iiinova — where your digital self keeps evolving

Reposted by Michele Frison

Osman Lab @osman-lab.bsky.social · 07/02/2026

🧬 Introducing the #mtDNA Lab Intel Pipeline! Our system daily scans PubMed and bioRxiv to bring you: 📄 #Gemini generated Daily Dossiers (PDF) and 🎙️ #NotebookLM generated Podcasts with a focus on #mtDNA-QC and #mtDNA-copy-number 📂 Full Archive: drive.google.com/drive/folder...

Square, neon-colored illustration announcing a “Daily Briefing” on mtDNA, showing mitochondria, DNA, AI icons, literature stacks, exercise symbols, and a bar graph, in a futuristic purple-pink style.

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Michele Frison @frisophagy.bsky.social · 26/01/2026

Good morning everyone, below is last issue of #mitophagy news 🪫 🔋 🗑️ biomed.news/bims-tofagi/... This week you'll find insights on the role of mitophagy in germline cells and in inheritance of mtDNA, in mice and in the male arabidopsis germline Thanks to @biomednews.bsky.social for pre-sorting

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Michele Frison @frisophagy.bsky.social · 11/01/2026

Welcome to another week of mitophagy papers! 🪫🗑️ biomed.news/bims-tofagi/... highlights: -A rab1 A Rab1 interactome illuminates a dual role in autophagy and membrane trafficking -a review on the role of superoxide in mitophagy -USP15 inhibition ameliorates PD phenotype in mouse models of disease

Figure 1. Rab1A and Rab1B MitoID ident ifies novel Rab1 effectors. (A) Schematic of the Rab1-MitoID approach in which Rab1 is fused to the promiscuous biotin ligase BirA* and a mitochondrial localization signal from monoamine oxidase (depicted in red), resulting in the relocalization of Rab1 to the mitochondrial membrane. Rab1 interactors will be efficiently biotinylated, while other Golgi proteins and Rab interactors are not. (B) Two-dimensional plot comparing the enrichment of proteins biotinylated by Rab1A-MitoID vs control (BirA alone), plotted against the enrichment of proteins biotinylated with GTP-locked Rab1A (QL) vs GDP-locked Rab1A (SN). For the x axis, the value plotted is that for the nucleotide form of Rab1 that gave the greatest fold change over background. For clarity, Rab1A itself is not shown, as it is part of the BirA* construct. Known effectors and regulators are indicated, with known effectors being enriched in the upper right quadrant. Zoomed regions to the right show a region demarcated by well-enriched known effectors with novel proteins of note identified. For all protein identities and enrichment values see Table S1. (C) as for (B) except with Rab1B rather than Rab1A. (D) Overrepresented GO terms for biological process of the proteins within the regions demarcated by known effectors shown in B and C with the known effectors removed. Ranking is by the summed FDR and enrichment rank. (E) Immunoblots of binding to GST-Rab1A–coated beads of the indicated proteins from HEK293A cell lysates. Rab1A was either Q70L (GTP) or S25N (GDP). The known Rab1 effector RABEP1 (rabaptin-5) is included as positive control (Valsdottir et al., 2001). Source data are available for this figure: SourceData F1.

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Reposted by Michele Frison

Sam J Wilson @samjwilsonphd.bsky.social · 27/11/2025

How does fever work? Our new Science paper shows how elevated body temperature can protect against severe influenza and that avian-origin viruses escape this defence. This is likely one reason why bird flus and some pandemic influenzas can be so severe.🧵 www.science.org/doi/10.1126/...

science.org

Avian-origin influenza A viruses tolerate elevated pyrexic temperatures in mammals

Host body temperature can define a virus’s replicative profile—influenza A viruses (IAVs) adapted to 40° to 42°C in birds are less temperature sensitive in vitro compared with human isolates adapted t...

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Reposted by Michele Frison

RyanLab_TCD @ryanlab.bsky.social · 23/11/2025

📢Last 2 weeks of #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️ biomed.news/bims-imicid/... biomed.news/bims-imicid/... Exciting to have a paper in the collection! An inherited mitochondrial DNA mutation remodels inflammatory cytokine responses in macrophages and in vivo in mice

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Michele Frison @frisophagy.bsky.social · 23/11/2025

In this week's mitophagy news: -a novel screen for endogenous modulators of PINK1-Parkin pathway uncovers unstudied dependencies -autophagy regulation by phase separation, avidity and wetting -a bacterial mitophagy receptor to evade inflammation biomed.news/bims-tofagi/...

