Super-enhancers have been proposed to cluster in the nucleus when compared to other genomic elements. Le et al. found that super-enhancer clustering was rare and driven by non-specific interactions. P...

Zhao et al. describe an enhancer-dense nuclear microenvironment in the cerebellum that includes long neuronal genes and mega-enhancers. This microenvironment partly depends on the transcription factor...

Nature - Base editing reveals an essential role for NANOG in human embryogenesis

Keogh et al. propose a nomenclature to clearly and concisely describe the post-translational modifications, proteoforms, and nucleoforms that drive chromatin function. This communicates experimental n...

This Comment posits that enhancers stimulate the transcription machinery only through short-range interactions and, therefore, that enhancer activity at a distance is mediated by chromatin loops betwe...

Challenging the prevailing view that H1 linker histones represent a general feature of repressed chromatin, Matthews et al. show a specific requirement for H1 in epigenetic repression by PRC2. Ablatio...