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Julien Sage

@juliensage.bsky.social
541 followers 328 following 24 posts

Stanford, cell cycle, RB, cancer, SCLC, mouse models

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Reposted by Julien Sage
Michael Lin, MD PhD @michaelzlin.bsky.social · 29/09/2026
Excited to share a new study from our lab in Cell: “Non-invasive control of gene editing in vivo by photoswitchable Cas12f and focused ultrasound” We engineered a compact CRISPR system that can be activated at specific locations in the body using focused ultrasound (🧵) www.cell.com/cell/fulltex...
cell.com
Non-invasive control of gene editing in vivo by photoswitchable Cas12f and focused ultrasound
Remote activation of a single-AAV-deliverable photoswitchable Cas12f system enables precise spatial and temporal control of genome editing in deep tissues without surgery or implanted devices.
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Reposted by Julien Sage
James Olzmann @olzmannlab.bsky.social · 23/09/2026
Save the date! 🔥 The 2027 FASEB Science Research Conference on Ferroptosis: From Mechanism to Medicine is coming to Denver, July 12–15! We are excited to bring the ferroptosis community together again. Experts and newcomers welcome! Please help spread the word! More info soon!
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Dmitri Petrov @petrovadmitri.bsky.social · 17/09/2026
We are searching for an Assistant Professor in Evolutionary Biology! Looking for colleagues asking fundamental questions relating to evolutionary processes and drivers of evolutionary patterns. If you think it is you, please do apply! And please repost. facultypositions.stanford.edu/jobs/assista...
facultypositions.stanford.edu
Assistant Professor in Evolutionary Biology - Stanford University, California, United States
The Department of Biology at Stanford University seeks applicants for a tenure-track Assistant Professor in Evolutionary Biology. A successful candidate will conduct research that asks fundamental que...
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Anca M. Hrastinski, MD (former Pasca) @braintherapies.bsky.social · 15/09/2026
As a #StemCells and #Organoid enthusiast, but also in my new role as expert advisor 😍 for the  Consortium on Advanced Stem Cell-Based Models in Drug Discovery and Development, I am truly looking forward to this amazing event: www.isscr.org/upcoming-pro...
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BrunetLab @brunetlab.bsky.social · 31/08/2026
Excited to share our paper on identification of secreted proteins during aging! Using proximity labeling and mass spectrometry, we identify secreted proteins that change during aging in C. elegans! Congrats to Jason Miklas and all collaborators! www.cell.com/cell-reports...
cell.com
An in vivo resource of age-regulated C. elegans intestinal secretory-pathway proteins highlights secreted enzymes associated with lifespan regulation
Miklas et al. characterize age-related C. elegans intestinal secretory-pathway proteins using proximity labeling tools and in vivo proteomics. They identify a conserved secreted phosphatase, ACP7, that extends lifespan in a secretion- and phosphatase-dependent manner. This resource highlights the role of extracellular enzymes in regulating lifespan.
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Silvia von Karstedt @vonkarstedtlab.bsky.social · 26/08/2026
For all things #lungcancer, #sclc, #plasticity etc. Join us at #CRUK lung cancer conference in Manchester UK this November with a fastastic line up of speakers if I may say so :-) cruklcce.org/cruk-lcce-co...
cruklcce.org
Cancer Research UK Lung Cancer Centre of Excellence Conference | CRUK Lung Cancer Centre of Excellence
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Ruth Huttenhain @rhuttenhain.bsky.social · 13/08/2026
My lab at Stanford University School of Medicine is recruiting! We are looking for a postdoc at the interface of quantitative proteomics, structural biology and G protein-coupled receptor (GPCR) biology: postdocs.stanford.edu/prospective/...
postdocs.stanford.edu
Open Postdoctoral position, faculty mentor Ruth Huttenhain | Office of Postdoctoral Affairs
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BrunetLab @brunetlab.bsky.social · 05/08/2026
Excited about our new manuscript @elife.bsky.social: Engulfment by brain macrophages in a short-lived vertebrate doi.org/10.7554/eLif...! Huge congratulations to Rahul Nagvekar and the team!! ✨⭐🍾🐟 We generated a genetic model to identify engulfing macrophages in the #killifish aging brain!
