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Angelica Ronald

@angelicaronald.bsky.social
230 followers 386 following 8 posts

Professor of Psychology and Genetics at University of Surrey

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Angelica Ronald @angelicaronald.bsky.social · 02/07/2026
So pleased to see this toddler genetics project published- an enormous group effort, coming from my lab but with many, many collaborators & highlighting the excellent first author and analyst @anjahollowell.bsky.social #autism #adhd and related blog: communities.springernature.com/posts/geneti...
communities.springernature.com
Genetic influences on early temperament: why some toddlers charge around and others cling to the door
Our study, based on up to 78,000 toddlers, identifies the genes influencing early temperament and uncovers links with later life. This work represents a new field of genetic research on infancy and to...
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Joni Coleman @jonicoleman.bsky.social · 08/01/2026
PGS also associated with brain regions, including in developing human connectome project and with motor area regions of the developing brain.
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Joni Coleman @jonicoleman.bsky.social · 08/01/2026
To come - infant genomics toolkit, several infancy GWASs
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Joni Coleman @jonicoleman.bsky.social · 08/01/2026
Gene based results show enrichment with intellectual disability and autism, implying a shared developmental genetics? Genetics of walking seems to be brain-enriched
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Joni Coleman @jonicoleman.bsky.social · 08/01/2026
PGS explain 3-6% of variance in walking. 11 GWS independent loci. Effect sizes range from 0.06 months to 0.23 months. One locus associated with RBL2 via eQTL. Associated with Brunet-Wagner (hypotonia, motor impairments, unsteady or absent walking).
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Joni Coleman @jonicoleman.bsky.social · 08/01/2026
60k+ GWAS (just in EUR, need moar data from outside EUR!): www.nature.com/articles/s41...
nature.com
Genome-wide association meta-analysis of age at onset of walking in over 70,000 infants of European ancestry - Nature Human Behaviour
A genome-wide association study of age at onset of walking in over 70,000 infants found 11 significant loci. Age at onset of walking showed SNP heritability of 24%, a reliable polygenic score and gene...
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Joni Coleman @jonicoleman.bsky.social · 08/01/2026
Age of onset at walking - varies between 8-18 months. Complex and highly heritable. Combines a lot of different factors (motivation, muscles, coordination). Delays are often viewed as a red flag.
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Joni Coleman @jonicoleman.bsky.social · 08/01/2026
Significant twin heritabilities for lots of infant traits. GWAS are largely missing (3 reasonably sized ones prior to AR's work), but lots of use of other trait PGS to examine this.
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Joni Coleman @jonicoleman.bsky.social · 08/01/2026
Now Geli Ronald will talk about a genome wide association study of age at onset walking. Why study this age? Critical period for environment, rapid onset of developmental milestones and brain changes. Arguably under appreciated in common variant genetics.
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Dr Georgina Hosang @drhosang.bsky.social · 22/09/2025
*New paper* showing that subclinical #hypomania @ 18: -sig linked to 14 psychiatric/neurodev diagnoses -Highest genetic correlations: ADHD, drug & alcohol misuse -Highest enviro correlations: psychosis, anorexia & bipolar acamh.onlinelibrary.wiley.com/doi/full/10.... @angelicaronald.bsky.social
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London Genetics Network @ldngenenet.bsky.social · 14/07/2025
Thanks to @uniofsurrey.bsky.social for funding this event. London Genetics Network is a special interest group funded by the UK Genetic Society. If you are a researcher working in human genetics in London or the surrounding areas please email us to join the network: LondonGeneticsNetwork@gmail.com
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London Genetics Network @ldngenenet.bsky.social · 14/07/2025
🔔 LGN Summer Lecture! Wed 16 Jul @ UCL Bloomsbury. @dr-appie.bsky.social (Amsterdam UMC) on “Genetic Architecture of a Social Construct”. ☕ 15:30 coffee | 16:00 talk | 🤝 17:00 networking. Members: check your email for the invite from the LGN mailing list.
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Mike Inouye @mikeinouye.bsky.social · 12/06/2025
Realizing the promise of genome-wide association studies for effector gene prediction www.nature.com/articles/s41...
