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Clinical & Experimental Immunology

@ceijournal.bsky.social
418 followers 25 following 191 posts

The journal of #translational #immunology 🔃 British Society for Immunology journal publishing high-quality & impactful research since 1966

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Clinical & Experimental Immunology @ceijournal.bsky.social · 17h
Join us in celebrating 60 years of pioneering clinical and translational immunology research! Explore our special collection showcasing the most-cited and widely-read articles that shaped our legacy: vist.ly/5kesp #CEIat60
Three different covers of the Clinical and Experimental Immunology journal on a bookshelf.
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Clinical & Experimental Immunology @ceijournal.bsky.social · 25/09/2026
Organoid co-culture and organ-on-chip systems are transforming how we study immune–epithelial interactions, enabling more precise, patient-relevant models of disease 🧬 🔗 vist.ly/5jth2 #Immunology #Organoids #Microfluidics #PrecisionMedicine
doi.org
Revolutionizing immune research with organoid-based co-culture and chip systems
Potential use and translational applications of patient-derived organoids are very diverse. Such models have revolutionized research in immunological disea
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Clinical & Experimental Immunology @ceijournal.bsky.social · 23/09/2026
Research in Crohn’s disease shows peripheral blood T cells are already less prone to apoptosis before reaching the gut, with reduced catalase activity contributing to this effect 🧬 🔗 vist.ly/5jhn5 #Immunology #CrohnsDisease #Tcells
doi.org
Catalase inhibition can modulate the ability of peripheral blood T cells to undergo apoptosis in Crohn’s disease
Blood T lymphocytes from CD patients are less prone to undergo apoptosis before migrating to the intestinal mucosa. The inhibition of catalase has a direct
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Clinical & Experimental Immunology @ceijournal.bsky.social · 21/09/2026
A simpler, highly specific way to detect AIH? This study shows that MF-SMA patterns on vascular smooth muscle cells are easy to recognize and match gold-standard specificity, offering a more reliable diagnostic approach. 🧬 vist.ly/5j8gu #Immunology #Autoimmunity #LiverDisease
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Easy recognition and high autoimmune hepatitis specificity of smooth muscle antibodies giving an actin microfilament immunofluorescent pattern on embryonal vascular smooth muscle cells
(i) The search for smooth muscle antibodies (SMA) is a cornerstone of hepatic autoimmune serology, being one of the diagnostic criteria of autoimmune hepat
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Clinical & Experimental Immunology @ceijournal.bsky.social · 18/09/2026
📢 This open‑access study identifies PSMB8 as a biomarker predicting proton pump inhibitor response in paediatric eosinophilic esophagitis, supporting more personalized treatment decisions. 🔗 vist.ly/5ixam
Infographic on PSMB8 as a therapy response marker in eosinophilic esophagitis with study details.
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Clinical & Experimental Immunology @ceijournal.bsky.social · 17/09/2026
Have you submitted to our new Immunometabolism Section yet? Led by Dr Lizzy Rosser (UCL), this is a dedicated home for cutting-edge research exploring how metabolism shapes immune function in health and disease. Learn more: vist.ly/58wxd #Immunometabolism #Immunology
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Reposted by Clinical & Experimental Immunology
British Society for Immunology @britsocimm.bsky.social · 17/09/2026
It's #PeerReviewWeek and we want to recognise the valuable contributions of peer reviewers for their vital role in ensuring science can be shared in a timely way. Thank you to all who generously give their time and expertise to improve the quality of research published in our journals and beyond!
Thank you to our reviewers poster with immunology journal covers.
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Clinical & Experimental Immunology @ceijournal.bsky.social · 15/09/2026
🧬 How does ageing with frailty reshape immune responses? This open‑access study links altered neutrophil signalling to impaired chemotaxis and increased ROS/NET production, highlighting key features of inflammageing. 👉 vist.ly/5ihau #ImmuneAgeing26
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Neutrophil Functional Analysis in Frailty and Health
In this study we have combined RNAseq with functional experiments to describe the phenotype of neutrophils from people with frailty. We found that frailty
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Reposted by Clinical & Experimental Immunology
British Society for Immunology @britsocimm.bsky.social · 14/09/2026
We're at #BSICambridge26 today! if you're attending, do come and say hello and ask us about our membership, journals and professional development opportunities.
