Hedgehog merbecoviruses utilize hedgehog aminopeptidase N, but not the human orthologue, as their entry receptor. Structural resolution of the glycoprotein–receptor interface reveals the molecular int...

Lee Se-dol retires from the game of Go after conceding that computers "cannot be defeated".

God save us from economists who think they can competently talk about biology

High mutation rates erode viral sequence similarity, obscuring deep evolutionary history. While protein structure is far more conserved than sequence, its use in evolutionary studies has historically ...

Preliminary reconstruction of the current MV Hondius Andes virus outbreak sequences Note on data use This is an informal analysis of currently available consensus sequences and is not intended as a fo...

Human CEACAM6, which is widely expressed in the lung, is identified as a receptor used by the spike proteins of Cardioderma cor (heart-nosed bat) alphacoronaviruses to enter cells.

An international team of researchers has identified an East African bat coronavirus capable of entering human cells.

Marburgvirus glycoprotein binds to the endosomal receptor NPC1 in a distinct orientation with higher affinity compared with Ebola virus glycoprotein, accompanied by fusion-relevant rearrangements...

Hepatitis D-like satellite viruses, known as deltaviruses, have been recently discovered in a wide range of animals. These viruses are thought to expr…

Hepatitis D-like satellite viruses, known as deltaviruses, have been recently discovered in a wide range of animals. These viruses are thought to expr…

Isomorphic Lab’s proprietary drug-discovery model is a major advance, but scientists developing open-source tools are left guessing how to achieve similar results.

‘Shocking’ data shows the climate crisis and invasive mosquitos mean chikungunya could spread in 29 countries

Snell et al. develop sequencing methodology to identify full-length spike haplotypes and show that persistent SARS-CoV-2 infections drive divergent haplotype emergence, accelerating viral evolution an...

Protein structure is conserved beyond sequence, making multiple structural alignment (MSTA) essential for analyzing distantly related proteins. Computational prediction methods have vastly extended ou...

Mirdita Lab builds scalable bioinformatics methods.

A General Solution to the Repeated Problems of Virus Genomics

Host body temperature can define a virus’s replicative profile—influenza A viruses (IAVs) adapted to 40° to 42°C in birds are less temperature sensitive in vitro compared with human isolates adapted t...

Analysis of RNA polymerase hallmark gene phylogenies supported by protein structure relationships of flaviviruses and ‘flavi-like’ viruses underpins the taxonomic expansion and reorganization of Flavi...

VAD is a Viral AlphaFold Database of protein monomers and homodimers from viruses infecting hosts across the tree of life.

Panoptes, an anti-phage defence system against virus-mediated immune suppression, is revealed.

Intrinsic innate immune barriers have evolved to suppress viral infection and can reduce effective gene delivery in gene therapy. We have developed BG147, a novel cyclosporine A analogue, optimised vi...