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Pauli Group (posts by Andi Pauli)

@pauligroup.bsky.social
1.5K followers 676 following 128 posts

Exploring the mysteries of how life starts - from fertilization to dormancy; combining in vivo & in vitro (fish, mouse, cell culture, biochem); privileged to work with an amazing team @IMP! paulilab.org www.imp.ac.at/groups/andrea-pauli

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Pauli Group (posts by Andi Pauli) @pauligroup.bsky.social · 16h
Big congratulations, Sascha! You can be really proud of what you achieved during your PhD!
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Diorge Souza @diorgeps.bsky.social · 02/10/2026
Finally out! Our work uncovers evolutionary links between bacterial and archaeal ribosome hibernation and eukaryotic energy sensing, through the archaeal hibernation factor AHA link.springer.com/article/10.1...
link.springer.com
A conserved archaeal protein with evolutionary links to bacterial ribosome hibernation and eukaryotic energy sensing - The EMBO Journal
Ribosome hibernation helps cells survive stress by reversibly silencing translation and preserving ribosomal complexes. Although well characterized in bacteria and eukaryotes, archaeal hibernation rem...
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Pauli Group (posts by Andi Pauli) @pauligroup.bsky.social · 24/09/2026
Is it a virus, or a retrotransposon? Amazing story how an endogenous retrotransposon uses a small, FAST-like protein to cause soma-to-oocyte transfer in Drosophila. Kudos to @mayavoichek.bsky.social, Kirsten Senti, @juliusbrennecke.bsky.social plus the entire team for this exciting discovery!
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Anna Obenauf @obenaufa.bsky.social · 21/09/2026
We are so excited to have @dorie00.bsky.social Doris Kaltenecker join the @impvienna.bsky.social soon. Doris is using cutting edge technologies to study cancer cachexia. I can highly recommend joining a junior lab and can't wait to have her around!
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Pauli Group (posts by Andi Pauli) @pauligroup.bsky.social · 23/09/2026
Seven stories of 'Frontier Science', including our own led by @vdeneke.bsky.social & Andreas Blaha, on the discovery of a trimeric complex bridging sperm and eggs in vertebrates. Thank you @hfspo.bsky.social for supporting out-of-the-box science & allowing us to push the boundaries of what is known!
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Baukje Hoogenberg @baukjeje.bsky.social · 11/09/2026
Do you want to label the nuclear envelope? Do you work on a non-model species? Try Concanavalin A! We tested ConA on various species across the eukaryotic tree and find it is a very useful ExM-compatible marker for the NE and ER. Read all about it in our preprint: www.biorxiv.org/content/10.6...
biorxiv.org
Concanavalin A as a pan-eukaryotic nuclear envelope marker for expansion microscopy
Across eukaryotes, the nuclear envelope exhibits distinct remodelling strategies during mitosis: complete breakdown (open mitosis), partial disruption (intermediate), or full retention (closed). Howev...
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Andres Bendesky @bendeskylab.com · 11/09/2026
We have a tenure-track faculty position in Evolutionary Biology in Columbia's E3B Department. Application deadline is October 15. Come be our colleague. Please RT! apply.interfolio.com/193016
apply.interfolio.com
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
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Nick Stroustrup @nstroustrup.bsky.social · 05/09/2026
Did you know that the cells of old animals contain much less mRNA than the cells of young ones? Let me share with you some results from an ongoing project in the lab, where we are finding that a progressive depletion of total mRNA abundance is a crucial part of aging 1/22
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Vienna BioCenter Scientific Training @vbcscitraining.bsky.social · 06/09/2026
🔔 Doctoral Insights Symposium is THIS Thursday. PhD programs across Europe. Live panels. Q&A with real students and coordinators. Free. Online. Undergrad thinking about a PhD? This is for you. Register → doctoralinsights.at #DocInsights #Symposium
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Vienna BioCenter Scientific Training @vbcscitraining.bsky.social · 04/09/2026
The #ViennaBiocenter Summer School 2026 has wrapped up! 🎊 19 early-career researchers from across the globe spent the summer at VBC institutes and presented at the Fellows' Symposium on 28 Aug. Want to join us in 2027? Check our website from mid-October 👉 ow.ly/S6v850ZIGNX #ViennaBiocenter
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Haselbach Lab @haselbachlab.bsky.social · 31/08/2026
Last call: registration for the 9th Austrian Cryo-EM (ACE) Symposium closes tomorrow, 1 September. 24-25 Sept at the IMP, Vienna BioCenter. Eight invited speakers, selected talks, poster session. events.vbc.ac.at/imp_events/c... #cryoEM #cryoET
events.vbc.ac.at
Cryo-EM Symposium 2026
Register here for the Cryo-EM Symposium 2026, 24-25 September at the IMP, Campus-Vienna-Biocenter 1, 1030 Vienna.Please select the applicable registration fee and add it to the cart. Please click on t...
