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Dr. Todd Ewing PhD.

@ewingt-phd.bsky.social
440 followers 732 following 576 posts

Drug Discovery / Aging / Fitness Convincing myself that aging is simply loss of regulation/repair and CAN BE reversed! I wrote a book! BIOLOGICAL YOUTH amazon.com/dp/1535584459

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Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 4h
Excellent study! In the competition of genome replication in the gut, pathobionts devote genes for microtoxins instead of complex carbohydrate catabolism We all need to reduce dietary refined carbs in order to promote diverse eutrophic gut microbiome
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Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 29/09/2026
Older adults still taking common drugs, despite new guidelines www.sfchronicle.com/health/aging... — medicines are like barnacles, easy to start, hard to stop — #benzodiazepines for insomnia, anxiety — #antibiotics for uncomplicated diverticulitis — #aspirin for primary prevention #aging 🧪🩺📊🧬🛟
sfchronicle.com
Guidelines changed on these common drugs. Many older adults still take them
New research shows how hard it can be to stop medications once they become routine, even after medical advice shifts.
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Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 26/09/2026
Why tech billionaires don't ask theoretical physicists for #longevity advice www.theguardian.com/science/2026... “We’re a blink of an eye compared with the age of the universe. If I spend that blink of an eye trying to extend it to two blinks of an eye, I’m not sure it's a worthwhile thing” 🧪
theguardian.com
Tech billionaires trying to live for ever? That’s a waste of time, says physicist
Exclusive: Prof Jim Al-Khalili says he will offer solution to ‘arrow of time’ problem in Royal Institution lectures
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Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 26/09/2026
More positive results for #creatine #supplement lifespan.io/creatine-pro... — 5g twice/day increases strength, endurance & (maybe) cognitive function — helps both in combination with #exercise & #diet or not
lifespan.io
Creatine Protects Lean Mass Even Without Exercise
According to a new study, creatine supplementation might help maintain and increase lean mass even without diet or exercise.
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Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 25/09/2026
Physiological resilience strengthens when social vs. lone?
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P. Inglish @gmpinglish.bsky.social · 23/09/2026
Good!
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Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 22/09/2026
More evidence added #sugar accelerates #aging theconversation.com/babies-born-... — Britain’s postwar sugar rationing reduced infant exposure — Rationing ended September 1953 & infant exposure 2X — Incr. sweetness preference — Incr. 5 types of cancer: breast, prostate, liver, rectal, lung #health
theconversation.com
Babies born under sugar rationing grew into adults with lower cancer risk
Britain’s postwar sugar rationing was an accidental experiment. Decades on, it’s revealing how early diet shapes cancer risk, ageing and eating habits for life.
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Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 21/09/2026
Can #nutrients in our foods mimic calorie restriction and increase our #healthspan? 🧪 theconversation.com/can-nutrient... — No evidence yet for #supplements spermidine, urolithin A, resveratrol — Overwhelming evidence for whole #plantbased foods via Prof Justin Roberts @us.theconversation.com
theconversation.com
Can nutrients in our foods mimic calorie restriction and increase our healthspan?
Researchers are investigating whether food compounds can imitate calorie restriction. The strongest evidence still comes from cells and animals.
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Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 19/09/2026
Why is #cysteine amino acid so toxic to cells? www.rockefeller.edu/news/40469-c... — intracellular cysteine stored as glutathione — excess cysteine frees iron from ferritin — excess iron in mitochondria damages iron-sulfur proteins — mitochondria fail — cell death #health #supplement #aging
rockefeller.edu
The Rockefeller University » Why high levels of the amino acid cysteine are toxic to cells
The findings explain why the cell prefers glutathione, and may lead to new therapies for certain types of neurodegeneration and cancers.
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marypsaeake.bsky.social @marypsaeake.bsky.social · 12/09/2026
See, it's not that hard to change to a plant-based diet at all!
