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Alicia Martin

@genetisaur.bsky.social
994 followers 153 following 32 posts

Population and statistical geneticist @MGH/HMS and Broad Institute

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Alicia Martin @genetisaur.bsky.social · 08/07/2026
So excited to see this published! This method was a long time in the making and is now being widely used to balance scale with depth, especially for participants where unbiased sequencing approaches are so much more useful than arrays
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Satoshi Yoshiji, MD, PhD @satoshiyoshiji.bsky.social · 30/06/2026
NIH All of Us has just released a massive multi-omics dataset, including: • 535K WGS (120K+ added; now larger than UKB) • ~10K proteomics + RNAseq + long-read • ML-curated clinical notes • 68K with Fitbit data Kudos to this great initiative and to the participants for advancing science
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Adam Auton @adamauton.bsky.social · 07/05/2026
Population geneticists! Come work at 23andMe! New role just posted. 23andme.wd5.myworkdayjobs.com/23/job/Palo-...
23andme.wd5.myworkdayjobs.com
Scientist, Population Genetics
23andMe is looking for a quantitative scientist with extensive experience in population genetics and statistical modeling of human genetics data to join our R&D team. You will leverage your expert...
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Alicia Martin @genetisaur.bsky.social · 29/04/2026
📣 𝐖𝐞’𝐫𝐞 𝐡𝐢𝐫𝐢𝐧𝐠 𝐚 𝐩𝐨𝐬𝐭𝐝𝐨𝐜 𝐢𝐧 𝐩𝐨𝐩𝐮𝐥𝐚𝐭𝐢𝐨𝐧 & 𝐬𝐭𝐚𝐭𝐢𝐬𝐭𝐢𝐜𝐚𝐥 𝐠𝐞𝐧𝐞𝐭𝐢𝐜𝐬! 🌍📈🧬 If you’re finishing a PhD (or know someone who is) and want to work on complex trait biology + 𝑟𝑒𝑎𝑙-𝑤𝑜𝑟𝑙𝑑 𝑖𝑚𝑝𝑎𝑐𝑡, read on 👇
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Ying Wang @yingwangyw.bsky.social · 23/04/2026
🎉New preprint: Phenome-derived polygenic scores and social determinants jointly shape context-dependent disease risk. We evaluate disease risk along 2 complementary axes: • how genetic liability is represented • the social context in which it is expressed
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Alicia Martin @genetisaur.bsky.social · 28/02/2026
Family quarantine complete! 3 yo had flu A and was confined to room with dad caretaking while I took care of 2 month old. Combo tests in the house meant we diagnosed right away, despite weird stomach flu-like symptoms. Tamiflu is a wonder drug if in time! Treated and prophylaxis: no one else sick
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Alicia Martin @genetisaur.bsky.social · 28/11/2025
Interested in pleiotropy dissection but not sure where to start, which methods are useful, which studies offer illustrative examples, or how to robustly validate your results? Look no further 👀 rdcu.be/eSfAZ
rdcu.be
Dissecting pleiotropy to gain mechanistic insights into human disease
Nature Reviews Genetics - Genome-wide association studies of increasing scale have revealed the prevalence of pleiotropic genetic variants that affect multiple traits. In this Review, the authors...
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Konrad @konradjk.bsky.social · 18/09/2025
A project many years in the process, we’re pleased to present our work on multi-ancestry meta-analysis across a boatload of traits in the UK Biobank: www.nature.com/articles/s41...
nature.com
Pan-UK Biobank genome-wide association analyses enhance discovery and resolution of ancestry-enriched effects - Nature Genetics
Genome-wide analyses for 7,266 traits leveraging data from several genetic ancestry groups in UK Biobank identify new associations and enhance resources for interpreting risk variants across diverse p...