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Reposted by Michele Frison

Journal of Cell Biology @jcb.org · 21/11/2025

Liu et al. discover that pathogenic bacteria use a shared strategy to exploit the host’s cellular recycling process, #mitophagy. Through an effector protein that acts as an external receptor, bacteria suppress inflammatory responses to promote #infection rupress.org/jcb/article/... #Autophagy

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Michele Frison @frisophagy.bsky.social · 16/11/2025

Only good papers on mitophagy this week! biomed.news/bims-tofagi/... Highlights: -The bottleneck for maternal transmission of mtDNA is linked to purifying selection by autophagy -Piecemeal Mitochondrial degradation in plants -Allophagy?! Thanks to @biomednews.bsky.social

Altered bottleneck and mitochondrial turnover affect mtDNA mutation load and selection efficiency.
(A) Mutational burden was quantified as the total number of mtDNA variants detected per animal. (B) For each animal, the mtDNA N/S ratio was calculated by dividing the number of nonsynonymous variants, normalized to the number of possible nonsynonymous variants in the mitochondrial genome, by the number of synonymous variants, normalized to the number of possible synonymous sites. For (A) and (B): dashed line, median value of the Polg+/+ control group; dotted line, modal value of the Polg+/+ control group; gray, Polg+/+ control group; orange, Polg+/+ Tfam+/− group; blue, Polg+/+ Tfam+/OE group; green, Polg+/+ Bcl2l13−/− group; and pink, Polg+/+ Ulk2−/− group.

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Michele Frison @frisophagy.bsky.social · 04/11/2025

Mitophagy updates of last week 🪫🗑️ biomed.news/bims-tofagi/... Highlights: -two papers on the beneficial effects of mitophagy in CD8+ T cells -VPS35 mutations in PD affect PINK1/Parkin mitophagy selectively -review on selective autophagy initiation Thanks to @biomednews.bsky.social for pre-sorting

Left, soluble SARs such as SQSTM1/p62, NDP52, OPTN, TAX1BP1, and NBR1 are cytosolic proteins that are recruited to cargo on demand. Their recruitment is commonly driven by ubiquitin (Ub) marks on damaged or misfolded cargo, enabling rapid and flexible targeting of diverse substrates. Upon recruitment, these SARs concentrate autophagy initiation factors at the cargo site to initiate autophagosome biogenesis. Right, transmembrane SARs such as NIX, BNIP3, FAM134B, and CCPG1 are stably integrated within organelle membranes. To prevent unwanted autophagy activation, these SARs require additional layers of control. Selective autophagy can be triggered by transcriptional upregulation (e.g., hypoxia-driven induction of NIX/BNIP3), post-translational modifications such as ubiquitination, or SAR clustering. ER-phagy SARs further promote local membrane bending and scission to excise a portion of the organelle for autophagic removal. While some SARs are transcriptionally induced, others—such as FAM134B—are constitutively present and rely primarily on clustering and post-translational regulation, providing SAR-specific modes of control over autophagosome formation.

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Reposted by Michele Frison

Christian Frezza @frezzalab.bsky.social · 04/11/2025

Wonderful work from @mito-oncogene.bsky.social and @edreznik.bsky.social on the role of mito ribosomal RNA in cancer.

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Michele Frison @frisophagy.bsky.social · 26/10/2025

In this week's issue of mitophagy news 🗑️🪫 biomed.news/bims-tofagi/... -High sugar diet inhbits renal mitophagy and disrupts renal function -a review by @soleimanpourlab.bsky.social on mitophagy in diabetic ß-cells -Optineurin is necessary for mitochondrial removal during erythrocyte maturation

Assessment of mitophagy in the Malphigian tubules of the dmt-Keima Drosophila kidney

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Reposted by Michele Frison

Scott Soleimanpour @soleimanpourlab.bsky.social · 22/10/2025

New from us! Had a question about mitophagy but were afraid to ask? 😂 Excited to review the latest advances in beta cell mitophagy research as a key adaptive response in all forms of diabetes in @cp-trendsendomet.bsky.social. We'd be honored if you have it a read! #T1D #T2D

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Reposted by Michele Frison

Jack Collier @mitocollier.bsky.social · 14/10/2025

🔥 Check out our new paper! @natcellbio.nature.com Also thanks to @embo.org for their Postdoctoral Fellowship and especially to Mai and Heidi, I learned more than I could ever have imagined in Montreal 🇨🇦 🍁

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Reposted by Michele Frison

Johannes Zuber @johanneszuber.bsky.social · 09/10/2025

Just out in @science.org: Together with the lab of @wilhelmpalm.bsky.social, we used sequential in-vitro/in-vivo CRISPR screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...