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Pauli Group (posts by Andi Pauli) @pauligroup.bsky.social · 30/08/2026
Applications for next summer will open in fall. Please note that there will be some updates to our #TalentsProgram specifically announced on the website soon, so stay tuned!
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Pauli Group (posts by Andi Pauli) @pauligroup.bsky.social · 30/08/2026
And now to the future: If you are an international bachelor/Master student interested in immersing yourself in an enriching research experience at the forefront of science next summer while also having fun, please check out our website for details on the program: training.vbc.ac.at/summer-school/
training.vbc.ac.at
Summer School
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Pauli Group (posts by Andi Pauli) @pauligroup.bsky.social · 30/08/2026
And last but not least, a big thank you to everyone who helped making this summer not only a wonderful science experience for our Fellows but also fun: ChrisRobinson, @arburga.bsky.social, NickIrwin, @dammermannlab.bsky.social, @dseruggia.bsky.social, @vdeneke.bsky.social & @evaschmid7.bsky.social.
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Pauli Group (posts by Andi Pauli) @pauligroup.bsky.social · 30/08/2026
Moreover, the #VBCSummerSchoolProgram would be impossible without the support from the Max Birnstiel Foundation and MILA Foundation, which generously support the Talents Program. Thank you!
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Pauli Group (posts by Andi Pauli) @pauligroup.bsky.social · 30/08/2026
A big thank you to all hosting labs and institutes @cemm.oeaw.ac.at @gmivienna.bsky.social @impvienna.bsky.social @imbavienna.bsky.social @maxperutzlabs.ac.at, and particularly to all direct mentors within the labs who supervised the Fellows over the past months with great dedication.
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Pauli Group (posts by Andi Pauli) @pauligroup.bsky.social · 30/08/2026
Special congratulations to Ximena Millan Hurtado (@ar-abdelfattah.bsky.social lab @cemm.oeaw.ac.at), Sara Soares Garcia da Fonseca (@johanneszuber.bsky.social lab @impvienna.bsky.social) & Deniz Bekat (@huis.bsky.social lab @maxperutzlabs.ac.at) for winning the awards for best presentations!
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Pauli Group (posts by Andi Pauli) @pauligroup.bsky.social · 30/08/2026
And it’s a wrap! Impressive finish to our 2026 #ViennaBioCenterSummerSchool with the Summer School Symposium, where our 19 international Fellows presented the results of their 2-3 months of research conducted in their host labs. Congratulations to all Fellows! training.vbc.ac.at/summer-school/
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Chris H. Hill @chillzaa.bsky.social · 24/08/2026
Thrilled to share that our paper describing protein-dependent frameshifting is now out in Molecular Cell @cellpress.bsky.social. Huge congratulations to @jemmabetts.bsky.social for publishing the first research paper from her PhD 🧬🧪🥳 www.sciencedirect.com/science/arti... 1/8
sciencedirect.com
A protein-dependent riboswitch activates ribosomal frameshifting in cardioviruses
Programmed −1 ribosomal frameshifting (PRF) is a translational control mechanism used by RNA viruses to regulate the relative abundance of proteins en…
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Yaniv Elkouby @yanivelkouby.bsky.social · 23/08/2026
Happy to share a new protocol for ex vivo #zebrafish #ovary culture from Amal Shawahny and Yoel Bogoch! Protocol for culture of zebrafish developing ovaries as an ex vivo system for investigating early oogenesis and ovarian development: STAR Protocols www.cell.com/star-protoco...
cell.com
Protocol for culture of zebrafish developing ovaries as an ex vivo system for investigating early oogenesis and ovarian development
A fundamental understanding of early oogenesis is lacking, and zebrafish serve as an excellent model for investigation, based largely on in vivo approaches. We present a protocol for long-term zebrafi...
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Biozentrum, University of Basel @biozentrum.unibas.ch · 21/08/2026
How do you visualize highly complex data without losing important information? Prof. Erik van Nimwegen’s team developed a new tool, Bonsai, that provides a faithful picture of the structure in the data. @erikvannimwegen.bsky.social @unibas.ch @dhdegroot.bsky.social @imbavienna.bsky.social
biozentrum.unibas.ch
Seeing the Unseen: A new tool for exploring complex biological data
Modern biology research can now generate valuable data on an unprecedented scale. But there is one major obstacle: making sense of these complex high-dimensional datasets. Prof. Erik van Nimwegen’s te...
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Pauli Group (posts by Andi Pauli) @pauligroup.bsky.social · 16/07/2026
Yay!! Happy to see our #EZM2026 Klimt-fish shirt (all credits to @theresazeisner.bsky.social from my lab) out in the world!
