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Jason Rehg

@rehg-j.bsky.social
41 followers 27 following 11 posts

Neuroscientist and musician 🧠🎶 mainly here for the pretty pictures 🎇🔬

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Reposted by Jason Rehg
Keri Martinowich @martinowk.bsky.social · 10/06/2026
Excited to see this preprint from @drjennkim.bsky.social @kr-maynard.bsky.social, Annie Ciernia and colleagues. I've highlighted this approach and toolset in several recent talks: spatial transcriptomics isn't just about the gene expression - www.biorxiv.org/content/10.6...
biorxiv.org
Spatially-resolved integration of microglia morphological diversity and gene expression using Visium with protein co-detection
Microglia exhibit a dynamic range of morphologies that actively shift in response to local environmental cues. There has been a concerted effort as a field to move away from dualistic characterization...
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Reposted by Jason Rehg
Keri Martinowich @martinowk.bsky.social · 15/05/2026
For #FluorescenceFriday, celebrating some more good paper news with this really pretty image labeling prefrontal cortical neurons with projections to the locus coeruleus with chemogenetic receptors. Image credit to @rehg-j.bsky.social @jorge-miranda.bsky.social 🧠🧪🔬
Fluorescent microscopy image of a section of mouse brain tissue with viral labeling with green and red fluorophores. Overlap makes neurons appear yellowish-orange on image.
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Reposted by Jason Rehg
Keri Martinowich @martinowk.bsky.social · 11/04/2026
For #FluorescenceFriday - really pretty neuron in the medial prefrontal cortex that projects to locus coeruleus. Image credit to @rehg-j.bsky.social, with a big round of congratulations on acceptance/matriculation to the Hopkins Neuro PhD program this Fall - we are so happy for you!! 🧠🔬
Virally labeled neuron in red in the medial prefrontal cortex of a section of mouse brain in a sea of blue (DAPI labeled cells)
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Reposted by Jason Rehg
Keri Martinowich @martinowk.bsky.social · 20/03/2026
For #FluorescenceFriday 🧠🔬🧪 - mPFC projection neurons heading to ventral tegmental area 🟢 or the locus coeruleus 🔴. Processes on some of these GPF+ neurons are just AMAZING! Image credit to our Circuits team! @jorge-miranda.bsky.social @rehg-j.bsky.social and Daniel Olivares!
Fluorescence microscopy of a section of mouse brain tissue with neurons labeled in green and red based on projection target
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Reposted by Jason Rehg
Jorge Miranda Barrientos @jorge-miranda.bsky.social · 13/02/2026
Great feeling for a friday. First cell from the new rig. Still a lot of work to do on the rig, but we are patching. Feels like going back to your first love ❤️ 😍
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Reposted by Jason Rehg
Jorge Miranda Barrientos @jorge-miranda.bsky.social · 13/03/2026
It is so nice to see some mPFC neurons lighting up. Maybe they know its friday and they are also excited for the weekend like me. #fluorescenceFriday #miniscope
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Reposted by Jason Rehg
Keri Martinowich @martinowk.bsky.social · 13/03/2026
For #FluorescenceFriday - really neat looking image from experiments optimizing dual projector labeling in the mouse brain for circuit-based spatial transcriptomic profiling that I am very excited about 🤩🔬🧠 Image credit to @rehg-j.bsky.social
Microscopy image showing viral labeling of a section of the mouse brain with fluorescent proteins to label projection neurons in the hippocampus in green and the amygdala in pink
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Reposted by Jason Rehg
Keri Martinowich @martinowk.bsky.social · 20/02/2026
For #FluorescenceFriday - some fresh off the scope images of intermingled (🔴 🟢) projection neurons in the mouse prefrontal cortex heading to locus coeruleus or ventral tegmental area. Image credit to Dan Olivares, @jorge-miranda.bsky.social @rehg-j.bsky.social 🔬🧠🧪
Microscope image of fluorescently labeled red and green neurons in a section of brain tissue
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Reposted by Jason Rehg
Keri Martinowich @martinowk.bsky.social · 19/12/2025
Some fiery prefrontal cortical neurons projecting to the locus coeruleus that are labeled in the mouse brain #FluorescenceFriday 🧠🔬🔥 Image credit to @rehg-j.bsky.social and the @lieberinstitute.bsky.social Circuits Team
Projection neurons in the mouse brain with a red fluorescent tag on them
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Reposted by Jason Rehg
Anthony Ramnauth @philoneurosci.bsky.social · 16/12/2025
Glad to have contributed to this cool project! spaTransfer: transfer learning for single- #cell and spatial #transcriptomics data using non-negative matrix factorization www.biorxiv.org/content/10.6...
biorxiv.org
spaTransfer: transfer learning for single-cell and spatial transcriptomics data using non-negative matrix factorization
Recent advances in spatially-resolved transcriptomics have enabled profiling of gene expression in a spatial context, which has led to the generation of large-scale single-cell and spatial atlases wit...
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Reposted by Jason Rehg
Jorge Miranda Barrientos @jorge-miranda.bsky.social · 15/12/2025
