During an immune response, metabolism changes dramatically. Metabolites are oxidized to power immune cell functions, serve as building blocks for proliferation, and act as effectors to regulate pathog...

Yang et al. show that α-satellite RNA, derived from human centromeric satellite repeats, forms R-loops at human centromeres to ensure faithful chromosome segregation by recruiting Shugoshin 1. This me...

Background: Glucagon-like peptide-1 receptor (GLP-1R) agonists have recently been suggested as effective therapies to treat or reduce the risk of developing secondary lymphedema in patients with obesi...

Spinal cord injury (SCI) is a devastating condition characterized by the accumulation of myelin debris (MD), persistent neuroinflammation, and impaire…

BACKGROUND: Dysregulation of TRPV4 (transient receptor potential vanilloid type 4)–mediated signaling has been associated with inflammation and tissue fibrosis, both of which are key features in the p...

Two evolutionary strategies allow the antiviral protein MxA to evolve simultaneous super-restriction against multiple viruses.

Dr. Ardem Patapoutian says he watches “with deep sadness as the United States’ remarkable scientific enterprise, which took generations of hard work and national investment to build, faces a concerted...

Nearly 2,000 scientists urged that Congress restore funding to federal agencies decimated by recent cuts.

I say this to myself regularly in the past weeks, mostly when it comes to sitting on my hands about my regular NIH-related and academic science career-related hobby horse issues as they arise. We h…

ICYMI: Murray Blasts Trump and Musk Decimating HHS, Risking Americans’ Health and Livelihoods Washington, D.C. — U.S. Senator Patty Murray (D-WA), Vice Chair of the Senate Appropriations Committee and...

NIH-related updates to the Federal Register, which are required for the scheduling of study sections and advisory councils, are on hold indefinitely, according to an email reviewed by <i>The Transmitt...

In 1984, Dr. Daniel Drucker, an endocrinologist from the University of Toronto, discovered a hormone that helped pave the way for popular diabetes drugs such as Ozempic.

LeBron James’ birthday on Monday will make him the first NBA player to play in his teens, 20s, 30s and 40s. Knowing when to walk away may be the hardest part of his journey

Feng et al. uncover a critical genetic interaction between the DNA translocases SMARCAL1 and FANCM. Their combined loss leads to catastrophic genome instability, particularly at simple-repeat sequence...