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Jack Kosmicki @jakphd.bsky.social · 11/09/2025
Kristin Tsuo, @genetisaur.bsky.social, & Mark Daly just wrote the best proteomics paper I've read. They convincingly show how smoking and alcohol (aka, the environment) dramatically influences proteomics data. Some 🤯 results 1) proteomics predicts frequency (5a) & quanity (5b) of alcohol consumed
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Carl Zimmer @carlzimmer.com · 29/08/2025
On the new acting CDC director. www.theguardian.com/us-news/2025...
O’Neill, unlike Monarez, has no training in medicine or infectious disease science. He is a former speechwriter for the health department, during the Bush years, who went on to work for the tech investor and conservative megadonor Peter Thiel.

During the Covid pandemic, O’Neill voiced public support for unproven treatments that were not supported by scientific evidence, including ivermectin and hydroxychloroquine, as well as vitamin D as a supposed “prophylaxis”.

He also posted a number of conspiratorial theories on social media, including the baseless claim that “the name #COVID was chosen to conceal the origin of the virus. This name made it harder to study and probably slowed the response.”
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anil oza @aniloza.bsky.social · 05/08/2025
The Govt. Accountability Office issued a report today finding that the Trump admin has violated a law blocking presidents from withholding funding Congress has approved @mmolteni.bsky.social & I break it down: www.statnews.com/2025/08/05/g...
statnews.com
Trump administration violated impoundment law by canceling NIH grants, slowing new awards, GAO finds
The Government Accountability Office found that the Trump administration, by abruptly canceling NIH grants, had violated a 1974 federal law
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Katie Mack @astrokatie.com · 05/08/2025
Every reputable expert I know considers mRNA vaccine technology to be one of the most revolutionary advances in medicine in our lifetimes. Its inventors won the Nobel Prize in 2023. Shutting it down now is pointless self-harm to humanity.
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Alicia Martin @genetisaur.bsky.social · 05/08/2025
Let’s not pretend this ends with Harvard. This will be every American university unless a resounding legal win establishes precedent
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Jeremy Berg @jeremymberg.bsky.social · 01/08/2025
Incredibly well reported deep dive on NIH and health disparities research in STAT. 🧵 www.statnews.com/2025/08/01/n... 1/31
statnews.com
Jay Bhattacharya once studied health disparities. As NIH director, he’s allowed such research to wither
Jay Bhattacharya’s tenure as NIH director has seen health disparities research swept up in the Trump administration’s attack on DEI
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Max Kozlov @maxkozlov.bsky.social · 30/07/2025
The NIH can’t award ANY grants to outside researchers under new WH restriction, reports @wsj.com. The pause came in the form of a footnote from OMB Director Vought, in a document that doles out federal funds to the NIH. Prelude to rescissions, especially after his comments over the weekend?
wsj.com
Trump Administration Puts New Chokehold on Billions in Health-Research Funding
The National Institutes of Health can’t award grants to outside researchers under a new White House restriction.
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Kirsten Bibbins-Domingo @kbibbinsdomingo.bsky.social · 25/06/2025
Wonderful tribute to a dear colleague- well worth the read www.ucsf.edu/news/2025/06...
ucsf.edu
UCSF Bioinformatics Pioneer Atul Butte Dies at 55
Atul Butte, who championed the use of big data in science and health care and inspired a generation of trainees at UC San Francisco and beyond to pursue the fields he pioneered — translational and cli...
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Eimear Kenny @eimearekenny.bsky.social · 17/06/2025
📢 Just posted: Our preprint introducing SPC — Spectral Components — is now live on medRxiv! Led by Dr. Ruhollah Shemirani and years in the making, this method offers a robust, scalable way to adjust for recent population structure in genomic analyses. 🔗 www.medrxiv.org/content/10.1... 1/9
medrxiv.org
SPC: a SPectral Component approach to address recent population structure in genomic analysis
Population structure is a well-known confounder in statistical genetics, particularly in genome-wide association studies (GWAS), where it can lead to inflated test statistics and spurious associations...
