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Rubén González

@rubengonzalez.bsky.social
1.2K followers 1.3K following 27 posts

Viral Infections and Virus Evolution. A happy postdoctoral researcher at @salehlabparis.bsky.social, Institut Pasteur (Paris, France). gonzalezrvirus.com

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Rubén González @rubengonzalez.bsky.social · 12/06/2026
The peer-reviewed version: www.science.org/doi/10.1126/...
science.org
Enteric viral infections promote systemic accelerated aging in Drosophila
Enteric viruses act as age-distorters, with infection severity tied to aging hallmarks and consequences.
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John Tuthill @tuthill.bsky.social · 24/03/2026
🧵 New preprint led by @bingbrunton.bsky.social, @elliottabe.bsky.social, @lawrencehu.bsky.social We gave a worm brain control of a fly body and it walked What did we learn? Nothing, other than deep reinforcement learning is effective We call it the digital sphinx www.biorxiv.org/content/10.6...
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Dmitri Petrov @petrovadmitri.bsky.social · 25/03/2026
The conference is quickly filling up! Don't wait to sign up. We also received some funding and can offer fellowships to graduate students and postdocs. Won't cover the whole cost but will certainly make it much easier!
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Björn Schumacher @bjornschumacher.bsky.social · 03/02/2026
🧠⏰our latest paper is out now: how each neuron ages differently allowed us to define in silico screens for new therapeutic molecules that could prevent neurodegeneration @cecad.bsky.social @unicologne.bsky.social @uniklinikkoeln.bsky.social @meyerdh.bsky.social www.nature.com/articles/s43...
nature.com
Aging clocks delineate neuron types vulnerable or resilient to neurodegeneration and identify neuroprotective interventions - Nature Aging
Gallrein et al. pair functional assays with clocks to compare chronological versus biological age of single neuron types in C. elegans, to probe their vulnerability or resilience to neurodegeneration,...
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Labex IBEID @ibeidlabex.bsky.social · 02/02/2026
🔬 Discover the latest advances from Labex IBEID We have released a new white paper highlighting recent scientific and technological advances from the partners. ➡️ Key results ➡️ Latest innovations ➡️ Future challenges for Emerging Infectious Diseases research www.labexibeid.fr/en/ibeid-whi...
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Rubén González @rubengonzalez.bsky.social · 21/01/2026
Not all bacteria are beneficial in every context. We found that enriching Drosophila with a commensal bacterium reduces tolerance to viral infection. The effect was virus-specific and occurred without changes in viral load, immune gene expression or intestinal damage. rdcu.be/eZ4Sd
rdcu.be
Microbiome composition modulates the lethal outcome of Drosophila A virus infection
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Manuel Collado @manuel-collado.bsky.social · 14/01/2026
We just uploaded our most recent paper to @biorxivpreprint.bsky.social and submitted the manuscript for publication. We are really excited with this collaboration between our lab (ColladoLab) @cimususc.bsky.social and the lab of @hanli-pasteur.bsky.social @pasteur.fr
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SalehLab @salehlabparis.bsky.social · 08/01/2026
Kicking off 2026 the best way we know how: together! 🥐👑 Our annual Galette des Rois brought the team together, and Mori Yoshida claimed the crown for the 4th year running! 🎉 But the real treasure? These moments that unite us before another year of discovery. Here's to an incredible 2026! 🔬✨
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Colin Carlson @colincarlson.bsky.social · 05/12/2025
If you want to help, you can share our story, check out our work at viralemergence.org, and - if you're the one in a million person who can save our project - reach out. (At this point, my job is to fundraise for the amazing scientists I work with, so they can focus on doing some actual science! 🦠)
viralemergence.org
Verena
Verena is an NSF-funded Institute working towards using open data, biological research, and artificial intelligence to predict and prevent the next pandemic.
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Mark A. Hanson @hansonmark.bsky.social · 28/11/2025
Now published as version of record at @elife.bsky.social ! Layers of Immunity: Deconstructing the Drosophila effector response. The tools are now deposited in the VDRC (link ⬇️) elifesciences.org/articles/107... shop.vbc.ac.at/vdrc_store/d... #Drosophila #IDsky #SymbioSky #Infection #Immunology
eLife Assessment
This work provides one of the first important attempts to look at Drosophila immune responses against bacterial, viral, and fungal pathogens in a way that combines the roles of four major arms in immunity (Imd signaling, Toll signaling, phagocytosis, and melanization) rather than studying them separately. The findings are compelling and the tools provided can be used as they are, or built upon, in various contexts.

