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Clive McKimmie

@clive-mckimmie.bsky.social
2.5K followers 714 following 147 posts

Team leader of the Virus Host Interaction Team University of York, Skin Research Centre; 🇬🇧🇪🇺🏳️‍🌈 (he/him) co-chairs @Arbovirus seminars. #immunology #virology #skin #vectors Website www.hyms.ac.uk/about/people/Clive-M…

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Reposted by Clive McKimmie
Colin Carlson @colincarlson.bsky.social · 23/09/2026
What's behind this tidal wave of epidemics? In the largest study ever conducted on emerging infectious diseases, we show that the popular explanation - "our relationship with nature is out of balance" - doesn't hold up. Out now in Nature, after half a decade of work: www.nature.com/articles/s41...
nature.com
The anthropogenic fingerprint on emerging infectious diseases - Nature
Emerging infectious disease outbreak risks are ubiquitous worldwide, and highest in landscapes where people, livestock and fragmented natural ecosystems coexist, but detection and data ...
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Arbovirus seminars @arbovirus.bsky.social · 11/09/2026
Come join us for the first seminar of the series - some fascinating work by Zhouming Liu on La Crosse Virus infection. All welcome - just email us for a Zoom link.
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Clive McKimmie @clive-mckimmie.bsky.social · 04/09/2026
Delighted to share the 2026–27 programme for the International Virtual Seminars in Arbovirus Biology, organised with @tulilab.bsky.social Tuli Mukhopadhyay and Tem Morrison. A fantastic range of speakers/topics this year. Please share with anyone in the arbovirus community who might be interested!🦟🦠
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Clive McKimmie @clive-mckimmie.bsky.social · 21/08/2026
Hot on the heels of #WorldMosquitoDay 🦟, we’re delighted to share our new paper. What if vaccines targeted not only the virus, but also the mosquito that helps transmit it? www.mdpi.com/2076-393X/14...
mdpi.com
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Arbovirus seminars @arbovirus.bsky.social · 14/05/2026
Next virtual seminar is with Dr María Mora González López Ledesma, Fundación Instituto Leloir, Argentina. She’ll discuss: “Dissecting NS5-mediated immune evasion across the four dengue virus serotypes”, exploring how dengue NS5 shapes antiviral immunity. All welcome! Message us for the ZOOM link.
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Clive McKimmie @clive-mckimmie.bsky.social · 13/05/2026
Happy to share new preprint is now on bioRxiv: "Ultraviolet exposure conditions skin to enhance arbovirus infection and mosquito probing" Led by our then PhD student now Dr. @ailishmccafferty.bsky.social this work asks how UV-exposed skin shapes mosquito-borne virus infection. (1/4)
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Waggoner Lab @labwaggoner.bsky.social · 09/05/2026
The ISG Atlas: a loss-of-function analysis characterizes antiviral properties of interferon stimulated genes www.nature.com/articles/s41... @natcomms.nature.com
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Clive McKimmie @clive-mckimmie.bsky.social · 21/04/2026
New News & Views out today in @natmicrobiol.nature.com with @mariekedoesscience.bsky.social — "When viral RNA lingers in joints" — on a new study by Zarrella et al. asking why chikungunya virus causes chronic arthralgia/arthritis. (1/3)
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Clive McKimmie @clive-mckimmie.bsky.social · 14/04/2026
At #Microbio26 see our PhD student Amani Alhazmi poster 232, Tuesday. She has interesting data showing how vitamin D regulates responsiveness and susceptibility of skin to mosquito borne virus infection. I know she would value any input and/or interest!
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Clive McKimmie @clive-mckimmie.bsky.social · 14/04/2026
🧫 The Microbiology Society AC26 has a session called "Out of Body Experience"; and it's not what you think! It's about cutting-edge infection models: organoids, tissue-on-chip, complex co-cultures that actually mimic how infections happen in real tissues. Engineering meets microbiology! #Microbio26
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Arbovirus seminars @arbovirus.bsky.social · 13/04/2026
🦟 Really excited for our next seminar! @chantalvogels.bsky.social (Yale) on how mosquito & virus factors shape Wolbachia-mediated inhibition of dengue; a key question for biocontrol. Thurs 16 April, 4pm UK / 11am ET 📍 Zoom — DM or email us for the link, all welcome!
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Clive McKimmie @clive-mckimmie.bsky.social · 11/03/2026
A thoughtful overview in Nature Medicine on the growing global importance of arboviruses and emerging strategies to counter them. It discusses our recent work on mosquito–host interactions. Encouraging to see this area receiving broader attention. www.nature.com/articles/d41...
nature.com
Mosquito-borne viruses, vaccine-borne hope
From chikungunya and dengue to yellow fever and Zika, mosquito‑transmitted diseases are spreading with urbanization, travel and climate change. A new generation of vaccines, trials and public‑health t...