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Aging Journal @aging-us.bsky.social · 18/09/2026
#PaperoftheDay: "Control theory of aging and longevity for gerotherapeutic drug discovery: state space, vector fields, modalities, safety, and the minimum safe cost of functional restoration" DOI ⬇️ bit.ly/3T8bQg0 #Aging #Research #OpenAccess #Gerontology #Publishing
doi.org
Control theory of aging and longevity for gerotherapeutic drug discovery: state space, vector fields, modalities, safety, and the minimum safe cost of functional restoration | Aging
Existing aging theories describe what changes with age but do not prescribe how to intervene. We propose a control-theoretic framework that is not merely descriptive but prescriptive: it specifies wh
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Simple as possible - not simpler @ockamsrazor.bsky.social · 11/09/2026
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Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 11/09/2026
Apple introduces #biological #aging in #health app🧪 www.apple.com/newsroom/202... Incorporates — resting heart rate, sleep, HRV — physical tests of flexibility, strength, balance, movement mechanics, VO2 max — 50 lab tests for $119 @ Quest Diagnostics #geronsky #gerosky @geronsociety.bsky.social
apple.com
Apple advances health and fitness capabilities using Apple Intelligence
Apple today announced its most advanced health and fitness experience yet, deepening the capabilities of Apple Watch and iPhone as intelligent, science-based tools for personal health.
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Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 08/09/2026
Eating nuts associates with reducing hypertension risk theconversation.com/eating-a-han... — largest risk factor for early death by #heart attack, #stroke, #kidney failure, #dementia — 35g/d nuts assoc w/ 26% lower risk hypertension — #plantbased may provide even further benefit #health #wellness
theconversation.com
Eating a handful of nuts each day is linked with lower risk of high blood pressure, our research shows
Consuming between 30-35g of nuts daily was linked with a 26% lower risk of hypertension.
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Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 08/09/2026
Here's another excellent study supporting my developing Regulation Theory of Aging wherein loss of physiological regulation underpins all #aging phenotypes "structural aging is coordinated across organs within individuals" credit to researchers @sbpdiscovery.bsky.social #science 🧪 #GeroSky
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Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 08/09/2026
Fascinating study of mouse brain waste clearance "Disruption of brain waste clearance has emerged as — a key feature of brain aging and — a common hallmark across neurodegenerative diseases"
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Dona Dickinson @donadickinson.bsky.social · 07/09/2026
It makes a lot of sense that our bodies adapt to dietary changes and optimize over time. Thanks for sharing this.
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Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 07/09/2026
Neutrophil NET clearance & predisposition to #disease www.sciencedirect.com/science/arti... DNASE1*2/Q222R gene variant assoc with — reduced DNase I activity — impaired NET clearance during inflammatory stress — myocardial infarction, autoimmunity, malignancy, liver disease #genetics 🧪 🧬
sciencedirect.com
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Scott McGrath @smcgrath.phd · 07/09/2026
🧪 New pre-print: A single-payer healthcare system would cut US health spending by $1.04 trillion annually and save 114k lives. Remarkably, nearly half of those preventable deaths aren't among the uninsured, but found within the 45M underinsured adults who still can't afford timely care. #MedSky 🛟
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Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 07/09/2026
Long-term adaptation to #plantbased #diet www.pcrm.org/news/news-re... Iron – absorbs more efficiently Creatine & carnosine – increases biosynthesis Protein – muscle mass, strength comparable Fiber – ferments more efficiently Polyphenols – higher levels of microbial metabolites
pcrm.org
The Body Doesn't Just Absorb a Plant-Based Diet—It Adapts to One, New Review Finds
WASHINGTON, DC — A new peer-reviewed review published in the journal Biology argues that much of the debate over whether plant-based diets deliver enough iron, protein, creatine, and other nutrients r...
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Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 07/09/2026
Conclusion: Tumor-targeted multifunctional extracellular vesicles — selective and enhanced tumor-targeted cell killing in vitro — opportunity for developing EV-based drug carriers for cancer therapy
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Dona Dickinson @donadickinson.bsky.social · 05/09/2026
Lovely to see science showing these results. Both yoga and Pilates emphasize mindfulness and the importance of breath, which may help reduce stress. I look forward to more research on these topics!