doi.org
Engulfment by brain macrophages in a short-lived vertebrate
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BrunetLab @brunetlab.bsky.social · 30/07/2026
Our new paper on lipids in neural stem cell aging!! Congratulations to Xiaoai Zhao for her fantastic work! ✨🥂 www.science.org/doi/10.1126/...
science.org
Lipidomic profiling reveals age-dependent changes in plasma membrane lipids that affect neural stem cell aging
Plasma membrane lipids are remodeled with age in neural stem cells, and rejuvenating membrane lipids boosts old cell function.
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Dmitri Petrov @petrovadmitri.bsky.social · 15/07/2026
Cannot be more excited about the lineup for the inaugural Function of Evolving Systems GRC conference I am co-organizing with the amazing Joy Bergelson. Less than a month away: August 9 - 14, 2026. Still a few spots left! And do check out the amazing list of speakers: www.grc.org/function-of-...
grc.org
2026 Function of Evolving Systems Conference GRC
The 2026 Gordon Research Conference on Function of Evolving Systems will be held in Waterville Valley, New Hampshire. Apply today to reserve your spot.
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Matt Bogyo @mbogyo.bsky.social · 10/07/2026
Check out this new listing for an Assistant Professor in my department at Stanford which is an amazing, collaborative department with clinical and basic scientists who study diverse aspects of basic biology and human diseases. Join us! med.stanford.edu/pathology/jo...
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Trudy G. Oliver @tgoliver.bsky.social · 23/06/2026
Excited that this story is now published at @theaacr.bsky.social Cancer Research! #Squamous tumors have transcriptional heterogeneity that resembles normal lung cell states, including a lowly-dividing stress-resistant KRT13+ #hillock-like state driven by KLF4. aacrjournals.org/cancerres/ar...
aacrjournals.org
KLF4 Promotes a KRT13+ Hillock-Like State in Lung Squamous Cell Carcinoma
Abstract. Lung squamous cell carcinoma (LUSC) is a basal-like subtype of lung cancer with limited treatment options. While prior studies have identified tumor-propagating cell states in squamous tumor...
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Kaylee Gentry MSc @kmgentry.bsky.social · 17/06/2026
The Venkatesh Lab is looking for post-docs! Happy to answer any questions about the lab, working at BWH/HMS, or anything in between!
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Reposted by Julien Sage
Jesse Engreitz @jengreitz.bsky.social · 06/06/2026
Planning a Perturb-seq experiment? Building virtual cells? First step to good models is good data. How many cells to profile? How deeply to sequence? What statistical power? Check out PerturbPlan — new tool from Ziang Niu in Katsevich Lab www.perturbplan.com www.biorxiv.org/content/10.6...
biorxiv.org
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Adrian Saurin @adesaurin.bsky.social · 28/05/2026
Multiple postdoc/RA vacancies to work on the Wellcome-funded team project shown below. I also have vacancies to study senescence and to develop a chemical-genetic approach to inhibit specific cyclin/CDK complexes. See thread for details. DM or email me with any questions.
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Michael Lin, MD PhD @michaelzlin.bsky.social · 20/05/2026
The Lin Lab is hiring! We're seeking motivated postdocs for projects on voltage imaging and optogenetics in the brain. If you're excited to develop new methods to undersatand and correct brain diseases, working together with other neuroscience labs at Stanford, drop us a line!
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Buttitta Lab @buttittalab.bsky.social · 16/05/2026
Check out this amazing lineup for the FASEB Cell Cycle conference this July. Abstract deadline is rapidly approaching on June 1st!
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Bardin Lab @bardinlab.bsky.social · 15/05/2026
The application portal for our annual Developmental Biology course for Master's, PhD students, et al at the @institutcurie.bsky.social and @sorbonne-universite.fr will open soon! Anyone can apply, courses are free, but we do not cover travel and lodging. lectures Oct 19-28! More info soon!
