Chromatin accessibility shapes the ability of transcription factors (TFs) and the transcriptional machinery to engage genomic DNA and therefore plays a central role in gene regulation. Two widely used...

NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Request for Information: Proposal to Cap the Number of Simultaneous Research Project Grants per Principal Investigator ...

Artificial intelligence is rapidly accelerating scientific output, but risks narrowing inquiry, weakening judgement and undermining how scientists are trained.

The metabolite αKG promotes carnitine synthesis and increases site-specific histone acetylation, thereby promoting homologous recombination-mediated DNA repair, which has potential implications f...

JHU president, University of Kansas chancellor urge federal agencies to release congressionally appropriated funds to fuel America's research engine

The science community fears the funding agency’s slow contract and grant making could result in another rush of multiyear obligations at the end of the fiscal year. The NIH director has said, “Don’t p...

Cellular responses to stimuli can involve learned behaviors through memory formation. Here, the authors show that cancer cells encode gene expression into cellular memories during therapy resistance v...