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Clinical & Experimental Immunology @ceijournal.bsky.social · 07/09/2026
Join us in celebrating 60 years of pioneering clinical and translational immunology research! Explore our special collection showcasing the most-cited and widely-read articles that shaped our legacy: vist.ly/5hjvm #CEIat60
Three different covers of the Clinical and Experimental Immunology journal on a bookshelf.
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Clinical & Experimental Immunology @ceijournal.bsky.social · 03/09/2026
This open‑access study shows the β‑blocker nebivolol prevents T‑cell exhaustion and boosts cytotoxicity against breast cancer cells via β₂‑adrenergic receptor–dependent signalling, highlighting a potential new immunomodulatory strategy. vist.ly/5h4ta
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Nebivolol prevents exhausted T cells and enhances cytotoxicity against MCF-7 breast cancer cells in a β2-adrenergic receptor-dependent manner
Prolonged TCR/CD3 and CD28 stimulation drives sustained NFATc1 signaling and TOX expression, resulting in increased inhibitory receptor expression and redu
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Clinical & Experimental Immunology @ceijournal.bsky.social · 02/09/2026
This review explores how long non-coding RNAs influence oral squamous cell carcinoma . The article brings together emerging evidence on the nerve–immune–cancer axis and highlights future directions for identifying new biomarkers and therapeutic targets. 📖 vist.ly/5gyuf #Immunology
doi.org
LncRNAs at the frontline of neuroimmune crosstalk in oral cancer
This review examines the current role of long non-coding RNAs (lncRNAs) in the neuroimmune crosstalk in oral squamous cell carcinoma and specifically their
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Clinical & Experimental Immunology @ceijournal.bsky.social · 01/09/2026
Early splenectomy delays inflammation and reduces joint damage in a mouse model of autoimmune arthritis, highlighting a surprising protective role when done at early stages. 🧬 vist.ly/5gvjy #Immunology #Autoimmunity #Arthritis
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Splenectomy at early stage of autoimmune arthritis delayed inflammatory response and reduced joint deterioration in mice
We propose that splenectomy in early stages of autoimmune arthritis could be beneficial because it prevents bone and cartilage destruction in the joints. T
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Clinical & Experimental Immunology @ceijournal.bsky.social · 14/08/2026
New open‑access review shows how, in Sjögren’s syndrome, salivary gland epithelial cells act not just as targets but as drivers of autoimmune inflammation. Their altered signalling and antigen‑presenting features can shape and sustain immune dysregulation. 🔗 vist.ly/5ests
The ‘target tissues’ as orchestrators of autoimmune responses: the paradigm of Sjögren’s syndrome
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Clinical & Experimental Immunology @ceijournal.bsky.social · 12/08/2026
Could antibodies help prevent TB disease? A new study reports higher TB-specific IgA and IgG responses in exposed, healthy individuals than in patients with active TB. 🔗 vist.ly/5eh5s #TBResearch #Immunology #GlobalHealth
The role of IgA and IgG in Mycobacterium tuberculosis infection: a cross-sectional study in Ethiopia
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Clinical & Experimental Immunology @ceijournal.bsky.social · 11/08/2026
What does living past 105 look like immunologically? Increased Vδ1 TEMRA, CD8+ T and NK cells suggest a resilient immune system shaped by lifelong adaptation. 🧬 vist.ly/5ed2q
doi.org
Sicilian semi- and supercentenarians: age-related Tγδ cell immunophenotype contributes to longevity trait definition
The aim of the present study was to investigate the impact of ageing on the blood levels of the two main Tγδ populations, including various subsets, in a c
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Clinical & Experimental Immunology @ceijournal.bsky.social · 07/08/2026
🧬 Could extracellular microvesicles help track rheumatoid arthritis activity? Anti-TNFα therapy reduced EMVs carrying disease-associated protein modifications, alongside improvements in disease activity, highlighting their potential as biomarkers. 🔬 🔗 vist.ly/5dybg
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Post-translational modifications in extracellular microvesicles from plasma of rheumatoid arthritis patients following anti-TNFα therapy
In RA patients anti-TNFa therapy significantly reduces the concentration of circulating EMVs.In RA patients anti TNFa therapy significantly reduces citrull
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Clinical & Experimental Immunology @ceijournal.bsky.social · 05/08/2026
IFNγ from activated CD4⁺ T cells is a key driver of B‑cell differentiation and autoantibody production in IMQ‑induced lupus mice. IFNγ deficiency dramatically reduced disease features, a promising immune pathway for future SLE therapies. vist.ly/5dp9p
Scientific diagram showing TLR7 pathway leading to SLE with immune cells.