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Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 05/09/2026
#yoga & #pilates may boost #longevity! news.asu.edu/20260904-hea... — researchers @arizonastateuni.bsky.social analyze 21 complementary & alternative medicine #lifestyle interventions — most show no #longevity benefit, except yoga & pilates — needs validation w follow-up studies! #health #geroage
news.asu.edu
ASU researchers find yoga and Pilates associated with longer lifespans | ASU News
Anti-aging advice is everywhere. After all, who doesn’t want to live a longer, healthier life?But according to Arizona State University researcher Connor Sheehan, not every wellness practice promoted ...
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Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 01/09/2026
NRF2 loss in #brain #cells associates with #dementia www.ed.ac.uk/news/support... — dementia linked to fewer but larger nerve fibers — excess myelin coating — loss of NRF2 in myelin producing cells — NRF2-targeted interventions could preserve cognition #health #aging #research
ed.ac.uk
‘Supportive’ brain cells may drive cognitive decline | News | The University of Edinburgh
Brain cells that produce the protective coating around nerve fibres can become dysfunctional with age and may actively contribute to cognitive decline, according to new research.
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Jungle Jane @jngljane.bsky.social · 29/08/2026
Vegans in Loma Linda, CA are some of the longest living people ("blue zone"). These findings may point to why.
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Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 29/08/2026
Month of #vegan vs. #carnivore #diet? www.verywellhealth.com/vegan-reduce... — epigenetic changes reduce #cancer risk, slow #aging — reduces pro-inflammatory white blood cells — increases anti-inflammatory CD4+ T cells via @miramiller.bsky.social verywellheath #plantbased #health #lifestyle
verywellhealth.com
1 Month of Eating Vegan May Reduce Inflammation and Slow Aging, Study Shows
A new study suggests just a month of plant-based eating can reduce inflammation slow biological aging.
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Boodreaux's Fjords @boodreaux.bsky.social · 20/08/2026
Rare disease/orphan drug win!
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Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 27/08/2026
Fascinating news update from @natureportfolio.nature.com — BDNF brain-derived neurotrophic factor supports neural connections — People with major depressive disorder have lower blood levels of BDNF — Over time, some antidepressants seem to increase production & signalling of BDNF #neurology 🧪
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Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 20/08/2026
Ozempic moment for #narcolepsy & #brain? www.nature.com/articles/d41... US FDA approves first drug for narcolepsy — oral pill agonist for orexin-peptide-deficient patients — 1 in 2000 US residents suffer orexin deficiency — disrupted sleep/wake cycle, cataplexy, paralysis, hallucination 🧪
nature.com
First-of-its-kind narcolepsy drug opens door to new therapies for the brain
The drug, called Orzeyful, takes aim at the root cause of the sleep disorder rather than at its symptoms.
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Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 20/08/2026
Can AI agents replace AI scientists? www.nature.com/articles/d41... With current tech, they failed, but they: — performed solid literature reviews — performed 100s experiments over several days — avoided getting stuck — caught self hallucinations — avoided cutting corners or ‘reward hacking’
nature.com
AI isn’t ready to research itself
An agentic system successfully developed concepts from two computer-science papers — but the original authors were not impressed.
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Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 19/08/2026
Biodegradable balloon? www.bbc.com/news/article... — biodegrades in 9 months — protects seabirds from balloon marine debris — 2 more yrs to market — future applications: gloves, surgical materials, medicinal apparatus, clothing, condoms #environment #health #engineering #science 🧪
bbc.com
Scientists invent 'world's greenest balloon'
Imperial College London experts say standard party balloons can take years to break down.
