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Timothy O'Leary

@timothyoleary.bsky.social
2.6K followers 541 following 756 posts

Neuroscientist

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Timothy O'Leary @timothyoleary.bsky.social · 01/10/2026
To all collaborators inside and outside academia: faculty at Cambridge *do not have money or resources* I know it's hard to believe and it's not a complaint just a fact. We get a few k startup (enough for a computer) and our salary is equivalent to a US postdoc. No institutional money for research.
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Timothy O'Leary @timothyoleary.bsky.social · 24/09/2026
I wonder how many LLM generated proposals survived UKRI's innovative triage process.
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Timothy O'Leary @timothyoleary.bsky.social · 22/09/2026
Also see this classic essay by Jeremy Gunawardena: www.molbiolcell.org/doi/10.1091/...
molbiolcell.org
Biology is more theoretical than physics | Molecular Biology of the Cell
The word “theory” is used in at least two senses—to denote a body of widely accepted laws or principles, as in “Darwinian theory” or “quantum theory,” and to suggest a speculative hypothesis, often re...
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Timothy O'Leary @timothyoleary.bsky.social · 22/09/2026
the dreaded Microsoft paperclip lives on
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(((Dr Hannah Wirtshafter))) 🔬 @aheadofthenerve.bsky.social · 15/09/2026
Hi friends & colleagues! I’m on the hunt for a tenure-track home! I’m a BRAIN Initiative K99/R00 scholar studying learning & memory at the intersection of experimental neuroscience, theory, & machine learning/AI. I’d love to connect & would appreciate help spreading the word! web.mit.edu/hsw/www/
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Timothy O'Leary @timothyoleary.bsky.social · 15/09/2026
Would this play out differently without designing research as a zero-sum game? From the methods: "Once a submission was accepted, the platform permanently locked the problem, crediting it to the first agent who solved it and removing it from the open pool." arxiv.org/abs/2609.04170
arxiv.org
A Case Study on Emergent Cheating and Whistleblowing in Autonomous Research Swarms
Multi-agent AI science ecosystems rely on agents possessing tools that allow them to communicate, coordinate, and build on each other's work. Yet this shared infrastructure can also introduce vulnerab...
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Timothy O'Leary @timothyoleary.bsky.social · 15/09/2026
Survey reveals that biomedical researchers continue to misunderstand the purpose of preprints (a preprint):
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London Mathematical Society @londmathsoc.bsky.social · 11/09/2026
A reminder of our Caring Grants, offering payments towards childcare/caring costs to attend conferences, events, meetings or other visits within the UK or internationally related to their research. Open to both LMS members and non-members. Apply now ➡️ www.lms.ac.uk/grants/carin...
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Timothy O'Leary @timothyoleary.bsky.social · 11/09/2026
This is not just a wake up call for AI in research, it's an inadvertent comment on what needs to change in research culture: "the mass production at faster and faster pace of "true/false" statements could destroy fertile ground instead of breathing life into new ideas"
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Cogan Lab @coganlab.bsky.social · 18/08/2026
How does a speech plan become fluent movement? In Nature Human Behaviour, led by Kumar Duraivel: Intracranial recordings reveal how hierarchical speech plans become continuous motor sequences across planning, articulation, and monitoring networks. doi.org/10.1038/s415... 1/5
doi.org
Distinct neural processes link speech planning and execution - Nature Human Behaviour
Direct recordings from the human brain reveal a hierarchy in planning to speak, with neural activity organizing whole syllables before the individual sounds that compose them are sequenced.
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Timothy O'Leary @timothyoleary.bsky.social · 08/09/2026
Trickle down economics: real wages will just keep on trickling down...
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The Transmitter @thetransmitter.bsky.social · 08/09/2026
When fruit flies catch a whiff of apple cider vinegar, they zigzag along the edge of the odor plume rather than traveling through the middle, new work shows. #neuroskyence By @callimcflurry.bsky.social www.thetransmitter.org/olfaction/fr...
thetransmitter.org
Fruit flies use memory to track odors
When flies encounter a tasty smell, they stroll in and out of the odor plume to keep track of it, encoding a memory of the angle they need to travel.