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Michele Frison @frisophagy.bsky.social · 10/10/2025

How can mitophagy be an effective quality control mechanism if mtDNA mutations reach high enough levels to cause disease? This question led us into a dark path, full of concepts of evolutionary genetics, germline stem cell biology and mito-nuclear compatibility. www.science.org/doi/10.1126/...

science.org

Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations

Mitochondrial synthesis of adenosine triphosphate is essential for eukaryotic life but is dependent on the cooperation of two genomes: nuclear and mitochondrial DNA (mtDNA). mtDNA mutates ~15 times as...

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Reposted by Michele Frison

Scott Soleimanpour @soleimanpourlab.bsky.social · 08/10/2025

🚨How do mitochondria sense and respond to metabolic stress from the environment in diabetes? 🤔 In new work out in #ScienceAdvances, we show that innate immune signaling promotes β cell compensation for metabolic stress by engaging mitophagy. 🚨1/n www.science.org/doi/10.1126/...

science.org

TRAF6 integrates innate immune signals to regulate glucose homeostasis via Parkin-dependent and Parkin-independent mitophagy

TRAF6 bridges innate immune signaling to mitophagy to promote glucose control during metabolic stress.

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Michele Frison @frisophagy.bsky.social · 05/10/2025

In this week's mitophagy news 🪫🗑️ biomed.news/bims-tofagi/... ⚡The PP2A-B55α phosphatase is a master regulator of mitochondrial degradation and biogenesis⚡ -Mitochondrial ROS triggers mitophagy through activating the DNA damage response signaling pathway Thanks to @biomednews.bsky.social

PP2A-B55α activates TFEB upon mitochondrial damage to support Parkin-dependent mitophagy.

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Reposted by Michele Frison

Mongabay @mongabay.com · 02/10/2025

Jane Goodall, who revealed the intimate lives of chimpanzees and gave the modern world a language of hope, has died at the age of 91. “Every individual matters. Every individual has a role to play. Every individual makes a difference,” she told audiences. Those words remain her truest epitaph.

news.mongabay.com

Jane Goodall (1934–2025): primatologist, conservationist, and messenger of hope

Jane Goodall, who revealed the intimate lives of chimpanzees and gave the modern world a language of hope, has died at the age of 91. Over the course of six decades, she moved from an unlikely young…

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Michele Frison @frisophagy.bsky.social · 29/09/2025

Lots of interesting papers in this week's mitophagy news! 🗑️🪫 biomed.news/bims-tofagi/... -Ubiquitin precursor with C-terminal extension promotes proteostasis and longevity -Pink1 KO leads to APP-induced dopaminergic pathology -An OMM-rupture sensor

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Michele Frison @frisophagy.bsky.social · 14/09/2025

In this week's issue of mitophagy news 🪫🗑️: -Urolithin A increases healthspan via MERCS and Ca2+-mitophagy -Parkin Induces Ubiquitination and Large Extracellular Vesicle Release of HMGB1 to Activate Antitumor Immunity -a Parkin and hTau mouse cross biomed.news/bims-tofagi/...

Urolithin A ameliorates the age-dependent decline of ER-mitochondria contacts and alters intracellular Ca2+ balance.

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Reposted by Michele Frison

Raywat Deonandan 🍁🇨🇦 @deonandan.bsky.social · 02/09/2025

I love looking at this graph, showing it to my students, and sharing it on social media, even though it unerringly brings out the trolls. This is the efficacy curve of Pfizer's mRNA COVID vaccine. This, people, is what ended the emergency phase of the COVID pandemic. Despite what RFK Jr says.

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Michele Frison @frisophagy.bsky.social · 30/08/2025

Interesting data from macrophages

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Michele Frison @frisophagy.bsky.social · 17/08/2025

In this week's issue of #mitophagy news: -Mitochondrial damage (AntA) in neurons trigger degradation of negative autophagy regulators -transcriptional dynamics of mitophagy during muscle development -And much more 🪫🗑️ Link 👇 biomed.news/bims-tofagi/...

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Reposted by Michele Frison

Jim Hurley @jimhurley.bsky.social · 31/07/2025

Congratulations @kev-in-situ-et.bsky.social and the whole team on in situ cryo-ET images of OA-induced mitochondria damage and Parkin-dependent mitophagy out now tinyurl.com/25b82cp4. We couldn't have done it without in situ guru @wilflinglab.bsky.social and mito guru @samlewis.bsky.social .‬

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Michele Frison @frisophagy.bsky.social · 05/08/2025

Last week's mitophagy news is packed with papers!! 📚🧑‍💻 Full list 👇 biomed.news/bims-tofagi/... Highlights: -in vitro reconstitution of receptor-mediated mitophagy reveals key principles -cytosolic phosphoUbiquitin inhibits proteasomal activity and is neurotoxic Thanks to @biomednews.bsky.social

Ubiquitin phosphorylation inhibits both ubiquitin chain elongation and ubiquitin proteasome interactions.

