Beyond exhaustion, CD8+ T cells can adopt various dysfunctional states, including tolerant, anergic, senescent, ignorant and dying states, that compromise their ability to eradicate viruses or tumours...

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Expression and functional analysis define how Piezo1-dependent cholinergic responses by enteric neurons directly sense luminal pressure to orchestrate digestion and inflammation in mice.

Mammalian cells present RNA-binding proteins on the cell surface that form clustered domains containing glycoRNAs.

Bacterial and host fucosylation protect against colitis by maintaining the IgA B cell response in the mouse gut.

Inflammatory monocytes are identified as important players in T cell restimulation in the tumour microenvironment.

Up to one-third of women receive antibiotics during pregnancy. Pietrasanta et al. show that antibiotic treatment of pregnant mice reduces the amount of breast milk antibodies (SIgA) and alters the neo...