Metastasis is a leading cause of mortality in breast cancer patients, yet the signaling promoting metastatic dissemination is not completely understood. Prior literature implicates neuronal innervatio...

The balance of protein phosphorylation is often disrupted in cancer, with hyperactivity of kinases and inactivation of phosphatases driving cell proliferation and survival pathways. PTPRH, a protein t...

The E2F transcription factors are well-established cell cycle regulators, but their roles in coordinating proliferation and differentiation remain poorly understood. Here, we investigated the function...

Metastasis is the leading cause of death in breast cancer, yet the mechanisms controlling organotropism are not well defined. Coagulation has emerged as a biologically relevant contributor to metastat...

Our previous work has uncovered key mechanisms linking systemic changes to tumor initiation, single cell signatures of models of breast normal and cancer development and identified epigenetic and...

Generative AI tools have arrived in PhD training environments faster than principled frameworks for their use. The debate has polarized between enthusiasts who argue trainees must adopt AI immediately...

The E2F transcription factors are well-established cell cycle regulators, but their roles in coordinating proliferation and differentiation remain poorly understood. Here, we investigated the function...

The delicate balance of protein phosphorylation is often disrupted in cancers, with hyperactivity of kinases and inactivation of phosphatases driving cell proliferation and survival pathways. PTPRH, a...

Metastasis is a leading cause of mortality in breast cancer patients, yet the signaling promoting metastatic dissemination is not completely understood. Prior literature implicates neuronal innervatio...

How circular extrachromosomal DNA is inherited during cell division is a puzzle. Key sequences enabling this DNA to journey with chromosomes have been identified. How circular extrachromosomal DNA is inherited during cell division is a puzzle. Key sequences enabling this DNA to journey with chromosomes have been identified.

The UNC Lineberger Comprehensive Cancer Center, in collaboration with departments in the School of Medicine and across the entire University of North Carolina at Chapel Hill, is seeking outstanding ca...

Victoria’s Secret Global Fund for Women’s Cancers Career Development Award 2025: Advancing Research in Breast and Gynecologic Cancers / Breast Cancer