iiinova — where your digital self keeps evolving

David Kuster @rnadavid.bsky.social · 21/07/2026

Leopard Moth, Zeuzera pyrina, encountered on the way home in the evening - on a bridge crossing the Elbe meadows in Dresden, Germany.

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David Kuster @rnadavid.bsky.social · 16/07/2026

Auch die Verbreitung ist interessant - aber wohl eher die von Brotkonsumenten mit iNaturalist

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David Kuster @rnadavid.bsky.social · 11/07/2026

Piping plovers are worth protecting at any cost!

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David Kuster @rnadavid.bsky.social · 05/07/2026

A couple of *very* exotic nucleobase modifications in this one.:D

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David Kuster @rnadavid.bsky.social · 05/07/2026

Beautiful zoological display with phylogenetic arrangement & many interesting details @cosheidelberg.bsky.social!

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David Kuster @rnadavid.bsky.social · 05/06/2026

The E. coli DEAD box helicase CsdA is a NAD+-capped RNA binding protein! With the NAD+-RNA-binding proteome in E. coli! Amazing work by Kaustuv Das, ..., @schraderlab.bsky.social, @childerslab-pitt.bsky.social and @drjeremygbird.bsky.social! www.biorxiv.org/content/10.6...

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David Kuster @rnadavid.bsky.social · 25/05/2026

Protein Disulfide Isomerase (PDI) disassembles TDP-43/G3BP1 condensates and antagonizes TDP-43 aggregates. By Jia-Qi Liu, ..., Mengchao Cui, Yi Liang, et al. advanced.onlinelibrary.wiley.com/doi/10.1002/...

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David Kuster @rnadavid.bsky.social · 03/05/2026

Kind of starts with phage lambda & Mark Ptashne's repressor octamer:)

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David Kuster @rnadavid.bsky.social · 08/01/2026

This looks genuine-(!)-ly interesting!! Amazing!! Thank you!

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David Kuster @rnadavid.bsky.social · 05/01/2026

And a more recent picture - it's also too cold to work and probably better to stay home altogether...

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David Kuster @rnadavid.bsky.social · 14/12/2025

Very happy to announce that a small part of my bird data, collected on a transect along the Elbe river, got successfully 'published' online.:) hymanlab.org/blog/2025/-c...

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David Kuster @rnadavid.bsky.social · 17/08/2025

Saw my first one two weeks ago & didn't suspect it of anything then, was just mesmerized! www.inaturalist.org/observations...

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David Kuster @rnadavid.bsky.social · 14/07/2025

Least - but very pretty - sandpiper roaming the Sippewissett Marsh (MA) today!

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David Kuster @rnadavid.bsky.social · 08/07/2025

Least Terns - exchanging a fish! Early July, Surf Drive Beach, MA

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David Kuster @rnadavid.bsky.social · 23/06/2025

Piping Plover family enjoying the beach life bordering the Great Sippewisett Marsh. Barnstable County, MA. #birds

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David Kuster @rnadavid.bsky.social · 04/06/2025

Rapid, nanoscale dynamics of individual IDPs determine bulk properties of the entire condensate, such as viscosity. Amazing work by Nicola Galvanetto & the Schuler lab! www.pnas.org/doi/10.1073/...

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David Kuster @rnadavid.bsky.social · 13/05/2025

European Peacock resting & sunbathing at the shores of the Elbe river. #butterflies

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David Kuster @rnadavid.bsky.social · 11/05/2025

Vielleicht stünde ihm eine Bartfrisur.

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David Kuster @rnadavid.bsky.social · 10/05/2025

Every Living Thing - Jason Roberts On the beauty of making inventories, lists and classifying the natural world. And the interesting, somewhat petty competition between Linnaeus (Systema Naturae) and Buffon (Histoire Naturelle) in doing so!

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David Kuster @rnadavid.bsky.social · 08/05/2025

Scarce Swallowtail resting & sunbathing at the shores of the Elbe river.:)

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David Kuster @rnadavid.bsky.social · 04/05/2025

And a plethora of pipers - with Wood sanpiper, Common sandpiper & the very small Temminck's stint!

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David Kuster @rnadavid.bsky.social · 04/05/2025

Little Ringed Plover roaming the Elbe shores in Dresden! #birds

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David Kuster @rnadavid.bsky.social · 16/04/2025

Brief lunch break encounters:) – very busy birds all along the Elbe now in April! #birds #Dresden

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David Kuster @rnadavid.bsky.social · 14/04/2025

Internal phase separation in synthetic DNA condensates Degree of mixing between A and B DNA Nanostars can be tuned by the fraction of AB Linker oligos (Fab). Amazing work by @dianatanase.bsky.social & @dimichelelab1.bsky.social. www.biorxiv.org/content/10.1...

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David Kuster @rnadavid.bsky.social · 12/04/2025

Context-dependent Interactors Regulate TDP-43 Dysfunction in ALS/FTLD TDP-43 APEX proximity labeling to identify interactors for cytoplasmic (ΔNLS) and RNA-binding deficient (5FL) TDP variants! By Longxin Xie and @donnellylab.bsky.social. www.biorxiv.org/content/10.1...

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David Kuster @rnadavid.bsky.social · 04/04/2025

Difficult to spot - but the plovers are back! :) At the shoreline of the Elbe River this morning in Dresden. #birds

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David Kuster @rnadavid.bsky.social · 21/03/2025

Grey heron sunbathing in a willow in the Great Garden of Dresden this week:)

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David Kuster @rnadavid.bsky.social · 05/03/2025

Granular component sub-phases direct ribosome biogenesis in the nucleolus Amazing super-resolution microscopy & in vitro reconstitutions by Priyanka Dogra, Kriwacki lab et al.! www.biorxiv.org/content/10.1...

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David Kuster @rnadavid.bsky.social · 03/03/2025

Condensates exhibit stronger interfacial electric fields than amyloid fibrils. Condensates generate more reactive oxygen species (ROS), like hydroxyl radicals, than fibrils. Amazing work by Michael Chen, ..., Richard Zare & Yifan Dai. pubs.acs.org/doi/full/10....

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David Kuster @rnadavid.bsky.social · 09/02/2025

Also supplementary Fig. 4A looks somewhat unexpected - as is part of the experimental validation of the model whereby 0/10 generated sequences localized to their designated target (nuclear speckles).

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David Kuster @rnadavid.bsky.social · 03/12/2024

Just depends how deep, or shallow, the energy landscape for a given IDP and its conformational ensemble is - but should be possible in principle to retain some information (i.e. a specific folding state of an IDP) in an IDP.

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David Kuster @rnadavid.bsky.social · 02/12/2024

While this amazing preprint beautifully demonstrates softening & fluidification of the cell's cytoplasm during mitosis - it attributes the effect to cytoskeletal elements, while not discussing global phosphorylation as contributor: www.biorxiv.org/content/10.1...

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David Kuster @rnadavid.bsky.social · 02/12/2024

There is this beautiful example of a fairly well defined number of clusters with equidistant spacing - found within the condensed phase of the nucleolus: www.sciencedirect.com/science/arti...

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David Kuster @rnadavid.bsky.social · 02/12/2024

Especially when combined your set of questions seems quite illuminating - the relationship between spatial arrangement of biomolecules & information processing and retention probably still holds many surprises for generations of cell biologists & biochemists!:)

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