Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 4hExcellent study! In the competition of genome replication in the gut, pathobionts devote genes for microtoxins instead of complex carbohydrate catabolism We all need to reduce dietary refined carbs in order to promote diverse eutrophic gut microbiome 000
Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 29/09/2026Older adults still taking common drugs, despite new guidelines www.sfchronicle.com/health/aging... — medicines are like barnacles, easy to start, hard to stop — #benzodiazepines for insomnia, anxiety — #antibiotics for uncomplicated diverticulitis — #aspirin for primary prevention #aging 🧪🩺📊🧬🛟sfchronicle.comGuidelines changed on these common drugs. Many older adults still take themNew research shows how hard it can be to stop medications once they become routine, even after medical advice shifts. 034
Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 26/09/2026Why tech billionaires don't ask theoretical physicists for #longevity advice www.theguardian.com/science/2026... “We’re a blink of an eye compared with the age of the universe. If I spend that blink of an eye trying to extend it to two blinks of an eye, I’m not sure it's a worthwhile thing” 🧪theguardian.comTech billionaires trying to live for ever? That’s a waste of time, says physicistExclusive: Prof Jim Al-Khalili says he will offer solution to ‘arrow of time’ problem in Royal Institution lectures 3327
Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 26/09/2026More positive results for #creatine #supplement lifespan.io/creatine-pro... — 5g twice/day increases strength, endurance & (maybe) cognitive function — helps both in combination with #exercise & #diet or notlifespan.ioCreatine Protects Lean Mass Even Without ExerciseAccording to a new study, creatine supplementation might help maintain and increase lean mass even without diet or exercise. 130
Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 25/09/2026Physiological resilience strengthens when social vs. lone? 010
Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 22/09/2026More evidence added #sugar accelerates #aging theconversation.com/babies-born-... — Britain’s postwar sugar rationing reduced infant exposure — Rationing ended September 1953 & infant exposure 2X — Incr. sweetness preference — Incr. 5 types of cancer: breast, prostate, liver, rectal, lung #healththeconversation.comBabies born under sugar rationing grew into adults with lower cancer riskBritain’s postwar sugar rationing was an accidental experiment. Decades on, it’s revealing how early diet shapes cancer risk, ageing and eating habits for life. 1177
Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 21/09/2026Can #nutrients in our foods mimic calorie restriction and increase our #healthspan? 🧪 theconversation.com/can-nutrient... — No evidence yet for #supplements spermidine, urolithin A, resveratrol — Overwhelming evidence for whole #plantbased foods via Prof Justin Roberts @us.theconversation.comtheconversation.comCan nutrients in our foods mimic calorie restriction and increase our healthspan?Researchers are investigating whether food compounds can imitate calorie restriction. The strongest evidence still comes from cells and animals. 2152
Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 19/09/2026Why is #cysteine amino acid so toxic to cells? www.rockefeller.edu/news/40469-c... — intracellular cysteine stored as glutathione — excess cysteine frees iron from ferritin — excess iron in mitochondria damages iron-sulfur proteins — mitochondria fail — cell death #health #supplement #agingrockefeller.eduThe Rockefeller University » Why high levels of the amino acid cysteine are toxic to cellsThe findings explain why the cell prefers glutathione, and may lead to new therapies for certain types of neurodegeneration and cancers. 171
Reposted by Dr. Todd Ewing PhD.marypsaeake.bsky.social @marypsaeake.bsky.social · 12/09/2026See, it's not that hard to change to a plant-based diet at all! 041
