treat ataxia in adults and pediatric patients with ataxia-telangiectasia (A-T) weighing ≥15 kg. 📊Aqneursa improved neurological function as measured by the functional Scale for the Assessment and Rating of Ataxia (fSARA).
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MedChemExpress @medchemexpress.bsky.social · 23/09/2026
A new study analyzed 12151 longitudinal metagenomes from 887 children in the TEDDY study, revealing three distinct patterns of gut microbiome maturation. The findings highlight how early-life microbiome development and host genetics may interact in #T1D susceptibility. ow.ly/i6Ow50ZPZLc
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MedChemExpress @medchemexpress.bsky.social · 22/09/2026
🧬Personalized ASO Therapy Shows Early Signs in Rare ALS A new N-of-1 study reports an individualized ASO therapy for CHCHD10-related ALS. One patient received nL-CHCHD-001 for 12 months. • No serious adverse events • Blood NfL ↓ ~50% • ALS function and breathing remained stable or slightly improved
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MedChemExpress @medchemexpress.bsky.social · 22/09/2026
The FDA approved #imlunestrant + #abemaciclib for adults with ER+, HER2-, ESR1-mutated advanced or metastatic breast cancer following progression on ≥1 line of endocrine therapy. In the phase 3 EMBER-3 trial: 🔹Median PFS: 11.1 vs 5.5 months 🔹HR for progression/death: 0.53 🔹ORR: 35% vs 15%
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MedChemExpress @medchemexpress.bsky.social · 22/09/2026
Nat Rev Drug Discovery: 🔹686 biomolecules modulated by 1,702 drugs as of June 2025 🔹312 new MoA targets introduced since 2000 (84%⬆️) 🔹7.2× increase in endogenous peptide targets Drug Target Identification Services from MCE: www.medchemexpress.com/us/en/drug-t…
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MedChemExpress @medchemexpress.bsky.social · 21/09/2026
💊New #DMD Development The FDA accepted the BLA for Delpacibart zotadirsen and granted Priority Review. A global #Phase3 SAFARI44™ study has also begun. Del-zota is an investigational #AOC designed to deliver PMO to muscle, enabling exon 44 skipping and near-full-length dystrophin production.
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MedChemExpress @medchemexpress.bsky.social · 21/09/2026
A new Nature study identifies mitochondrial fission factor (MFF) as a key regulator linking organelle dynamics to ferroptotic cell death. 🔗https://ow.ly/n17350ZPvms
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MedChemExpress @medchemexpress.bsky.social · 18/09/2026
🧬Prime Assembly: A New Approach to DNA Integration A recent study introduces prime assembly, a #CRISPR-based approach for targeted DNA integration in human cells. 🔹 Cell-cycle independent 🔹 No DSBs 🔹 No dsDNA donors 🔹 Medium-to-large DNA integration 🧪MCE Research Tools for Advancing Research.
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MedChemExpress @medchemexpress.bsky.social · 18/09/2026
💊#Semaglutide: From GLP-1 to Metabolic Health A long-acting GLP-1 receptor agonist first approved for Type 2 Diabetes (#T2D), semaglutide now extends to weight management, cardiovascular risk reduction, and #MASH (F2–F3 fibrosis). 🔬One pathway, multiple therapeutic possibilities.
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MedChemExpress @medchemexpress.bsky.social · 18/09/2026
HIV targets CD4+ T cells, weakening the immune system. Without effective treatment, HIV can progress to AIDS. Antiretroviral therapy (ART) can suppress HIV and help preserve immune function. Fiji has reported a sharp increase in new HIV infections and declared a national HIV crisis in response.
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MedChemExpress @medchemexpress.bsky.social · 17/09/2026
#Endometriosis affects ~10% of women worldwide. 🔬ENDO-205 is an experimental, non-hormonal peptide designed to target endometriotic lesions: lesion tissue → intracellular pathway → lesion regression/disappearance. 🎯With an IND cleared for Phase 1, ENDO-205 is moving into first-in-human evaluation.
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MedChemExpress @medchemexpress.bsky.social · 17/09/2026
89 #CitationLaureates have gone on to receive #NobelPrizes since 2002. The 2026 #CitationLaureates spotlight breakthroughs in: 💊GLP-1 🧬Gene editing 🔬Optical imaging 🧪Immunology Featuring Daniel Drucker, Jens Juul Holst, Svetlana Mojsov, David R. Liu, James G. Fujimoto & Timothy A. Springer.