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Vincent Bonin @boninlab.bsky.social · 08/09/2026
PISA 2025 results are out and they are very concerning. Education performance continues to decline, with huge drops in reading and math. This should be a wake-up call to politicians and education leaders. www.oecd.org/en/publicati...
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Timothy O'Leary @timothyoleary.bsky.social · 04/09/2026
Everything, everywhere, all at once, again.
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lastpositivist.bsky.social @lastpositivist.bsky.social · 28/08/2026
It's being treated as a policy victory that we have less of the world's smart young people coming to learn from us, participate in our society and economy. This is just so depressing to me, it feels like a complete victory for know-nothing ignorant bigotry over enlightened sensibilities.
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Timothy O'Leary @timothyoleary.bsky.social · 21/08/2026
It's remarkable that no neuroscientists can convincingly articulate why artificial systems cannot be conscious, despite strong convictions. The argument seems to be "because they are artificial". Could more brain-like chips provide a path to consciousness? economist.com/briefing/202...
economist.com
Could more brain-like chips provide a path to consciousness?
Some experts believe computers will need biological aspects to become self-aware
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Kate Jackson @katejackson.bsky.social · 21/08/2026
The search for AI ROI continues. University admin gave a presentation to faculty senate on AI. They begged us to discover use cases for them. All they have is a bespoke Ai tutoring agent and hopes and dreams for improved internal operations All senate had to offer was complaints about cheating
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Sung Kim @sungkim.bsky.social · 19/08/2026
Mathematics in the age of AI by Terence Tao An essay on how the mathematical community might respond to the arrival of AI tools that are capable of performing research-level mathematical tasks. arxiv.org/abs/2608.16753
arxiv.org
Mathematics in the age of AI
An essay, based on a public lecture delivered at the 2026 International Congress of Mathematicians, on how the mathematical community might respond to the arrival of artificial intelligence tools that...
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Timothy O'Leary @timothyoleary.bsky.social · 18/08/2026
One of the UK's last globally competitive exports is being dismantled by governmental decision makers who can't mention "research" or "education" without "economy", "innovation" or "national interest" in the same sentence. Even if you buy into their worldview you can't ignore their fecklessness.
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Timothy O'Leary @timothyoleary.bsky.social · 18/08/2026
One of the UK's last globally competitive exports is being dismantled by governmental decision makers who can't mention "research" or "education" without "economy", "innovation" or "national interest" in the same sentence. Even if you buy into their worldview you can't ignore their fecklessness.
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Research Professional News @resprofnews.bsky.social · 17/08/2026
‘Wheels rapidly falling off university funding system’. “No sign of awareness” at Treasury as international recruitment decline worsens financial outlook, experts warn. www.researchprofessionalnews.com/rr-news-uk-p...
researchprofessionalnews.com
‘Wheels rapidly falling off university funding system’ - Research Professional News
“No sign of awareness” at Treasury as international recruitment decline worsens financial outlook, experts warn
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Margot Finn @eicathomefinn.bsky.social · 18/08/2026
'A prolonged fall in the number of international students applying to study in the UK means “the wheels are rapidly falling off” the student loan-funded higher education system in England, sector experts have warned.' The world's 2nd best university system being killed by malign neglect. 1/3
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Maria Popova @mariapopova.bsky.social · 17/08/2026
The story of the world's first seed bank and the botanist who defended it with his life during the Siege of Leningrad www.themarginalian.org/2023/03/08/n...
themarginalian.org
Nikolai Vavilov and the Living Library of Resilience: The Story of the World’s First Seed Bank and the Tragic Hero of Science Who Set Out to End Humanity’s Suffering
The most moving story of self-sacrifice in the history of science.
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Timothy O'Leary @timothyoleary.bsky.social · 18/08/2026
I find this puzzling. Ephapsis on one hand entrains neural activity, on the other desynchronises it. On the one hand is supposedly great for neural circuit function, on the other hand is a hallmark of devastating demyelinating diseases. Biology isn't black and white but at some level it must add up.