https://doi.org/10.7554/eLife.107030.3.sa0Figure 1 validating the mutations usedFigure 3 summarising the survival results from a 14-genotype 25-pathogen panel.Tracking of mortality and pathogen growth over time, complemented by Figure 5 (not shown) looking at pathogen load upon death.
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Proceedings of the National Academy of Sciences @pnas.org · 26/11/2025
All hail Caenorhabditis elegans, one of the most researched organisms on Earth. Collaborative data sharing in the nematode research community led to four Nobel Prize-winning discoveries about human development and disease. In PNAS: ow.ly/uNqU50Xyj4e
Caenorhabditis elegans, imaged with confocal laser scanning microscopy, and modeled by surface rendering software. Stock image.
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Rubén González @rubengonzalez.bsky.social · 16/11/2025
Version 2 is out! More comprehensive text plus new tissue- and pathway-specific analysis revealing how different viruses trigger systemic aging through diverse mechanisms. www.biorxiv.org/content/10.1...
biorxiv.org
Enteric viral infections promote systemic accelerated aging in Drosophila
Do viral infections accelerate aging, and does this acceleration scale with pathogenicity? Using transcriptomic aging clocks, we measured biological age in Drosophila infected with four enteric RNA vi...
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SFM Microbial Pathogenesis @sfmpathogenesis.bsky.social · 14/11/2025
In flies and worms, more pathogenic viruses caused greater aging acceleration, and the effect lingered even after clearance, new study reveals. #Aging #Infection #MicroSky #Virology 📖 shorturl.at/OeYVp ✍️ @rubengonzalez.bsky.social @castellosanjuan.bsky.social @salehlabparis.bsky.social @pasteur.fr
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Harmit Singh Malik @harmitmalik.bsky.social · 12/11/2025
Are you an early-stage graduate student (2nd or 3rd year) or early-stage postdoc based in the US or Canada, working primarily in Drosophila? Would you like to help improve the experience of all trainees working in Drosophila research? If so, read on. (Please repost to reach a broad audience.)
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Oded Rechavi @odedrechavi.bsky.social · 06/11/2025
IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇
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Joe Grove @grovearmada.bsky.social · 06/11/2025
🧬 Thrilled to share our latest paper in @natmicrobiol.nature.com 📄 A collaboration to give the Flaviviridae (home to Zika, Dengue & HCV) a much-needed taxonomic re-think. Our at-scale AI structure prediction gave a complementary perspective on viral evolution. www.nature.com/articles/s41...
nature.com
Taxonomic expansion and reorganization of Flaviviridae - Nature Microbiology
Analysis of RNA polymerase hallmark gene phylogenies supported by protein structure relationships of flaviviruses and ‘flavi-like’ viruses underpins the taxonomic expansion and reorganization of Flavi...
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Kat Holt @katholt.bsky.social · 03/11/2025
Apart from the AI junk part… the notion that one should not offer a potential mechanistic explanation for an observation, without first spending years & (unavailable) $$ trying to test possibilities before sharing the observation with others (who may be better equipped to investigate the mechanism)…
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eric lai @lucksmith.bsky.social · 29/10/2025
🪰 folks! I spoke to the Transmitter about FlyBase. As noted at flybase.org, bridge $ ran out and many staff were laid off. Good news is stopgap contributions will keep core FlyBase operations active. But community support remains essential. Please donate @FlyBase and share! 1/2 tinyurl.com/FlyBase
tinyurl.com
FlyBase secures funding for year, but future still uncertain
The FlyBase team’s fundraising efforts have proven successful in the short term, but restoration of its federal grant remains uncertain.
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Daniel J Nicholson @djnicholson.bsky.social · 23/10/2025
Last chance to download my book for free! It's still available until tomorrow.
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Bibiana Rojas @biobiiana.bsky.social · 23/10/2025
What makes PhD students happy? Good supervision www.nature.com/articles/d41...
nature.com
What makes PhD students happy? Good supervision
Supervisors who invest in positive mentoring relationships with their PhD candidates also reap the benefits for their own research.
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Rubén González @rubengonzalez.bsky.social · 17/10/2025
Science is so much fun!
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Mauro Castelló Sanjuán @castellosanjuan.bsky.social · 17/10/2025
I'm so excited to share this with all of you! This is the very first paper where I am the first author 🥹 Let me share some insights about our work 👇🧵(1/5): How do persistent viral infections impact the host? What happens when a fly becomes persistently infected by a virus?
