Microdosing, the prolonged ingestion of psychedelics at sub-hallucinogenic doses, has gained popularity for its perceived cognitive and emotional benefits. Psychedelics have high affinity for 5-HT2B r...

A pyramidal cell type and the 5-HT2A receptor in the medial frontal cortex have essential roles in psilocybin’s long-term drug action.

A challenge in psychiatric drug discovery is to predict the therapeutic potential of a novel compound. Here, the authors show that brain-wide imaging of immediate early gene expression can be used to ...