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Jorge Castorena

@jcastorena.bsky.social
53 followers 54 following 17 posts
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Jorge Castorena @jcastorena.bsky.social · 05/06/2026
Our newest study is now published. Here we show that GLP-1Rs are expressed in the lymphatic vasculature and enriched in LECs. And pharmacological activation by semaglutide enhances the pumping capacity of collectors. onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
GLP‐1 Receptors Are Enriched in the Lymphatic Endothelium and Their Pharmacological Activation With Semaglutide Improves the Pumping Capacity of Lymphatic Vessels
Objectives Recent clinical studies have suggested that glucagon-like peptide-1 receptor (GLP-1R) agonists may be effective therapies to treat or reduce the risk of developing secondary lymphedema. I.....
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Jorge Castorena @jcastorena.bsky.social · 13/02/2026
We had a very productive day at the lab today, testing yet-another antibody for GLP-1R and a potential new marker for lymphatic endothelial cells… we also had our last King Cake of the season as a lab. We are on home stretch for Mardi Gras 2026!
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Jorge Castorena @jcastorena.bsky.social · 05/02/2026
We decided to start keeping track of the number of isolated lymphatics we successfully study. A strong 138 vessels in January… and not too shabby for a PI to run 52. @maryschulz.bsky.social is killing it, her and I hogged our 2 systems. I’m sure @keithkeane.bsky.social will have a strong February.
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Jorge Castorena @jcastorena.bsky.social · 27/12/2025
Our new preprint led by @maryschulz.bsky.social is now up. We show that semaglutide enhances the pumping capacity of collecting lymphatics. Our results support recent case reports suggesting beneficial effects of GLP-1R agonists in secondary lymphedema patients. www.biorxiv.org/content/10.6...
biorxiv.org
GLP-1R Agonism Directly Improves the Pumping Capacity of Murine Collecting Lymphatic Vessels
Background: Glucagon-like peptide-1 receptor (GLP-1R) agonists have recently been suggested as effective therapies to treat or reduce the risk of developing secondary lymphedema in patients with obesi...
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Jorge Castorena @jcastorena.bsky.social · 13/08/2025
Very proud of my student @maryschulz.bsky.social, who just received a NOA for her NIH-F31 project to study obesity-induced lymphatic dysfunction and explore novel therapeutics. Also, her recent paper (www.ahajournals.org/doi/10.1161/...), has been highlighted by an Editorial at ATVB. Congrats, Mary!
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Hans schoofs @hansschoofs.bsky.social · 15/07/2025
This beautiful work from the lab in Uppsala @taijamakinenlab.bs made it to the cover ! Happy to be part of it ! Congrats again to the first author Marle Kraft ! Stunning images
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Reposted by Jorge Castorena
Hao Yin @haoyin.bsky.social · 19/06/2025
scRNAseq of🐭collecting lymphatic vessels😎 Cell type-specific #LymphaticEndothelialCell vs peri-lymphatic myeloid cell contributions of TRPV4 in distinct stages of lymphatic contractile activity @maryschulz.bsky.social @jcastorena.bsky.social #ATVB 2025 www.ahajournals.org/doi/full/10....
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Jorge Castorena @jcastorena.bsky.social · 15/06/2025
Our lab had a great time learning and catching up with friends and colleagues at the Lymphatic Forum 2025. Congrats to @maryschulz.bsky.social and @keithkeane.bsky.social for receiving Travel Awards! Thank you @navbo.bsky.social, LE&RN, and @mcsociety.bsky.social for your support.
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Reposted by Jorge Castorena
Mary Schulz @maryschulz.bsky.social · 02/06/2025
Excited to share our work on TRPV4 channels in lymphatic contractile function! www.ahajournals.org/doi/10.1161/... @jcastorena.bsky.social @ahajournals.bsky.social @ahascience.bsky.social
ahajournals.org
Regulation of Collecting Lymphatic Vessel Contractile Function by TRPV4 Channels | Arteriosclerosis, Thrombosis, and Vascular Biology
BACKGROUND: Dysregulation of TRPV4 (transient receptor potential vanilloid type 4)–mediated signaling has been associated with inflammation and tissue fibrosis, both of which are key features in the p...
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Jorge Castorena @jcastorena.bsky.social · 01/05/2025
Our study with Mike Davis showing that a component of the lymphatic contractile impairment in db/db mice is mediated by the activation of KATP channels in lymphatic muscle cells, in part due to chronic metabolic stress associated with elevated glucose, is now out. www.frontiersin.org/journals/phy...
frontiersin.org
Frontiers | Chronic metabolic stress impairs lymphatic contractility via activation of KATP channels in a mouse model of Type-2 diabetes
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Reposted by Jorge Castorena
Vincenza Cifarelli, PhD @cifarelliv.bsky.social · 12/03/2025
Our latest publication investigating the role of #palmitoylation in #lymphatic endothelial integrity. Big shoutout to Silvia Gonzalez-Nieves, Simon GUIGNARD and Thi Nguyen for their incredible work and dedication. 👏👏 www.sciencedirect.com/science/arti...
sciencedirect.com
Insulin regulates lymphatic endothelial integrity via palmitoylation
Lipid metabolism plays a critical role in lymphatic endothelial cell (LEC) development and vessel maintenance. Altered lipid metabolism is associated …
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Reposted by Jorge Castorena
Kalev Freeman @uvmtraumalab.bsky.social · 04/02/2025
We are studying the biology of wound healing, using the smallest possible acute vascular injury we can imagine—a 5 um micropoint pulsed laser deformation of the endothelial cell plasma membrane. 🧪 #MedSky #EMSky #EMedSky #immunosky
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Brant Isakson @brantisakson.bsky.social · 07/01/2025
🦕🦕 I’m happy this fun little book is finally out exploring how the physiology of the sauropod dino helped contribute to its dominance on earth for so long. However, I think I’ll stick to my day job 😁 🦕🦕
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