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Kate Miroshnikova

@katemiro.bsky.social
670 followers 388 following 31 posts

Bioengineer interested in #mechanobiology of cell state regulation, cancer, genome integrity, #chromatin & nuclear mechanics

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Reposted by Kate Miroshnikova
Fusion Conferences @fusionconf.bsky.social · 21/09/2026
Our 3rd #StemGastro conference is just around the corner, and is set to be our biggest series yet. Full of networking, collaboration & the latest research, dont miss out! There's still time to join us this November➡️ bit.ly/4y64skB
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Pablo J. Sáez @pjsaez.bsky.social · 18/09/2026
#Mechanobiology rules! Today, it's not only Chile's independence day🇨🇱😋 ...but also Sara Wickström @sarawickstrom.bsky.social is getting the Körber Prize 👏🏽👏🏽👏🏽 for being a "curiosity's junkie" 😂 Of note, Kate photobombing is top @katemiro.bsky.social @focalplane.bsky.social @koerber-ip.bsky.social
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Kate Miroshnikova @katemiro.bsky.social · 19/09/2026
It was so nice to see you after so many years, cant wait to catch in again more properly in Muenster soon!
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@MEmilieTerret @memilieterret.bsky.social · 02/09/2026
Great speakers, great science, great location = great meeting! EMBO workshop Forces across scale April 27-30, 2027 in Porto. meetings.embo.org/event/27-for...
meetings.embo.org
Forces across scales
This EMBO Workshop on Forces Across Scales will provide an integrative perspective on mechanobiology, a rapidly advancing field that examines how mechanical forces shape biological systems across mol…
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Reposted by Kate Miroshnikova
Hawa Racine Thiam @hawa-racine.bsky.social · 20/08/2026
Turns out the way DNA is packed inside the nucleus can tune the mechanics of the entire cell! Super excited that our first paper is out in Nature Communications! www.nature.com/articles/s41... !
nature.com
Chromatin decompaction within the nucleus increases plasma membrane tension promoting NETosis execution, independently of transcription - Nature Communications
Chromatin organizes nuclear DNA, but whether it actively regulates whole-cell mechanics remains unknown. Here, we used NETosis to show that chromatin decompaction within the nucleus increases plasma membrane tension and cell volume, establishing chromatin as a regulator of cell mechanics.
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Alex Eve @amjeve.uk · 26/07/2026
Congratulations, @jeffreyafarrell.bsky.social, on winning the @socdevbio.bsky.social #2026SDB Elizabeth D. Hay New Investigator Award! Learn more about Jeff's science and career in his @dev-journal.bsky.social interview with @saanjbati.bsky.social.
doi.org
Transitions in development – an interview with Jeffrey Farrell
Jeffrey Farrell is an Earl Stadtman Investigator at the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), USA, where he heads the Unit on Cell Specification and ...
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Kate Miroshnikova @katemiro.bsky.social · 24/07/2026
🤩🤩🤩It was a pleasure & a lot of fun, as always, to work with @jcellsci.bsky.social on this - congratulations on a fantastic issue all about the #nucleus 😎😎😎
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Reposted by Kate Miroshnikova
Journal of Cell Science @jcellsci.bsky.social · 23/07/2026
Our Cell Scientist to Watch interviews in our Cell Biology of the Nucleus Special Issue are with Kate Miroshnikova @katemiro.bsky.social and Andrew Stephens @andrewdstephens.bsky.social. journals.biologists.com/jcs/issue/13...
Kate MiroshnikovaAndrew Stephens
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Kate Miroshnikova @katemiro.bsky.social · 08/07/2026
Thanks for being such a great host @simonereber.bsky.social & looking forward to expanding #biophysics analyses of #chromatin together! 🎉
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Journal of Cell Science @jcellsci.bsky.social · 01/07/2026
Our Special Issue: Cell Biology of the Nucleus is complete Explore our Toc: journals.biologists.com/jcs/issue/13... Our cover image shows the posteriorly positioned nuclei (Nup50-mCherry - pink) of notochord cells in Ciona embryos. See article by Peng et al. journals.biologists.com/jcs/article/...
JCS Cover: Posterior nucleus positioning in Ciona notochord cells. Co-expression of hCD4–eGFP (green, cell boundary) and Nup50–mCherry (pink, nuclei) in notochord cells in Ciona embryos. The cells and the nuclei are 3D reconstructed and highlighted by Imaris software. See article by H. Peng et al. (jcs264699).

