Quantile aggregation may lead to overstated claims about amyloid-cognition relationships

This study evaluates the quantile-aggregation method using both simulated data and publicly available Alzheimer disease randomized trial data.

This study evaluates the quantile-aggregation method using both simulated data and publicly available Alzheimer disease randomized trial data.

<em>Alzheimer's & Dementia: Translational Research & Clinical Interventions</em> journal bridges drug discovery research and clinical studies for dementia & Alzheimer's.

Background Amyloid removal has been used as a surrogate outcome in Alzheimer’s disease trials, allowing accelerated approval of aducanumab and lecanemab. The A4 (Alzheimer’s Clinical Trial Consortium ...

Federal officials said Harvard must enact “merit-based reform” in hiring and admissions and report international students who broke rules, among other steps. Harvard called the demands unlawful.

The administration has now targeted five schools’ federal funding as part of a pledge to combat what it considers to be antisemitism on university campuses.

"The criteria we use to discuss science and pseudoscience are incredibly context dependent."

INTRODUCTION Studies use multiple different instruments to measure dementia-related outcomes, making head-to-head comparisons of interventions difficult. METHODS To address this gap, we developed ...

“Lecanemab has given us more years together. That’s not ‘minute’ nor ‘minimal’ to me,” writes one reader in STAT’s letters to the editor this week.

Epidemiologists have advocated for reporting confidence intervals and deemphasizing P values to address long-standing concerns about null-hypothesis statistical-significance testing, P hacking, and re...