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Max Kozlov @maxkozlov.bsky.social · 16/06/2025
🚨 BREAKING: Nearly 4 months the NIH cut its first grants, a judge has ruled that the directives and process that led to cuts are arbitrary and capricious. "The explanations are bereft of reasoning — virtually in their entirety... unsupported by [facts]." Each of them are VOID and ILLEGAL, he says.
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Dr. Lucky Tran @luckytran.com · 09/06/2025
"We are speaking on behalf of hundreds of NIH staff who are standing up together to say: WE DISSENT. I am so scared about doing this but I am trying to be brave for my kids because it's only gonna get harder to speak up." Thank you to Dr. Jenna Norton and NIH scientists for your courage!
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Eric Topol @erictopol.bsky.social · 30/05/2025
"Our calculations suggest that the proposed budgetary cuts to the NIH will create a social cost that is 16 times greater than the savings that the administration is attempting to achieve." jamanetwork.com/journals/jam...
jamanetwork.com
Cutting the NIH—The $8 Trillion Health Care Catastrophe
This JAMA Forum discusses the recent budget cuts to National Institutes of Health (NIH), the effects of these cuts on scientific research and health of individuals in the US, and the prospects for cha...
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Alicia Martin @genetisaur.bsky.social · 29/05/2025
Now published! Congrats Yon Ho on this huge lift conducting dozens of GWAS in Korea and performing meta-analyses with other Asian biobanks reaching a sample size comparable to UK Biobank. The fine-mapping, novel loci, and ancestry-enriched discoveries are very cool. www.nature.com/articles/s41...
nature.com
Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures - Nature Communications
Here the authors identify hundreds of genetic loci linked to 36 traits in East Asians, revealing population-specific associations and emphasizing the importance of diverse ancestry groups in genome-wi...
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Carl Zimmer @carlzimmer.com · 27/05/2025
Statement from the American College of Obstetricians and Gynecologists
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Pete Buttigieg @petebuttigieg.bsky.social · 23/05/2025
America cannot long remain free, nor first among nations, if it becomes the kind of place where universities are dismantled because they don't align politically with the current head of the government.
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Aaron Reichlin-Melnick @reichlinmelnick.bsky.social · 22/05/2025
🚨This is a HUGE escalation and a deliberate effort to use the government against Trump's enemies. Weaponizing the Student and Exchange Visitor Program certification against Harvard to punish them for pushing back is a new low — and needlessly punishes thousands of innocent students.
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Neil deGrasse Tyson @neildegrassetyson.com · 17/05/2025
The 80-year recipe stoking America’s Prosperity: 1) Free-market capital investments in brilliant ideas… 2) enabled by Engineering Innovations… 3) based on Science Research in Universities… 4) funded by Grants from the US Government. It’s time more people understood this.
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Allison Gill @muellershewrote.com · 09/05/2025
She’s out!! They have released Ozturk from ICE custody!
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Larry Hunter @proflhunter.bsky.social · 24/04/2025
And just today the EIC of Nature Neuroscience told me in public that they are a for-profit company and if they had to pay reviewers they would "need" to raise prices.
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Andrea Love, PhD | Biomedical Scientist @drandrealove.bsky.social · 21/04/2025
Breast cancer diagnoses rose by over 300% between 1973 and 1992. Was there a breast cancer epidemic?! NO. Mammograms were implemented for screening in 1976. PREVALENCE is a function of being able to correctly diagnose something. This is also about autism.