Special Issue on Cell Biology of the Nucleus 
Guest Editor: Abby Buchwalter
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Kate Miroshnikova @katemiro.bsky.social · 23/06/2026
Congratulations, Sara on the #KörberPrize 🤩 🤩 🤩 for your pioneering work in #mechanobiology 🎉 🎉 🎉 It has been an honor to be a part of the amazing scientific discovery journey!!! 😎
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Sara Wickstrom @sarawickstrom.bsky.social · 23/06/2026
Truly honored to recieve this recognition-a testament to the dedication, hard work and creativity of past and current lab members, I am grateful to be able to do science with them. Also want to thank all our wonderful collaborators that facilitate interdisciplinary work essential for new discoveries
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Ana Pombo @apombo1.bsky.social · 23/06/2026
bioRxiv alert! CoPhasing resolves haplotype-specific 3D chromatin structures from GAM data, revealing extensive structural heterogeneity between human homologous chromosomes and its interplay with histone modifications and gene expression! Thanks to all coauthors! www.biorxiv.org/content/10.6...
biorxiv.org
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SFB 1348 @sfb1348.bsky.social · 13/05/2026
The @sfb1348.bsky.social Meeting “Mechanochemical Signals at Cellular Interfaces” is just around the corner! We are excited to welcome an outstanding lineup of international speakers to #Münster for three days of inspiring scientific exchange and discussion. @uni-muenster.de
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Petrova Lab – Vascular and Tumor Biology @petrovalab.bsky.social · 06/05/2026
Very happy to see our work on the cover of @jem.org 🤩
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Stefan Luschnig @luschnig.bsky.social · 22/04/2026
We´re hiring a #PhD student - if you´re interested in combining genetics, cell biology and state-of-the-art imaging to study #epithelial tissue dynamics in #Drosophila, apply to the CiM-IMPRS PhD program by May 1st (see below) Please RT @uni-muenster.de @sfb1348.bsky.social
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Turlier lab @turlierlab.bsky.social · 12/04/2026
How can we learn tissue mechanics directly from cell patterns and images? In our new preprint, we introduce VertAX, a differentiable vertex-model framework in JAX for simulating epithelia, inferring parameters, and designing target tissue behaviors. shorturl.at/PUzT0 1/5
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Fusion Conferences @fusionconf.bsky.social · 08/04/2026
@katemiro.bsky.social we are looking forward to your presentation at the #StemGastro this November.☀️Please share to let your followers know you're speaking & talk submission closes on 07 May 2026! More details: bit.ly/4c0LX8y
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Alex Hughes Lab @hugheslabpenn.bsky.social · 03/04/2026
@lsprahl.bsky.social and Ronald Canlla in the lab just published a detailed study on remote-controlled epithelial budding morphogenesis. We can direct budding, tubule elongation, and perhaps branching in human kidney organoids via a light-activated RET receptor. www.biorxiv.org/content/10.6...
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Stefan Luschnig @luschnig.bsky.social · 13/03/2026
The CiM-IMPRS PhD program in #Münster is offering 16 #PhD positions in Life and Natural Sciences! Perform cutting-edge resesearch in a vibrant international setting and lively city! Apply by May 1st, 2026 - see www.uni-muenster.de/CiM-IMPRS/ap... @uni-muenster.de @mpi-muenster.bsky.social
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Max Planck Institute for Molecular Biomedicine @mpi-muenster.bsky.social · 04/03/2026
We are offering 5 Postdoc Positions within the Max Planck Postdoc Program! Take advantage and apply by April 13, 2026 to the positions in the labs of @ralfhadams.bsky.social, @ruibenedito.bsky.social and @katemiro.bsky.social. Link to our website: www.mpi-muenster.mpg.de/max-planck-p...
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A/Prof Sam Stehbens PhD (She/Her) @samstehbens.bsky.social · 22/02/2026
Home from a great #EMBO workshop in Barcelona. Intracellular mechanics & organelle Mechanobiology was such a fun topic! @christanny.bsky.social made sure I didn’t get lost. It was great to catch up with @katemiro.bsky.social 1st time in almost 10yrs!!. Thank you to the hosts.. (continued) 1/2
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Universität Münster @uni-muenster.de · 21/11/2025
Große Freude! Die @dfg.de richtet einen neuen Sonderforschungsbereich zur männlichen Unfruchtbarkeit ein und verlängert den etablierten Verbund @sfb1348.bsky.social. Insgesamt fließen rund 24 Millionen Euro an die Universität Münster.
uni-muenster.de
24 Millionen Euro für zwei Sonderforschungsbereiche
Die Deutsche Forschungsgemeinschaft richtet einen neuen Sonderforschungsbereich zur männlichen Unfruchtbarkeit ein und verlängert einen etablierten Verbund zu zellulären Grenzflächen. Insgesamt fließe...
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Juanma García-Arcos @juanmagararc.bsky.social · 11/11/2025
Launching celldynamicslab.com, the homepage of our new group at EPFL working on cell fragmentation, membrane and cortex mechanics, FLIM imaging, and microfluidics tools. MSc/PhD or postdocs interested in quantitative cell biology are welcome to reach out. We're also hiring a lab manager in 2026!
celldynamicslab.com
Main - Cell Dynamics and Fragmentation Lab
The Cell Dynamics and Fragmentation lab at We study how single cells move and fragment in complex environments using microfluidics. We bring tools and concep...