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Simon Gosden @simongosden.bsky.social · 18/08/2026
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Liron Rozenkrantz @lironrozenkrantz.bsky.social · 17/08/2026
🔥🔥New paper alert! Super excited to share our paper, out today in @nathumbehav.nature.com, led by the wonderful Dr. Nofar Mizrachi! nature.com/articles/s41... To me, this finding fundamentally changes how we should think about the relationship between cognition and immune regulation:
nature.com
Voluntary attention regulates acute immune responses in humans - Nature Human Behaviour
Mizrachi et al. show that directing attention to bodily sensations, rather than away, promotes more regulated acute inflammatory responses in healthy volunteers, revealing sensory and vagal pathways l...
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Dan Jagger @auditorynerves.bsky.social · 18/08/2026
Open access link to new study in The Lancet Public Health: Exceeding human heat tolerance in a warming, ageing world: a global projection modelling study. "..our findings can inform targeted heat action plans & guide resource allocation & response planning." 🧪🌡️👵👨‍🦳 www.thelancet.com/journals/lan...
thelancet.com
Exceeding human heat tolerance in a warming, ageing world: a global projection modelling study
Our results suggest accounting for age stratified vulnerability, intolerable heat will be experienced at much larger scales and for longer durations, affecting far more people than previously estimate...
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Timothy O'Leary @timothyoleary.bsky.social · 18/08/2026
And just 24h later, in another realm, AI alignment expert says "The plan is we will have to trust AI agents . . . and have to hope that agents are aligned to what we want." Hope. Solid plan. giftarticle.ft.com/giftarticle/... AI hasn’t gone rogue. It’s worse than that
giftarticle.ft.com
AI hasn’t gone rogue. It’s worse than that
Recent cyber attacks reflect what the technology was trained to do but safeguards are falling short
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Timothy O'Leary @timothyoleary.bsky.social · 17/08/2026
Gift article link for those who want to read @wiringthebrain.bsky.social 's pithy analysis of new embryo screening tech in context: 'Trust us, this is a bit shit right now, but it’ll be good soon’ www.economist.com/business/202...
economist.com
How much would you pay for a smarter baby?
Startups claim they can screen embryos for everything from genetic diseases to IQ. Not everyone is convinced
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Cian O'Donnell @cianodonnell.bsky.social · 13/08/2026
I gave a talk in our ISRC CN3 summer school yesterday on computational modelling of learning and memory, at the end I threw in a list of what I consider the big open questions in the the theory of learning in neural circuits. What did I miss??
Slide with title text "Open directions in theory of learning in neural circuits". List of points:
- Does the brain learn by gradient descent? If so, how?
- How are memories stable if synaptic strengths − and brain representations − fluctuate over time?
- How do brains learn continually over a lifetime?
- How do brains learn so efficiently? (In terms of energy, data, wiring constraints)
- Why are synapses so molecularly complex, compared to ANN weights?
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Timothy O'Leary @timothyoleary.bsky.social · 14/08/2026
Normative
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vincentholst.bsky.social @vincentholst.bsky.social · 13/08/2026
In 2023, @nature.com published 'Papers and patents are becoming less disruptive over time', receiving world-wide media attention. Our Matters Arising, published after a 32 month delay (more on that soon), shows that the reported decline can largely be attributed to dataset artefacts. 🧵
The average CD_5 index per year for Web of Science. The original Park et al. decline (top curve) becomes essentially flat (bottom curve) when removing papers with CD_5=1. Those papers largely correspond to dataset artefacts.
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Timothy O'Leary @timothyoleary.bsky.social · 08/08/2026
What I find disturbing about this is that a major safety breach is so clearly an advertising opportunity. The glee is palpable. Contrast with other sectors: despite Boeing trying to escape blame for MCAS related crashes, they were still bad press. Not so for agentic AI escaping the lab.
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Timothy O'Leary @timothyoleary.bsky.social · 08/08/2026
I'm going to switch to hallucinating instead of plain screwing up. It's far more fun.
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Eiko Fried @eikofried.bsky.social · 08/08/2026
You know you’re in Bavaria when ..
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Timothy O'Leary @timothyoleary.bsky.social · 08/08/2026
Yes: whether we call the mechanics of LLM based agents "reasoning" or anything else will make little difference if they are used at scale to hack and undermine systems that are critical for society to function safely.
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Timothy O'Leary @timothyoleary.bsky.social · 07/08/2026
This is very solid work. It prompts a question I have never had a satisfying answer for: why do people want to infer spikes from calcium imaging data? The calcium signal contains sufficient information for *any* inference procedure, and none of the bias. Why don't people work directly with calcium?
