AKT phosphorylates the glycosyltransferase ALG3. The PI3K/AKT signaling pathway is frequently dysregulated in cancer and controls key cellular processes such as survival, proliferation, metabolism, an...

Breakdown of every transmembrane protein trafficked to lysosomes requires proteolysis of their hydrophobic helical transmembrane domains. Combining lysosomal proteomics with functional genomic dataset...

Three distinguished scientists on leaving academia to advance biomedical research

Discussion meeting organised by Professor Mark A Lemmon FRS.

Capivasertib plus abiraterone and ADT improved rPFS in PTEN-deficient metastatic hormone-sensitive prostate cancer.

The Department of Molecular Metabolism (MET) at the Harvard T.H. Chan School of Public Health invites applications for the level of assistant professor. The shared interest of MET faculty is to explor...

Two FDA-approved compounds, AKT inhibitors and pitavastatin, synergize to induce cell death in triple-negative breast cancer, motivating evaluation of the efficacy of this combination in clinical tria...

Research funded by the National Institutes of Health (NIH) generated $2.46 in economic activity for every $1 of funding in 2023, a total of $92.9 billion, according to an

Clinical trial targeted recurrence of hard-to-treat triple-negative breast cancer