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Uri Alon

@urialonlab.bsky.social
698 followers 32 following 38 posts

The Alon lab explores design principles of biological circuits, focusing on systems medicine, aging, and healthspan.

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Uri Alon @urialonlab.bsky.social · 09/09/2026
Excited to be speaking at the 2026 Biomarkers of Aging Conference, October 5-6, at Harvard Medical School's Joseph B Martin Conference Center. www.agingconsortium.org/2026-confere...
agingconsortium.org
2026 Biomarkers of Aging Conference — Biomarkers of Aging Consortium
Join the 2026 Biomarkers of Aging Conference to explore cutting-edge research in geroscience, aging biomarkers, and longevity interventions. Connect with global experts and leaders driving innovation ...
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Uri Alon @urialonlab.bsky.social · 20/08/2026
Happy to share that I was named one of TIME’s 2026 Longevity Leaders. Our work uses physics-style theory to look for simple principles that can explain the complex dynamics of aging. x.com/UriAlonWeizm...
x.com
Uri Alon (@UriAlonWeizmann) on X
Happy to share that I was named one of TIME’s 2026 Longevity Leaders. Our work uses physics-style theory to look for simple principles that can explain the complex dynamics of aging. https://t.co/Y7Kc...
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Uri Alon @urialonlab.bsky.social · 02/07/2026
Why do animals age in such similar ways, yet live for wildly different spans - from days to a century? Our new paper in @NatureAging fits a damage accumulation model across 9 species and finds the knob that best predicts lifespan doi.org/10.1038/s435...
doi.org
A damage accumulation model identifies distinct aging regimes across species - Nature Aging
Raz and colleagues fit survival data across species to a stochastic model of damage accumulation and removal. They report that damage production rate best predicts lifespan and reveal two distinct agi...
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Uri Alon @urialonlab.bsky.social · 07/06/2026
What happens just before we die? Are the last stages of deterioration driven by different dynamics, or the same processes driving aging all our lives? Turns out it's the latter, as we show in our new preprint! 🔬 doi.org/10.64898/202... 🧵 1/5 #AgingResearch #SystemsBiology
doi.org
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Uri Alon @urialonlab.bsky.social · 06/05/2026
Identify. Attack. Resolve. The immune system follows a perfect defense program: ignore weak/self signals, attack true threats with force, then shut down to avoid damage. (1/2) www.science.org/doi/10.1126/...
science.org
Excitability as a design principle in the immune system
A simple pulse-and-rest circuit may explain how immune cells strike hard at threats yet avoid self-destruction.
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Uri Alon @urialonlab.bsky.social · 04/12/2025
Recommended listening. I was hosted on the podcast “Gil Hameever” to discuss our latest paper about the sudden physiological changes at menopause. The conversation is in Hebrew. open.spotify.com/episode/0EVA...
open.spotify.com
פרק 36: חשיפת בכורה של מחקר פורץ דרך של מכון ויצמן בנושא מנפאוזה
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Uri Alon @urialonlab.bsky.social · 03/12/2025
We analyzed changes in physiology relative to menopause using two large scale studies that include millions of lab tests. Rather than align by age, we used statistical inference to align tests to final menstrual period. (1/2) arunamed.com/the-menopaus...
arunamed.com
The Menopause Cliff: What a Million Women's Lab Tests Reveal
TLDR: A massive study of 300+ million lab tests from 1+ million women just proved what women have been saying for years: menopause isn't a gradual slope—it's a physiological cliff. Nearly e
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Uri Alon @urialonlab.bsky.social · 25/05/2025
Why does innovative research necessitate a jump into the unknown? Find out (and much more) in episode 147 of רעב לידע עם אור דניאל (Hungry for Knowledge with Or Daniel)! www.learntech.co.il/podcast/pod1...
learntech.co.il
מדוע מדע חדשני דורש קפיצה אל הלא נודע? | פרופ' אורי אלון | פרק 147 · LearnTech
הכירו את פרופ' אורי אלון, מנהל מעבדת סגול לאריכות ימים במכון ויצמן. בפרק מרתק זה תגלו מדוע תסכול וכישלון הם לא רק חלק מהמחקר אלא המפתח לגילויים פורצי דרך, איך "ענן המחקר" יכול להפוך מאויב למדריך, ומה ...
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Uri Alon @urialonlab.bsky.social · 23/04/2025
Sweet moment in life, our 25th lab anniversary. In a circle, we looked at each other, a group of people with shared values and a soft approach, who want each other to succeed and be happy. (1/2)
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Uri Alon @urialonlab.bsky.social · 16/04/2025
Masterpiece by a masterful scientist Natural Neuroscience by Nachum Ulanovsky @mitpress.bsky.social mitpress.mit.edu/978026204499...
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Uri Alon @urialonlab.bsky.social · 11/04/2025
Our latest on aging, where we reveal an unexpected link between healthspan and equality of lifespans. By @y1fanyang.bsky.social , out now @naturecomms.bsky.social www.nature.com/articles/s41...
nature.com
Compression of morbidity by interventions that steepen the survival curve - Nature Communications
Longevity research aims to extend lifespan and reduce sickspan in aging. Here, the authors show that only interventions that steepen survival curves can compress the sickspan relative to lifespan.
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Uri Alon @urialonlab.bsky.social · 31/03/2025
Now in French and Spanish - our pregnancy paper is highlighted also in @lefigaro.fr and @elpais.com sante.lefigaro.fr/medecine/com... elpais.com/salud-y-bien...
sante.lefigaro.fr
Comment la grossesse chamboule le corps de la future mère, et pourquoi elle ne redevient jamais vraiment elle-même
Une étude menée sur plus de 300 000 femmes révèle les bouleversements visibles dans le sang et l’urine des femmes enceintes. Des résultats qui pourraient aider à mieux prédire les complications de la ...