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MedChemExpress @medchemexpress.bsky.social · 17/09/2026
🧠A new JCI review highlights how mutations in CACNA1A, ATP1A2, and #SCN1A can alter neuronal excitability and increase susceptibility to cortical spreading depression (CSD), a key mechanism underlying migraine aura. www.jci.org/articles/view/208001
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MedChemExpress @medchemexpress.bsky.social · 16/09/2026
The #FDA has approved #Isembyld (#apitegromab-mstn) for adults and children ≥2 years with spinal muscular atrophy (#SMA) who are receiving an SMN2-targeted treatment. 🔬MedChemExpress offers apitegromab for research use only: www.medchemexpress.com/apitegromab.…
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MedChemExpress @medchemexpress.bsky.social · 16/09/2026
🧪Explore 1,000+ compounds across Oncology, Neuroscience, Immunology&Inflammation, and Metabolic Diseases. From HER2, TRIM21 & RAS(ON) inhibitors to PGK1 activators, CCR7 antagonists, and Wnt/β-catenin agonists—new tools for target discovery and translational research. www.medchemexpress.com
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MedChemExpress @medchemexpress.bsky.social · 16/09/2026
A new study in Science uncovers a surprising mechanism linking chronic type II interferon signaling to tumor growth and immunotherapy resistance: IFN-II → mitochondrial RNA release → IFN-I signaling → COX-2/PGE₂ → immunosuppression www.science.org/doi/10.1126/science…
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MedChemExpress @medchemexpress.bsky.social · 15/09/2026
💤The 2026 Lasker Basic Medical Research Award recognizes Emmanuel Mignot and Masashi Yanagisawa for identifying #orexin and uncovering its essential role in maintaining wakefulness. Read more: ow.ly/eNeM50ZN7AP
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MedChemExpress @medchemexpress.bsky.social · 15/09/2026
WCLC26 Highlights 🔹EGFR: Adjuvant #osimertinib → 74% 8-year OS in stage II-IIIA disease 🔹ROS1+: #Zidesamtinib → 94% response rate with strong intracranial activity 🔹HER2: T-DXd → improved PFS, but pulmonary safety remains a concern 🔹EGFR exon 20ins: #Amivantamab + chemotherapy → 34.3-month median OS
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MedChemExpress @medchemexpress.bsky.social · 15/09/2026
🧬PROTAC vs. Molecular Glue: What’s the Difference? Exploring the key differences between two approaches to targeted protein degradation. 🔗 Read on Medium: medium.com/@medchemexpr...
medium.com
PROTAC vs. Molecular Glue: What’s the Difference?
Targeted Protein Degradation (TPD) has transformed the way researchers think about drug discovery. Instead of simply inhibiting a protein…
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MedChemExpress @medchemexpress.bsky.social · 15/09/2026
💊 #TNBC in 2026: New hope through #TROP2 -directed ADCs, including Datroway(datopotamab deruxtecan) and Trodelvy(sacituzumab govitecan), alongside immunotherapy and biomarker-driven strategies. 🚀What new vulnerabilities can we target? MCE supports breast cancer research toward the next breakthrough.
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MedChemExpress @medchemexpress.bsky.social · 15/09/2026
Could #fibronectin be a missing link between #APOE4 and BBB dysfunction in #Alzheimers disease? A new Nature Aging study identifies astrocyte-derived fibronectin (FN1) as a key mediator of APOE4-driven BBB dysfunction. AD-related research tools from MedChemExpress: ow.ly/ftrS50ZNEtg
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MedChemExpress @medchemexpress.bsky.social · 14/09/2026
💊 #WCLC 2026 | Key Advances in #LungCancer Research From B7-H3 ADCs to next-generation TKIs and combination strategies, WCLC 2026 highlights evolving approaches in #NSCLC and #SCLC: 🔗https://bit.ly/4xW10sT #WCLC2026 #B7H3 #ADCs #TKI #CancerResearch
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MedChemExpress @medchemexpress.bsky.social · 14/09/2026
Presented at WCLC26, the Phase 3 TAISHAN-302 study evaluated tambotatug pelitecan (Tam-Pel), a B7-H3-targeted ADC, in patients with SCLC after platinum-based therapy. 📈Compared with #topotecan, Tam-Pel demonstrated improved overall survival, progression-free survival, and objective response rate.
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MedChemExpress @medchemexpress.bsky.social · 14/09/2026
🚨The #FDA has approved #Joenja (leniolisib) as the first treatment for children aged 4-11 years with activated phosphoinositide 3-kinase delta syndrome (#APDS), a rare genetic disorder affecting the immune system. 📊Phase 3 study showed reduced lymphadenopathy and increased naïve B cells.
