Cavanaugh et al. show that embryos from aged mice have increased contractility and tissue viscosity on embryonic day 4.5, which leads to poor spreading and attachment. Similar age-associated mechanica...

Amygdala astrocyte primary cilia are disrupted during stress, and their restoration leads to improvements in stress-related behaviour in mice.

Budding yeasts are thought to use septins to mark mother–bud necks as sites for cytokinesis. Here, Colarusso et al. find that the multibudding yeast Aureob

Microscopy preprints – new tools and techniques in imaging - News

The ciliary transition zone gates bidirectional protein trafficking to maintain the specialized ciliary proteome using microtubule doublets as a scaffold. While ciliary axonemal doublets are well-char...

Shi, Manzi et al. demonstrate that in polarizing epithelial spheroids from mouse embryonic stem cells, ZO-1 clusters are transported by cortical flows to e

This Perspective positions cellular self-organization as a foundational principle for the origin of multicellular life and discusses how decoding this concept with stem cell-based models will advance ...

Tissue phase transitions are key to morphogenesis. Now adhesion-driven rigidification is identified as key to epithelial organization but only if uncoupled from density-driven jamming.

Quantitative analysis of bacterial dynamics in time-lapse microscopy requires robust tracking pipelines, yet selecting and optimizing algorithms for specific experiments remains challenging. Indeed, ...

Theoretical and computational analyses demonstrate that cell intercalation within epithelial cell layers is analogous to the unbinding of topological defects in hexatic liquid crystals, offering a framework...