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Carlos Caldas 🇵🇹🇮🇱🇪🇺🇬🇧 @carloscaldas1960.bsky.social · 30/03/2025
Amazing clinical epidemiology! The power of numbers! @urialonlab.bsky.social www.nature.com/articles/d41...
nature.com
Pregnancy’s true toll on the body: huge birth study paints most detailed picture yet
Data from 300,000 births reveal how essential biological measurements are altered by carrying and delivering a baby.
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Carissa Wong @carissacwwong.bsky.social · 28/03/2025
We now have our most detailed picture yet of how pregnancy affects the body on a weekly basis from 20 weeks pre-conception to 1.5 years after delivery. Fab work from @urialonlab.bsky.social Read @newscientist.com. www.newscientist.com/article/2473...
newscientist.com
Pregnancy’s lasting effects on different parts of the body revealed
An "unprecedented view" of how the body changes during and after pregnancy has revealed many long-lasting impacts on the liver, kidneys and more
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Uri Alon @urialonlab.bsky.social · 30/03/2025
"Pregnancy’s true toll on the body: huge birth study paints most detailed picture yet" Our study highlighted in @nature.com News www.nature.com/articles/d41...
nature.com
Pregnancy’s true toll on the body: huge birth study paints most detailed picture yet
Data from 300,000 births reveal how essential biological measurements are altered by carrying and delivering a baby.
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Uri Alon @urialonlab.bsky.social · 27/03/2025
Excited to share our new study revealing the intricate dynamics of pregnancy & postpartum physiology! We analyzed 40M lab tests from 300K pregnancies and 160K women (cross-sectional) and mapped week-by-week changes starting from preconception to months-long postpartum recovery.
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Waggoner Lab @labwaggoner.bsky.social · 27/03/2025
Harnessing huge data from pregnancy natural experiments @urialonlab.bsky.social www.science.org/doi/10.1126/... www.science.org/doi/10.1126/...
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Uri Alon @urialonlab.bsky.social · 24/03/2025
Theory predicted two kinds of fibrosis, hot and cold. We show in vivo that hot and cold fibrosis describe heart failure, and heart attack, respectively, showing that they are very different disease states. @shovalmiyara.bsky.social @eldadtzahor.bsky.social
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Uri Alon @urialonlab.bsky.social · 18/03/2025
Sagol lecture in longevity research - Myriam Grunewald on vasculature maintenance for longevity
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Uri Alon @urialonlab.bsky.social · 24/02/2025
Join us at the ICSB in Dublin this October - I will chair the session on aging systems biology icsb2025.com
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Shoval Miyara @shovalmiyara.bsky.social · 19/02/2025
It’s finally here! My PhD work, five years in the making, is now published @CellSystems @cellpress.bsky.social 🚨 Cold and hot fibrosis define clinically distinct cardiac pathologies. www.cell.com/cell-systems...
cell.com
Cold and hot fibrosis define clinically distinct cardiac pathologies
Miyara et al. identify two types of fibrosis in cardiac pathologies: “hot fibrosis,” involving macrophage-myofibroblast interactions in chronic injuries, and acute-injury-driven “cold fibrosis,” contr...
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Uri Alon @urialonlab.bsky.social · 10/02/2025
My brilliant PhD student @Yaelebel.bsky.social gave a talk at the Azrieli Graduate Students forum about her research on using excitable dynamics to explain pulsatile immune phenomena, and how research questions can come from the most unexpected places. Well done Yael! youtu.be/MdwqWx5emo4
youtu.be
Yael Lebel
YouTube video by Azrieli Fellows Program
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Uri Alon @urialonlab.bsky.social · 09/02/2025
Will be attending the Quantitative Immunology workshop at the Princeton Center for Theoretical Science later month. pcts.princeton.edu/events/2025/...
pcts.princeton.edu
Quantitative Immunology
Organizers: Andrea Graham; Julia Merkenschlager; Alexander Ploss; Colin Scheibner; Ned WingreenThe immune system functions across diverse scales, from the recognition of molecules to the evolution of ...
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Uri Alon @urialonlab.bsky.social · 04/02/2025
Why do cortisol-lowering drugs work for Cushing’s but fail in mood disorders & chronic stress? We propose that the ability of the pituitary and adrenal glands to adjust their functional masses—normally beneficial—counteracts the drug’s effect. Using a math. model, we screened HPA interventions (1/2)
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Molecular Systems Biology @molsystbiol.org · 04/02/2025
@urialonlab.bsky.social lab reveals a hormone circuit that explains why most HPA drugs fail for mood disorders and predicts the few that work ➡️ www.embopress.org/doi/full/10....
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The Elowitz Lab at Caltech @elowitzlab.bsky.social · 24/12/2024
Really enjoying Uri Alon’s characteristically wonderful lectures on aging: www.weizmann.ac.il/mcb/alon/cou...
weizmann.ac.il
Systems Aging (autumn 2024)
Course Theme Song
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Uri Alon @urialonlab.bsky.social · 30/01/2025
Videos and lecture notes from my latest course, Systems Aging, are available now at: www.weizmann.ac.il/mcb/alon/cou...
weizmann.ac.il
Systems Aging (autumn 2024)
Course Theme Song
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Uri Alon @urialonlab.bsky.social · 28/01/2025
Excited to speak at the Global Conference on Gerophysics, where we'll explore how physics can revolutionize our understanding of aging and mortality. Join us and get 10% off registration with code GCGP10. See you there, and sign up here: medicine.nus.edu.sg/trp/healthy-...
Invitation poster to the Global Gerophysics conference
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