Nicoli’s lab discovered mRNA that changes how proteins behave. Now she wants to turn it into medicine, starting with diseases of the blood vessels.

The New York City mayor has an antidote to globe-spanning distemper.

Akbari et al. investigated the mechanisms of linker histone H1.0 loading onto nucleosomes. H1.0 directly binds nucleosomes and DNA, while DNA-bound H1.0 is mobile but does not load onto nucleosomes. Linker histone chaperones facilitate H1.0 loading through enhancing nucleosome binding, increasing H1.0 mobility, and enabling H1.0 loading through DNA sliding.

Nature Structural & Molecular Biology, Published online: 02 October 2026; doi:10.1038/s41594-026-01895-4Single-molecule imaging reveals diverse, megabase-scale heterochromatin domains in C. elegans. Some resemble TADs and depend on condensin I; others are independent of condensin and histone H3K9me, including one domain that encloses the 5S rDNA locus.

PhD (f/m/d)

Nature Structural & Molecular Biology, Published online: 30 September 2026; doi:10.1038/s41594-026-01877-6Koenig et al. present a phosphoproteome atlas of 33 human cell lines covering >200,000 phosphosites, advancing cellular kinase activity scoring and drug sensitivity prediction, providing a resource for cell signaling insights and precision oncology.

Assigning peaks in NMR spectra to specific residues is an essential but time-consuming step in the study of intrinsically disordered proteins (IDPs). Conventional approaches rely on building chains of...

Simulations integrating micro-C and imaging data provide a coherent view of chromatin organization from nucleosomes to clutches to domains, revealing that most regions form compact domains but short r...

In eukaryotes, ribosome biogenesis initiates within the nucleolus, a hallmark multilayered compartment of the nucleus. Structures of pre-ribosomes have been characterized ex situ, but their assembly p...

Abstract. Efficient purification of specific RNAs from lysates remains a major challenge. Existing methods, such as MS2 tagging or oligonucleotide hybridiz

Die Linke candidate, a lawyer affected by her experiences as the child of political migrants from Turkey, poised to head Berlin coalition government

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Alzheimer's disease and prion diseases are linked to unnatural aggregation of proteins into amyloid fibrils.