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Angelica Ronald @angelicaronald.bsky.social · 10/06/2025
On 26th June check out the conference @acamh.bsky.social ‘Neurodiversity: Cutting-Edge Research, Evolving Perspectives, and Effective Innovations - 2025 Jack Tizard Memorial International Conference’. www.acamh.org/event/neurod... Talks on new research and innovative approaches to #Neurodiversity
acamh.org
Neurodiversity: Cutting-Edge Research, Evolving Perspectives, and Effective Innovations - 2025 Jack Tizard Memorial International Conference
'Neurodiversity: Cutting-Edge Research, Evolving Perspectives, and Effective Innovations' is the 2025 Jack Tizard Memorial Conference that brings together leading experts to explore neurodiversity res...
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Nature @nature.com · 31/05/2025
Researchers with ADHD discuss its peaks and valleys and how they structure their work lives to succeed go.nature.com/3FitQh4
go.nature.com
Scientists with ADHD speak up: when fire meets focus
Nature - Researchers with ADHD discuss its peaks and valleys and how they structure their work lives to succeed.
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Melanie de Wit @mmdewit.bsky.social · 31/05/2025
(9/9) It was a great pleasure working on this with Morgan Morgan, Ilan Libedinsky, Chloe Austerberry, Sander Begeer, @dr-appie.bsky.social, @angelicaronald.bsky.social and @tincatwin.bsky.social
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Melanie de Wit @mmdewit.bsky.social · 31/05/2025
(8/9) To conclude, due to inconsistent associations and limited generalizability, we underscore that the autism polygenic score does not have clinical utility and should only be applied for scientific purposes, with improvements needed for a deeper understanding of autism’s polygenic underpinnings
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Melanie de Wit @mmdewit.bsky.social · 31/05/2025
(7/9) We show that the autism polygenic score, as a standalone variable associates consistently with autism diagnostic status but is unable to capture the spectrum’s complex phenotypical and etiological differences and its genetic overlap with other traits and conditions.
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Melanie de Wit @mmdewit.bsky.social · 31/05/2025
(6/9) Associations with outcomes other than those mentioned above were inconclusive and effect sizes generally small (median r = 0.03). Hence, our results suggest the autism polygenic score may lack the statistical power to adequately capture polygenic effects.
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Melanie de Wit @mmdewit.bsky.social · 31/05/2025
(5/9) Our systematic review also revealed evidence for associations with social behavior, depression, motor skills and physical activity, although these results show incongruency over samples.
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Melanie de Wit @mmdewit.bsky.social · 31/05/2025
(4/9) A meta-analysis of nine studies revealed strong evidence for an association between the autism polygenic score and autism diagnosis in independent cohorts (meta-analytic r = 0.158 (95% CI 0.067 – 0.249)), which supports the polygenic score’s specificity.
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Melanie de Wit @mmdewit.bsky.social · 31/05/2025
(3/9) The latest autism GWAS, led by @jakobgrove.bsky.social led to a wealth of studies assessing the relations between the autism PGS and various phenotypes. We included a total of 72 of these studies.
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Melanie de Wit @mmdewit.bsky.social · 31/05/2025
(2/9) 🧬Genetic factors play a substantial role in the etiology of autism and its co-occurrence with other conditions and traits. We aimed to clarify the associations between the autism polygenic score and autism diagnosis, autistic traits, and related behavioral and neurobiological traits
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Melanie de Wit @mmdewit.bsky.social · 31/05/2025
(1/9) 📣 OUT NOW! 📣 So excited to share that our systematic review and meta-analysis on the autism polygenic score is now published in JAACAP Open @jaacapjournals.bsky.social. doi.org/10.1016/j.ja... A (long) thread of our main findings ⤵️
doi.org
Redirecting
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Daniel MacArthur @dgmacarthur.bsky.social · 24/05/2025
Excited to be in Milan for #eshg2025! If you’re interested in leading analysis of large, diverse cohorts with WGS and cellular genomic data in Australia, I’d be keen to chat - we’re looking to fill a variety of senior comp bio roles: populationgenomics.org.au/careers/ #eshg25
populationgenomics.org.au
Careers - Centre for Population Genomics
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Ted Schwaba @tedmond.bsky.social · 20/05/2025
Extremely excited to share the first effort of the Revived Genomics of Personality Consortium: A highly-powered, comprehensive GWAS of the Big Five personality traits in 1.14 million participants from 46 cohorts. www.biorxiv.org/content/10.1...
