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Papalopulu Lab

@papalopululab.bsky.social
99 followers 99 following 21 posts

Interested in how changes in gene expression dynamics underlie cell state transitions in development and cancer. Our team is led by Prof Nancy Papalopulu and we are based at the University of Manchester.

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Reposted by Papalopulu Lab
Development @dev-journal.bsky.social · 12/06/2026
Read the Research Article 'Oscillatory co-expression of HES1 and HES5 enables a hybrid state in a cross-repressive transcription factor regulatory motif' here. journals.biologists.com/dev/article/...
journals.biologists.com
Oscillatory co-expression of HES1 and HES5 enables a hybrid state in a cross-repressive transcription factor regulatory motif
Highlighted Article: Expression of the cross-repressing proteins HES1 and HES5 is mutually exclusive but when they oscillate, a cell can express both, creating a hybrid state that later resolves into…
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Reposted by Papalopulu Lab
Development @dev-journal.bsky.social · 12/06/2026
To learn more about this work and the people behind it, we talked to Veronica Biga and Cerys Manning. journals.biologists.com/dev/article/...
Veronica Biga (left) and Cerys Manning (right). Image courtesy of Kunal Chopra.
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Papalopulu Lab @papalopululab.bsky.social · 16/06/2026
Read the Research Highlight article!
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Papalopulu Lab @papalopululab.bsky.social · 16/06/2026
The latest article by @veronicabiga.bsky.social uses live-imaging and mathematical modelling to understand how hybrid states emerge in a cross-repressive transcription factor motif!
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Papalopulu Lab @papalopululab.bsky.social · 10/03/2026
Join the Physics of Life ECR online seminar series from 2pm today to see our colleague Andrew Rowntree deliver a talk on computational strategies (informing experiments) to control protein oscillations via microfluidics! A collaborative project with @anzymiller.bsky.social
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Papalopulu Lab @papalopululab.bsky.social · 03/03/2026
Dynamics, dynamics, dynamics! We asked how ER+ breast cancer cells transition from dormancy to reactivation. Inspired by developmental biology, we show that HES1 protein oscillations change during this shift — and that disrupting these dynamics prevents reactivation. www.pnas.org/doi/10.1073/...
pnas.org
HES1 oscillations are required for cell cycle reentry in oestrogen receptor–positive breast cancer cells | PNAS
Long-term recurrence in breast cancer is driven by reactivation of dormant disseminated tumor cells (DTCs) and remains a major clinical challenge, ...
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Papalopulu Lab @papalopululab.bsky.social · 04/11/2025
With the deadline fast approaching don't miss these opportunities to study at Manchester!
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Papalopulu Lab @papalopululab.bsky.social · 21/10/2025
Looking for a PhD? Don't miss this opportunity to work with @anzymiller.bsky.social @lovegrovelab.bsky.social Karel Dorey and @veronicabiga.bsky.social. The deadline is Nov 8th! www.findaphd.com/phds/project...
findaphd.com
(MRC DTP) The impact of cell division on the decoding of oscillatory protein expression during spinal cord development and regeneration at The University of Manchester on FindAPhD.com
PhD Project - (MRC DTP) The impact of cell division on the decoding of oscillatory protein expression during spinal cord development and regeneration at The University of Manchester, listed on FindAPh...
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Papalopulu Lab @papalopululab.bsky.social · 21/10/2025
Two exciting PhD opportunities at the University of Manchester! Apply before Nov 8th!
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Reposted by Papalopulu Lab
the Node @the-node.bsky.social · 12/09/2025
ICYMI, the recordings of our #DevPres webinar on gene regulation are now available. Check out the talks from @dev-journal.bsky.social PI fellows Anzy Miller @anzymiller.bsky.social and Marlies Oomen @marliesoomen.bsky.social. thenode.biologists.com/catch-up-on-... #devbio 🎥
thenode.biologists.com
Catch up on Development presents… webinar on gene regulation - the Node
Catch up on the Development presents... gene regulation webinar, featuring talks from two of Development's PI fellows.
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Papalopulu Lab @papalopululab.bsky.social · 30/09/2025
Check out the Perspective piece by our colleague @anzymiller.bsky.social and other fellows on the Pathway to Independence programme!
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Papalopulu Lab @papalopululab.bsky.social · 04/07/2025
This exciting study led by @anzymiller.bsky.social is now published! NGN3 oscillations control the timing of differentiation during pancreas development through a fold-change sensitive gene regulatory motif. Congratulations to all authors!
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Papalopulu Lab @papalopululab.bsky.social · 30/05/2025
A must read!
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Papalopulu Lab @papalopululab.bsky.social · 29/05/2025
In our latest study by @veronicabiga.bsky.social, we explore how the “Oscillatory Co-expression of HES1 and HES5 Enables a Hybrid State in a Bistable Transcription Factor Regulatory Motif”: www.biorxiv.org/content/10.1...
biorxiv.org
Oscillatory Co-expression of HES1 and HES5 Enables a Hybrid State in a Bistable Transcription Factor Regulatory Motif
Many cell fate decisions in the developing neural tube are directed by cross-repressive transcription factor (TF) motifs that generate bistability, enforcing expression of one dominant TF. However, ev...
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Papalopulu Lab @papalopululab.bsky.social · 07/05/2025
We're very excited to announce that our colleague @anzymiller.bsky.social is about to begin her @dev-journal.bsky.social Pathway to Independence journey! This will provide mentoring and support to emerging researchers in developmental biology and stem cells . journals.biologists.com/dev/pages/pi...
journals.biologists.com
PI programme | Development | The Company of Biologists
PI programme | Development | The Company of Biologists Development's Pathway to Independence programme Development is excited to announce our call for our Pathway to Independence program...
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Reposted by Papalopulu Lab
The Company of Biologists @biologists.bsky.social · 10/04/2025
We are also highlighting John Gurdon, 2012 Nobel laureate in Physiology or Medicine and former Chair of the Board of Directors at @biologists.bsky.social, as an extraordinary biologist. #100biologists
The Company of Biologists 100 logo to the left and QR code to the right.
 