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bioRxivpreprint @biorxivpreprint.bsky.social · 16/10/2025
Microbiome composition modulates the lethal outcome of Drosophila A virus infection www.biorxiv.org/content/10.1101/202…
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plasmidsaurus @plasmidsaurus.bsky.social · 15/10/2025
🦖 Something HUGE just hatched. Plasmidsaurus now offers RNA sequencing for gene expression analysis: • As fast as 3 day turnaround • $50/sample for academia, $80 for industry • Up to ~10M unique transcript 3’ end reads per sample • Interactive results Explore Plasmidsaurus RNA-Seq today.
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Rubén González @rubengonzalez.bsky.social · 13/10/2025
1/3 What happens when a fly gets persistently infected by a virus? In our latest work, we established persistent infections to examine their impact on this model organism. By tracking four natural, persistent RNA viruses...
Cartoon illustration depicting a sick Drosophila melanogaster surrounded by different viruses, symbolizing the impact of persistent viral infections on the model organism. Image credit Rubén González.
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Junior European Drosophila Investigators @fly-jedi.bsky.social · 26/09/2025
Dear JEDIs, as we are self-organizing using the #EDRC as a nucleator we decided it is time for a JEDI database to boost our network! If you identify as a JEDI, please contact us here or send a mail to katja.rust@uni-marburg.de to be added to our database. #Drosophila @fly-eds.bsky.social
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Kenichi Tsuda @kenichitsuda.bsky.social · 10/09/2025
Cheaper defense first, costly one later. This makes sense. journals.plos.org/plosbiology/...
journals.plos.org
Plants respond to herbivory through sequential induction of cheaper defenses before more costly ones
Plants encounter natural threats of varying intensity and respond by activating multiple defense traits. This study of six defense traits in Ambrosia artemisiifolia reveals that when attacked by insec...
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Sarah Merkling @merklinglab.bsky.social · 08/09/2025
Virology lost one of his monuments, David Baltimore. To learn more about him and his contributions, I recommend (re)-listening to this great TWIV episode : www.microbe.tv/twiv/twiv-10...
microbe.tv
TWiV 100: TWiV catches a big fish | This Week in Virology
Vincent, Alan, and Rich celebrate the 100th episode of TWiV by talking about viruses with Nobel Laureate David Baltimore.
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Michael Rera @michaelrera.bsky.social · 03/09/2025
if you have your team and grants, not forget to support @flybase.bsky.social www.philanthropy.cam.ac.uk/give-to-camb... meanwhile, we need to think longterm and protect this data, dl it, share it portal.datarescueproject.org/datasets/fly...
portal.datarescueproject.org
FlyBase
Links to public data archived through combined efforts and coordinated by the Data Rescue Project.
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José Cerca @naturalselection.bsky.social · 19/08/2025
The 2025-26 Eco-Evo job list is out. Good luck to those applying! docs.google.com/spreadsheets...
docs.google.com
ecoevojobs.net 2025-26
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Flo Débarre @flodebarre.eurosky.social · 18/08/2025
This week, the capital of Evolution is Barcelona! Over 1900 evolutionary biologists are gathering for the biennial meeting of the European Society for Evolutionary Biology, coorganised with its Spanish sister #ESEB2025. Over 540 of us are on Bluesky! You can use these starter packs to connect: 1/n
Photo of the welcome address at ESEB2025
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PLOS Biology @plosbiology.org · 12/08/2025
Forecasting the effects of #epidemics is complicated by a population’s pathogen exposure history. @pfvale.bsky.social @chadisaadroy.bsky.social & Mike Boots argue for the use of experimental #DiseaseEcology to better understand the consequences of variations in #infection history 🧪 plos.io/4mdDVvW
plos.io
The ghost of infections past: Accounting for heterogeneity in individual infection history improves accuracy in epidemic forecasting
Variable pathogen exposure history contributes to individual immune differences, complicating epidemic forecasting. This Essay argues that experimental disease ecology can offer powerful tools and app...
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Jorge Hernández-García @jorgehg.bsky.social · 22/07/2025
We've tried to gather and unite the streptophyte algae community all around the world to join forces and develop tools and methods for these critters. Learn more about it on @currentbiology.bsky.social! With @jandevries.bsky.social, @dolfweijers.bsky.social, and (many) others! tinyurl.com/29n4zwen
cell.com
A roadmap to developing unified streptophyte algal model systems