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Arbovirus seminars @arbovirus.bsky.social · 11/03/2026
Join Prof Gong Cheng (Tsinghua University) for our International Arbovirus Biology Seminar, exploring the molecular basis of flavivirus infection in mosquitoes and determinants of vector competence. All welcome! Please help with a repost. #Arbovirus #Flavivirus #VectorBiology
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Arbovirus seminars @arbovirus.bsky.social · 02/03/2026
Looks set to be a very useful and collaborative meeting on arboviruses and their vectors, later this year. 👇
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Clive McKimmie @clive-mckimmie.bsky.social · 18/02/2026
New modelling suggests chikungunya transmission in Europe may be possible at lower temperatures than previously thought—expanding the seasonal and geographic risk as the Asian tiger mosquito spreads north with warming climate. : royalsocietypublishing.org/rsif/article...
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Arbovirus seminars @arbovirus.bsky.social · 13/02/2026
Prof. Claudia Nunes Duarte dos Santos (Fiocruz, Brazil) will present the discovery of Pirahy virus—a newly identified alphavirus from Brazilian mosquitoes with features suggesting emergence potential. Thursday 19th Feb by Zoom. All welcome! Just DM your email for the link.
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Clive McKimmie @clive-mckimmie.bsky.social · 13/01/2026
Great visit to @roslininstitute.bsky.social yesterday to give a seminar on how skin inflammation and environmental stress shape antiviral susceptibility. Many thanks to Rute Pinto for the warm welcome and excellent hosting. Lots of scope for future conversations and collabs.
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Arbovirus seminars @arbovirus.bsky.social · 13/01/2026
Zoom seminar: Drawing on recent mechanistic and genetic studies, Prof Andres Merits' talk will highlight how #alphavirus #replication complex function intersects with innate #immune sensing and restriction, offering fresh perspectives on virus–host co-evolution and antiviral targeting. All welcome!
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Clive McKimmie @clive-mckimmie.bsky.social · 02/01/2026
Oddly positive
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Clive McKimmie @clive-mckimmie.bsky.social · 11/12/2025
Looking forward to this seminar, all welcome to attend by Zoom.
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Clive McKimmie @clive-mckimmie.bsky.social · 02/12/2025
Fantastic start to #BSI25 with @profjudiallen.bsky.social ; a masterclass in scientific storytelling. Her career journey was engaging and full of long-view perspectives. Loved her celebration of mentees, and the message to chase those exciting “distractions” in science. #macrophage #Th2 #infections
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Arbovirus seminars @arbovirus.bsky.social · 13/11/2025
Psyched to say that Mike Diamond is talking at our next seminar. THURSDAY 20th Nov. All welcome! World leading #virology not to be missed - just email us for a Zoom link. Please help us with a re-post to get the word out 👍
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Clive McKimmie @clive-mckimmie.bsky.social · 03/11/2025
New paper out in iScience @cellpress.bsky.social We show that #sand_fly biting reprograms skin fibroblasts, making them more permissive to virus infection => #fibroblasts aren’t bystanders, they help define severity/clinical outcome to infection AND #vector biting is key 👉 doi.org/10.1016/j.is...
Diagram showing how sand fly saliva changes fibroblast state to promote arbovirus infection.
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Clive McKimmie @clive-mckimmie.bsky.social · 31/10/2025
New PhD opportunity! Can skin inflammation protect us from mosquito-borne viruses like Zika? Join our MRC PhD project at York exploring how psoriasis and eczema change skin immunity to virus. Our grads thrive in academia, biotech & beyond. Apply now 👉 tinyurl.com/bfmd2rf4
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Arbovirus seminars @arbovirus.bsky.social · 09/10/2025
NEW SEMINAR - Thursday 16th October, all welcome! 🦟 How do mosquitoes fight infection at the gene level? Using precision nuclear run-on sequencing (PRO-seq), Pascal and team captured transcription as it happens in Ae aegypti, offering new insights into vector biology and host–pathogen interactions.
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Clive McKimmie @clive-mckimmie.bsky.social · 01/10/2025
We all know vaccines target the pathogen, but can you also target the vector? 📢 in a new paper out today in Vaccines, we show that a vaccine targeting mosquito salivary peptides, AGSv-PLUS, enhances human skin immune response to biting. Open access: www.mdpi.com/2076-393X/13... 1/6
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Clive McKimmie @clive-mckimmie.bsky.social · 24/09/2025
Farewell, Zahra! Celebrating the end of a successful PhD journey with some well-deserved fun.