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Lorenzo Posani @lorenzoposani.com · 06/08/2026
For a neural circuit to be "specialized", does it need specialized neurons? In our new work - now out in @NatureNeuro - we address this question in the BLA, using representational geometry to propose a new population-centric way of defining circuit specialization. 🧵👇 1/
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Earl K. Miller @earlkmiller.bsky.social · 05/08/2026
Today's AI systems learn mostly by passively absorbing data, but the brain builds intelligence in the reverse order. Grounded world models in biological organisms and future embodied AI arxiv.org/abs/2607.13560 #neuroscience
arxiv.org
Grounded world models in biological organisms and future embodied AI
Recent advances in generative and embodied AI have been driven by large-scale predictive learning over multimodal data. However, the resulting systems remain largely based on passive training regimes ...
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Satpreet (Sat) Singh @satpreetsingh.bsky.social · 29/07/2026
How do you "see" with electric eyes? How does collective behavior emerge from individual interactions? Nocturnal weakly electric fish evolved to do this, but studying naturalistic social behavior is very hard. Our solution? Virtual 'fish' 🤖🐟⚡ 📄 arxiv.org/abs/2511.08436
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Ctenophores Rock! @ctenophoresrock.bsky.social · 28/07/2026
Happy #CtenophoreCtuesday! Have you ever wondered how a comb jelly propels itself in the water? They utilize a metachronal rhythm of beating cilia (located on comb plates), which appear like a moving wave! Credit to @kei-jokura.bsky.social. Read more in this original paper: doi.org/10.1016/j.cu... 🦑
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Gaute Einevoll @gauteeinevoll.bsky.social · 25/07/2026
Episode #43 in #TheoreticalNeurosciencePodcast: On the computational neuroscience legacy of Valentino Braitenberg - with Ad Aertsen theoreticalneuroscience.no/thn43 The 100th birthday of Valentino Braitenberg was just celebrated in Tübingen. What legacy did he leave in our field?
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Juan Linde-Domingo @lindedomingo.bsky.social · 24/07/2026
Replay of procedural memory is independent of the hippocampus 👀👀 www.nature.com/articles/s41...
nature.com
Replay of procedural memory is independent of the hippocampus - Nature Neuroscience
Thompson, Rollik and colleagues show that, during sleep, the brain replays procedural memories in the striatum independently of the hippocampus. Replay content was shaped by prior reward and error out...
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Timothy O'Leary @timothyoleary.bsky.social · 24/07/2026
Post pub peer review seems to suffer similar issues to pre pub: it's all about reviewer 2.
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Gavin Buckingham @drgbuckingham.bsky.social · 23/07/2026
Great visual illusion, accompanied by a lovely variation on Shepard Tones if you have the sound on Posted on Reddit by bigjobbyx, who is a bit of an artist genius
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Andrew D Wilson @adw.bsky.social · 22/07/2026
Absolutely every frame of this video is perfect, I’m dying laughing
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Timothy O'Leary @timothyoleary.bsky.social · 22/07/2026
Encouraging standards sometimes makes the problem worse:
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Timothy O'Leary @timothyoleary.bsky.social · 22/07/2026
Is raised opportunity cost a bad thing for science? People keep saying we need to publish less by being more selective in what we pursue...
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Sue Librarian Ph.D. @suelibrarian.bsky.social · 22/07/2026
"OpenAI said its AI used stolen credentials and discovered a previously unknown vulnerability to access Hugging Face servers." OpenAI says its AI technology acted on its own in an 'unprecedented' hack of another company apnews.com/article/open...
apnews.com
OpenAI says its AI technology acted on its own in an 'unprecedented' hack of another company
OpenAI has disclosed an "unprecedented cyber incident" where its AI system allegedly hacked into another AI company.
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UK Research and Innovation @ukri.org · 21/07/2026
The UK Metascience Unit has launched the ‘National AI in Research’ Survey. We're looking for researchers across all disciplines and career stages to share their views on the use of AI in research. The survey will be published and used to inform national policy on AI in research.
smartsurvey.co.uk
National AI in Research Survey
Please take the time to complete our survey. Your feedback is important.
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