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Jonathan Sebat

@sebatlab.bsky.social
2.1K followers 810 following 203 posts

Psychiatric genetics, complex trait genetics, genome sequencing, rare variants are my jam

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Reposted by Jonathan Sebat
Boca Scientific Inc. @bocascientificinc.bsky.social · 10/03/2026
Researchers @sebatlab.bsky.social utilized long-read whole #genome sequencing and identified new #genetic variants associated with Autism. This enhanced the discovery of variants, leading to the potential for accurate testing and new therapies. #AutismSpectrumDisorder today.ucsd.edu/story/long-r...
today.ucsd.edu
Long-Read Genome Sequencing Uncovers New Autism Gene Variants
By utilizing long-read sequencing, an emerging technique that reads large sections of the genome at once, scientists at UC San Diego have revealed new genetic variants associated with autism spectrum ...
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Jonathan Sebat @sebatlab.bsky.social · 01/01/2026
Happy new year from Sofia!
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Jonathan Sebat @sebatlab.bsky.social · 26/10/2025
Now we need a Fu-index
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Reposted by Jonathan Sebat
Samara Reck-Peterson @samreckpeterson.bsky.social · 29/09/2025
We are hiring an Assistant Professor of Biochemistry and Biophysics at Weill Cornell Medicine. Come join our collaborative research environment with state-of-the-art facilities in NYC! Application review starts Oct 22. biochem.weill.cornell.edu/join-our-fac...
biochem.weill.cornell.edu
Join our Faculty | Department of Biochemistry & Biophysics
Call for applications:We invite applications for a tenure-track Assistant Professor position in the newly established Department of Biochemistry and Biophysics. We are conducting an open search for ou...
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Jonathan Sebat @sebatlab.bsky.social · 02/10/2025
Please repost: we are recruiting a postdoc for a project in my lab on genes and environment in autism
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Jonathan Sebat @sebatlab.bsky.social · 02/10/2025
Many clinicians and scientists agree that spectrum has become too broad. Question for me really is how to split, and what are the objectives? www.nytimes.com/2025/10/01/h...
nytimes.com
Should the Autism Spectrum Be Split Apart?
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Reposted by Jonathan Sebat
Iron Spike @ironspike.bsky.social · 29/09/2025
Says a lot about the state of popular science reporting that some techbro doofus can pretend he's going to be immortal and that will grab more headlines than "Hey we have a gene therapy that slows the advance of Huntington's by 75%," or "We gengineered a pothos into a living air purifier."
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Jonathan Sebat @sebatlab.bsky.social · 26/09/2025
We are proud to be one of the 13 projects funded by the NIH Autism Data Science Initiative. Our project: "Elucidating the Interplay of Genes and Environment in Autism Using Genomic and Exposure Data from Large Populations" 🧵https://www.nytimes.com/2025/09/26/health/autism-research-trump-kennedy.html
nytimes.com
Despite False Claims, Trump Funnels Millions Into Credible Autism Research
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Jonathan Sebat @sebatlab.bsky.social · 19/09/2025
Today's ACIP meeting had a presentation on the genetics of myocarditis following COVID vaccine based on Whole exome sequencing of 50 cases. See time stamp 2:26 www.youtube.com/live/_9ChY9S...
youtube.com
Advisory Committee on Immunization Practices (ACIP) - September 19, 2025 – Day 2 of 2
YouTube video by Centers for Disease Control and Prevention (CDC)
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Jonathan Sebat @sebatlab.bsky.social · 15/09/2025
Pfff, big deal. My social media accounts are powered by edibles
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Reposted by Jonathan Sebat
MwahahahahahadScientist @mads100tist.bsky.social · 30/08/2025
This is it. I cannot explain it, but this is it. This is how -and why- we should be doing science
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Jonathan Sebat @sebatlab.bsky.social · 16/08/2025
Bad ass mom of the year 🤘. This was NOT an easy coffee ride. This was the Saturday Cadence Cyclery ride in SD.
