Cancer cells frequently show elevated glucose consumption to support proliferation and survival. This led to the assumption that glycolytic inhibitors could be effective in cancer treatment. However, ...

A postdoctoral position is available in the laboratory of Dr. Joseph Longo in the Department of Immunology at Roswell Park Comprehensive Cancer Center. The Longo Lab studies how metabolism and nutriti...

Metastasis is the leading cause of death in breast cancer, yet the mechanisms controlling organotropism are not well defined. Coagulation has emerged as a biologically relevant contributor to metastat...

She was inspired to become a scientist after losing her mother to cancer, devoted herself to health equity issues in her community

Read about Study reveals how dietary restriction helps fuel cancer-fighting immune cells on Van Andel Institute – Stay updated on the latest research and groundbreaking discoveries in science and heal...

Glucose has traditionally been considered the primary fuel for T cells. Longo et al. present evidence for a revised, “nutrient allocation” model, in which effector T cells channel diverse nutrient sources into specific metabolic pathways to fuel T cell-mediated immunity.

Nature Metabolism, Published online: 08 September 2025; doi:10.1038/s42255-025-01366-yKaluba, Rogers et al. show that in cancer cells that can metabolize ketones, they may reroute them to produce cytosolic acetyl-CoA and support tumour growth.

The cortex fuels essential physiological processes with glucose-derived carbon, while gliomas fuel their aggressiveness by rerouting glucose carbon pathways and scavenging alternative carbon sources s...

Read about ‘Sweet’ discovery reveals how glucose fuels cancer-fighting immune cells on Van Andel Institute – Stay updated on the latest research and groundbreaking discoveries in science and health.

Read about What’s next in metabolism research? on Van Andel Institute – Stay updated on the latest research and groundbreaking discoveries in science and health.

Nature Metabolism - By developing a method for single-embryo multi-omics in Drosophila, the authors provide a high-resolution view into the transcriptional and metabolic underpinnings of early...

Glucose is required for T cell proliferation and function, but its key metabolic fates in vivo are not well defined. Longo et al. demonstrate that in CD8+ effector T cells, glucose metabolism extends ...

Glucose is required for T cell proliferation and function, but its key metabolic fates in vivo are not well defined. Longo et al. demonstrate that in CD8+ effector T cells, glucose metabolism extends beyond energy production by fueling glycosphingolipid biosynthesis, a pathway critical for T cell expansion and cytotoxic function.

Glucose is required for T cell proliferation and function, but its key metabolic fates in vivo are not well defined. Longo et al. demonstrate that in CD8+ effector T cells, glucose metabolism extends ...

Using metabolic dysfunction-associated steatohepatitis-driven hepatocellular carcinoma mouse models, an ATP citrate lyase inhibitor reduces tumour burden and enhances efficacy of current standards of ...

This study shows that animal-based high-fat diets accelerate tumour growth and impair anti-tumour response to melanoma in obese mice, whereas plant-based high-fat diets do not.

This study shows that animal-based high-fat diets accelerate tumour growth and impair anti-tumour response to melanoma in obese mice, whereas plant-based high-fat diets do not.

Join us for 2025 Midwest Metabolism Meeting at Van Andel Institute Stay informed about exciting upcoming events and activities.

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T cell therapies for cancer currently rely on extensive in vitro expansion in hypermetabolic conditions. Frisch et al. demonstrate that T cells grown in vitro perform extensive aerobic glycolysis. Rer...

Panzeri et al. use a Trim28+/D9 mouse model with intrinsic developmental heterogeneity to show that ‘heavy’ and ‘light’ developmental morphs exhibit different timing, type and severity of cancer, link...

Ellrott et al. provide a means to assign patient samples from clinical trials and other cancer genome studies to published TCGA molecular subtypes. Applying machine learning to data from five different molecular platforms for 8,791 TCGA tumor samples, they contribute a public resource of 737 top classifier models, which can form the foundation for clinical assay development.

Lien et al. report a characterization of metabolism with aging across three different strains of mice. They find that glucose metabolism is robust during healthy aging; however, aging tissues exhibit....

ACLY-deficient CAR T cells targeting the tumor-associated antigen disialoganglioside GD2 (GD2 CAR T cells) also resisted acquiring TEX-like properties, exhibiting reduced CD39 expression when co-cultu...

The Roswell Park Emerging Leaders in Cancer Research Seminar Series features lectures by outstanding junior scientists from around the country on a diverse range of cancer-focused topics. This include...

YouTube video by Van Andel Institute

Two FDA-approved compounds, AKT inhibitors and pitavastatin, synergize to induce cell death in triple-negative breast cancer, motivating evaluation of the efficacy of this combination in clinical tria...

Conserved ketone body-amino acid metabolites suppress food intake in mice, demonstrating that secondary ketone body metabolism contributes to energy balance.

VAI scientists Russell Jones, Ph.D., and Peter W. Laird, Ph.D., are included in this year’s Clarivate Highly Cited Researchers list, a distinction marking them as leaders in their fields.