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Trudy G. Oliver @tgoliver.bsky.social · 13/05/2026
The Oliver Lab is #hiring. I have never been more excited about the next project & the potential to help people with cancer. If you want to transform #SCLC & how we think about #cancer in general, please come join us! #postdoc #PhD Thanks to ChatGPT for a high octane ad with more info below!
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Kissil Lab @kissillab.bsky.social · 11/05/2026
It's #moleratmonday, where we provide the naked mole rat facts you've been dying to know! 🐀 They use their long teeth to help them dig tunnels 🦷 it looks like they have two, but it's actually four! And they can move each one independently! (Image: Smithsonian's National Zoo (CC BY-NC-ND 2.0))
A naked mole rat facing forward. It's teeth are pointed at the camera, where you can clearly see 4 long, blunt incisors.
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Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · 07/05/2026
#RIP Pierre Chambon (1931-2026) 1963 PARP 1970 RNA Pol II 1975 Nucleosome 1977 Split genes 1980 Promoter 1983 enhancer 1986 Nuclear receptor
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Julien Sage @juliensage.bsky.social · 06/05/2026
Incredible first day at the SCLC consortium, amazing progress in the last 10 years!!
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Kissil Lab @kissillab.bsky.social · 05/05/2026
Hello Monday! #moleratmonday is here 🐀 Naked mole rats can run backwards as fast as they can run forward 🏃 This no doubt helps them navigate the tight tunnel systems they live in! ⛏️
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Kissil Lab @kissillab.bsky.social · 27/04/2026
It's #moleratmonday, where you get to learn about naked mole rats🐀 Today's fact: Naked mole rat's are known to be resistant (but not immune!) to cancer development. Of course, we all want to know how! To learn more, why not check out our 2020 review? www.nature.com/articles/s41...
nature.com
The use of non-traditional models in the study of cancer resistance—the case of the naked mole rat - Oncogene
Oncogene - The use of non-traditional models in the study of cancer resistance—the case of the naked mole rat
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Itai Yanai @itaiyanai.bsky.social · 27/04/2026
What do you do when you get stuck? You need to pop out into the world of night science, into the world of ideas, where you use abstract thinking. You're going to use every trick you got to find the way forward. From Nature's new podcast on cultivating creativity in science!
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Aaron Straight @astraight.bsky.social · 22/04/2026
I'm incredibly honored at election into the American Academy for Arts and Sciences. And Jodi Foster and Rita Moreno too! Credit goes to the amazing people I've been lucky to work with over many years. www.amacad.org/news/new-mem...
amacad.org
Electing New Members: Recognizing America’s 250th Anniversary
Building on America’s 250-year-old commitment to knowledge, the American Academy of Arts & Sciences announces the leaders in academia, the arts, industry, journalism, philanthropy, policy, research, a...
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Eric Topol @erictopol.bsky.social · 20/04/2026
The worst cancers with respect to lethality get the least federal funding support jamanetwork.com/journals/jam...
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Trevor Graham @trevorgraham.bsky.social · 12/11/2024
I've started a list of people working on #cancer #evolution. Many more to be added, so do let me know if that is you. Also if you would like to be removed. go.bsky.app/QuAF4Mo
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IGMM-Montpellier @igmm-montpel.bsky.social · 17/04/2026
🔬IGMM (CNRS/ Univ Montpellier) is hiring Group Leaders in Innovative Biology. @cnrsbiologie.bsky.social @cnrs.fr @umontpellier.bsky.social 📅 1 May–15 June 2026 📩 search2026@igmm.cnrs.fr 📎Full information 👇 #LifeScience #MolecularBiology #Research #PI #CNRS
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Winkler Laboratory @winklerlab.bsky.social · 17/04/2026
What are the current and emerging topics in Cancer Neuroscience, and what comes next for the field? In our new review, now online @cp-cell.bsky.social, we discuss previous and ongoing research from leading laboratories and propose future directions for research. 🧠🔬 Curious? See link below 😀👇
sciencedirect.com
Cancer neuroscience: The past, the present, and the road ahead
Both the nervous system and cancer-intrinsic neural features can govern cancer initiation, growth, progression, metastasis, and treatment resistance, …
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Kissil Lab @kissillab.bsky.social · 14/04/2026
Welcome back to #moleratmonday, your place to learn everything there is to know about naked mole rats 🐀 Today’s fact: Naked mole rats are poikilothermic, meaning their body temperature fluctuates considerably with the ambient temp, rendering them effectively cold-blooded 🌡️🩸
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BrunetLab @brunetlab.bsky.social · 09/04/2026
Interested in aging and rejuvenation? We have a new Research Assistant position to understand aging at the cellular level!! Come join our team!!! 😎 careersearch.stanford.edu/jobs/life-sc...
