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The search for neural mechanisms of behaviour often relies on a synchronic, driving view of causation, where neural activity drives more neural activity, which eventually drives behaviour. The real c...

Rhythmic neural activity is considered essential for adaptively modulating responses in the visual system. In this opinion article we posit that visual brain rhythms also serve a key function in the r...

ZAPBench evaluates how well different models can predict the activity of over 70,000 neurons in a novel larval zebrafish dataset.

Behavioural-state-dependent pyramidal neurons have a distinct pattern of long-range glutamatergic inputs, with a larger proportion of thalamic versus motor cortex inputs compared with non-behavio...

Behavioural experiments in mice demonstrate that GABAergic (γ-aminobutyric acid-expressing), glutamatergic and serotonergic neurons in the median raphe nucleus have distinct and complementary function...

<p>Join this interactive session as Tim Spellman discusses his paper, “An Open-Source 3D-Printable Platform for Testing Head-Fixed Cognitive Flexibility in Rodents”, with eNeuro Reviewing Editor Mark ...

A challenge in psychiatric drug discovery is to predict the therapeutic potential of a novel compound. Here, the authors show that brain-wide imaging of immediate early gene expression can be used to ...

Pyramidal cells are classically thought to comprise the excitatory output of the subiculum. Here, the authors show the existence of “ovoid cells”, excitatory subiculum neurons with specialized gene ex...

The temporal microstructure of the brain can multiplex distinct cognitive processes during sleep to support continuous learning.

Optimizing study design is critical for increasing standardized effect sizes and replicability, and the features that increase replicability in cross-sectional and longitudinal brain-wide association ...

The algorithm of the prefrontal working memory system on sequence memory tasks is not well understood, whereas it is well understood for the hippocampal episodic memory system. This work shows a mathematical duality between working and episodic sequence memory. This leads to a computational understanding of sequence working memory—as structured activity slots. This theory algorithmically explains recurrent neural network (RNN) and prefrontal representations during sequence memory tasks.

Vibrational fiber photometry enables Raman spectroscopy in the mouse brain with low impact, owing to the use of tapered fibers.

The finding may help explain autism’s association with multiple co-occurring conditions that involve cilia defects.

IntroductionA fundamental property of the neocortex is its columnar organization in many species. Generally, neurons of the same column share stimulus prefer...

Animals capable of complex behaviors tend to have more distinct brain areas than simpler organisms, and artificial networks that perform many tasks tend to self-organize into modules (1-3). This sugge...

A temporally asymmetric synaptic plasticity kernel results from bidirectional modifications of synaptic weights around the induction of a place field.

Scientists have identified a unique form of cell messaging occurring in the human brain, revealing just how much we still have to learn about its mysterious inner workings.

There is notable heterogeneity in how clinical and phenotypic data are measured by mental health researchers. There is a proliferation of self-report measures (eg, over 280 for depression alone), mean...

Deep-learning typically does not outperform tree-based models on tabular data. Often this may be explained by the small size of such datasets. For image&hellip;

Organisms in fluctuating environments must constantly adapt their behavior to survive. In clonal populations, this may be achieved through sensing followed by response or through the generation of div...

Inhibiting CaMKII impairs short-term memory (STM) in mice during an avoidance task but does not affect long-term memory (LTM). This suggests that STM and LTM are processed differently, with CaMKII cri...