Gallrein et al. pair functional assays with clocks to compare chronological versus biological age of single neuron types in C. elegans, to probe their vulnerability or resilience to neurodegeneration,...

Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the n...

Gallrein et al. pair functional assays with clocks to compare chronological versus biological age of single neuron types in C. elegans, to probe their vulnerability or resilience to neurodegeneration,...

Gallrein et al. pair functional assays with clocks to compare chronological versus biological age of single neuron types in C. elegans, to probe their vulnerability or resilience to neurodegeneration,...

Scientific Reports - A sex-adjusted 7-biomarker clinical aging clock for translational preventative medicine

Growing evidence suggests that the gut microbiota is closely intertwined with life-history evolution in a wide range of species, including well-studied model organisms like Drosophila melanogaster. Al...

Two early career bioinformaticians have been recognized for their mathematical and AI models, along with a collaborative resource for single-cell data analyses. The three 2025 SIB Bioinformatics Award...

The dauer diapause is a naturally occurring extraordinarily long-lived alternative C. elegans larval stage that, upon dauer exit, lives a normal adult life with full reproductive capacity. Here, we d...

Imbalanced nucleotide metabolism leads to age- and mtDNA-dependent inflammatory responses and senescence-associated secretory phenotype in senescence.

Meyer and colleagues refute the idea that, as aging can be tracked precisely by clocks, it must be driven by a biological program. They propose that imperfect maintenance and repair processes resultin...

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Meyer and colleagues refute the idea that, as aging can be tracked precisely by clocks, it must be driven by a biological program. They propose that imperfect maintenance and repair processes resultin...

Meyer and Schumacher use simulations to show that accumulation of stochastic variation is sufficient to build clocks that can measure both chronological and biological age, sensitive to changes induce...

Meyer and Schumacher use simulations to show that accumulation of stochastic variation is sufficient to build clocks that can measure both chronological and biological age, sensitive to changes induced by smoking, calorie restriction, parabiosis and reprogramming.

Aging is a risk factor for neurodegenerative diseases associated with protein aggregation. Here the authors identify age-related hyperactivation of EPS8/RAC signaling in C. elegans as a driver of path...

Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient-derived neurons and C. elegans models, w...

In this symposium, leaders in the aging and longevity field will describe the latest progress in the molecular, cellular and organismal basis of aging and our search for interventions. A panel of thou...

Aging is a major risk factor for neurodegeneration and is characterized by diverse cellular and molecular hallmarks. To understand the origin of these hallmarks, we studied the effects of aging on the...

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The authors provide evidence that, together with Dietary Restriction, Rapamcyin and not Metformin, provides a significant lifespan extension in vertebrates.

The Evolution of Ageing: Traversing the interdisciplinary divide | Gutenberg Workshops in the Life Sciences

Intermittent fasting and fasting-refeeding regimens can slow biological aging across taxa[1][1]. Shifts between fed and fasted states activate ancient nutrient-sensing pathways which alter cellular an...

Do you want to contribute to groundbreaking research into healthy ageing using advanced omics data? At the Department of Biomedical Data Sciences at the Leiden University Medical Center (LUMC) and the...

A new DFG-funded research group investigates how proteostasis is regulated at the organismal level and its impact on aging and disease.

March 7, 2025. Washington DC and nationwide. Because science is for everyone.

It’s ugly, but necessary to face.

An overlay journal curating the world’s most exciting longevity research. Presented in partnership with VitaDAO and DeSci Labs.

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Joris Deelen obtained his PhD at the Leiden University Medical Center (LUMC) in 2014. In 2016 he joined the Max Planck Institute for Biology of Ageing as a postdoctoral researcher and was promoted to ...