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Michele Frison @frisophagy.bsky.social · 27/07/2025

Below is the link to another week of #mitophagy papers! 🔋🗑️ biomed.news/bims-tofagi/... Thanks to @biomednews.bsky.social for pre-sorting. This week's highlight: PNPLA7 is required for the Parkin-dependent mitophagy shut-down that leads to mitochondrial accumulation in adipose tissue browning

PNPLA7 is a MAM protein and interacts with Parkin to facilitate mitochondrial translocation of Parkin.

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Reposted by Michele Frison

Elias Adriaenssens @elias-adriaenssens.bsky.social · 25/07/2025

And it's out! I'm thrilled to share our new paper (Adriaenssens et al., Nat Cell Biol 2025). This paper describes a new mechanism for the initiation of autophagosome biogenesis. We found that this WIPI-ATG13-driven pathway is preferentially used by a group of transmembrane autophagy receptors.

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Reposted by Michele Frison

Scott Soleimanpour @soleimanpourlab.bsky.social · 21/07/2025

Type 2 diabetes is often considered a protein misfolding disease. But where are these toxic proteins found? 🤔 🚨In new work out today in @natmetabolism.nature.com, we show that mitochondrial protein misfolding (yes mitos🤯) leads to beta cell damage in T2D. 🚨 nature.com/articles/s42... 1/n

nature.com

LONP1 regulation of mitochondrial protein folding provides insight into beta cell failure in type 2 diabetes - Nature Metabolism

LONP1, whose expression is downregulated in islets from donors with type 2 diabetes, is vital to mediate efficient mitochondrial protein folding, thus preventing proteotoxicity and promoting islet β c...

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Reposted by Michele Frison

Eric Topol @erictopol.bsky.social · 17/07/2025

A big day for preventing mitochondrial diseases from transmitting to the next generation www.nature.com/articles/d41... www.nejm.org/doi/full/10.... www.nejm.org/doi/full/10.... www.nejm.org/doi/full/10....

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Michele Frison @frisophagy.bsky.social · 06/07/2025

In this week's mitophagy news🫀🪫🗑️: -cardiac deficiency in fatty acid oxidation (Cpt2 KO) inhibits cardioprotective mitophagy and is rescued by Usp30 KO -neuronal metabolism prioritises mitophagy over glycolysis -Rab7 downregulation impairs cardioprotective mitophagy in ischemic heart failure

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Michele Frison @frisophagy.bsky.social · 29/06/2025

In this week's #mitophagy news we have novel insights into: -Parkin's ubiquitination of Miro1🚙 -Swine Fever Virus's induction of mitophagy 🐽🤒 -cardioprotective mitophagy in obesity-associated heart failure🫀🗑️🪫 Papers in the link below biomed.news/2025-06-29 Thanks to @biomednews.bsky.social

Active Parkin processes ubiquitin most efficiently with Miro1 as substrate

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Michele Frison @frisophagy.bsky.social · 22/06/2025

Another fantastic week of #mitophagy papers! 🪫🗑️📚 biomed.news/bims-tofagi/... Highlights: -astrocyte HK2 interacts with PINK1 to facilitate glucose-rich mitophagy -Nipsnap1/2 KO accelerates murine ageing -UBR4 is a mitophagy linked risk factor in lung adenocarcinoma @biomednews.bsky.social

PINK and Parkin-dependent mitophagy is faster in astrocytes than neurons after mitochondrial depolarization in primary mouse neuronal-glial cultures

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Michele Frison @frisophagy.bsky.social · 15/06/2025

This week I will be finally presenting my postdoc data in an exciting webinar on #ubiquitin biology, together with an old classmate of mine. If your interested, follow the link below

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Michele Frison @frisophagy.bsky.social · 15/06/2025

A short, but exciting report on #mitophagy papers this week!! 🪰🐒 biomed.news/bims-tofagi/... Thanks to @biomednews.bsky.social -Mitochondrial fumarate impairs Parkin-dependent mitophagy, but *not* in invertebrates 🪰 -swapping 🚹 mtDNA with 🐒 in iPSCs gives surprising results

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Michele Frison @frisophagy.bsky.social · 08/06/2025

Fascinating science in this week's #mitophagy news 👁️👁️🔥 biomed.news/bims-tofagi/... -Retinal development requires a wave of PINK1-dependent mitophagy -an AI-assisted imaging technique identified a novel mitophagy drug that decreases Abeta aggregation Thanks to @biomednews.bsky.social

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