Portrait of John Gurdon to the left, text to the right
 
100 extraordinary biologists

John Gurdon

John Gurdon was Chair of the Board of Directors from 2001 to 2011. He published many articles in Development, including some of the work that led to his 2012 Nobel Prize for cloning amphibians by nuclear transfer.

#100biologists #biologists100
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Reposted by Papalopulu Lab
@physicsoflifeuk @physicsoflifeuk.bsky.social · 10/04/2025
We're excited to host two fantastic speakers at our next online @physicsoflifeuk.bsky.social ECR Seminar on Tuesday 15 April, 2–3 PM BST: Tisma Milos and Thomas McLean chaired by @veronicabiga.bsky.social Please register below for the Zoom link: lnkd.in/dSynrAe8
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Reposted by Papalopulu Lab
The Company of Biologists @biologists.bsky.social · 08/04/2025
We are highlighting Kate Storey, who served as a Director at @biologists.bsky.social from 2007 to 2022 and co-founded the Company’s Workshop programme, as an extraordinary biologist. #100biologists
The Company of Biologists 100 logo to the left and QR code to the right.
 
Portrait of Kate Storey to the left, text to the right
 
100 extraordinary biologists

Kate Storey

Kate Storey served as a Director from 2007 to 2022. She initiated the Company's Workshops programme and co-organised the first Workshop. Kate also co-initiated the Company's support for Sustainable Conferencing. Kate's lab researches nervous system development at the University of Dundee, UK.

#100biologists #biologists100
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Papalopulu Lab @papalopululab.bsky.social · 08/04/2025
We just joined Bluesky and we're hoping to connect with fellow scientists interested in quantitative and developmental biology! Follow us for future updates! Logo credit goes to @golgigraphics.bsky.social
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