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Jonathan Sebat @sebatlab.bsky.social · 09/08/2025
Tahoe Zen
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Reposted by Jonathan Sebat
Brain and Mind Centre @brainandmindcentre.bsky.social · 11/06/2025
Great turnout! Decoding Genetics of Autism Speakers: Prof Jonathan Sebat - UCSD Prof Lilia Lakoucheva - UCSD Dr. Alan Ma - Children’s Hosp Westmead, Prof. Katrina Williams - @MonashUni Hosted by BMC/Child Neurodevelopment team @adamguastella.bsky.social
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Reposted by Jonathan Sebat
Hank Green @hankgreen.bsky.social · 28/07/2025
I doubt that there is a single family in America that hasn’t benefitted directly from the NIH.
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Jonathan Sebat @sebatlab.bsky.social · 28/07/2025
Leaf blowers on lizards is pretty innovative if you ask me
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Jonathan Sebat @sebatlab.bsky.social · 28/07/2025
Not the most accurate analogy. In this example there is a real difference between the 4th percentile and the 15th percentile
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Reposted by Jonathan Sebat
Gregg Gonsalves @gregggonsalves.bsky.social · 26/07/2025
The former NIH director on the catastrophe unfolding for American research. youtu.be/lW9c6t4potU
youtu.be
A Scientific Brain Drain Has Followed Trump’s Gutting Of The NIH - Dr. Francis Collins
YouTube video by The Late Show with Stephen Colbert
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Jonathan Sebat @sebatlab.bsky.social · 24/07/2025
I'm pretty sure that there would not be any context in my chatGPT conversations in which the chatbot would inclined to say "Hail Satan". I'm really missing out.
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Jonathan Sebat @sebatlab.bsky.social · 23/07/2025
Structural variants are significant contributor to autism. But many SVs & TRs are hard to detect with short reads. Long read sequencing with @pacbio.bsky.social and @nanoporetech.com captures and maps out alot of what short reads miss. So what can LR-WGS tell us about autism? 🧵
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Jonathan Sebat @sebatlab.bsky.social · 23/07/2025
Is there a limit to how many times someone can listen to “war pigs“ in one day? Asking for a friend.
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Jonathan Sebat @sebatlab.bsky.social · 16/07/2025
As we have learned, genes have dose-dependent effects on psychiatric traits. DOSAGE, it turns out, is a key element that helps unravel mechanisms of gene → pathway → cell type → brain region → diagnosis. Here we developed a framework to characterize cellular processes that mediate genetic effects.
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Jonathan Sebat @sebatlab.bsky.social · 16/07/2025
The field of neuroscience views the goal of human genetics as "finding genes". This is an outdated view. In whole genome studies of rare variants, finding genes is the easy part. The more interesting and important goal is to map out the causal pathway from genes to brain function to cognitive traits
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Reposted by Jonathan Sebat
Molly Przeworski @mollyprz.bsky.social · 23/05/2025
Now published in PNAS: www.pnas.org/doi/10.1073/...
pnas.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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Reposted by Jonathan Sebat
Abraham Palmer @abepalmer.bsky.social · 21/05/2025
I think this is great news for both companies.
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Jonathan Sebat @sebatlab.bsky.social · 19/05/2025
I really need to get a weiner dog. Every time I see someone walking their Dachshund, it's like an episode of Monty Python
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Jonathan Sebat @sebatlab.bsky.social · 15/05/2025
Harvard has a solid legal case, which makes their balls much bigger than Trump’s: “All PIs should continue to work on and charge project funds for now even if your grant has been terminated”
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Jonathan Sebat @sebatlab.bsky.social · 13/05/2025
Idea for in-depth peice of science journalism. Attend the conferences (1) American Association for Cancer Research, (2) JP Morgan Health, (3) MAHA 2025. Report what they are doing and what they are talking about. The average American can recognize real science when they see it
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Reposted by Jonathan Sebat
Angelica Ronald @angelicaronald.bsky.social · 07/05/2025
Our gene discovery project on age at onset of walking is out today! Find the paper here www.nature.com/articles/s41... Huge thanks to the cohorts, collaborators & coauthors, in particular first author Dr Anna Gui 1/n
nature.com
Genome-wide association meta-analysis of age at onset of walking in over 70,000 infants of European ancestry - Nature Human Behaviour
A genome-wide association study of age at onset of walking in over 70,000 infants found 11 significant loci. Age at onset of walking showed SNP heritability of 24%, a reliable polygenic score and gene...