careersearch.stanford.edu
Life Science Research Professional 1 in School of Medicine, Stanford, California, United States
Stanford University is seeking a Life Science Research Professional 1 to study the mechanisms of aging and rejuvenation, particularly in a variety of....
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Ashley Webb, PhD @aewebb.bsky.social · 05/03/2026
✨Registration is OPEN for the 2026 FASEB on Epigenetics in Aging and Disease in Malahide, Ireland!✨ Featuring @denadubal.bsky.social and Yang Shi from @ludwigcancer.bsky.social as Keynotes. Speaker slots available! With: @bbparis1984.bsky.social Ashby Morrison, Ernesto Guccione
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Kissil Lab @kissillab.bsky.social · 06/04/2026
It’s Monday, so it’s time for #moleratmonday 🐀 Today’s fact: Watch them live! 📹 The Smithsonian National Zoo has two live webcams featuring their naked mole rat enclosure. Check them out: nationalzoo.si.edu/webcams/nake... #nakedmolerat
nationalzoo.si.edu
Naked Mole-rat Cam
Watch the Naked Mole-Rat Cam for an inside look at how these unusual rodents spend their lives.
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Chris Marine Lab @marinelab.bsky.social · 02/04/2026
Cancer cell plasticity is viewed as a driver of therapy resistance. Here, we propose the concept of “Field-Oriented” Therapy—leveraging plasticity rather than merely enduring it. To learn more, read: aacrjournals.org/cancerdiscov...
researchsquare.com
Simple cell geometry metrics reveal cancer cell diversity and plasticity and guide combination therapy
Intra-tumour heterogeneity (ITH) and cellular plasticity contribute to therapy resistance. Single-cell transcriptomics is the gold standard for assessing ITH, but this approach remains costly and slow...
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Sarafan ChEM-H @stanford-chemh.bsky.social · 01/04/2026
Young-Min Kim, in the lab of Livnat Jerby, in collaboration with Fabrizia Urbinati in the IMA has engineered immune cells to act as cellular ‘bloodhounds’, tracking the metabolic byproducts of cancer cells to better infiltrate and destroy solid tumors:
med.stanford.edu
Immune cell ‘bloodhounds’ track cancer cells’ unique metabolic signatures, eliminate tumors in mice
Immune cells engineered to sense metabolic byproducts secreted by cancer cells ‘follow their noses’ to migrate to and infiltrate solid tumors in mice in a Stanford Medicine study.
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Trudy G. Oliver @tgoliver.bsky.social · 31/03/2026
I have so many words about this. And I think its effects could be bigger than they seem on the surface.
