Single-molecule imaging reveals diverse, megabase-scale heterochromatin domains in C. elegans. Some resemble TADs and depend on condensin I; others are independent of condensin and histone H3K9me, inc...

What To Fear from AI Agents and How to Reclaim Our Human Agency

10/09/2026: Timothy Heinichen got his degree on Biomedical Research in Medicine! This was long due: It was great to see Timothy graduating in July the 20th in San Raffaele University with his work o...

Comparing signaling response profiles and fate outcomes in single cells reveals logic and limits of signal interpretation.

01/04/2026: A wrap-up of EMBL's Biological Oscillators meeting It was great to visit the EMBL in Heidelberg for be Biological Oscillators 2026 meeting, by far one of my favourite ones. An occasion to ...

Real-time, single-cell imaging reveals ERK signaling dynamics in response to T cell receptor stimulation.

In defense of the role of theory in innovation

We are a team interested in (nonlinear) dynamical systems, in cell biology, in systems biology and in combinations of these elements. Here you can learn about us, who we are, what we publish, how to c...

Our ever-growing capacity to observe dynamic processes at the single-cell level has highlighted how cells use complex signaling dynamics to provide adequate ...

Genetic deficiency of otoferlin, a protein critical to synaptic transmission by the sensory hair cells of the ear, causes congenital deafness. Medicines to treat the condition are lacking; children...

A group of Italian physicists was awarded the Ig Nobel Prize in Physics for their study of the phase diagram of a cheesy sauce renowned in Italy.

A Response to Thomas Friedman's Recent AI Columns in the New York Times

Each of us is a story. Mine is a story of doing science for 60 years, and I am honored to be asked to tell it. Even though this autobiography was written for the Annual Review of Immunology, I have ch...

The United States’ democratic leadership, commitment to freedom of expression, and investment in the pursuit of knowledge have long enabled its preeminence in science and technology. Yet today we are ...

By the authority vested in me as President by the Constitution and the laws of the United States of America, and to improve the process of Federal

Nernst's theorem—a general experimental observation presented in 1905 that entropy exchanges tend to zero when the temperature tends to zero—has been directly linked to the second principle of thermodynamics in a paper published in The European Physical Journal Plus, whose sole author is University of Seville professor José Martín-Olalla.

Single-cell omics methods promise to revolutionize our understanding of gene regulatory processes during cell differentiation, but analysis of such data continues to pose a major challenge. Apart from...

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...