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Clinical & Experimental Immunology @ceijournal.bsky.social · 31/07/2026
Altered B-cell homeostasis and elevated IL10/TNFA expression in #CIDP suggest chronic humoral immune activation. Immune markers also correlated with nerve fiber loss and disability, highlighting potential biomarkers of disease activity. vist.ly/5d68e #Neurology #Neuroimmunology
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Disease activity in chronic inflammatory demyelinating polyneuropathy: association between circulating B-cell subsets, cytokine levels, and clinical outcomes
B-cell homeostasis is significantly altered in chronic inflammatory demyelinating polyneuropathy (CIDP) and is not reversed by immunomodulatory treatments.
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Clinical & Experimental Immunology @ceijournal.bsky.social · 30/07/2026
T-cell integrins play a central role in immune cell trafficking, tissue retention, and inflammation. This review examines how targeting these molecules is shaping treatments for autoimmune and inflammatory diseases, including IBD, multiple sclerosis, and psoriasis. 🔗 vist.ly/5cycj
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Targeting T-cell integrins in autoimmune and inflammatory diseases
Activated T cells bind to the endothelium using activated integrins as part of the multi-step process of extravasation. The expression of specific repertoi
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Clinical & Experimental Immunology @ceijournal.bsky.social · 29/07/2026
🔬 New research suggests that individuals exposed to Mycobacterium tuberculosis without developing active disease have stronger IgA and IgG antibody responses than TB patients. High salivary IgA levels also point to an important role for mucosal immunity in TB protection. vist.ly/5cuf7
The role of IgA and IgG in Mycobacterium tuberculosis infection: a cross-sectional study in Ethiopia
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Clinical & Experimental Immunology @ceijournal.bsky.social · 23/07/2026
🔬 New evidence suggests β-tubulin 5 (TBB5) is unlikely to be the pANCA target in primary sclerosing cholangitis (PSC), narrowing the search for the underlying autoantigen. 📖 vist.ly/5c73w #Immunology #Autoimmunity
Tubulin beta 5 is not the target of antineutrophil antibodies in primary sclerosing cholangitis
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Clinical & Experimental Immunology @ceijournal.bsky.social · 22/07/2026
🧬 New insight into rituximab resistance: CD40L and IL-4 shield B cells from NK cell-mediated killing via the HLA-E/NKG2A and HLA/KIR inhibitory pathways. Targeting these checkpoints could enhance B-cell depletion in autoimmune disease. 📖 vist.ly/5c37t
CD40L and IL-4 lymph node-associated signals protect B cells from rituximab-induced ADCC via KIR and NKG2A
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Clinical & Experimental Immunology @ceijournal.bsky.social · 20/07/2026
🧬 Targeting TIM pathways in RA? In a murine arthritis model, blockade of TIM-1 or TIM-3 reduced disease severity, inflammatory cytokines (IL-6, IL-17A, TNF-α), and joint damage, highlighting both receptors as promising therapeutic targets in rheumatoid arthritis. 📖 vist.ly/5btfj
Graphs and microscope images showing histological scores and cell counts for rIgG and RMT1-10 treatments.
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Clinical & Experimental Immunology @ceijournal.bsky.social · 17/07/2026
Crohn’s disease lesions show enrichment of CD4⁺CD39⁺ TCRαβ⁺ TEM cells producing IL‑17/IL‑21 and terminally differentiated TCR Vδ1⁺ cells producing TNF‑α/IFN‑γ. Distinct inflammatory roles point to Vδ1⁺ cells as a potential therapeutic target. 📄vist.ly/5bipi
Diagram comparing T cells in not inflamed and inflamed tissues with cytokine and marker labels.