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Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 13/08/2026
Secret to longevity? Active #muscle! 💪 absorbs 80% of glucose in bloodstream 💪 strength training 2 hrs / wk reduces mortality by 13% 💪 adding aerobic 2.5 hrs / wk reduces mortality by 45% theconversation.com/people-who-l... credits @us.theconversation.com #health #lifestyle #aging
theconversation.com
People who lift weights live longer – new study
People who did around 90 to 120 minutes of strength training each week have a 13% lower risk of dying from any cause.
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Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 12/08/2026
Editorial on anti- #aging by @natmed.nature.com www.nature.com/articles/s41... My faves: — clinical trials using surrogate markers of biological aging — #proteomics, #metabolomics, #transcriptomics, #imaging — functional tests of body systems, physical strength, exercise capacity 🧪 #longevity
nature.com
Anti-aging interventions need less hype and more clinical evidence - Nature Medicine
The aging field needs to develop reliable biomarkers of aging and a solid evidence base for the safety and efficacy of anti-aging treatments.
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Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 10/08/2026
A typical human cell experiences 100,000 damages to #DNA every day! — most damage is repaired, especially nightly — un-repaired damage contributes to #cancer and #aging — consider minimizing daily damage & maximizing nightly repair #health #lifestyle #longevity
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Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 10/08/2026
How we can align mealtimes with #metabolism & #circadian #rhythm www.bbc.com/future/artic... — breakfast like a king — lunch like a prince — dinner like a pauper
bbc.com
We're getting mealtimes wrong - here's the best time to have dinner
The emerging science of chrononutrition suggests you should pay more attention to your body clock when planning your meals.
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🌴 Scott Zona, Ph.D. 🌴 @scottzona.bsky.social · 10/08/2026
Buddleja davidii is often called “invasive.” It certainly colonizes disturbed areas (like RR lines), but I’ve never seen it invade intact ecosystems. Weedy on ecosystem edges? Definitely! Invasive? I’m not convinced. 📷: Bluebell Railway nigelmenzies CCBYNCND2 #Scrophulariaceae #Botany 🌾🧪🌱
Photo of a railway line running through a small, shallow ravine. The slopes of the ravine are covered by pink flowering shrubs (Buddleja davidii). A bridge across the ravine is visible in the background.
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Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 10/08/2026
Extracellular vesicles (EVs) offer: — low immunogenicity — biocompatibility — intercellular communication Major challenges: — EV heterogeneity — functional EV subpopulations — targeted delivery — engineering strategies — biologically relevant potency assays 🧪 #pharma #tech #health #science
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Tess @itstessinadress.bsky.social · 10/08/2026
Me: how the fuck did I lose 10kg since last weigh-in eating junk food and not exercising ☹️ Science: remember your childhood? Me: ...nno? 🤨 Science: well, it may have put you in a permanent elevated metabolic rate for survival! You literally, biologically, lack a "resting" state, on a cellular level!
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Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 09/08/2026
Fascinating! "We carried out longitudinal, multi-omic analyses of — nasal swabs — peripheral blood mononuclear cells — endotracheal aspirates and found significant reactivation of chronic viruses, particularly from the Herpesviridae & Anelloviridae families, associated with COVID-19 severity" 🧪
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AquamarineinCA @aquamarineinca.bsky.social · 09/08/2026
Methinks the study methodology needs refinement, if fruits and veggies were concluded irrelevant? But, yeah, in the UK...?🤔🤪
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Nobilis Reed @nobilis.bsky.social · 08/08/2026
Some of these make sense but I wonder how much fiber would be in this diet. Legumes can do some of the work, but still...
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Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 08/08/2026
Perhaps #longevity can be taken too far? robbreport.com/lifestyle/he... — longevity-fixation syndrome: obsession of longevity at expense of #health, #relationships — "you can optimize the life out of your life" — wellness industry valued at $5 billion in 2024
robbreport.com
The Mental Toll of Being Obsessed With Living Longer
Longevity-fixation syndrome isn’t an official diagnosis, but here's how methods to live longer are impacting today's wellness-obsessed enthusiasts.