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Pauli Group (posts by Andi Pauli) @pauligroup.bsky.social · 07/07/2026
Wonderful to see so many @mblscience.bsky.social Woods Hole Zebrafish Course friends here in Vienna for #EZM2026 - from student alumni, current & former faculty to TAs. As @cohouart.bsky.social put it, a truly cross-generational 'historical' picture (and a few were even missing in the pic....).
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Pauli Group (posts by Andi Pauli) @pauligroup.bsky.social · 07/07/2026
A big thank you also to all volunteers from @heisenbergcplab.bsky.social @dianapinheiro.bsky.social @pauligroup.bsky.social for your help, and a particular shout-out to @theresazeisner.bsky.social for the wonderful Klimt-fish T-shirt design, which turned out to be a real hit!
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Pauli Group (posts by Andi Pauli) @pauligroup.bsky.social · 07/07/2026
Thank you also to my co-organizers Stefan Schulte-Merker, @dianapinheiro.bsky.social, @heisenbergcplab.bsky.social, @mvargam.eurosky.social and Przemko Tylzanowski as well as the WMA (Wiener Medizinische Agentur) for working together for >1 year to organize this meeting.
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Pauli Group (posts by Andi Pauli) @pauligroup.bsky.social · 07/07/2026
The #EZM2026 (European Zebrafish Society @ezsociety.bsky.social meeting) is in full swing! More than 500 (not only zebra-)fish researchers from all over the world gather here in Vienna for the next 5 days to discuss science, exchange ideas and make new connections. #Fish #Zebrafish #Friends
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Pauli Group (posts by Andi Pauli) @pauligroup.bsky.social · 07/07/2026
Thanks for visiting us Claudia @kellervalsecchi.bsky.social and sharing your creative and out-of-the-box science with us!
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Houart Lab @houartlab.bsky.social · 07/07/2026
Looking for a research technician job? Come join our lab! We are hiring a part-time Research Technician to work in our lab at @devneuro.bsky.social @kingsioppn.bsky.social on Guy's Campus. A perfect opportunity for a recent graduate to get wet lab experience. www.kcl.ac.uk/jobs/151245-...
kcl.ac.uk
Research Technician | King's College London
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Plaschka lab @plaschkalab.bsky.social · 18/06/2026
Now published! We investigated how polyadenylated RNAs are targeted for decay in the human nucleus. www.nature.com/articles/s41... (1/5)
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Tessa Montague @tessamontague.bsky.social · 06/06/2026
Do you know an outstanding aquarist? We're hiring a Senior Aquarist to help run our cephalopod facility at Columbia University. Our team maintains a colony of 250+ cuttlefish, develops new husbandry techniques (inc transgenics) & studies cuttlefish camouflage and social behavior. 1/3 [Pls repost!]
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Laura Lorenzo Orts @lorenzoorts.bsky.social · 22/05/2026
New preprint by my former colleagues in the Pauli lab 🫶 When I first joined the lab, I naively thought Bouncer’s interacting partner was a single protein. Years later, it turns out that at least 7 components on the sperm side may mediate fertilization - meet the SPARK complex! ✨
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Pauli Group (posts by Andi Pauli) @pauligroup.bsky.social · 22/05/2026
Big congratulations to all authors, particularly @vdeneke.bsky.social & Johannes Suwita who jointly led the work, and our amazing Viennese & external collaborators (Masahito Ikawa's and Pauli team members, VBC proteomics and bioinformatics, @jeremyahollis.bsky.social, @arburga.bsky.social and Hana)!
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Pauli Group (posts by Andi Pauli) @pauligroup.bsky.social · 22/05/2026
New insights into #fertilization from the @pauligroup.bsky.social & Ikawa labs! In a tour-de-force study, we discovered ✨ SPARK ✨, a conserved sperm fertilization complex that couples sperm-egg binding to membrane fusion. Read on 🧵👇 and check out our preprint for more details! tinyurl.com/34cm4xat
tinyurl.com
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Pauli Group (posts by Andi Pauli) @pauligroup.bsky.social · 17/05/2026
Big congrats @yinanwan.bsky.social! See you in Vienna in less than two months!!
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Igor Ulitsky @igorulitsky.bsky.social · 15/05/2026
Now out @natbiotech.nature.com ! Do lncRNAs commonly bind 1000s of genomic sites? Maybe they do, but the dozens of studies that report genomic binding maps of lncRNAs are deeply flawed, with probes binding suprious DNA sites rather than RNA-bound ones.