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Stefan Luschnig @luschnig.bsky.social · 12/11/2025
Job Alert! The Institute for Neuro- and Behavioural Biology at the Faculty of Biology @uni-muenster.de invites applications for a Full Professorship (W3) in “Systems Neuroscience” - Highly attractive research environment at the Multiscale Imaging Center. Apply by January 5th. See shorturl.at/VczFp
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Sara Wickstrom @sarawickstrom.bsky.social · 06/11/2025
Excited to embark on this scientific journey with Ewa Paluch and Daniel StJohnston to understand fundamentals of epithelial tissue and cell shapes! Thank you to @erc.europa.eu for the support!
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Rob Klose @robklose.bsky.social · 17/10/2025
Come join us in Geneva for everything epigenetics and gene regulation. It will be a great meeting! Please repost! www.keystonesymposia.org/conferences/...
keystonesymposia.org
Epigenetics and Gene Regulation in Health and Disease: Linking Basic Mechanisms with Therapeutic Opportunities | Keystone Symposia
Join us at the Keystone Symposia on Epigenetics and Gene Regulation in Health and Disease: Linking Basic Mechanisms with Therapeutic Opportunities, March 2026, in Geneva, with field leaders!
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Nature Cell Biology @natcellbio.nature.com · 04/10/2025
💫NEW: @sarawickstrom.bsky.social @katemiro.bsky.social & co show that mechano-osmotic changes in the #nucleus induce general #transcriptional repression and prime #chromatin for cell fate transitions by relieving repression of specific differentiation genes. #pluripotency bit.ly/3VMcyNZ
bit.ly
Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology
McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.
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Kate Miroshnikova @katemiro.bsky.social · 30/09/2025
Thanks Jesse!!!
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Kate Miroshnikova @katemiro.bsky.social · 29/09/2025
Amazing to have our work finally out!!! 😍🤩😍
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Fusion Conferences @fusionconf.bsky.social · 28/09/2025
Amy, Leanne, Maria & Kate welcomed our #SCC25 attendees to the beautiful Malta this afternoon, a great 4 days ahead for this group, discussing all things Stem Cells & Cancer! @joneslabucsf.bsky.social @mariapalcolea.bsky.social @katemiro.bsky.social
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Edouard Hannezo @ehannezo.bsky.social · 17/12/2024
Happy to share the latest work from Preeti Sahu, with Adriana Sanchez-Danes on the biomechanics of cell fate choices during tumor initiation! We implement/test a 3D vertex model with proliferation and fate choices for multilayered tissues! See 🧵 below (1/n) bit.ly/3ZXxJzk
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Carmelo Ferrai @carmeloferrai.bsky.social · 23/09/2025
Paper accepted!!!! Congratultions to @lizebonaaugust.bsky.social Blanca del Rosal and Leslie Yeo it was a pleasure to work together on this amazing project! 🎊🎊🎊🎊
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SFB 1348 @sfb1348.bsky.social · 10/09/2025
Exciting new paper by the group of Carsten Grashoff @sfb1348.bsky.social @uni-muenster.de shows conformational change in alpha-Catenin during maturation of #epithelial junctions www.uni-muenster.de/news/view.ph...
uni-muenster.de
How epithelial junctions mature: Study shows conformational transition in key protein
Epithelial tissues cover the inner and outer surfaces of the body. A study by the working group of cell biologist Prof. Carsten Grashoff now provides insight into the molecular details underlying the ...
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Reposted by Kate Miroshnikova
Sara Wickstrom @sarawickstrom.bsky.social · 12/09/2025
My lab @mpi-muenster.bsky.social is looking for a computational biologist with a passion for imaging and spatial biology. A staff scientist position with long-term perspective! Apply and spread the word 🙏 jobs.mpi-muenster.mpg.de/jobposting/0...
jobs.mpi-muenster.mpg.de
Computational image analyst (m/f/d)
The Max Planck Institute for Molecular Biomedicine in Münster, Germany, has an opening for a
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Pedro Rocha @pedroprocha.bsky.social · 08/09/2025
🚨🚨🚨 Please repost We are looking for postdocs to join our lab at NIH. Apply: www.nichd.nih.gov/research/atNICHD/Investigators/rocha/apply Learn more about training at NIH : www.training.nih.gov/research-tra...
Job add showing the lab logo and the following text: 
WHAT WE OFFER
Fully-funded fellowships up to five years  Opportunity to start your own research program or lead ongoing projects.
Large, diverse and extraordinary scientific network at the NIH/Bethesda campus. 

