Sodium-glucose cotransporter 2 inhibitors (SGLT2i) reduce mortality in heart failure, but their pharmacological target remains unclear. In this study, we showed that SGLT2i directly activate pantothen...

The metabolite αKG promotes carnitine synthesis and increases site-specific histone acetylation, thereby promoting homologous recombination-mediated DNA repair, which has potential implications f...

The metabolite αKG promotes carnitine synthesis and increases site-specific histone acetylation, thereby promoting homologous recombination-mediated DNA repair, which has potential implications f...

Metabolic adaptations are key to cancer cell survival in nutrient-limited microenvironments, but strategies for coping with arginine scarcity are poorly understood. Dunlap et al. use CRISPR screening and metabolomics to identify the plasma membrane transporter SLC7A5 as a citrulline transporter essential for cancer cell growth under arginine limitation.