Carrillo-Carrasco and colleagues highlight the importance of the establishment of streptophyte algal model systems and the community efforts towards this goal.
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Mark A. Hanson @hansonmark.bsky.social · 10/07/2025
The "reproducibility crisis" in science constantly makes headlines. Repro efforts are often limited. What if you could assess reproducibility of an entire field? That's what @brunolemaitre.bsky.social et al. have done. Fly immunity is highly replicable & offers lessons for #metascience A 🧵 1/n
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François Leulier @francoisleulier.bsky.social · 21/04/2025
Anyone pushing forward a « microbiome and beyond » WS proposal, that would be an awesome topic… 😉
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SalehLab @salehlabparis.bsky.social · 10/04/2025
Thrilled to receive @anrs-mie.bsky.social grant with @lambrechtslab.bsky.social & @retrogenomics.bsky.social! Making mosquitoes intolerant to arboviruses. Thanks @pasteur.fr, @inserm.fr & @cnrs.fr for support. Exciting times for #ARBORETRO project! Stay tunned.
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Pedro Vale @pfvale.bsky.social · 09/04/2025
Hi #Drosophila folk: I'm advertising a 2-year #Postdoc, funded by a BBSRC grant on the genetic and immune determinants and evolutionary constraints underlying extreme pathogen transmission phenotypes. Deadline 29 April, details in the link below, or feel free to email: www.jobs.ac.uk/job/DMQ231/p...
jobs.ac.uk
Postdoctoral Research Associate at The University of Edinburgh
Apply now for the Postdoctoral Research Associate role on jobs.ac.uk - the leading job board for higher education jobs. View details.
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Rubén González @rubengonzalez.bsky.social · 04/04/2025
Amazing new tools for studying fly immunity!! Fantastic work
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Carolina Monzó @carolinamonzo.bsky.social · 28/03/2025
It's finally out!!!! Our review on long-reads transcriptomics was published in @natrevgenet.bsky.social!! You can have a look at the paper here rdcu.be/efugl! We hope you like it 😀
rdcu.be
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Michael Rera @michaelrera.bsky.social · 25/03/2025
A friend sends me that picture and I'm very happy of my 14 years fighting to get this model accepted within the ageing research community. A serendipitous discovery I made that really changes everything !
A picture of neo (matrix) subtitled "this is how I feel now" under a sentence saying "ok, I know what a Smurf phenotype is now"
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Sarah Ashley @sarah-ashley.bsky.social · 21/03/2025
A new way to conduct GWAS meta-analysis? Preprint shows Genomic Network Analysis can be used to identify conditionally independent associations between traits, controlling for shared genetic signals. Also enables multi-level biological analysis within the framework to probe underlying aetiology🧬🖥️
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Jon Douglas @atranscendedman.bsky.social · 20/03/2025
Scientists in China developed SCLIMS, a tool that links metabolism to oxidative stress at the single-cell level. They found that metabolic differences predict cell fate under stress and that key metabolites can extend lifespan in C. elegans. www.nature.com/articles/s41...
nature.com
Integrative single-cell metabolomics and phenotypic profiling reveals metabolic heterogeneity of cellular oxidation and senescence - Nature Communications
Integrated analysis of metabolome and oxidative stress at single-cell level is challenging. Here, the authors develop SCLIMS, enabling simultaneous profiling of metabolome and oxidative stress levels ...
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Buck Samuel 🪱🦠🧬🔬 @microbeminded.bsky.social · 12/11/2024
To all the newskies, welcome! #HiSciSky As #firstgen PI at BCM in Houston, my lab studies how the #microbiome alters host physiology using genetics & genomics in #Celegans. Our lens is #BasicResearch, but aim to promote human health on earth and beyond. 🧪🖥️🧬 #AcademicSky #MicroSky 1/3
Cartoon illustration of C. elegans nematodes and their microbiome. By Adrien Assié.
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European Drosophila Society @fly-eds.bsky.social · 18/03/2025
European Drosophila Board election call for nominations. Join the EDB to represent and support Drosophila research in Europe! Five representatives will be elected for different regions. Check our election page for details: europeandrosophilasociety.org/european-dro... #Drosophila, #EDRC2025
A fly voting in the European Drosophila Board election
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Harmit Singh Malik @harmitmalik.bsky.social · 19/03/2025
Please consider nominating deserving colleagues (including yourselves) who would be excellent candidates for five open positions on the Council, including Nominations for President-elect, Secretary, Treasurer, and 2 Councilors. Please share widely! @official-smbe.bsky.social
Dear SMBE Members,