So happy to share this preprint and so proud of @rehg-j.bsky.social and his hard work and determination. Here we showed circuit-specific effect after activation of mPFC-LC projectors to sustained attention during rCPT.
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Reposted by Jason Rehg
Keri Martinowich @martinowk.bsky.social · 16/12/2025
Huge congratulations and kudos to RA @rehg-j.bsky.social @jorge-miranda.bsky.social who led this study that is a continuation of ongoing collaboration between the Circuits group in our division with the @lieberinstitute.bsky.social Behavioral Pharmacology group led by Greg Carr! 🧠🧪
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Jason Rehg @rehg-j.bsky.social · 15/12/2025
Finally on Bluesky and I’m really excited to share this latest preprint with @jorge-miranda.bsky.social in which we functionally examined the role of a medial prefrontal cortex (mPFC)- Locus Coeruleus (LC) circuit in regulating sustained attention. 1/7 www.biorxiv.org/content/10.6...
biorxiv.org
Top-down control of sustained attention by the medial prefrontal cortex (mPFC)- locus coeruleus (LC) circuit during the rodent continuous performance task (rCPT)
The medial prefrontal cortex (mPFC) plays a pivotal role in attention by exerting top-down control to allocate cognitive resources toward behaviorally relevant stimuli based on learned context and exp...
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Reposted by Jason Rehg
Keri Martinowich @martinowk.bsky.social · 10/01/2025
For #FluorescenceFriday - cortical neurons projecting to the locus coeruleus 🔵 in the mouse brain 🔬🧠🧪👩‍🔬
Microscope image of a tissue section from mouse brain showing cortical neurons projecting to the locus coeruleus labeled with a fluorophore.
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Reposted by Jason Rehg
Keri Martinowich @martinowk.bsky.social · 16/01/2025
Multiple times this week in one of our conference rooms… HR/leadership peep: That’s weird, who’s trapping who? Me (visibly excited): Oh!!! That’s probably us!! It’s cells, like some CELLS get trapped, or we trap all the cells! Blank stares Me: Like with viruses, in the brain! Raised eyebrows
Writing on a whiteboard that says “everybody gets trapped”
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Reposted by Jason Rehg
Keri Martinowich @martinowk.bsky.social · 17/01/2025
Well, for this experiment we definitely TRAPPED some! Fresh data off the scope from Hopkins Neuro grad student Suhaas Adirajiu for a 2nd #FluorescentFriday from me :)
Cells in the mouse medial prefrontal cortex labeled with mCherry using the TRAP2 system for capturing stimulus-dependent neuronal ensembles
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Reposted by Jason Rehg
Keri Martinowich @martinowk.bsky.social · 31/01/2025
In honor of some really exciting new data manipulating this cell population - image for #FluorescenceFriday shows activated neurons in the mouse amygdala that project to the lateral septum. Image credit to @rphillips3.bsky.social 🔬🧠😍
Microscopy image of activated labeled projection neurons in the mouse amygdala
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Reposted by Jason Rehg
Keri Martinowich @martinowk.bsky.social · 25/04/2025
The 20X zoom might be even prettier 🤩 Image credits to the Circuits team in the @lieberinstitute.bsky.social Translational Neuroscience division #FluorescenceFriday
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Reposted by Jason Rehg
Keri Martinowich @martinowk.bsky.social · 24/10/2025
For #FluorescenceFriday - projection neurons from the mouse prefrontal cortex to the locus coeruleus 🔴 with Fos labeling activated cells 🟢. Image credit to the Circuits team in the Translational Neuroscience Division @lieberinstitute.bsky.social 🧠🔬🧪
Image captured at 4X on a fluorescence microscope showing a tissue section through the mouse prefrontal cortex where neurons that project to the locus coeruleus in the brainstem are virally labeled in red and neurons that are activated are labeled with Fos in green.
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Reposted by Jason Rehg
Keri Martinowich @martinowk.bsky.social · 14/11/2025
Me lurking in people's folders on the server for #FluorescenceFriday. Image is so fresh off the scope that I don't even know what it is so I can't even tell you what the channels are - but, somebody (RA Jason Rehg) is doing something in the VTA and whatever it is, it looks super cool 🤩🧠🔬🧪
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Reposted by Jason Rehg
Keri Martinowich @martinowk.bsky.social · 21/11/2025
One more #FluorescenceFriday to give some ❤️ to the mouse 🧠 - I really like the orientation of this slice - locus coeruleus is labeled here with tyrosine hydroxylase in PINK with some virally-labeled axons traversing through in ORANGE 🔬🧪 Image credit to RA Daniel Olivares on our Circuits team!
Immunostaining on a section of the mouse brain for tyrosine hydroxylase to label the locus coeruleus
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Reposted by Jason Rehg
Keri Martinowich @martinowk.bsky.social · 12/12/2025
For #FluorescenceFriday - experiment was apparently a stereotaxic injection "miss", but resulted in a lovely image nevertheless. Credit to @rphillips3.bsky.social and JHU undergrad Natalia Gonzalez-Perez 🧠🔬🧪
Viral labeling of projection neurons in the mouse brain with green fluorescence protein
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