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Julien Sage @juliensage.bsky.social · 31/03/2026
New preprint from the lab! Close collaboration with Silvia von Karstedt @vonkarstedtlab.bsky.social and her lab. We find that #SCLC cells are strikingly dependent on exogenous cysteine #LungCancer #CancerMetabolism #Ferroptosis 🧵 biorxiv.org/content/10.64898/2026.03.27.714827v1
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Silvia von Karstedt @vonkarstedtlab.bsky.social · 26/03/2026
Ever wondered how cellular #metabolism, #ROS, cellular confluence and #Ferroptosis are connected? Read our new study with theoretical physicist Johannes Berg @unicologne.bsky.social @cecad.bsky.social @uniklinikkoeln.bsky.social @dtg-cologne.bsky.social www.frontiersin.org/journals/cel...
frontiersin.org
Frontiers | A feedback loop between cell proliferation and ROS regulates ferroptosis sensitivity
BackgroundFerroptosis is a form of regulated cell death characterized by iron-dependent lipid peroxidation and membrane rupture. While cellular populations r...
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The Mark Foundation for Cancer Research @themarkfdn.bsky.social · 25/03/2026
We're back with Day 2 of #MarkSymposium! Our first session, on novel cancer therapies, featured a powerhouse lineup including William Sellers, @amanglik.bsky.social, and @juliensage.bsky.social. The future of targeted treatment is bright. ⚡️ #CancerTherapy
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Kissil Lab @kissillab.bsky.social · 23/03/2026
Once again, it’s #moleratmonday, where we provide a naked mole rat fact every Monday 🐀 Today’s fact: Their scientific name is Heterocephalus glaber, which means “different-headed” and “hairless”, a pretty on-the-nose description! #nakedmolerat
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Hiten Madhani @hitenmadhani.bsky.social · 21/03/2026
Very sad to hear of the passing today of our UCSF colleague Mike Bishop at the age of 90. A legendary and inspiring figure. He also led UCSF as Chancellor. Have a listen to his Nobel lecture. youtube.com/watch?v=CDv7...
youtube.com
Michael Bishop, Nobel Prize in Physiology or Medicine 1989: Official Lecture
YouTube video by Nobel Prize
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AndreaVentura @andreaventura.bsky.social · 18/03/2026
We are seeking a highly motivated scientist with expertise in mouse embryo manipulation and the generation of genetically engineered mouse models. This is a permanent position with competitive compensation. Contact me via direct message if interested. Please share!
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stanfordbrain.bsky.social @stanfordbrain.bsky.social · 12/03/2026
On today's podcast, we talk with neuroscientists Claire Bedbrook and Ravi Nath about their new study, which found that an animal's lifespan can be predicted surprisingly early by observing its behavior. @brunetlab.bsky.social @deisseroth.bsky.social 🔗 neuroscience.stanford.edu/news/why-do-...
Ravi Nath and Claire Bedbrook stand in an aisle of shelves filled with fish tanks. Photo by Andrew Brodhead.
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Stanford Medicine @stanfordmedicine.bsky.social · 12/03/2026
Meet Steven Artandi, a physician-scientist who studies cancer biology. His work helps uncover the mechanisms that enable cancer to grow and persist. Learn what he wanted to be when he was a kid — and the quote he lives by. youtu.be/UWwT5owtCdc?... @stanford-cancer.bsky.social
youtu.be
Walk With Me: Steven Artandi, oncologist studying cancer biology and aging
YouTube video by Stanford Medicine
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Kissil Lab @kissillab.bsky.social · 09/03/2026
It’s #moleratmonday, where we bring you a fun fact about the naked mole rat, every Monday 🐀 Last week we mentioned their long lifespans, but saved the best part for this week: The current record for the oldest naked mole rat is 40 years old! It lived in the care of the Rochelle Buffenstein lab ❤️
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Capucine Van Rechem @vanrechemlab.bsky.social · 06/03/2026
Register to the Biological Methylation meeting! June 15-18 in Dublin Many award opportunities for trainees (see the award page) Several talks selected from abstracts (deadline Apr 20) Come listen to and share awesome science, meet colleagues and make new connections! events.faseb.org/event/biolog...
events.faseb.org
Biological Methylation: Mechanisms and Therapeutics.
Join experts exploring methylation, epigenetics, and RNA biology in development and disease, with a focus on cancer and emerging therapeutics.
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CRBM-Montpellier @crbm-montpellier.bsky.social · 30/01/2026
We are hiring!
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