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Reposted by Jonathan Sebat
Carl T. Bergstrom @carlbergstrom.com · 30/04/2025
Our canceled grant was one of many among these.
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Reposted by Jonathan Sebat
The Washington Post @washingtonpost.com · 16/04/2025
Thirty-eight of 43 experts cut last month from the boards that review the science and research that happens in laboratories at the National Institutes of Health are female, Black or Hispanic, according to an analysis by the chairs of a dozen of the boards.
washingtonpost.com
Women, minorities fired in purge of NIH science review boards
Scientists, with expertise in fields that include mental health, cancer and infectious disease, typically serve five-year terms and were not given a reason for their dismissal.
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Reposted by Jonathan Sebat
Aaron Besterman @abesterman.bsky.social · 09/04/2025
6/ Genetic diagnoses like this do more than end the “diagnostic odyssey.” They open the door to: 🧠 Understanding biology 🧬 Family cascade testing 👨‍👩‍👧‍👦 Reproductive planning 🧪 Natural history studies 💊 And—someday—targeted therapies
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Jonathan Sebat @sebatlab.bsky.social · 09/04/2025
Structural variants are often more complex than meets the eye! In this fun collaboration with @abesterman.bsky.social , long read WGS made it possible for us to get a genetic diagnosis in a complex mental health case of his at @radychildrensoc.bsky.social
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Jonathan Sebat @sebatlab.bsky.social · 09/04/2025
IF U SEE THIS POST A BEACH PHOTOGRAPH FROM UR TELEPHONE
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Jonathan Sebat @sebatlab.bsky.social · 08/04/2025
I just received the year 5 notice award on our R01 (genome wide studies of rare variants in psychiatric conditions). The NIH is alive!!!
media.tenor.com
a man wearing glasses and a brown suit is sitting on a couch and making a funny face .
ALT: a man wearing glasses and a brown suit is sitting on a couch and making a funny face .
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Jonathan Sebat @sebatlab.bsky.social · 19/03/2025
congrats @jaredwyoung.bsky.social !
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Reposted by Jonathan Sebat
bbrfoundation @bbrfoundation.bsky.social · 18/03/2025
Congratulations to the 2025 Distinguished Investigator Grantees! . Read the Press Release: ow.ly/oVn050Vk6vx . #mentalhealth #mentalhealthawareness #neuroscience #depression #anxiety #schizophrenia #autism #OCD #PTSD #BPD #bipolardisorder #ADHD #ADD
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Jonathan Sebat @sebatlab.bsky.social · 19/03/2025
The public wants answers on WHAT ARE THE CAUSES OF #AUTISM. This lecture takes a deep dive on genes, environment and #vaccines and how it works. Video quality is poor in the beginning, but don't skip the first 5 slides or the segment at 20:00-25:00 www.youtube.com/watch?v=Jiy9...
youtube.com
The Causes of Autism
YouTube video by UC San Diego Autism Center of Excellence
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Reposted by Jonathan Sebat
Annika Barber @annikabarber.bsky.social · 07/03/2025
Signs from #standupforscience in New Jersey (photos by K. Goodrich). Plus a bonus image of me being a loud little lady. 😝
Clever signs at science rallyMore clever signs! And Annika at top right being loud
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Brittany Barker @brittanysbarker.bsky.social · 07/03/2025
We had as much as 750 people at our Stand Up For Science rally today in Salem, OR!!! Huge success!! @standupforscience.bsky.social #standupforscience #sciencenotsilence
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Science Magazine @science.org · 07/03/2025
Breaking news: Thousands of researchers and their supporters, including recently fired federal workers, have gathered across the U.S. in response to layoffs and funding cuts ordered by the Trump administration. scim.ag/41zlPv4
scim.ag
Thousands gather across U.S. in Stand Up for Science events
Scientists rally across the country in response to layoffs and funding cuts ordered by the Trump administration
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Reposted by Jonathan Sebat
J. Chris Pires @jchrispires.bsky.social · 08/03/2025
Over 1,000 people, including community members, students, faculty, and staff, united today for a #MarchForScience event at Colorado State University in Fort Collins. It was inspiring to see us advocating for #science, #research and educational opportunities for all! #AcademicSky #MarchForScience2025
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