Summary: This Review explores proteomic strategies for investigating cilia, tracing the evolution from early discoveries to recent advancements enabled by proximity labeling techniques.

Nature - Repeated damage from extreme heat over time seems to be a leading factor causing kidneys to fail.

Spd-2 organizes the assembly of two distinct centriole-scaffolds to build mitotic centrosomes in Drosophila.

An atlas mapping organ-specific metabolite production and consumption across various pathophysiological states in pigs shows impaired metabolic activity across organs by a Western diet or hypercholest...

BSCB GenSoc UK Cilia and Centrosome Network e-Symposia Series

Cilia and flagella are eukaryotic organelles involved in multiple cellular functions. The primary cilium is generally non motile and found in numerous vertebrate cell types where it controls key signa...

Decoding the content of extracellular vesicles (EVs) is key to understanding cell communication. Nikonorova et al. used targeted proximity labeling to uncover polycystin EV cargo and cargo-loading mec...

Nature Reviews Nephrology, Published online: 27 March 2025; doi:10.1038/s41581-025-00946-1In this Review, the authors discuss mass spectrometry (MS) imaging and spatially resolved MS approaches that are being employed in nephrology applications. They also highlight emerging MS methods and applications, as well as the integration of MS data with data from other omics approaches.

For cells to polarize collectively along a tissue plane, asymmetrically localized planar cell polarity (PCP) complexes must form intercellular contacts between neighboring cells. Yet, it is unknown wh...

Genetic screen finds lipoylation as a target to improve radiation success in lung cancer by blocking DNA damage repair.

Dynamic control of ciliary membrane protein content is crucial for organelle homeostasis and signaling function and involves removal of ciliary components by BBSome-mediated export, endocytic retrieva...

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