iiinova — where your digital self keeps evolving

Reposted by Sauer Lab

Ignacio Vega-Vásquez @igvegvas.bsky.social · 07/08/2026

(1/4) We are very excited to share our latest preprint from @sauer-lab.bsky.social: Mega Expansion Microscopy (Mega-ExM)! We combine iterative hydrogel expansion with whole-proteome NHS labeling and post-expansion immunostaining, reaching tunable expansion factors up to ~1500× in whole cells 🤯

34618

Sauer Lab @sauer-lab.bsky.social · 30/07/2026

Explore how Expansion-dSTORM resolves unresolvable cellular structures in our new papers: • 8-nm microtubule periodicity, clathrin lattices & NUP96 dimers • Presynaptic vesicle docking sites (40-nm Munc13-1/RIM rings) All using unmodified cells & standard immunolabeling: ▶️ rdcu.be/fwBYY

0123

Sauer Lab @sauer-lab.bsky.social · 30/07/2026

If you are interested in resolving the structure of isolated proteins with ~1 nm resolution using Expansion Localization Microscopy with spontaneously blinking dyes (JF635b), then take a look here: ▶️ pubs.acs.org/cbihbp/artic...

pubs.acs.org

Single-Step Expansion SMLM Enables Molecular-Resolution Imaging in Cells and Isolated Proteins

Abstract. Expansion microscopy (ExM) enables nanoscale fluorescence imaging on standard microscopes, but its combination with single-molecule localization

021

Reposted by Sauer Lab

Gerti Beliu @beliulab.bsky.social · 28/07/2026

Excited to share our new preprint! 📄 We introduce cTRP PicoRulers as programmable reference standards for benchmarking sub-10 nm fluorescence microscopy. From dSTORM over DNA-PAINT to Expansion Microscopy - one platform, many applications.🔬 👉Read it here: www.biorxiv.org/content/10.6...

073

Reposted by Sauer Lab

Stella Hurtley @smhsci.bsky.social · 16/05/2026

@science.org is looking for a new editor to look after regenerative medicine and neuroscience submissions. Come join us! Check out this Associate or Senior Editor opportunity recruiting.ultipro.com/AME1123ASEM/...

recruiting.ultipro.com

12017

Reposted by Sauer Lab

Pedro Friedmann Angeli @angelifriedmann.bsky.social · 31/03/2026

Very grateful to receive the Deutscher Krebspreis 2026 (Experimental Cancer Research) together with Marcus Conrad. This recognition reflects the incredible efforts of our teams and collaborators over the years @uni-wuerzburg.de

8386

Reposted by Sauer Lab

Gerti Beliu @beliulab.bsky.social · 24/02/2026

Expansion microscopy improves resolution, but integration with SMLM remains challenging. In our new preprint, we present a simplified strategy using spontaneously blinking dyes, validated against well-defined reference structures including NPCs and PicoRulers! ➡️ www.biorxiv.org/content/10.6...

1143

Sauer Lab @sauer-lab.bsky.social · 11/11/2025

Congratulations Arindam and welcome back to Würzburg!

150

Sauer Lab @sauer-lab.bsky.social · 19/08/2025

🚨 New Preprint! Ex-dSTORM resolves fine details of the molecular architecture of CCPs, the 8-nm periodicity of microtubules, and the docking site of synaptic vesicles at the presynapse of hippocampal neurons. ▶️ www.biorxiv.org/content/10.1...

14920

Reposted by Sauer Lab

SMLMS 2025 @smlm-symposium.bsky.social · 17/06/2025

Welcome to the youngSMLMS, a pre-SMLMS event for students, PhDs & PostDocs! We’ll explore science & career in workshops, talks, roundtables, a panel and with time to network. --> Thanks to our sponsors, youngSMLMS is free & we cover accommodation for all presenting their work. Thus, register now!

0139

Reposted by Sauer Lab

Bornabrit1 @lindarothwell.bsky.social · 04/03/2025

Look what's happening at the French Embassy in Washington DC.

6406585410327

Reposted by Sauer Lab

Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 12/02/2025

Chemical Solutions to Structural Biology symposium. Registration and abstract submission now open: isbuc.ku.dk/chemical-sol...

0177

Reposted by Sauer Lab

Jörg Enderlein @joergenderlein.bsky.social · 14/02/2025

An excellent review about fluorescence labeling strategies by @beliulab.bsky.social Gerti Beliu and colleagues from Würzburg University - highly recommended reading for everybody interested in fluorescence microscopy!

0202

Reposted by Sauer Lab

Fyodor Urnov @urnov.bsky.social · 10/02/2025

NIH-supported research saves lives: here are two "poster" human beings to prove it. Emily Whitehead: cured of her leukemia by CAR-T developed at Penn. Victoria Gray: major symptoms of her sickle cell disease resolved following CRISPR gene editing - path paved at Boston Childrens, UW, UC Berkeley.

412732

Reposted by Sauer Lab

Julius-Maximilians-Universität Würzburg @uni-wuerzburg.de · 10/01/2025

Delighted to launch our activities on Bluesky with this great news: Our researchers @sauer-lab.bsky.social show in @science.org, how therapeutic #antibodies interact with B cells – thanks to an innovative method of super-resolution microscopy. Congratulations! ➡️ www.uni-wuerzburg.de/en/news-and-...

Mode of action of the new microscopy method LLS-TDI-DNA-PAINT. On the top right, the RTX antibody was visualised on a Raij-B cell: it is easy to see how it links the CD20 molecules in the membrane. Bottom right: the hedgehog-shaped appearance of a living Raji B cell after the antibody has bound. The surface protein CD45, which is homogeneously distributed on the cell surface, is also labelled in green. (Image: Arindam Ghosh / University of Würzburg)

37517

Sauer Lab @sauer-lab.bsky.social · 10/01/2025

🔬 Ever wondered how therapeutic antibodies work? 3D LLS-TDI-DNA-PAINT and live-cell LLS microscopy allow decoding of the molecular interplay of endogenous CD20 on B cells with therapeutic antibodies. 📄 Read more: www.science.org/doi/10.1126/...

23511

Reposted by Sauer Lab

Benjamin Compans @bencompans.bsky.social · 02/12/2024

Happy to see my MSCA project with @jbneuro.bsky.social lab available on @biorxiv-neursci.bsky.social We Increased network activity in vivo and used dSTORM to look at the nanoscale organization of inhibitory synapses formed onto the AIS and onto tufts dendrites of L2/3 S1 Cortex!

194