Key Points. The fetal HSC state is permissive, with mixed in vitro output, whereas adult HSCs exhibit chromatin-level and functional myeloid biasFetal lymp

Cell differentiation is governed by dynamic changes in chromatin accessibility, and its dysregulation underlies multiple disease states. Prior to birth, development of the hematopoietic system constit...

We are seeking a postdoctoral Research Associate to work on an exciting new multi-disciplinary project studying B-cell acute lymphoblastic leukaemia (B-ALL). The project is a collaboration between Dr

FindAPhD. Search Funded PhD Projects, Programmes & Scholarships in dave boucher. Search for PhD funding, scholarships & studentships in the UK, Europe and around the world.

FindAPhD. Search Funded PhD Projects, Programmes & Scholarships in dave boucherare. Search for PhD funding, scholarships & studentships in the UK, Europe and around the world.

FindAPhD. Search Funded PhD Projects, Programmes & Scholarships in william grey. Search for PhD funding, scholarships & studentships in the UK, Europe and around the world.

This October marks ten years since Leukaemia UK launched its John Goldman Fellowship (JGF) programme. In this blog, and the next, we’ll explore its impact and successes.

10% of acute leukemias carry rearrangements of the KMT2A gene (Mixed-Lineage Leukemia-1, MLL-1). More than 80 fusion partners have been identified, and differences in fusion partner have been linked t...

Modeling human epithelial diseases and developing cell-based therapies require robust methods to expand and manipulate epithelial stem and progenitor cells in vitro. Basal stem/progenitor cells from s...

Myeloproliferative Neoplasms (MPN) are malignancies of hematopoietic stem and progenitor cells (HSPCs) that lead to the overproduction of mature blood cells. These disorders include Essential Thrombo....

Lund University. This spring Barncancerfonden, the Swedish Childhood Cancer Foundation, awarded SEK 64 million to 29 researchers across the country. The funding includes positions of up to six years f...

Leukemia - Ontogeny-specific induction of the KMT2A::AFF1-fusion drives development of a distinct CD24 positive pre-leukemic state

Beta-secretase 1 promotes the spread of lung cancers to the brain through epidermal growth factor receptor signaling.

Oncogene - Post-transcriptional control of gene expression by β-catenin: expanding the non-canonical ARMoury

Hematopoietic stem cells (HSCs) acquire somatic mutations throughout life, with the frequency of mutational incidence increasing with age [1]. Occasionally, certain mutations confer a fitness advantag...

Leukemia - Is the bone marrow microenvironment the hidden catalyst in malignant haematopoiesis?

Discover a PhD Studentship: Structure and function of tyrosine fusion kinases in leukaemia and their regulation by the HSP90 molecular chaperone on jobs.ac.uk. Apply now and explore other PhD opportun...

Summary: A high-throughput screen of 1429 compounds in primary human airway epithelial cells was used to identify that Wnt pathway-activating compounds increase cell proliferation.

Sickle Cell Disease (SCD) is a blood disorder affecting millions worldwide. Emerging evidence reveals that SCD pathophysiology increases risk of myeloid malignancies and hematopoietic stem cell (HSC) ...

Residing at the top of the hematopoietic hierarchy, long-term hematopoietic stem cells (HSCs) are capable of self-renewal and sustained blood cell regeneration. Over the past decades, single-cell and ...

A new, career-focused program that provides individual mentoring support for early and mid-career clinicians and researchers in hematology.The call for mentees is open until 15:00 (CET) on February 20...

Hematopoiesis changes to adapt to the physiology of development and aging. Temporal changes in hematopoiesis parallel age-dependent incidences of blood diseases. Several heterochronic regulators of he...

Congratulations—you have just been appointed a new group leader! That position that you coveted from the time you first set foot in a laboratory as an undergraduate student. You have a great hypothesi...

Large-scale experimental analysis of Human Domainome 1, a library containing more than 500,000 missense mutation variants across more than 500 human protein domains, reveals that 60% of pathogenic mis...

PhD Project - Multi-omic analysis of human blood cancer stem cells to develop new predictive tools, and develop novel culture systems at University of York, listed on FindAPhD.com

Only in the last decade have clinicians in India, with support from colleagues from the west, organized to develop multi-centre modern protocols for children with acute leukaemia. These protocols inc…