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Clive McKimmie @clive-mckimmie.bsky.social · 19/09/2025
Super happy to announce Zahra Alfaheeda has passed her PhD viva. 🥳 She worked hard to combine diverse resources from cancer biology, virology and vector biology for a really unique project. Looking forward to sharing her story soon. Thanks to @maringerlab.bsky.social and Gina Doody for examining.
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Arbovirus seminars @arbovirus.bsky.social · 12/09/2025
See you Thursday 18th for our first seminar of the series with the inspiring @priyashah.bsky.social from @ucdavis.bsky.social with her talk “Harder, better, faster, stronger: integrating virology and engineering to drive discovery”. All welcome! email us for the zoom link.
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Clive McKimmie @clive-mckimmie.bsky.social · 31/08/2025
Psyched to be co-chairing this great line up of diverse speakers who represent the best in arbovirus research. See you there! Send us your email for a Zoom login. Please help with a re-post :-)
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Clive McKimmie @clive-mckimmie.bsky.social · 28/08/2025
Not just wild fires that follow hot weather, clusters of locally acquired mosquito-borne virus infection in south France, an update on numbers.
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Clive McKimmie @clive-mckimmie.bsky.social · 27/08/2025
Was sad to say farewell to @yoncakeskekturk.bsky.social today. She transformed our understanding of the sandfly-skin interface during virus infection for her PhD, and just finished testing a new Zikv vaccine. She returns home to 🤞start her career as lecturer/PI. Take care Yonca! You will be missed.
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Clive McKimmie @clive-mckimmie.bsky.social · 06/08/2025
We knew this deeply misguided man was bad news, but now his actions threaten us all. RNA-based vaccines are safe, effective at preventing disease, and can be rapidly manufactured at scale. Just as the threat of infectious disease increases, we remove our best defence. www.bbc.co.uk/news/article...
bbc.co.uk
RFK Jr cancels $500m in mRNA vaccine development in the US
Since taking office, the vaccine sceptic has made a number of changes to how vaccines are regulated.
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Prof Sheena Cruickshank @sheencr.bsky.social · 04/08/2025
I thought it might be helpful to do a more general immunology explainer which I can then build on for example when I discuss specific papers or political actions. Do let me know if its useful and other topics if so. This first one is a general one about how we tackle infections... 🧪 #ImmunoSky
open.substack.com
Fundamental immunology 101: the basics of an immune response
Tackling infections
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Hugo Perdomo @hugodperdomo.bsky.social · 29/07/2025
How can mosquitoes tolerate viral infections? In our latest preprint we show that mosquitoes that can regulate their metabolism after infection can tolerate viral infections better. Thanks to all the authors for all your ideas and contributions www.biorxiv.org/content/10.1...
biorxiv.org
Metabolic homeostasis favors tolerance to persistent viral infection in Aedes aegypti mosquitoes
The mosquito Aedes aegypti harbors a wide range of persistent viral infections, including both medically important arboviruses and insect-specific viruses (ISVs). However, the mechanisms underpinning ...
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European Centre for Disease Prevention and Control @ecdc.europa.eu · 21/07/2025
🧵 Dengue is no longer just a tropical disease - it's showing up in Europe. This season, France, Italy, and Portugal (Madeira) have already reported locally acquired dengue cases. Check the latest #CDTR on #dengue here: bit.ly/3TQpDVu #IdSky #EpiSky #MosquitoBorne #Prevention #PublicHealth
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The Global Vector Hub @globalvectorhub.bsky.social · 23/07/2025
🦟"World Health Organization @who.int raises concern about spread of #mosquito-borne #chikungunya #virus" via @reuters.com #arbovirus #GLAI www.reuters.com/business/hea...
reuters.com
World Health Organization raises concern about spread of mosquito-borne Chikungunya virus
The World Health Organization issued an urgent call for action on Tuesday to prevent a repeat of an epidemic of the mosquito-borne chikungunya virus that swept the globe two decades ago, as new outbreaks linked to the Indian Ocean region spread to Europe and other continents.
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brackneylab @brackneylab.bsky.social · 01/07/2025
Despite all the shit going on, we have to celebrate our victories. New publication with @entomososwin.bsky.social and @vectorimmunity.bsky.social showing that hemocytes play a central role in disseminating flaviviruses to secondary tissues potentially functioning as a Trojan Horse(TBD) rdcu.be/euj4g
rdcu.be
Mosquito immune cells enhance dengue and Zika virus infection in Aedes aegypti
Nature Communications - Infection of mosquito immune cells by dengue and Zika virus enhances the spread of virus infection to mosquito tissues, such as the salivary glands, to promote virus...
