Background and ObjectivesSerum myelin oligodendrocyte glycoprotein (MOG) antibodies are a hallmark of the newly defined neuroinflammatory disease entity MOG antibody–associated disease (MOGAD). Yet, t...

This study reports the distinct effects of IL-4, IL-13, and IL-22 on bio-stabilized human skin with intact barriers and immune cells. IL-4, IL-13, and IL-22 upregulate inflammatory mediators, disrupt...

Single-cell immunoprofiling uncovered systemic immune cell signatures of neurological MOG antibody–associated disease.

A population of neutrophils in the skin produces extracellular matrix, providing a defence strategy by reinforcing the barrier properties of the skin and helping to block the entry of pathogens.

The endothelial blood-brain barrier (BBB) tightly controls T cell entry into the central nervous system (CNS). T cell extravasation across the BBB involves a multi-step cascade with a predominant role...

Colonization of the intestinal lumen precedes invasive infection for a wide range of enteropathogenic and opportunistic pathogenic bacteria. We show that combining oral vaccination with engineered or ...

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Multiple sclerosis (MS), is an autoimmune disease of the central nervous system (CNS), characterized by demyelination and neuronal loss, along with immune cell brain infiltration and inflammation.

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Traditional gers in rural Mongolia. Photo taken by author. By Deeksha Raju INTRODUCTION Your immune system isn’t just built from DNA – it’s shaped by where you live, what you eat, and e…

By Johanna Lueckel. What if we could grow a lymph node it in the lab, and watch T and B cells go about their business? No mice, no scalpel, no drama? That’s exactly the promise of so called immune …