Reposted by Dr. Todd Ewing PhD.Aging Journal @aging-us.bsky.social · 18/09/2026#PaperoftheDay: "Control theory of aging and longevity for gerotherapeutic drug discovery: state space, vector fields, modalities, safety, and the minimum safe cost of functional restoration" DOI ⬇️ bit.ly/3T8bQg0 #Aging #Research #OpenAccess #Gerontology #Publishingdoi.orgControl theory of aging and longevity for gerotherapeutic drug discovery: state space, vector fields, modalities, safety, and the minimum safe cost of functional restoration | AgingExisting aging theories describe what changes with age but do not prescribe how to intervene. We propose a control-theoretic framework that is not merely descriptive but prescriptive: it specifies wh 122
Reposted by Dr. Todd Ewing PhD.Simple as possible - not simpler @ockamsrazor.bsky.social · 11/09/2026 021
Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 11/09/2026Apple introduces #biological #aging in #health app🧪 www.apple.com/newsroom/202... Incorporates — resting heart rate, sleep, HRV — physical tests of flexibility, strength, balance, movement mechanics, VO2 max — 50 lab tests for $119 @ Quest Diagnostics #geronsky #gerosky @geronsociety.bsky.socialapple.comApple advances health and fitness capabilities using Apple IntelligenceApple today announced its most advanced health and fitness experience yet, deepening the capabilities of Apple Watch and iPhone as intelligent, science-based tools for personal health. 242
Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 08/09/2026Eating nuts associates with reducing hypertension risk theconversation.com/eating-a-han... — largest risk factor for early death by #heart attack, #stroke, #kidney failure, #dementia — 35g/d nuts assoc w/ 26% lower risk hypertension — #plantbased may provide even further benefit #health #wellnesstheconversation.comEating a handful of nuts each day is linked with lower risk of high blood pressure, our research showsConsuming between 30-35g of nuts daily was linked with a 26% lower risk of hypertension. 1111
Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 08/09/2026Here's another excellent study supporting my developing Regulation Theory of Aging wherein loss of physiological regulation underpins all #aging phenotypes "structural aging is coordinated across organs within individuals" credit to researchers @sbpdiscovery.bsky.social #science 🧪 #GeroSky 062
Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 08/09/2026Fascinating study of mouse brain waste clearance "Disruption of brain waste clearance has emerged as — a key feature of brain aging and — a common hallmark across neurodegenerative diseases" 010
Reposted by Dr. Todd Ewing PhD.Dona Dickinson @donadickinson.bsky.social · 07/09/2026It makes a lot of sense that our bodies adapt to dietary changes and optimize over time. Thanks for sharing this. 021
Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 07/09/2026Neutrophil NET clearance & predisposition to #disease www.sciencedirect.com/science/arti... DNASE1*2/Q222R gene variant assoc with — reduced DNase I activity — impaired NET clearance during inflammatory stress — myocardial infarction, autoimmunity, malignancy, liver disease #genetics 🧪 🧬sciencedirect.com 040
Reposted by Dr. Todd Ewing PhD.Scott McGrath @smcgrath.phd · 07/09/2026🧪 New pre-print: A single-payer healthcare system would cut US health spending by $1.04 trillion annually and save 114k lives. Remarkably, nearly half of those preventable deaths aren't among the uninsured, but found within the 45M underinsured adults who still can't afford timely care. #MedSky 🛟 11410
Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 07/09/2026Long-term adaptation to #plantbased #diet www.pcrm.org/news/news-re... Iron – absorbs more efficiently Creatine & carnosine – increases biosynthesis Protein – muscle mass, strength comparable Fiber – ferments more efficiently Polyphenols – higher levels of microbial metabolitespcrm.orgThe Body Doesn't Just Absorb a Plant-Based Diet—It Adapts to One, New Review FindsWASHINGTON, DC — A new peer-reviewed review published in the journal Biology argues that much of the debate over whether plant-based diets deliver enough iron, protein, creatine, and other nutrients r... 4173
Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 07/09/2026Conclusion: Tumor-targeted multifunctional extracellular vesicles — selective and enhanced tumor-targeted cell killing in vitro — opportunity for developing EV-based drug carriers for cancer therapy 021
Reposted by Dr. Todd Ewing PhD.Dona Dickinson @donadickinson.bsky.social · 05/09/2026Lovely to see science showing these results. Both yoga and Pilates emphasize mindfulness and the importance of breath, which may help reduce stress. I look forward to more research on these topics! 021
Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 05/09/2026#yoga & #pilates may boost #longevity! news.asu.edu/20260904-hea... — researchers @arizonastateuni.bsky.social analyze 21 complementary & alternative medicine #lifestyle interventions — most show no #longevity benefit, except yoga & pilates — needs validation w follow-up studies! #health #geroagenews.asu.eduASU researchers find yoga and Pilates associated with longer lifespans | ASU NewsAnti-aging advice is everywhere. After all, who doesn’t want to live a longer, healthier life?But according to Arizona State University researcher Connor Sheehan, not every wellness practice promoted ... 2162
Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 01/09/2026NRF2 loss in #brain #cells associates with #dementia www.ed.ac.uk/news/support... — dementia linked to fewer but larger nerve fibers — excess myelin coating — loss of NRF2 in myelin producing cells — NRF2-targeted interventions could preserve cognition #health #aging #researched.ac.uk‘Supportive’ brain cells may drive cognitive decline | News | The University of EdinburghBrain cells that produce the protective coating around nerve fibres can become dysfunctional with age and may actively contribute to cognitive decline, according to new research. 171
Reposted by Dr. Todd Ewing PhD.Jungle Jane @jngljane.bsky.social · 29/08/2026Vegans in Loma Linda, CA are some of the longest living people ("blue zone"). These findings may point to why. 022
Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 29/08/2026Month of #vegan vs. #carnivore #diet? www.verywellhealth.com/vegan-reduce... — epigenetic changes reduce #cancer risk, slow #aging — reduces pro-inflammatory white blood cells — increases anti-inflammatory CD4+ T cells via @miramiller.bsky.social verywellheath #plantbased #health #lifestyleverywellhealth.com1 Month of Eating Vegan May Reduce Inflammation and Slow Aging, Study ShowsA new study suggests just a month of plant-based eating can reduce inflammation slow biological aging. 12310
Reposted by Dr. Todd Ewing PhD.Boodreaux's Fjords @boodreaux.bsky.social · 20/08/2026Rare disease/orphan drug win! 031
Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 27/08/2026Fascinating news update from @natureportfolio.nature.com — BDNF brain-derived neurotrophic factor supports neural connections — People with major depressive disorder have lower blood levels of BDNF — Over time, some antidepressants seem to increase production & signalling of BDNF #neurology 🧪 084
Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 20/08/2026Ozempic moment for #narcolepsy & #brain? www.nature.com/articles/d41... US FDA approves first drug for narcolepsy — oral pill agonist for orexin-peptide-deficient patients — 1 in 2000 US residents suffer orexin deficiency — disrupted sleep/wake cycle, cataplexy, paralysis, hallucination 🧪nature.comFirst-of-its-kind narcolepsy drug opens door to new therapies for the brainThe drug, called Orzeyful, takes aim at the root cause of the sleep disorder rather than at its symptoms. 0143
Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 20/08/2026Can AI agents replace AI scientists? www.nature.com/articles/d41... With current tech, they failed, but they: — performed solid literature reviews — performed 100s experiments over several days — avoided getting stuck — caught self hallucinations — avoided cutting corners or ‘reward hacking’nature.comAI isn’t ready to research itselfAn agentic system successfully developed concepts from two computer-science papers — but the original authors were not impressed. 164
Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 19/08/2026Biodegradable balloon? www.bbc.com/news/article... — biodegrades in 9 months — protects seabirds from balloon marine debris — 2 more yrs to market — future applications: gloves, surgical materials, medicinal apparatus, clothing, condoms #environment #health #engineering #science 🧪bbc.comScientists invent 'world's greenest balloon'Imperial College London experts say standard party balloons can take years to break down. 196
Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 13/08/2026Secret to longevity? Active #muscle! 💪 absorbs 80% of glucose in bloodstream 💪 strength training 2 hrs / wk reduces mortality by 13% 💪 adding aerobic 2.5 hrs / wk reduces mortality by 45% theconversation.com/people-who-l... credits @us.theconversation.com #health #lifestyle #agingtheconversation.comPeople who lift weights live longer – new studyPeople who did around 90 to 120 minutes of strength training each week have a 13% lower risk of dying from any cause. 1166
Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 12/08/2026Editorial on anti- #aging by @natmed.nature.com www.nature.com/articles/s41... My faves: — clinical trials using surrogate markers of biological aging — #proteomics, #metabolomics, #transcriptomics, #imaging — functional tests of body systems, physical strength, exercise capacity 🧪 #longevitynature.comAnti-aging interventions need less hype and more clinical evidence - Nature MedicineThe aging field needs to develop reliable biomarkers of aging and a solid evidence base for the safety and efficacy of anti-aging treatments. 0124
Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 10/08/2026A typical human cell experiences 100,000 damages to #DNA every day! — most damage is repaired, especially nightly — un-repaired damage contributes to #cancer and #aging — consider minimizing daily damage & maximizing nightly repair #health #lifestyle #longevity 2103
Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 10/08/2026How we can align mealtimes with #metabolism & #circadian #rhythm www.bbc.com/future/artic... — breakfast like a king — lunch like a prince — dinner like a pauperbbc.comWe're getting mealtimes wrong - here's the best time to have dinnerThe emerging science of chrononutrition suggests you should pay more attention to your body clock when planning your meals. 180
Reposted by Dr. Todd Ewing PhD.🌴 Scott Zona, Ph.D. 🌴 @scottzona.bsky.social · 10/08/2026Buddleja davidii is often called “invasive.” It certainly colonizes disturbed areas (like RR lines), but I’ve never seen it invade intact ecosystems. Weedy on ecosystem edges? Definitely! Invasive? I’m not convinced. 📷: Bluebell Railway nigelmenzies CCBYNCND2 #Scrophulariaceae #Botany 🌾🧪🌱 8539
Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 10/08/2026Extracellular vesicles (EVs) offer: — low immunogenicity — biocompatibility — intercellular communication Major challenges: — EV heterogeneity — functional EV subpopulations — targeted delivery — engineering strategies — biologically relevant potency assays 🧪 #pharma #tech #health #science 161
Reposted by Dr. Todd Ewing PhD.Tess @itstessinadress.bsky.social · 10/08/2026Me: how the fuck did I lose 10kg since last weigh-in eating junk food and not exercising ☹️ Science: remember your childhood? Me: ...nno? 🤨 Science: well, it may have put you in a permanent elevated metabolic rate for survival! You literally, biologically, lack a "resting" state, on a cellular level! 5171
Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 09/08/2026Fascinating! "We carried out longitudinal, multi-omic analyses of — nasal swabs — peripheral blood mononuclear cells — endotracheal aspirates and found significant reactivation of chronic viruses, particularly from the Herpesviridae & Anelloviridae families, associated with COVID-19 severity" 🧪 14718
Reposted by Dr. Todd Ewing PhD.AquamarineinCA @aquamarineinca.bsky.social · 09/08/2026Methinks the study methodology needs refinement, if fruits and veggies were concluded irrelevant? But, yeah, in the UK...?🤔🤪 111
Reposted by Dr. Todd Ewing PhD.Nobilis Reed @nobilis.bsky.social · 08/08/2026Some of these make sense but I wonder how much fiber would be in this diet. Legumes can do some of the work, but still... 111
Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 08/08/2026Perhaps #longevity can be taken too far? robbreport.com/lifestyle/he... — longevity-fixation syndrome: obsession of longevity at expense of #health, #relationships — "you can optimize the life out of your life" — wellness industry valued at $5 billion in 2024robbreport.comThe Mental Toll of Being Obsessed With Living LongerLongevity-fixation syndrome isn’t an official diagnosis, but here's how methods to live longer are impacting today's wellness-obsessed enthusiasts. 040
Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 08/08/2026Chinese researchers use machine learning to identify the optimal anti- #aging #diet Curiously, they name it the MYTH diet! www.nature.com/articles/s41... Perhaps the study population skewed the results? UK residents? LMK what you think 🧐 #health #lifestyle #longevitynature.comA machine learning-derived dietary pattern for aging - npj Science of Foodnpj Science of Food - A machine learning-derived dietary pattern for aging 140
Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 06/08/2026Excitement is growing over #glutathione and #peptide injections — but risk of #endotoxin contamination persists www.expressnews.com/news/texas/a... — Texas pharmacy recalls compounded glutathione vials — Even >99% purity can contain toxic levels of endotoxin — Resistant to sterilizationexpressnews.comTexas pharmacy recalls injectable peptides over life-threatening endotoxin riskThe Austin pharmacy said it received reports of fever, chills, severe headaches, nausea, vomiting, rapid heart rate, blood pressure changes, body aches and injection-site reactions. 342
Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 30/07/2026Are you burning #fat? A breathalyzer might tell you www.nature.com/articles/d41... #ketosis — a metabolic state when free fatty acids are metabolized into ketones by the liver for fuel — diets low in #carbohydrate — high-intensity #exercise — difficult to measure in real time #health #lifestylenature.comBreathalyser can tell if you are burning fat from a single exhalationThe compact device can measure when the body is in ketosis and could help people to manage weight loss. 161
Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 16/07/2026Long periods sitting a hazard? www.health.harvard.edu/cancer/takin... incr risk for — obesity — diabetes — heart disease — deep-vein thrombosis — some cancershealth.harvard.eduTaking breaks from sitting to move around may lower cancer risk - Harvard HealthA 2026 study of more than 91,000 adults found that uninterrupted sitting raised risk for death from cancer. Replacing prolonged sitting with light, moderate, or vigorous activity significantly redu... 174
Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 15/07/2026Does targeting zombie cells actually fight #aging? www.medicaldaily.com/can-removing... — Many clinical trials of dasatinib + quercetin in progress — Showing modest benefits for some idiopathic age-related disorders — No broad-spectrum #longevity benefits observed for healthy peoplemedicaldaily.comCan Removing "Zombie Cells" Slow Aging? Human Clinical Trials Are Starting to Deliver AnswersSenolytics — drugs that selectively eliminate senescent cells — have moved from mouse experiments to human clinical trials across kidney disease, Alzheimer's, and frailty. Here is an honest account of... 131
Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 15/07/2026When is #longevity unhealthy? www.theguardian.com/wellness/202... — when ageisms blocks people from career opportunities — when pressure to look youthful drives people surgery & pharmaceuticals — when people pursue high-tech interventions instead of evidence-based healthy lifestyle interventions🧪theguardian.com‘Anti-ageing is anti-life’: why longevity culture is just ageism in a lab coatRapid scientific progress has given us the tools to stop time more convincingly than ever – but lurking behind these claims is the same fear of ageing 0198
Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 14/07/202695% chance you're not eating enough #dietary #fiber? news.stanford.edu/stories/2026... — 5% of American adults eat 25 g recommended — gut microbes convert fiber to short-chain fatty acids lowering inflammation, #cancer & #diabetes risk 🧪 — try whole fruits, vegetables, smoothies vs. processed foodnews.stanford.eduAre you getting enough fiber?Only 5% of American adults meet the daily recommended intake for fiber – and the consequences go well beyond digestion. Here’s what nutrition researchers want you to know. 1145
Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 14/07/2026#longevity researchers begin focusing on our disappearing #thymus glands www.nature.com/articles/d41... thymus shrinks with #aging — slowly converts to fatty tissue & stops making T cells — age 40, only 25% T cells made — age 65, only 10% T cells made — increased risk of #cancer & #infection 🧪nature.comCould this mysterious disappearing organ hold the key to longevity?Researchers are racing to regrow the thymus, an ephemeral immune organ, in the hope that it will slow ageing. 1142