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Ahmad Jomaa @jomaalab.bsky.social · 13/05/2026
Excited to share our work uncovering SNOR, a ribosome-associated factor that promotes translation restart after dormancy published in Nature!! This was, as usual, a wonderful collaborative effort between our group and the Mattei Lab @simonemattei.bsky.social @embl.org www.nature.com/articles/s41...
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Pauli Group (posts by Andi Pauli) @pauligroup.bsky.social · 13/05/2026
Join us at our special anniversary Symposium on RNA biology at the @vbcscitraining.bsky.social campus! We promise 3 days of interesting science, discussions and hopefully new ideas and learnings for everyone - plus a symposium dinner at the Vienna city hall!
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James Gagnon @james-gagnon.bsky.social · 28/04/2026
Using light-activated CRISPR in zebrafish, we triggered synchronized DNA breaks and track the repair process. ⚡🐟⚡ 

 Well ... DNA repair is very different in embryos compared to tissue culture cells. Embryos repair DNA breaks incredibly fast - within minutes! www.biorxiv.org/content/10.6...
A cartoon showing how a caged guide RNA poises CRISPR cleavage until release by light. Below, a cartoon of injection of "light-activated CRISPR" into the embryo, followed by activation.
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Theresa Zeisner @theresazeisner.bsky.social · 22/04/2026
Want to find out how a zebrafish develops from a small ball of cells into a functioning organism? 🐠 Then join us at the microscopes this Friday at @viennabiocenter.bsky.social for the Long Night of Research 🔬👩‍🔬 langenachtderforschung.at/station/592 📍Vienna BioCenter, 1030 Wien ⏰ 17:00-23:00
langenachtderforschung.at
Wie entwickelt sich ein Fisch? - #LNF26 Lange Nacht der Forschung
Wie schafft es der Zebrafisch sich binnen eines Tages aus einem Zellhaufen zu einem schwimmenden Fisch zu entwickeln? Beobachten Sie mit Hilfe eines Mikroskops, wie Zebrafische wachsen und finden Sie ...
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Pauli Group (posts by Andi Pauli) @pauligroup.bsky.social · 14/04/2026
Thank you to the Biochemical Society for having established such an Award for the 'Leaders of Tomorrow', and thank you for awarding it to such a deserving candidate like @lorenzoorts.bsky.social! Big congrats Laura!
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Pauli Group (posts by Andi Pauli) @pauligroup.bsky.social · 14/04/2026
Big congratulations to our former postdoc @lorenzoorts.bsky.social, now leading her own at the @imbmainz.bsky.social, for receiving the Biochemical Society Early Career Research Award! Amazing news and so well deserved - super proud of you, Laura!
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Diana Pinheiro @dianapinheiro.bsky.social · 30/03/2026
👇👇👇 If are you excited about helping us recruit and train the next generation of scientists, don't hesitate to apply! The @viennabiocenter.bsky.social is a great place to work. 🙂
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Pauli Group (posts by Andi Pauli) @pauligroup.bsky.social · 20/03/2026
A big shout-out for @lorenzoorts.bsky.social and @hohmannulrich.bsky.social - super happy for both of you that it worked out! If I was a student starting my career and interested in mechanistic work at the interphase of biochemistry/structural biology/development, I would immediately apply!
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Alex Schier @schierlab.bsky.social · 12/03/2026
Very happy to see this out. 👏 @yinanwan.bsky.social Bogdan Bintu and team. Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis | free link Science www.science.org/eprint/5MHTM...
science.org
Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis
Gene expression patterns underlie development, but their systematic detection in whole embryos has remained elusive. We introduce a whole-embryo imaging platform using multiplexed error-robust fluores...
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Rob Klose @robklose.bsky.social · 13/03/2026
We are excited to be recruiting into 3 Associate Professorship's in @oxfordbiochemistry.bsky.social. Come join us as a colleague and benefit from our vibrant and multidisciplinary environment. Reach out to me if you have any questions. Please repost! (tinyurl.com/48deybuu) (tinyurl.com/4pdvjaft).
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Vienna BioCenter Scientific Training @vbcscitraining.bsky.social · 13/03/2026
Learn more about the collaboration possibilities offered at Vienna BioCenter as Victoria Deneke shares her insights as a Postdoc at the Research Institute of Molecular Pathology. The VIP³ PostDoc Program call is open – apply now! training.vbc.ac.at/post-docs/vi... #VBCPostDoc
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Nadine Vastenhouw @nvastenhouw.bsky.social · 13/03/2026
What an opportunity! Don’t miss it!!
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Pauli Group (posts by Andi Pauli) @pauligroup.bsky.social · 10/03/2026
Thanks a lot Yasin for the shout-out!
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Pauli Group (posts by Andi Pauli) @pauligroup.bsky.social · 10/03/2026
Congrats Annika on launching the Nichols lab - fantastic news!!
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