Very nice paper from @agnelsfeir.bsky.social and colleagues on the role of MMEJ in ecDNA maintenance and rearrangements.
www.nature.com/articles/s41...
nature.com
MMEJ repair of breaks at TA repeats maintains ecDNA and cancer fitness - Nature
Stability of extrachromosomal DNA (ecDNA) relies on microhomology-mediated end joining at fragile TA-rich sites, with FANCM suppressing break formation, suggesting that Polθ disruption may destab...