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Clinical & Experimental Immunology @ceijournal.bsky.social · 15/07/2026
Despite elevated KLR and mitochondrial gene expression, Tregs in autoimmune PAI show normal frequency and suppressive function, suggesting limited involvement in disease pathogenesis. 📄 vist.ly/5ba6v
Infographic with Treg cell images, graphs, and transcript information.
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Clinical & Experimental Immunology @ceijournal.bsky.social · 14/07/2026
Important CIDP research shows significant changes in circulating B‑cell subsets and elevated IL10/TNFA expression, correlating with disability scores and nerve fiber density. Valuable insights for understanding disease activity. 📄 vist.ly/5b74h
Cover of Clinical & Experimental Immunology journal with geometric design.
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Clinical & Experimental Immunology @ceijournal.bsky.social · 10/07/2026
This study highlights 2B4 (CD244) as a key receptor driving Staphylococcus aureus–associated allergic inflammation. SEB binds and activates 2B4, amplifying eosinophil responses, pointing to a promising therapeutic target. 📄 vist.ly/5aser
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Clinical & Experimental Immunology @ceijournal.bsky.social · 08/07/2026
🧬 Research shows newborn immunity differs sharply from adults: NK cells and ILCs are functionally mature at birth, while NKT‑like cells are far less abundant and less active. Important context for understanding early‑life infection risk. 🔗 vist.ly/5ag5y
UMAP plots of immune cells and a heatmap comparing cell types from adults and cord blood.
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Clinical & Experimental Immunology @ceijournal.bsky.social · 07/07/2026
Type 1 Diabetes arises from a loss of immune tolerance. Our article explores how hyperglycaemia and immunometabolic changes may influence regulatory T cell function, offering new insights into disease mechanisms and therapeutic opportunities. 🔗 vist.ly/5adnr
Immunometabolism crosstalk between regulatory T cells and glucose homeostasis of type 1 diabetes
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Clinical & Experimental Immunology @ceijournal.bsky.social · 03/07/2026
IFNγ from activated CD4⁺ T cells is a key driver of B‑cell differentiation and autoantibody production in IMQ‑induced lupus mice. IFNγ deficiency dramatically reduced disease features, a promising immune pathway for future SLE therapies. vist.ly/59xti
Scientific diagram showing TLR7 pathway leading to SLE with immune cells.
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Clinical & Experimental Immunology @ceijournal.bsky.social · 02/07/2026
🔬 LPA drives macrophages toward an anti-inflammatory M2-like phenotype via LPAR1, reducing inflammatory signals and promoting oxidative metabolism, highlighting a potential target for inflammatory and autoimmune diseases. 🔗 vist.ly/59uqq #Immunology #Macrophages
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Lysophosphatidic acid regulates macrophage polarization via LPAR1 by suppressing inflammatory responses and promoting M2-like characteristics
Lysophosphatidic acid (LPA) is a crucial bioactive lipid mediator involved in various physiological processes. However, its role in macrophage polarisation
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Clinical & Experimental Immunology @ceijournal.bsky.social · 01/07/2026
IFNγ from activated CD4⁺ T cells plays a key role in driving lupus by promoting B‑cell differentiation and autoantibody production. Mice lacking IFNγ showed reduced symptoms, highlighting these cells as a potential therapeutic target. vist.ly/59qty #Immunology #SLE #LupusResearch
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Clinical & Experimental Immunology @ceijournal.bsky.social · 26/06/2026
Phase 3 vaccine trials are moving beyond traditional designs, with adaptive methods and modern analytics helping to improve efficiency and decision-making in vaccine research. 📖 vist.ly/595z4 #Vaccines #ClinicalTrials #Biostatistics
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Past, present, and future of Phase 3 vaccine trial design: rethinking statistics for the 21st century
This paper provides an overview of the evolution of Phase 3 vaccine trial design and statistical analysis methods from traditional to more innovative conte
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Clinical & Experimental Immunology @ceijournal.bsky.social · 25/06/2026