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MedChemExpress @medchemexpress.bsky.social · 12/09/2026
How does one enzyme control Glycosphingolipid diversity? A Nature study reveals the structure and mechanism of UGCG, uncovering its triple-pass membrane architecture, bipartite active site, and arginine-driven catalysis—offering new insights into glycosphingolipid biosynthesis and lipid homeostasis.
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MedChemExpress @medchemexpress.bsky.social · 11/09/2026
Peptide-Drug Conjugates (#PDCs) combine targeted peptides with potent drug payloads. 🎯TwoStep Therapeutics’TS-104 is a multispecific PDC targeting five tumor-associated integrins: αvβ3, αvβ5, αvβ6, αvβ1, and α5β1, with MMAE as its cytotoxic payload. FDA-cleared IND, with Phase 1 expected this year.
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MedChemExpress @medchemexpress.bsky.social · 11/09/2026
In the #STEP Young trial, 40.4% of children aged 6 to <12 years receiving once-weekly semaglutide were no longer classified as having obesity after 68 weeks, compared with 0% in the placebo group. Read more: ow.ly/KMRM50ZMsn4
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Novo Nordisk STEP Young phase 3 data 40 percent of children living with obesity achieved a BMI below the obesity threshold with semaglutide and lifestyle modification
ovo Nordisk today announced first results from the STEP Young phase 3 trial, evaluating once-weekly semaglutide in combination with a reduced-calorie diet and increased physical activity in children aged 6 to under 12 years old with obesity. Obesity prevalence is growing in this age group, for whom there are limited clinically tested and approved treatments available when lifestyle modifications are not sufficient.
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MedChemExpress @medchemexpress.bsky.social · 11/09/2026
The #FDA has granted accelerated approval to #sevabertinib (#Hyrnuo) for adults with locally advanced/metastatic non-squamous NSCLC harboring activating HER2 (#ERBB2) tyrosine kinase domain mutations. SOHO-01 trial: 75% objective response rate in patients who had not received prior systemic therapy
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MedChemExpress @medchemexpress.bsky.social · 10/09/2026
🌍Global Cancer Statistics 2024 Latest GLOBOCAN estimates across 186 countries and 34 cancer types: 🎗️20.6M new cases 🩺9.8M deaths 📊Lung cancer: #1 in incidence & mortality, with ~2.6M new cases and ~1.9M deaths. Top 5 by incidence: 1️⃣Lung 2️⃣Female Breast 3️⃣Colorectal 4️⃣Prostate 5️⃣Stomach
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MedChemExpress @medchemexpress.bsky.social · 10/09/2026
A new NEJM study reports promising Phase 3 results for #tozorakimab, an IL-33–targeting monoclonal antibody, in patients with COPD. 📊Across the OBERON and TITANIA trials, tozorakimab reduced the rate of moderate-to-severe COPD exacerbations by ~30% versus placebo.
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MedChemExpress @medchemexpress.bsky.social · 10/09/2026
🏆 Nobel Prize Predictor: The #Lasker Awards announce the 2026 winners! 🧬 Basic: Emmanuel Mignot & Masashi Yanagisawa — orexin and wakefulness. 💊 Clinical: Hattori, Kitazawa & Igawa — bispecific antibody for hemophilia A. 🩺 Public Service: Michael J. Fox — Parkinson’s advocacy.
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MedChemExpress @medchemexpress.bsky.social · 10/09/2026
A new review in Sports Medicine explores how physical exercise may enhance cancer immunotherapy by reshaping the TME Exercise may: 🔸Increase CD8⁺ T/NK-cell infiltration/function 🔸Reduce immunosuppressive MDSCs, Tregs & pro-tumor TAMs 🔸Potentially sensitize tumors to PD-1/PD-L1 checkpoint blockade
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MedChemExpress @medchemexpress.bsky.social · 09/09/2026
🚨Phase 3 DeLLphi-305 showed that #tarlatamab-dlle (#IMDELLTRA, Amgen) + #durvalumab (#IMFINZI, AstraZeneca) significantly improved overall survival versus durvalumab alone in the first-line maintenance setting.
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MedChemExpress @medchemexpress.bsky.social · 09/09/2026
I just published AI Can Rewrite DNA. It Still Can’t Explain What Happens Next. medium.com/@medchemexpr...
medium.com
AI Can Rewrite DNA. It Still Can’t Explain What Happens Next.
Scientists changed nearly every letter in a tiny viral genome. What they found reveals just how much we still don’t understand about life.
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