I am writing to solicit nominations for SMBE President-Elect, Secretary, Treasurer and 2 Councilors whose terms will begin on January 1, 2026. Each of these positions is for a duration of three years.

Council members play important roles in guiding the development of the society, soliciting and implementing programs that support our members, while enriching opportunities for young scientists from around the world. They also have a role in overseeing our two excellent journals (MBE and GBE) as well as our annual meeting, regional meetings, and satellite meetings.

Nominations will be reviewed by the nominations committee who will then put forward a slate of two candidates for each position for vote by the SMBE membership. Past and current council members are listed HERE.

Nominations (self-nominations are welcome) should consist of a brief statement in support of your suggestion (why this nomination, what the nominee can bring to SMBE, work subject, other biographical information). For Presidential nominees please include previous involvement with SMBE.

We ask the nominators to confirm explicitly that the person they are nominating has already confirmed their willingness to run for office.

Please send your nominations to Harmit Malik <hsmalik@fredhutch.org> AND to Emmanuelle Lerat <secretary.smbe@gmail.com> by April 18, 2025.

We look forward to hearing from you!

Sincerely yours,
Emmanuelle Lerat
Secretary of SMBE, on behalf of the Nominations Committee*

*The Nominations Committee is composed as follows:
Harmit S Malik (Chair) USA.
Xuming Zhou, China.
Mary O'Connell, UK.
Nicolas Galtier, France.
Deepa Agashe, India.
Emmanuelle Lerat (ex officio), France.
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PLOS Biology @plosbiology.org · 19/03/2025
Genome sequencing & single-cell transcriptomics continue to produce findings that challenge the idea that #cancer is purely a genetic disease. This Essay delves into #omics data that questions the somatic mutation theory & presents alternative theories based on GRNs & tissue fields.🧪 plos.io/3DRtAEW
A figure depicting the concept of cancer attractor states within Waddington's landscape, and how gene regulatory network dynamics influence these states.
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Théo Maire @theomaire.bsky.social · 27/01/2025
Thrilled to share 'BuzzWatch', my post-doc work with Felix Hol and @lambrechtslab.bsky.social ➡️Filming mosquitoes in a cage with a €15 camera but for 700h(1month) revealed fascinating insights into their behavior⌛🦟🎥⏳ preprint🔍 doi.org/10.1101/2025... DIY guide 🛠️ theomaire.github.io/buzzwatch 🧵⬇️
doi.org
BuzzWatch: uncovering multi-scale temporal patterns in mosquito behavior through continuous long-term monitoring
Understanding the temporal dynamics of mosquito behavior is essential for developing effective interventions against pathogen transmission. However, limited knowledge exists about the environmental, p...
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Maya Voichek @mayavoichek.bsky.social · 17/03/2025
1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬 But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯 Our new study reveals how retrotransposons invade the germline directly from somatic cells. www.biorxiv.org/content/10.1... A short thread 🧵👇
Drosophila follicle showing retrotransposons (pink & yellow) expressed in somatic cells infecting the oocyte
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Michael Rera @michaelrera.bsky.social · 27/02/2025
I am happy to announce with @hanli-pasteur.bsky.social that we'll organise a summer school titled "Senescence from Cell Cultures to Humans through Model Organisms" in Paris, Fr on June 23-24, 2025 Aimed at 2nd and 3rd year PhD student + postdocs Submit your provisional project tinyurl.com/2uhfzxbp
flyer of the event with the name of confirmed trainers Cléo Bishop, Eric Boulanger, Manuel Collado and Bill Keyes, 
Deadline for application May 30th 2025,
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EMBO @embo.org · 12/02/2025
Hello everyone on Bluesky! 🧪 We are EMBO, the organization of more than 2,100 leading researchers that promotes excellence in #lifesciences in Europe and beyond. Read more: www.embo.org/about-embo/m...
Text: EMBO is on Bluesky.
Butterfly icon with text: @embo.org
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