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Clive McKimmie @clive-mckimmie.bsky.social · 24/06/2025
These images are just stunning, generated using the largest mirror paired with the largest digital camera ever made. @vrubinobs.bsky.social
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Reposted by Clive McKimmie
Nature @nature.com · 19/06/2025
Nature research paper: Kupffer cell programming by maternal obesity triggers fatty liver disease go.nature.com/4laOA9s
go.nature.com
Kupffer cell programming by maternal obesity triggers fatty liver disease - Nature
In a mouse model, maternal obesity during pregnancy can lead to fatty liver disease in the offspring, driven by aberrant developmental programming of Kuppfer cells.
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Clive McKimmie @clive-mckimmie.bsky.social · 12/06/2025
Last seminar in the series with latest insights from Jonathan Abraham's team - #alphavirus-fest 🤓
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Clive McKimmie @clive-mckimmie.bsky.social · 22/05/2025
A great talk at GRC on tick-borne #CCHFV #pathogenesis. GP38, a secreted viral protein, drives vascular leak by disrupting the endothelial glycocalyx, similar to DENV NS1. Antibodies blocked leak and protected mice; => GP38 can be considered a viral Toxin; www.science.org/doi/10.1126/...
science.org
Antibodies targeting Crimean-Congo hemorrhagic fever virus GP38 limit vascular leak and viral spread
Glycoprotein GP38-specific antibodies reduce viral dissemination and GP38-mediated vascular leak in Crimean-Congo hemorrhagic fever virus infection.
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Clive McKimmie @clive-mckimmie.bsky.social · 22/05/2025
@chatel-chaixlab.bsky.social just gave excellent summary of their paper on a new #zebrafish model #ZIKV at GRC viruses and cells. Useful new tool for assessing #neuropathogenesis when paired with unprecedented genetic and imaging capabilities. Worth checking out. journals.plos.org/plospathogen...
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Clive McKimmie @clive-mckimmie.bsky.social · 13/05/2025
Looking forward to a day of Yorkshire Immmnology at @york.ac.uk with my former colleague Gerry Graham of @crgglasgow.bsky.social as keynote. If you’re coming do say hi! 👋 #BSIYorkshire25
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Arbovirus seminars @arbovirus.bsky.social · 09/05/2025
Super psyched to have leading investigator @thehornerlab.bsky.social presenting her team's work THURSDAY 15th May on Zoom. #flavivirus #virus-host-interactions #innate_immunity #DENV #ZIKV All are very welcome and please re-post to get the word out. Email organisers for Zoom link. See you there!
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Dave Itzkoff @ditzkoff.bsky.social · 23/04/2025
The free speech website where the owner (who believes in free speech) will throttle your access if you criticize him - even if you support all the far-right conspiracy theories and bigotry he supports. www.nytimes.com/interactive/...
nytimes.com
They Criticized Musk on X. Then Their Reach Collapsed. (Gift Article)
Three users who disagreed with the site’s owner saw views for their posts plummet.
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Clive McKimmie @clive-mckimmie.bsky.social · 16/04/2025
This rather sad decision seems to miss the point that our understanding of the biological underpinning of gender is not complete. Binary concepts inferred from the inheritance of whole chromosomes is outdated and not helpful. www.theguardian.com/society/2025...
theguardian.com
UK’s supreme court rules that legal definition of woman is based on biological sex
Judges say Equality Act definition excludes transgender women holding gender recognition certificates after gender critical campaigners’ challenge
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Arbovirus seminars @arbovirus.bsky.social · 10/04/2025
It's finally time for some #bunyavirales and #tick borne viruses with Ben Brennan from @cvrinfo.bsky.social and his much anticipated talk, this THURSDAY 17th. All welcome! Please help us with a re-post. 🕷️🦠🧫
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Clive McKimmie @clive-mckimmie.bsky.social · 02/04/2025
So proud of this diverse, international team, excelling at presenting the results of their hard work, all of who gave superb talks at #microbio25 🥲👏🏼
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Rebee @rebee.bsky.social · 01/04/2025
Please go check out poster 311 during the poster session to hear all about the inspiring project that is Flow.Walk.Drag 💧👣👩‍🎤 So cool to have this at @microbiologysociety.org this year 🤩 #MicroBio25 #QueerInSTEM #QueerinMicro 🏳️‍🌈🦠🧫
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