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Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 08/08/2026
Chinese researchers use machine learning to identify the optimal anti- #aging #diet Curiously, they name it the MYTH diet! www.nature.com/articles/s41... Perhaps the study population skewed the results? UK residents? LMK what you think 🧐 #health #lifestyle #longevity
nature.com
A machine learning-derived dietary pattern for aging - npj Science of Food
npj Science of Food - A machine learning-derived dietary pattern for aging
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Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 06/08/2026
Excitement is growing over #glutathione and #peptide injections — but risk of #endotoxin contamination persists www.expressnews.com/news/texas/a... — Texas pharmacy recalls compounded glutathione vials — Even >99% purity can contain toxic levels of endotoxin — Resistant to sterilization
expressnews.com
Texas pharmacy recalls injectable peptides over life-threatening endotoxin risk
The Austin pharmacy said it received reports of fever, chills, severe headaches, nausea, vomiting, rapid heart rate, blood pressure changes, body aches and injection-site reactions.
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Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 30/07/2026
Are you burning #fat? A breathalyzer might tell you www.nature.com/articles/d41... #ketosis — a metabolic state when free fatty acids are metabolized into ketones by the liver for fuel — diets low in #carbohydrate — high-intensity #exercise — difficult to measure in real time #health #lifestyle
nature.com
Breathalyser can tell if you are burning fat from a single exhalation
The compact device can measure when the body is in ketosis and could help people to manage weight loss.
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Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 16/07/2026
Long periods sitting a hazard? www.health.harvard.edu/cancer/takin... incr risk for — obesity — diabetes — heart disease — deep-vein thrombosis — some cancers
health.harvard.edu
Taking breaks from sitting to move around may lower cancer risk - Harvard Health
A 2026 study of more than 91,000 adults found that uninterrupted sitting raised risk for death from cancer. Replacing prolonged sitting with light, moderate, or vigorous activity significantly redu...
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Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 15/07/2026
Does targeting zombie cells actually fight #aging? www.medicaldaily.com/can-removing... — Many clinical trials of dasatinib + quercetin in progress — Showing modest benefits for some idiopathic age-related disorders — No broad-spectrum #longevity benefits observed for healthy people
medicaldaily.com
Can Removing "Zombie Cells" Slow Aging? Human Clinical Trials Are Starting to Deliver Answers
Senolytics — drugs that selectively eliminate senescent cells — have moved from mouse experiments to human clinical trials across kidney disease, Alzheimer's, and frailty. Here is an honest account of...
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Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 15/07/2026
When is #longevity unhealthy? www.theguardian.com/wellness/202... — when ageisms blocks people from career opportunities — when pressure to look youthful drives people surgery & pharmaceuticals — when people pursue high-tech interventions instead of evidence-based healthy lifestyle interventions🧪
theguardian.com
‘Anti-ageing is anti-life’: why longevity culture is just ageism in a lab coat
Rapid scientific progress has given us the tools to stop time more convincingly than ever – but lurking behind these claims is the same fear of ageing
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Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 14/07/2026
95% chance you're not eating enough #dietary #fiber? news.stanford.edu/stories/2026... — 5% of American adults eat 25 g recommended — gut microbes convert fiber to short-chain fatty acids lowering inflammation, #cancer & #diabetes risk 🧪 — try whole fruits, vegetables, smoothies vs. processed food
news.stanford.edu
Are you getting enough fiber?
Only 5% of American adults meet the daily recommended intake for fiber – and the consequences go well beyond digestion. Here’s what nutrition researchers want you to know.
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Dr. Todd Ewing PhD. @ewingt-phd.bsky.social · 14/07/2026
#longevity researchers begin focusing on our disappearing #thymus glands www.nature.com/articles/d41... thymus shrinks with #aging — slowly converts to fatty tissue & stops making T cells — age 40, only 25% T cells made — age 65, only 10% T cells made — increased risk of #cancer & #infection 🧪
nature.com
Could this mysterious disappearing organ hold the key to longevity?
Researchers are racing to regrow the thymus, an ephemeral immune organ, in the hope that it will slow ageing.
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