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Max Kozlov @maxkozlov.bsky.social · 18/04/2025
I've received additional confirmation, as well as an email I can share publicly. See the directive NIH grants management staff received from Michelle Bulls, director of extramural policy at NIH:
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PGC Africa @pgc-africa.bsky.social · 17/04/2025
🚨 PGC Africa Monthly Meeting Alert! We are delighted to have Dr Lerato Majara from the Martin Lab @genetisaur.bsky.social, @broadinstitute.org join our 3rd virtual meeting of 2025 📆 24th April 2025 ⏲️ 2PM GMT | 2PM WAT | 3PM CAT | 4PM EAT 📢 More details on the flyer below #Psychosis #Africa #GWAS
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Malinda Lo @malindalo.bsky.social · 14/04/2025
Harvard redid its whole homepage to push back against the administration’s demands. I mean, this is just a website but I think it’s kind of a great PR move: www.harvard.edu
harvard.edu
Harvard University
Harvard University is devoted to excellence in teaching, learning, and research, and to developing leaders who make a difference globally.
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Niko Bowie @nikobowie.bsky.social · 12/04/2025
BREAKING: Last night, the Harvard faculty chapter of the AAUP and the national AAUP filed a lawsuit & TRO to block the Trump administration from illegally demanding that we keep quiet and change how we teach and research at the point of a financial gun. actionnetwork.org/user_files/u...
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Eric Topol @erictopol.bsky.social · 09/04/2025
A high polygenic risk score (PRS) for screening prostate cancer was superior to a PSA test or MRI for detecting clinically significant disease (Gleason ≥7). A big step forward for supporting utility of PRS @nejm.org www.nejm.org/doi/full/10....
nejm.org
Assessment of a Polygenic Risk Score in Screening for Prostate Cancer | NEJM
The incidence of prostate cancer is increasing. Screening with an assay of prostate-specific antigen (PSA) has a high rate for false positive results. Genomewide association studies have identified...
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Alicia Martin @genetisaur.bsky.social · 10/04/2025
How many of these are in blue states you ask? 🙄 Turns out, it was never about “antisemitism” or they would have ousted the Nazi billionaire gutting the government’s functionality while somehow also wasting $ www.ed.gov/about/news/p...
ed.gov
U.S. Department of Education’s Office for Civil Rights Sends Letters to 60 Universities Under Investigation for Antisemitic Discrimination and Harassment
The Office for Civil Rights today sent letters to 60 institutions of higher education warning them of potential enforcement actions if they do not fulfill their obligations under Title VI of the Civil...
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Molly Jong-Fast @mollyjongfast.bsky.social · 05/04/2025
So we’re 75 days into trumps second term, people are protesting everywhere. Markets have had two days of absolutely apocalyptic losses. There are grad students being disappeared and a man with an autism awareness tattoo was sent to a super scary prison in El Salvador. They’ve cut cancer research..
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Niko Bowie @nikobowie.bsky.social · 04/04/2025
“Harvard now faces one of the most consequential choices in its history: Submit to extortion and make itself complicit in the most profound assault on academic freedom and constitutional governance of our time—or go to court. The stakes are high, but the choice should not be difficult.” (Fixed link)
bostonglobe.com
Harvard’s moment of truth - The Boston Globe
The stakes are high, but the choice should not be difficult.
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Jeremy Berg @jeremymberg.bsky.social · 04/04/2025
New lawsuit filed today in Massachusetts aginst NIH from many state Attorneys General First, plaintiffs seek relief for the unreasonable and intentional delays currently plaguing the grant-application process 1/n
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ACLU @aclu.org · 02/04/2025
BREAKING: We're suing the National Institutes of Health over their politically-motivated purge of research grants. This is an unlawful attack on scientific progress that puts lives at risk.
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Jeremy Berg @jeremymberg.bsky.social · 03/04/2025
www.nbcnews.com/health/healt...
nbcnews.com
ACLU sues National Institutes of Health for ‘ideological purge’ of research projects
The lawsuit says that NIH has canceled more than 670 research grants, which were due more than $1.1 billion in funding.