🔬 Organoids are transforming immunology research. By incorporating immune and microbial cells, these increasingly complex 3D models are helping uncover new immune–epithelial interactions, disease mechanisms, and therapeutic opportunities. 🔗 vist.ly/593kk
doi.org
Expanding organoid complexity to advance immunology research
Historically, immunological research, especially when involving human cells, has relied heavily on the use of in vitro cultures. While this has led to coun
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Reposted by Clinical & Experimental Immunology
British Society for Immunology @britsocimm.bsky.social · 24/06/2026
🚀 Excited to announce the Immunometabolism Section in @ceijournal.bsky.social led by Dr Lizzy Rosser (UCL) A dedicated home for cutting-edge research exploring how metabolism shapes immune function in health and disease. Learn more: vist.ly/58wxd #Immunometabolism #Immunology
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Reposted by Clinical & Experimental Immunology
Oxford Academic @academic.oup.com · 17/06/2026
Discover the benefits available when peer reviewing for the @britsocimm.bsky.social journals, including a chance to work with immunology experts to advance research. 🔗 oxford.ly/4fWq6kZ #ImmunoSky | @ceijournal.bsky.social | @imtadvances.bsky.social | @discovimmunol.bsky.social
Call for reviewers: become an ad hoc reviewer for the BSI journals
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Clinical & Experimental Immunology @ceijournal.bsky.social · 18/06/2026
🩸 Could blood-based immune markers help monitor treatment response in eosinophilic oesophagitis (EoE)? Using CyTOF, researchers identified immune cell changes following orodispersible budesonide treatment, including shifts in T cells and eosinophil populations. 🔗 vist.ly/588me
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Investigating immune profile by CyTOF in patients with eosinophilic esophagitis after treatment with orodispersible budesonide
(A) Minimum spanning tree of eosinophil populations present in the blood of 10 patients with EoE before and after treatment with orodispersible budesonide
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Clinical & Experimental Immunology @ceijournal.bsky.social · 17/06/2026
Primary humoral immunodeficiencies (sIgAD, CVID, THI) remain complex, overlapping conditions with diagnostic challenges & evolving management. The field continues moving toward more personalised approaches to care. 🔬 vist.ly/584aq #Immunology #RareDiseases
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Clinical and experimental treatment of primary humoral immunodeficiencies
Comparison of the most common forms of primary antibody deficiencies: THI, CVID, and sIgAD, including main characteristic features and the possibility of p
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Clinical & Experimental Immunology @ceijournal.bsky.social · 17/06/2026
Huge congratulations to Prof Stephen Jolles on his OBE in the King’s Birthday Honours for services to immunology & rare diseases 👏 A leader in the field and valued CEI editorial board member! 🎉 #Immunology
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Clinical & Experimental Immunology @ceijournal.bsky.social · 12/06/2026
🔬 New for #DiabetesWeek2026: Insulin or proinsulin, what’s the first autoimmune target in #T1D? Study shows similar potency for both, highlighting heterogeneity in early immune responses & age/sex differences. 🔗 vist.ly/57irp #DiabetesResearch #Immunology
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Heterogeneity between insulin and proinsulin in the potency for insulin autoantibodies in newly diagnosed type 1 diabetes children
Displacement of IAA binding by increasing log10 concentrations (0–100 nM) of unlabeled insulin (green; actual concentrations 0–86 nM) or proinsulin (purple
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Clinical & Experimental Immunology @ceijournal.bsky.social · 12/06/2026
📢 Explore the #FOCIS2026 Virtual Issue A curated virtual issue from Clinical & Experimental Immunology highlighting advances in immune microenvironments, immune evasion, and bioengineering 🧬 Discover the research shaping translational immunology: vist.ly/57h5j #Immunology
Promotional image for the FOCIS 26 Virtual Issue by Clinical & Experimental Immunology. Includes abstract molecular graphics and text about research complementing FOCIS Annual Meeting.