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 16/05/2025
Want to learn more? Read: 'Scientists discover the genes influencing when babies take their first steps' www.surrey.ac.uk/news/scienti.... And 'Genes influencing when babies walk discovered, and these genes affect longer-term outcomes too' communities.springernature.com/posts/genes-...
surrey.ac.uk
Scientists discover the genes that influence when babies start walking | University of Surrey
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 16/05/2025
📣Out now 📣 In a GWAS meta-analysis, @angelicaronald.bsky.social and colleagues identified 11 independent genome-wide significant loci associated with age at onset of walking. www.nature.com/articles/s41...
nature.com
Genome-wide association meta-analysis of age at onset of walking in over 70,000 infants of European ancestry - Nature Human Behaviour
A genome-wide association study of age at onset of walking in over 70,000 infants found 11 significant loci. Age at onset of walking showed SNP heritability of 24%, a reliable polygenic score and gene...
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King's Perinatal Functional Imaging Group, Tomoki Arichi @kingspfig.bsky.social · 08/05/2025
Very excited about this important piece of work with @angelicaronald.bsky.social characterising gene associations with age of walking onset. We also show using dHCP data that these are related to volume in key brain motor regions (like the deep grey nuclei and cerebellum) even as a newborn infant
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Surrey Psychology @surreypsychology.bsky.social · 07/05/2025
🧬 👶 🐥 How do genes influence when a baby takes their first step? Our colleague Prof Angelica Ronald explores this question in a fascinating new blog post on Psychology Today. Drawing on her team’s recent publ in #NatureHumanBehaviour and #NatureGenetics. www.psychologytoday.com/us/blog/surr...
psychologytoday.com
How Genes Influence the Timing of a Baby's First Step
The science behind motor milestones and learning to walk.
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Nature Human Behaviour @nathumbehav.nature.com · 07/05/2025
A genome-wide association study of age at onset of walking in over 70,000 infants found 11 significant loci. Age at onset of walking showed SNP heritability of 24%, a reliable polygenic score and genetic overlap with ADHD and brain phenotypes.
nature.com
Genome-wide association meta-analysis of age at onset of walking in over 70,000 infants of European ancestry - Nature Human Behaviour
A genome-wide association study of age at onset of walking in over 70,000 infants found 11 significant loci. Age at onset of walking showed SNP heritability of 24%, a reliable polygenic score and genetic overlap with ADHD and brain phenotypes.
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University of Surrey @uniofsurrey.bsky.social · 07/05/2025
Scientists discover the genes influencing when babies take their first steps, study finds: www.surrey.ac.uk/news/scienti... @angelicaronald.bsky.social
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Simon Fisher @profsimonfisher.bsky.social · 07/05/2025
Common DNA variants account for around a quarter of variability in age at onset of walking "...an important milestone that links genetically to a range of later health, educational & behavioural outcomes", according to new @nathumbehav.nature.com paper by @angelicaronald.bsky.social & colleagues.🧬🧪
nature.com
Genome-wide association meta-analysis of age at onset of walking in over 70,000 infants of European ancestry - Nature Human Behaviour
A genome-wide association study of age at onset of walking in over 70,000 infants found 11 significant loci. Age at onset of walking showed SNP heritability of 24%, a reliable polygenic score and gene...
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Angelica Ronald @angelicaronald.bsky.social · 07/05/2025
Our gene discovery project on age at onset of walking is out today! Find the paper here www.nature.com/articles/s41... Huge thanks to the cohorts, collaborators & coauthors, in particular first author Dr Anna Gui 1/n
nature.com
Genome-wide association meta-analysis of age at onset of walking in over 70,000 infants of European ancestry - Nature Human Behaviour
A genome-wide association study of age at onset of walking in over 70,000 infants found 11 significant loci. Age at onset of walking showed SNP heritability of 24%, a reliable polygenic score and gene...
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Angelica Ronald @angelicaronald.bsky.social · 11/03/2025
The London Genetics Network has arrived on Bluesky! Follow us here if you'd like @ldngenenet.bsky.social
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Nature Reviews Psychology @natrevpsychol.nature.com · 05/03/2025
Compassion as a transdiagnostic target to reduce mental health symptoms and promote well-being Review by James N. Kirby (@jameskirby.bsky.social) Web: go.nature.com/43lyXqc PDF: rdcu.be/echYo #psychology #clinicalpsych #psychscisky
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BPS Developmental Section @bpsdevsection.bsky.social · 25/02/2025
Hear from our prize winners and our keynote speakers Prof Gaia Scerif and @angelicaronald.bsky.social at our Annual Conference at Royal Holloway, University of London
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