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Nicholas Tatonetti, PhD @tatonetti.bsky.social · 03/04/2025
Our OnSIDES db -- the worlds most up-to-date resource of drug side effects is published at @MedCellPress For all your drug safety analysis and prediction needs. OnSIDES is the first resource to combine US, UK, EU, and Japanese data all in one place. www.cell.com/med/abstract...
cell.com
OnSIDES database: Extracting adverse drug events from drug labels using natural language processing models
Tanaka et al. present OnSIDES (on-label side effects resource), a database of drug adverse events extracted from drug labels using a fine-tuned PubMedBERT model, including pediatric-specific adverse e...
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Katie Phang @katiephang.bsky.social · 02/04/2025
“Dr. Richard Youle, a leading researcher in the field of neurodegenerative disorders…including identifying mechanisms behind Parkinson’s disease” was one of several top scientists PURGED from the NIH today courtesy of Trump/Musk/DOGE. www.wired.com/story/doctor...
wired.com
Doctor Behind Award-Winning Parkinson’s Research Among Scientists Purged From NIH
Leading scientists at the National Institutes of Health, the US’s leading medical research agency, were swept up Tuesday in the Trump administration’s latest firing blitz.
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Ben Ewen-Campen @benforward3.bsky.social · 26/03/2025
Massive turnout in solidarity with Rumeysa Ozturk, a Tufts graduate student who was abducted from a Somerville street by Trump’s government - Somerville stands with Rumeysa
Huge crowd at Powder House
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Elizabeth Warren @warren.senate.gov · 26/03/2025
This arrest is the latest in an alarming pattern to stifle civil liberties. The Trump admin is targeting students with legal status and ripping people out of their communities without due process. This is an attack on our Constitution and basic freedoms — and we will push back.
abcnews.go.com
Tufts PhD student on visa arrested by immigration authorities, school says
Rumeysa Ozturk is a Turkish national, according to her lawyer, Mahsa Khanbabai.
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The Boston Globe @bostonglobe.com · 26/03/2025
The Tufts graduate student detained by federal authorities in Somerville has been sent to a Louisiana detention facility, despite a federal judge’s order telling US Immigration and Customs Enforcement not to remove her from Massachusetts without notice.
bostonglobe.com
Tufts graduate student detained by federal authorities sent to Louisiana - The Boston Globe
Masked plainclothes officers arrested Rumeysa Ozturk outside a Somerville home Tuesday evening.
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👻 Spooky Elle 🎃🧙🏼‍♀️🍄 @hecatestorch.bsky.social · 21/03/2025
Just found out NIH has officially canceled our grant, a longitudinal study of Alzheimer's disease in Black Americans. I cannot even put into words how angry I am. The truth is they are canceling it because it has Black in the title. That's it, there is no other reason to do this.
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Tuuli Lappalainen @tuuliel.bsky.social · 21/03/2025
This is excellent; a very clear explanation of what’s at stake at Columbia.
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Aida Andres @aidaandres.bsky.social · 21/03/2025
UCL is a fantastic place to work, London a great city to live in, in the UK. From the UCL Genetics Institute (UGI) we are happy to support applications to work on genetics and genomics of populations, broadly speaking. www.ucl.ac.uk/biosciences/...
ucl.ac.uk
UCL Genetics Institute
UCL Genetics Institute (UGI) is a multi-faculty Centre dedicated to the analysis of Big Genetic Data.
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Alicia Martin @genetisaur.bsky.social · 20/03/2025
How many Columbia PIs who lost grants are Jewish? This isn’t about antisemitism. How many Penn PIs know the name of the trans swimmer who followed all the rules to swim on their team in 2022? This isn’t about gender minorities. It’s about destroying universities and hushing dissent. Who’s next?
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Theresa Kim, PhD, MS @tyk314.net · 20/03/2025
It looks like councils are on the federal register now, @jeremymberg.bsky.social!
federalregister.gov
Agencies - National Institutes of Health
The National Institutes of Health publishes documents in the Federal Register. Explore most recent and most cited documents published by the National Institutes of Health.
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