Working at NIH offers the possibility of living in a diverse, liberal and vibrant city: Washington DC
Or in a calm residential area with great schools and good affordable housing: Bethesda and Rockville.
 
WHO YOU ARE
You share our enthusiasm for epigenetics, gene regulation, nuclear organization and mouse development. You have PhD-experience in one or more of the following: mouse development, mouse genetics, epigenetics, or computational biology.
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Institut Curie @institutcurie.bsky.social · 04/09/2025
▶️ Pour en savoir plus ⏩ Lire l'actu : curie.fr/actualite/di... ⏩ Lire la publication : www.nature.com/articles/s41...
nature.com
DNA methylation influences human centromere positioning and function - Nature Genetics
Genome-wide and targeted perturbation of DNA methylation at centromeres affects CENP-A positioning and centromere structure, resulting in aneuploidy and reduced cell viability.
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Kate Miroshnikova @katemiro.bsky.social · 03/09/2025
Would love to be a part of the group if still space! Thanks!
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Xavier Trepat @xaviertrepat.bsky.social · 01/09/2025
New preprint! 🚨 We uncover a slow adaptation to stretch that links star-bundling of keratin filaments with nuclear escape from its keratin cage. Led by @tomgolde.bsky.social‬ 🙌 @IBECBarcelona www.biorxiv.org/content/10.1...
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Jan Lammerding - Lab @lammerdinglab.bsky.social · 29/08/2025
Final call to register and submit abstracts for the @faseborg.bsky.social conference on the Mechanobiology of the Cell Nucleus (#MBNSRC) to be considered for platform presentations. The conference takes place in Melbourne, FL, Oct. 26-30, 2025. See more info at: events.faseb.org/event/Mechan...
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Kate Miroshnikova @katemiro.bsky.social · 18/08/2025
Thanks so much for the kind words Adrien! 🤩 would love to discuss the next steps to integrate more mechanical measurements as planned soon!
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Kate Miroshnikova @katemiro.bsky.social · 15/08/2025
Pathologists have used nuclear & tissue shapes to diagnose #cancer for decades, but what is the molecular basis for this? In our latest work, we develop a computational pipeline to figure this out in #colorectalcancer! Check out 🧵& preprint #mechanobiology #stemcells www.biorxiv.org/content/10.1...
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Kate Miroshnikova @katemiro.bsky.social · 15/08/2025
Thanks so much Martin, hope all is well - would love your feedback!
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Kate Miroshnikova @katemiro.bsky.social · 15/08/2025
Very proud of this work performed by the super talented Fabien Bertillot with essential support from @sol-herve.bsky.social and our amazing collaborators, especially Toni Seppälä and @sarawickstrom.bsky.social. Grateful for support from @mpi-muenster.bsky.social, NIH, and @helsinki.fi
media.tenor.com
a woman with a big hairdo is singing and the words simply the best are above her
ALT: a woman with a big hairdo is singing and the words simply the best are above her
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Kate Miroshnikova @katemiro.bsky.social · 15/08/2025
Collectively, our work supports a model where disruption of tissue architecture & stromal cues initiate a co-evolutionary feed forward loop that drives disease aggression & suggests that quantitative analysis of tumor heterogeneity with architecture as proxy may be the key to diagnostic precision
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Kate Miroshnikova @katemiro.bsky.social · 15/08/2025
Interestingly, while epithelial-to-mesenchymal transition states were also enriched in fragmented architectures, mechanical confinement was not sufficient to trigger #EMT. Combination of compression & soluble signals from the stroma drove further separation of regenerative stem cell and EMT states.
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Kate Miroshnikova @katemiro.bsky.social · 15/08/2025
To figure out causation we turned to patient derived #organoids. Together with our #bioengineering colleagues in the Lutolf lab we generated topographies that mimic poor prognosis architectures. Indeed, regenerative stem cell states emerged in response to mechanical constraints and compression
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Kate Miroshnikova @katemiro.bsky.social · 15/08/2025
Analyzing single patient biopsies with heterogeneous architectures showed that cell states and architectures co-evolve, and we can predict likely tissue shape transitions based on the transcriptional signatures! So now the chicken & egg question: which comes first – abnormal shapes or cell states?
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Kate Miroshnikova @katemiro.bsky.social · 15/08/2025
Intriguingly, nuclear shapes correspond with tissue architectures, both independently predicting patient survival. Overlaying this with #spatialtranscriptomics revealed that fragmented architectures associate with regenerative stem cell states that have been shown to drive metastasis.
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Kate Miroshnikova @katemiro.bsky.social · 15/08/2025
Pathologists have used nuclear & tissue shapes to diagnose #cancer for decades, but what is the molecular basis for this? In our latest work, we develop a computational pipeline to figure this out in #colorectalcancer! Check out 🧵& preprint #mechanobiology #stemcells www.biorxiv.org/content/10.1...
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