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innate-immuno.bsky.social @innate-immuno.bsky.social · 01/09/2026

🚨New #inflammasome #research with great collaborators [C. Bryant, F. Schmidt, L. Andreeva, @cmfi.bsky.social ]: human NLRC4 can sense #bacteria #flagellin and induce oligomerization and IL-1beta processing without human NAIP - differently to the multi-Naip mouse system. Check link 👇

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innate-immuno.bsky.social @innate-immuno.bsky.social · 16/07/2026

Check out our latest #biorxiv #preprint on #chitin oligomers inducing #NLRP3 #inflammasome activation and trained innate immunity via #TLR2 👉https://www.biorxiv.org/content/10.64898/2026.06.19.733345v1.full.pdf+html

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innate-immuno.bsky.social @innate-immuno.bsky.social · 16/07/2026

🚨Novel Concepts in #Innate_Immunity #conference (NCII) 18-20 May 2027 speaker list is out: 🚨 Join us @uni_tue also to hear @giedretamulaitiene.bsky.social @reisesousalab.bsky.social, @immunobladder.bsky.social! Link 👉https://innate-immunity-conference.de/programme-abstracts/confirmed-speaker

innate-immunity-conference.de

Confirmed speaker

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innate-immuno.bsky.social @innate-immuno.bsky.social · 08/06/2026

Finally out @NatureComms: our latest study on #NLRP3 #inflammasome pathways. Here, we describe an oligomer-/MTOC-independent pathway that dominates in primary human #neutrophils. Special thanks to Maria Mateo Tortola, Ana Tapia Abellan, and great additional collaborators! Link👇

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innate-immuno.bsky.social @innate-immuno.bsky.social · 24/04/2026

Exciting new insights into zebrafish #NLRP3 structure: an exciting novel 'cage' and new implications for #inflammsame activation mechanisms across species. Well done, Andreeva lab @uni_tue / @uktuebingen @CoE_ifit, fantastic work! Check it out👇

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innate-immuno.bsky.social @innate-immuno.bsky.social · 08/04/2026

New #research just out: unique structural features in the #probiotic E. coli Nissle 1917 flagellin hypervariable region are vital for optimal motility in certain environments but apparently less for #TLR5 innate #immunity recognition. Check out the whole story 👇

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innate-immuno.bsky.social @innate-immuno.bsky.social · 17/03/2026

New interesting #conference on "Mechanobiology in #Infection" at Ascona, Switzerland from June 7-11, 2026

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innate-immuno.bsky.social @innate-immuno.bsky.social · 12/03/2026

New mechanistic insights on an old but fundamental mystery in innate immunity: how the #NLRP3 #inflammasome senses efflux of intracellular potassium ions - check out our new #biorxiv #preprint👇here: www.biorxiv.org/content/10.6...

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Reposted by innate-immuno.bsky.social

bioRxiv Immunology @biorxiv-immuno.bsky.social · 01/03/2026

CRY-NLRP3 complexes define a circadian checkpoint controlling inflammasome activation www.biorxiv.org/content/10.64898/20…

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Reposted by innate-immuno.bsky.social

Broz Lab @brozlab.bsky.social · 16/02/2026

We're thrilled to share the lab's latest publication demonstrating how caspase-4 and the non canonical inflammasome recognize cytosolic LPS by preferentially binding to the convex portions of membranes - both bacterial and micelles @cp-immunity.bsky.social www.sciencedirect.com/science/arti...

sciencedirect.com

Caspase-4 binds to LPS membranes with positive curvature for non-canonical inflammasome activation

The non-canonical inflammasome, comprising caspase-4 in humans, initiates pyroptosis upon sensing cytosolic lipopolysaccharide (LPS) from Gram-negativ…

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Reposted by innate-immuno.bsky.social

Waggoner Lab @labwaggoner.bsky.social · 07/02/2026

Cancer cell-intrinsic inflammasome protein ASC links innate immunity with mitochondrial metabolism in driving pancreatic cancer @natcomms.nature.com nature.com/articles/s41...

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Reposted by innate-immuno.bsky.social

Michael Gantier @gantierlab.bsky.social · 10/02/2026

I am delighted to share our characterisation of natural antagonism of TLR7/8 in Nature Immunology. We propose a model where 2’O-Methyl RNA fragments keep TLR7/8 in check, preventing autoimmunity. > www.nature.com/articles/s41...

nature.com

2′-O-Methyl-guanosine RNA fragments antagonize TLR7 and TLR8 to limit autoimmunity | Nature Immunology

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