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Clinical & Experimental Immunology @ceijournal.bsky.social · 11/06/2026
Exosomes are emerging as key regulators of immune communication, shaping responses in cancer, infection, and immunotherapy 🧬 Featured in the #FOCIS2026 Virtual Issue, this review explores their roles in immune signalling, evasion, and therapeutic potential 🔗 vist.ly/57eab #Immunology
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Exosomal nanocarriers of immune fate: molecular insights into cancer immunity, pathogen defense, and emerging immunotherapies
Exosomes are nanoscale extracellular vesicles that integrate molecular cues to modulate immune responses across cancer and infection contexts. This review
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Clinical & Experimental Immunology @ceijournal.bsky.social · 10/06/2026
NK cell receptors play a key role in viral immunity, shaping activation, exhaustion, and immune evasion pathways 🧬 Featured in our #FOCIS2026 Virtual Issue, this review explores how viruses including SARS-CoV-2 modulate NK cell responses 🔗 vist.ly/579eq #Immunology #InfectiousDisease
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NK-cell receptor modulation in viral infections
This review summarizes recent knowledge on NK cell receptor alterations mediated by viral infections, along with the mechanisms responsible for this modula
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Clinical & Experimental Immunology @ceijournal.bsky.social · 09/06/2026
Part of our Clinical & Experimental Immunology FOCIS 2026 Virtual Issue: New research on thymic myoid cells reveals their role in shaping immune microenvironments and driving tumour-associated myasthenia gravis. vist.ly/575h9 #FOCIS2026 #Autoimmunity
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Deletion of thymic myoid cells regulates the thymic microenvironment involved in the progression of tumor-associated myasthenia gravis
Myasthenia gravis (MG) is an autoimmune disease commonly associated with immune disorders in thymoma. The role of thymus myoid cells (TMCs) in the pathogen
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Clinical & Experimental Immunology @ceijournal.bsky.social · 05/06/2026
Environmental pollution may worsen asthma 🌍 This research shows that 3-methyl-4-nitrophenol (MNP) promotes ER stress in airway epithelial cells, driving oncostatin M → macrophage TNF-α → increased allergic inflammation. 🔗 vist.ly/56ra4 #Immunology #Asthma #AirPollution
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Environmental pollutant 3-methyl-4-nitrophenol promotes the expression of oncostatin M to exacerbate airway allergic inflammation
The objective of this study is to elucidate the role of 3-methyl-4-nitrophenol (MNP), an environmental pollutant, in asthma exacerbation. In this study, an
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Clinical & Experimental Immunology @ceijournal.bsky.social · 27/05/2026
Long non-coding RNAs are emerging as key drivers of neuroimmune interactions in oral cancer, shaping immune evasion and nerve invasion and pointing to new therapeutic targets 🧬 🔗 vist.ly/55mgj #Immunology #CancerResearch #Neuroimmunology
doi.org
LncRNAs at the frontline of neuroimmune crosstalk in oral cancer
This review examines the current role of long non-coding RNAs (lncRNAs) in the neuroimmune crosstalk in oral squamous cell carcinoma and specifically their
011
Clinical & Experimental Immunology @ceijournal.bsky.social · 27/05/2026
🎉 Registration is open for FOCIS 2026! 📅 June 9–12, 2026 📍 San Francisco Get ready to ignite innovation, connect with global immunology leaders, and experience the forefront of translational immunology at FOCIS 2026! Learn More: vist.ly/55krq #FOCIS2026
Promotional graphic for the FOCIS 2026 Annual Meeting held from June 9-12 in San Francisco, California, featuring the theme 'Where the World of Immunology Connects'.
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Clinical & Experimental Immunology @ceijournal.bsky.social · 22/05/2026
Organoid co-culture and organ-on-chip systems are transforming how we study immune–epithelial interactions, enabling more precise, patient-relevant models of disease 🧬 🔗 vist.ly/555tb #Immunology #Organoids #Microfluidics #PrecisionMedicine
doi.org
Revolutionizing immune research with organoid-based co-culture and chip systems
Potential use and translational applications of patient-derived organoids are very diverse. Such models have revolutionized research in immunological disea
021
Clinical & Experimental Immunology @ceijournal.bsky.social · 21/05/2026
Research in Crohn’s disease shows peripheral blood T cells are already less prone to apoptosis before reaching the gut, with reduced catalase activity contributing to this effect 🧬 🔗 vist.ly/5422x #Immunology #CrohnsDisease #Tcells
doi.org
Catalase inhibition can modulate the ability of peripheral blood T cells to undergo apoptosis in Crohn’s disease
Blood T lymphocytes from CD patients are less prone to undergo apoptosis before migrating to the intestinal mucosa. The inhibition of catalase has a direct
021