Harnessing Brazilian microbial diversity, comprehensive phenotypic screening of 79 yeast isolates identified non-conventional strains with superior multi-stress tolerance and metabolic versatility co...

Retrotransposons can infect neighboring cells using a mechanism that relies on a small fusogen-like protein rather than on the envelope protein that is typically required for infection.

Cell-cycle remodeling is fundamental to pluripotency and lineage commitment, yet whether its transcriptional and post-transcriptional architecture is conserved across species and developmental states ...

Whole-genome sequencing of 1,011 natural isolates of the yeast Saccharomyces cerevisiae reveals its evolutionary history, including a single out-of-China origin and multiple domestication events, and ...

The fitness of an organism determines its likelihood of succeeding in short-term competition, but many other factors can influence its long-term success. In this study, we investigate the relative con...

Abstract. The Genetics Society of America Medal honors an individual member of the Society for their contributions to the field of genetics at the midcaree

The authors created a barcoded collection of 520 wild yeast strains and screened them against over 600 compounds, revealing how natural genetic variation shapes compound resistance and identifying gen...

Research provides insight into how yeast cells respond to stressful conditions with implications for larger organisms that share the same proteins.

Yeasts and related fungi isolated from cacti or nearby non-cactus plants were characterized phenotypically and genomically, revealing differences that hint at modes of adaptation to the cactus host.

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Abstract. The genome of the seasonal acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has a 12-nucleotide insertion that produced a furin cleava

We are excited to announce the early-stage release of our S. cerevisiae  structural interactome mapping project. Using AlphaFold3 (AF3), w...

Visit our website to learn more.

This year’s award recipients bring to the table expertise and leadership that have shaped, and will shape, science for years to come.

David was a beloved husband, father, brother, scientist, teacher, mentor, musician, friend, who touched the lives of thousands. David’s wide-ranging scientific career spanned decades with a legacy o…

Abstract. The long-standing notion that genotypes map to phenotypes through simple one gene–one trait relationships continues to shape both research in the

Evolutionarily related ‘proto-point’ centromeres providing resolution to the evolutionary origins of point centromeres are identified in yeast, and comparison shows they evolved in an ancestor with re...

Whole-genome duplication (WGD) has had profound macroevolutionary impacts on diverse lineages,1,2 preceding adaptive radiations in vertebrates,3,4,5 t…

A newly compiled atlas of species-wide structural variants and gene-based and graph pangenomes derived from highly complete assemblies of genomes from 1,086 natural isolates enable integrative genome-...

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...